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Enhanced Amyloidogenic Processing of the β-Amyloid Precursor Protein in Gene-targeted Mice Bearing the Swedish Familial Alzheimer's Disease Mutations and a “Humanized” Aβ Sequence
Open accessAbstract
The processing of the beta-amyloid precursor protein (APP) in vivo has been characterized in a novel animal model that recapitulates, in part, the APP genotype of a familial form of Alzheimer's disease (AD). A gene-targeting strategy was used to introduce the Swedish familial AD mutations and convert mouse Abeta to the human sequence. The mutant APP is expressed at normal levels in brain, and cleavage at the mutant beta-secretase site is both accurate and enhanced. Furthermore, human Abeta production is significantly increased to levels 9-fold greater than those in normal human brain while nonamyloidogenic processing is depressed. The results on Abeta production extend similar findings obtained in cell culture to the brain of an animal and substantiate Abeta as a etiological factor in Swedish familial AD. These animals provide several distinguishing features over others created by conventional transgenic methodologies. The spatial and temporal expression patterns of human Abeta are expected to be faithfully reproduced because the gene encoding the mutant APP remains in its normal chromosomal context. Thus, the neuropathological consequences of human Abeta overproduction can be evaluated longitudinally in the absence of potential mitigating effects of APP overexpression or presence of the mouse Abeta peptide.
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“To overcome these issues, KI mouse models with familial AD mutations have been generated [10, 24, 31, 32].”
From Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease (2019) · cites this paper as [24]
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“These genetic findings led to several transgenic mouse models that successfully recapitulated Aβ plaque formation, increasing support for the hypothesis (Table 1) [23–29].”
From Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau (2021) · cites this paper as [28]
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Schägger, H., & von Jagow, G. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90587-2 · Cited by 11,420
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404
Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Manipulating the mouse embryo: A laboratory manual
Hogan, B. L. M., Costantini, F. D., & Lacy, E. (1986) · Cited by 4,460
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
The molecular pathology of Alzheimer's disease
Selkoe, D. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90052-2 · Cited by 2,708
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.
Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., & Roder, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8424 · Cited by 2,328
Manipulating the mouse embryo: A laboratory manual
Johnson, M. (1986) · Trends in Genetics · doi:10.1016/0168-9525(86)90275-1 · Cited by 2,259
Altering the Genome by Homologous Recombination
Capecchi, M. R. (1989) · Science · doi:10.1126/science.2660260 · Cited by 2,037
Amyloid β-peptide is produced by cultured cells during normal metabolism
Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., et al. (1992) · Nature · doi:10.1038/359322a0 · Cited by 1,921
Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., & Selkoe, D. J. (1992) · Nature · doi:10.1038/360672a0 · Cited by 1,757
Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schiossmacher, M., Whaley, J., Swindlehurst, C., et al. (1992) · Nature · doi:10.1038/359325a0 · Cited by 1,731
Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683
Rapid induction of Alzheimer A beta amyloid formation by zinc
Bush, A., Pettingell, W., Multhaup, G., d Paradis, M., Vonsattel, J., Gusella, J., Beyreuther, K., Masters, C., & Tanzi, R. (1994) · Science · doi:10.1126/science.8073293 · Cited by 1,522
Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B., & Lannfelt, L. (1992) · Nature Genetics · doi:10.1038/ng0892-345 · Cited by 1,513
Suzuki, N., Cheung, T. T., Cai, X.-D., Odaka, A., Otvos, L., Eckman, C., Golde, T. E., & Younkin, S. G. (1994) · Science · doi:10.1126/science.8191290 · Cited by 1,471
Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor
Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D., & Ward, P. J. (1990) · Science · doi:10.1126/science.2111583 · Cited by 1,403
Goldgaber, D., Lerman, M. I., McBride, O. W., Saffiotti, U., & Gajdusek, D. C. (1987) · Science · doi:10.1126/science.3810169 · Cited by 1,359
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., & Mulligan, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90011-m · Cited by 1,281
Cardiac Malformation in Neonatal Mice Lacking Connexin43
Reaume, A. G., Sousa, P. A. D., Kulkarni, S., Langille, B. L., Zhu, D., Davies, T. C., Juneja, S. C., Kidder, G. M., & Rossant, J. (1995) · Science · doi:10.1126/science.7892609 · Cited by 1,243
Self-citationChartier-Harlin, M.-C., Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., Goate, A., Rossor, M., Roques, P., Hardy, J., et al. (1991) · Nature · doi:10.1038/353844a0 · Cited by 1,214
Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome
Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985) · Annals of Neurology · doi:10.1002/ana.410170310 · Cited by 1,159
Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity
Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S., & Ito, H. (1988) · Nature · doi:10.1038/331530a0 · Cited by 1,083
A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors
Ponte, P. A., Gonzalez‐DeWhitt, P. A., Schilling, J., Miller, J., Hsu, D. K., Greenberg, B., Davis, K. L., Wallace, W., Lieberburg, I. M., Fuller, F. H., et al. (1988) · Nature · doi:10.1038/331525a0 · Cited by 1,050
Self-citationRelease of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor
Cai, X.-D., Golde, T. E., & Younkin, S. G. (1993) · Science · doi:10.1126/science.8424174 · Cited by 913
Beta-amyloid precursor protein cleavage by a membrane-bound protease.
