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Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse
Open accessAbstract
The spontaneous mutant mouse strain,plt/plt, lacks the secondary lymphoid organ chemokine (SLC)-ser gene and has disrupted trafficking of T cells and dendritic cells (DCs) to lymphoid tissues. We demonstrate here that the gene for the related chemokine, Epstein–Barr virus-induced molecule-1 ligand chemokine (ELC), is also deleted in this immunodeficient mouse strain. Using a combination of approaches, including bone marrow reconstitution and double in situ hybridization, we show in wild-type mice that ELC is expressed by T zone stromal cells that also make SLC. Smaller amounts of ELC are made by DCs, predominantly of the CD8+phenotype. We propose that ELC- and SLC-expressing T zone stromal cells play a central role in bringing naive T cells and DCs together for the initiation of immune responses.
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Citations
Cited by
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Förster, R., Davalos-Misslitz, A. C., & Rot, A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2297 · Cited by 1,410
Moussion, C., Ortega, N., & Girard, J.-P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003331 · Cited by 1,179
Dendritic-cell trafficking to lymph nodes through lymphatic vessels
Randolph, G. J., Angeli, V., & Swartz, M. A. (2005) · Nature Reviews Immunology · doi:10.1038/nri1670 · Cited by 1,111
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Ohl, L., Mohaupt, M., Czeloth, N., Hintzen, G., Kiafard, Z., Zwirner, J., Blankenstein, T., Henning, G., & Förster, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.014 · Cited by 1,086
Stromal Cell Networks Regulate Lymphocyte Entry, Migration, and Territoriality in Lymph Nodes
Bajénoff, M., Egen, J. G., Koo, L. Y., Laugier, J. P., Brau, F., Glaichenhaus, N., & Germain, R. N. (2006) · Immunity · doi:10.1016/j.immuni.2006.10.011 · Cited by 963
Metadata
- Authors
- Luther, S. A., Tang, H. L., Hyman, P. L., Farr, A. G., & Cyster, J. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-11-07
- Volume
- 97
- Issue
- 23
- Pages
- 12694-12699
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2081487051
- Cited by
- 595
- References
- 0
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. https://app.cochat.ai/papers/10.1073/pnas.97.23.12694
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- Luther, S. A., Tang, H. L., Hyman, P. L., Farr, A. G., & Cyster, J. G. (2000). Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.23.12694
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