The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27
Open accessAbstract
Memory B cells isolated from human tonsils are characterized by an activated cell surface phenotype, localization to mucosal epithelium, expression of somatically mutated immunoglobulin (Ig) variable (V) region genes, and a preferential differentiation into plasma cells in vitro. In spleens of both humans and rodents, a subset of memory B cells is believed to reside in the marginal zone of the white pulp. Similar to tonsil-derived memory B cells, splenic marginal zone B cells can be distinguished from naive follicular B cells by a distinct cell surface phenotype and by the presence of somatic mutations in their Ig V region genes. Although differences exist between human naive and memory B cells, no cell surface molecules have been identified that positively identify all memory B cells. In this study, we have examined the expression of the receptor-type protein tyrosine phosphatase CD148 on human B cells. CD148+ B cells present in human spleen exhibited characteristics typical of memory B cells. These included an activated phenotype, localization to the marginal zone, the expression of somatically mutated Ig V region genes, and the preferential differentiation into plasma cells. In contrast, CD148− B cells appeared to be naive B cells due to localization to the mantle zone, the expression of surface antigens typical of unstimulated B cells, and the expression of unmutated Ig V region genes. Interestingly, CD148+ B cells also coexpressed CD27, whereas CD148− B cells were CD27−. These results identify CD148 and CD27 as markers which positively identify memory B cells present in human spleen. Thus, assessing expression of these molecules may be a convenient way to monitor the development of memory B cell responses in immunocompromised individuals or in vaccine trials.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MacLennan, I. C. M. (1994) · Annual Review of Immunology · doi:10.1146/annurev.immunol.12.1.117 · Cited by 1,729
Clonal selection and learning in the antibody system
Rajewsky, K. (1996) · Nature · doi:10.1038/381751a0 · Cited by 1,709
Mechanism of antigen-driven selection in germinal centres
Liu, Y.-J., Joshua, D. E., Williams, G. T., Smith, C. A., Gordon, J., & MacLennan, I. C. M. (1989) · Nature · doi:10.1038/342929a0 · Cited by 1,081
Self-citationB70 antigen is a second ligand for CTLA-4 and CD28
Azuma, M., Ito, D., Yagita, H., Okumura, K., Phillips, J. H., Lanier, L. L., & Somoza, C. (1993) · Nature · doi:10.1038/366076a0 · Cited by 909
Self-citationKüppers, R., Zhao, M., Hansmann, M. L., & Rajewsky, K. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06189.x · Cited by 663
Analysis of somatic mutation in five B cell subsets of human tonsil.
Pascual, V, Liu, Y. J., Magalski, A., de Bouteiller, O., Banchereau, J., & Capra, J. D. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.1.329 · Cited by 648
Self-citationTomlinson, I. M., Walter, G., Marks, J. D., Llewelyn, M. B., & Winter, G. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90223-7 · Cited by 603
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.
Cifone, M. G., De Maria, R., Roncaioli, P., Rippo, M. R., Azuma, M., Lanier, L. L., Santoni, A., & Testi, R. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.4.1547 · Cited by 573
Generation of Memory B Cells and Plasma Cells in Vitro
Arpin, C., Déchanet, J., Van Kooten, C., Merville, P., Grouard, G., Brière, F., Banchereau, J., & Liu, Y.-J. (1995) · Science · doi:10.1126/science.7537388 · Cited by 571
Self-citationCells in the Marginal Zone of the Spleen
Kraal, G. (1992) · International Review of Cytology · doi:10.1016/s0074-7696(08)62453-5 · Cited by 401
Cited by
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Alizadeh, A. A., Eisen, M. B., Davis, R. E., Ma, C., Lossos, I. S., Rosenwald, A., Boldrick, J. C., Sabet, H., Tran, T., Yu, X., et al. (2000) · Nature · doi:10.1038/35000501 · Cited by 9,925
Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease
Yazar, S., Alquicira-Hernandez, J., Wing, K., Senabouth, A., Gordon, M. G., Andersen, S., Lu, Q., Rowson, A., Taylor, T. R. P., Clarke, L., et al. (2022) · Science · doi:10.1126/science.abf3041 · Cited by 682
Sanz, I., Wei, C., Jenks, S. A., Cashman, K. S., Tipton, C., Woodruff, M. C., Hom, J., & Lee, F. E.-H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02458 · Cited by 569
Autoreactivity in Human IgG+ Memory B Cells
Tiller, T., Tsuiji, M., Yurasov, S., Velinzon, K., Nussenzweig, M. C., & Wardemann, H. (2007) · Immunity · doi:10.1016/j.immuni.2007.01.009 · Cited by 478
Peripheral development of B cells in mouse and man
Carsetti, R., Rosado, M. M., & Wardmann, H. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0109.x · Cited by 473
Metadata
- Authors
- Tangye, S. G., Liu, Y.-J., Aversa, G., Phillips, J. H., & de Vries, J. E.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1998-11-02
- Volume
- 188
- Issue
- 9
- Pages
- 1691-1703
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2170620478
- Cited by
- 455
- References
- 47
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27. https://app.cochat.ai/papers/10.1084/jem.188.9.1691
- The paper
- Tangye, S. G., Liu, Y.-J., Aversa, G., Phillips, J. H., & de Vries, J. E. (1998). Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.188.9.1691
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
