The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans
Open accessAbstract
Somatically mutated IgM+-only and IgM+IgD+CD27+B lymphocytes comprise ≈25% of the human peripheral B cell pool. These cells phenotypically resemble class-switched B cells and have therefore been classified as postgerminal center memory B cells. X-linked hyper IgM patients have a genetic defect characterized by a mutation of the CD40L gene. These patients, who do not express a functional CD40 ligand, cannot switch Ig isotypes and do not form germinal centers and memory B cells. We report here that an IgM+IgD+CD27+B cell subset with somatically mutated Ig receptors is generated in these patients, implying that these cells expand and diversify their Ig receptors in the absence of classical cognate T–B collaboration. The presence of this sole subset in the absence of IgM+-only and switched CD27+memory B cells suggests that it belongs to a separate diversification pathway.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Alizadeh, A. A., Eisen, M. B., Davis, R. E., Ma, C., Lossos, I. S., Rosenwald, A., Boldrick, J. C., Sabet, H., Tran, T., Yu, X., et al. (2000) · Nature · doi:10.1038/35000501 · Cited by 9,925
CD40 AND CD154 IN CELL-MEDIATED IMMUNITY
Grewal, I. S., & Flavell, R. A. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.111 · Cited by 1,539
Klein, U., Rajewsky, K., & Küppers, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.9.1679 · Cited by 1,154
Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T., & Kikutani, H. (1994) · Immunity · doi:10.1016/1074-7613(94)90095-7 · Cited by 1,108
T Cell-Independent Antigens Type 2
Mond, J. J. (1995) · Annual Review of Immunology · doi:10.1146/annurev.immunol.13.1.655 · Cited by 824
CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM
DiSanto, J. P., Bonnefoy, J. Y., Gauchatt, J. F., Fischer, A., & Saint Basile, G. D. (1993) · Nature · doi:10.1038/361541a0 · Cited by 704
Self-citationHumoral immune responses in CD40 ligand-deficient mice.
Renshaw, B. R., Fanslow, W. C., Armitage, R. J., Campbell, K. A., Liggitt, D., Wright, B., Davison, B. L., & Maliszewski, C. R. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.5.1889 · Cited by 536
Hollenbaugh, D., Grosmaire, L. S., Kullas, C. D., Chalupny, N. J., Braesch-Andersen, S., Noelle, R. J., Stamenkovic, I., Ledbetter, J. A., & Aruffo, A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05530.x · Cited by 511
Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27
Tangye, S. G., Liu, Y.-J., Aversa, G., Phillips, J. H., & de Vries, J. E. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.9.1691 · Cited by 455
Oliver, A. M., Martin, F., Gartland, G. L., Carter, R. H., & Kearney, J. F. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270935 · Cited by 427
Cited by
Chiorazzi, N., Rai, K. R., & Ferrarini, M. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041720 · Cited by 1,296
Sanz, I., Wei, C., Jenks, S. A., Cashman, K. S., Tipton, C., Woodruff, M. C., Hom, J., & Lee, F. E.-H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02458 · Cited by 569
Autoreactivity in Human IgG+ Memory B Cells
Tiller, T., Tsuiji, M., Yurasov, S., Velinzon, K., Nussenzweig, M. C., & Wardemann, H. (2007) · Immunity · doi:10.1016/j.immuni.2007.01.009 · Cited by 478
Pillai, S., Cariappa, A., & Moran, S. T. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115728 · Cited by 466
Transcriptional analysis of the B cell germinal center reaction
Klein, U., Tu, Y., Stolovitzky, G. A., Keller, J. L., Haddad, J., Miljkovic, V., Cattoretti, G., Califano, A., & Dalla-Favera, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437996100 · Cited by 409
Metadata
- Authors
- Weller, S., Faili, A., Garcia, C., Braun, M. C., Le Deist, F., de Saint Basile, G., Hermine, O., Fischer, A., Reynaud, C.-A., & Weill, J.-C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-01-30
- Volume
- 98
- Issue
- 3
- Pages
- 1166-1170
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1990826881
- Cited by
- 398
- References
- 29
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans. https://app.cochat.ai/papers/10.1073/pnas.98.3.1166
- The paper
- Weller, S., Faili, A., Garcia, C., Braun, M. C., Le Deist, F., de Saint Basile, G., Hermine, O., Fischer, A., Reynaud, C.-A., & Weill, J.-C. (2001). CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.98.3.1166
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