Sisodia, S. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.6075 · Cited by 738
Mattson, M. P., Cheng, B., Culwell, A. R., Esch, F. S., Lieberburg, I., & Rydel, R. E. (1993) · Neuron · doi:10.1016/0896-6273(93)90315-i · Cited by 656
Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease
Rumble, B. A., Retallack, R. W., Hilbich, C., Simms, G., Multhaup, G., Martins, R. N., Hockey, A., Montgomery, P., Beyreuther, K. T., & Masters, C. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906013202203 · Cited by 656
Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.
Busciglio, J., Gabuzda, D. H., Matsudaira, P., & Yankner, B. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.2092 · Cited by 569
Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide
Seubert, P. A., Oltersdorf, T., Lee, M., Barbour, R., Blomquist, C. L., Davis, D. L., Bryant, K., Fritz, L. C., Galasko, D., Thal, L. J., et al. (1993) · Nature · doi:10.1038/361260a0 · Cited by 559
Hsiao, K., Borchelt, D., Olson, K., Johannsdottir, R., Kitt, C. A., Yunis, W. S., Xu, S., Eckman, C., Younkin, S. G., Price, D., et al. (1995) · Neuron · doi:10.1016/0896-6273(95)90107-8 · Cited by 526
The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice
LaFerla, F. M., Tinkle, B. T., Bieberich, C. J., Haudenschild, C. C., & Jay, G. (1995) · Nature Genetics · doi:10.1038/ng0195-21 · Cited by 513
Formation of β-amyloid protein deposits in brains of transgenic mice
Quon, D. H., Wang, Y., Catalano, R., Scardina, J. M., Murakami, K., & Cordell, B. (1991) · Nature · doi:10.1038/352239a0 · Cited by 405
Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.
Hung, A. Y., Haass, C., Nitsch, R. M., Qiu, W. Q., Citron, M., Wurtman, R. J., Growdon, J. H., & Selkoe, D. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49409-x · Cited by 400
Citron, M., Vigo-Pelfrey, C., Teplow, D. B., Miller, C., Schenk, D., Johnston, J., Winblad, B., Venizelos, N., Lannfelt, L., & Selkoe, D. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.11993 · Cited by 366
The pathological association between down syndrome and Alzheimer disease
Mann, D. M. A. (1988) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(88)90041-3 · Cited by 346
Haass, C., Hung, A. Y., Selkoe, D. J., & Teplow, D. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32503-6 · Cited by 319
Metabolism of the “Swedish” Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells
Thinakaran, G., Teplow, D. B., Siman, R., Greenberg, B., & Sisodia, S. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9390 · Cited by 317
Self-citationIntroduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice
Lamb, B. T., Sisodia, S. S., Lawler, A. M., Slunt, H. H., Kitt, C. A., Kearns, W. G., Pearson, P. L., Price, D. L., & Gearhart, J. D. (1993) · Nature Genetics · doi:10.1038/ng0993-22 · Cited by 311
Secreted Forms of β‐Amyloid Precursor Protein Protect Against Ischemic Brain Injury
Smith‐Swintosky, V. L., Pettigrew, L. C., Craddock, S. D., Culwell, A. R., Rydel, R. E., & Mattson, M. P. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63020781.x · Cited by 284
Naruse, S., Igarashi, S., Aoki, K., Kaneko, K., Iihara, K., Miyatake, T., Kobayashi, H., Inuzuka, T., Shimizu, T., Kojima, T., et al. (1991) · The Lancet · doi:10.1016/0140-6736(91)91612-x · Cited by 281
Genomic organization of the human amyloid beta-protein precursor gene
Yoshikai, S.-I., Sasaki, H., Doh‐ura, K., Furuya, H., & Sakaki, Y. (1990) · Gene · doi:10.1016/0378-1119(90)90310-n · Cited by 276
Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.
