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Cited by 417

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands

Open access
Jalali, Shila, del Pozo, Miguel A., Chen, Kuang-Den, Miao, Hui, Li, Yi-Shuan, Schwartz, Martin A., Shyy, John Y.-J., Chien, Shu·2001·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.98.3.1042
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Abstract

The aim of this study is to elucidate the role of integrins in transducing fluid shear stress into intracellular signals in vascular endothelial cells, a fundamental process in vascular biology. We demonstrated that shear stress activates specific integrins in endothelial cells plated on substrates containing the cognate extracellular matrix (ECM) ligands. The shear stress-induced mechanotransduction, as manifested by integrin–Shc association, was abolished when new integrin–ECM ligand interactions were prevented by either blocking the integrin-binding sites of ECM ligands or conjugating the integrins to immobilized antibodies. Our results indicate that the dynamic formation of new connections between integrins and their specific ECM ligands is critical in relaying the signals induced by shear stress to intracellular pathways.

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Metadata

Authors
Jalali, S., del Pozo, M. A., Chen, K.-D., Miao, H., Li, Y.-S., Schwartz, M. A., Shyy, J. Y.-J., & Chien, S.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2001-01-23
Volume
98
Issue
3
Pages
1042-1046
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.98.3.1042
OpenAlex
W2161054601
Cited by
417
References
22
FWCI
8.99
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. https://app.cochat.ai/papers/10.1073/pnas.98.3.1042
The paper
Jalali, S., del Pozo, M. A., Chen, K.-D., Miao, H., Li, Y.-S., Schwartz, M. A., Shyy, J. Y.-J., & Chien, S. (2001). Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.98.3.1042

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.