Buxbaum, J. D., Koo, E. H., & Greengard, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9195 · Cited by 274
Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice
Mucke, L., Masliah, E., Johnson, W. B., Ruppe, M. D., Alford, M. F., Rockenstein, E. M., Forss‐Petter, S., Pietropaolo, M., Mallory, M. E., & Abraham, C. R. (1994) · Brain Research · doi:10.1016/0006-8993(94)90767-6 · Cited by 270
Rockenstein, E. M., McConlogue, L., Tan, H. T., Power, M., Masliah, E., & Mucke, L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.47.28257 · Cited by 255
Research advances in Alzheimer's disease and related disorders
Iqbal, K., & Disorders, R. (1995) · Wiley eBooks · Cited by 228
König, G., Mönning, U., Czech, C., Prior, R., Banati, R. B., Schreiter-Gasser, U., Bauer, J., Masters, C. L., & Beyreuther, K. T. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50090-4 · Cited by 217
Suzuki, T., Oishi, M., Marshak, D. R., Czernik, A. J., Nairn, A. C., & Greengard, P. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06360.x · Cited by 216
Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells
Anderson, J. P., Esch, F. S., Keim, P. S., Sambamurti, K., Lieberburg, I. M., & Robakis, N. K. R. K. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90775-o · Cited by 212
Strooper, B. D., Simons, M., Multhaup, G., LEUVEN, F. V., Beyreuther, K. T., & Dotti, C. G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00176.x · Cited by 176
Tamaoka, A., Odaka, A., Ishibashi, Y., Usami, M., Sahara, N., Suzuki, N., Nukina, N., Mizusawa, H., Shoji, S., & Kanazawa, I. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)30050-8 · Cited by 168
Amyloidogenicity of rodent and human βA4 sequences
Dyrks, T., Dyrks, E., Masters, C. L., & Beyreuther, K. T. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81399-k · Cited by 158
Strooper, B. D., Umans, L., Leuven, F. V., & BERGHE, H. V. D. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.2.295 · Cited by 153
Complementary DNA for the mouse homolog of the human amyloid beta protein precursor
Yamada, T., Sasaki, H., Furuya, H., Miyata, T., Goto, I., & Sakaki, Y. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90419-0 · Cited by 151
Kammesheidt, A., Boyce, F. M., Spanoyannis, A., Cummings, B. J., Ortegón, M. E., Cotman, C. W., Vaught, J. L., & Neve, R. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10857 · Cited by 150
Ötvös, L., Szendrei, G. I., Lee, V. M.-Y., & Mantsch, H. H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb19893.x · Cited by 122
Simple and efficient production of embryonic stem cell-embryo chimeras by coculture.
Wood, S. A., Pascoe, W. S., Schmidt, C., Kemler, R., Evans, M. J., & Allen, N. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4582 · Cited by 98
Fuller, S. J., Storey, E., Li, Q.-X., Smith, A. I., Beyreuther, K., & Masters, C. L. (1995) · Biochemistry · doi:10.1021/bi00025a015 · Cited by 80
Pearson, B. E., & Choi, T. K. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.22.10578 · Cited by 77
Amyloid precursor protein secretion and βA4 amyloid generation are not mutually exclusive
Dyrks, T., Mönning, U., Beyreuther, K. T., & Turner, J. D. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00671-7 · Cited by 75
Strooper, B. D., Craessaerts, K., Dewachter, I., Moechars, D., Greenberg, B., LEUVEN, F. V., & BERGHE, H. V. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.4058 · Cited by 63
Self-citationHiggins, L. S., Catalano, R., Quon, D. H., & Cordell, B. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb23056.x · Cited by 50
Savage, M. J., Iqbal, M., Loh, T., Trusko, S. P., Scott, R., & Siman, R. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90490-1 · Cited by 42
Self-citationMutant and native human β-amyloid precursor proteins in transgenic mouse brain
Howland, D. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00078-s · Cited by 40
Self-citationAraki, E., Yamada, T., Takemura, K., Yamaguchi, H., Sakimura, K., Goto, I., & Sakaki, Y. (1995) · Amyloid · doi:10.3109/13506129509031894 · Cited by 4
Research works printed but not linked: 2
- Sauer, 1990, New Biol., 2, 441
- Kim, 1990, Neurosci. Res. Commun., 7, 113
Cited by
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APP mouse models for Alzheimer’s disease preclinical studies.
Sasaguri, H., Nilsson, P., Hashimoto, S., Nagata, K., Saito, T., De Strooper, B., Hardy, J., Vassar, R., Winblad, B., & Saido, T. C. (2017) · The EMBO Journal · doi:10.15252/embj.201797397 · Cited by 793
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Götz, J., Bodea, L., & Goedert, M. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0054-8 · Cited by 419
Sago, H., Carlson, E. J., Smith, D. J., Kilbridge, J., Rubin, E. M., Mobley, W. C., Epstein, C. J., & Huang, T.-T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6256 · Cited by 382
Metadata
- Authors
- Reaume, A. G., Howland, D. S., Trusko, S. P., Savage, M. J., Lang, D. M., Greenberg, B. D., Siman, R., & Scott, R. W.
- Corresponding author
- Scott, Richard W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-09
- Volume
- 271
- Issue
- 38
- Pages
- 23380-23388
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2001834310
- Cited by
- 150
- References
- 69
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 2 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 7 · 2012: 8
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid precursor protein, amyloidogenic processing, gene-targeted mice, animal models of Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Animals, Base Sequence, Brain Chemistry, Chimera, Disease Models, Animal, Genotype, Humans, Molecular Sequence Data, Mutation, Peptide Fragments, Endopeptidases, Protein Processing, Post-Translational, Sweden, Aspartic Acid Endopeptidases, Amyloid beta-Protein Precursor, Gene Targeting, Mice, Amyloid Precursor Protein Secretases
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