Interferon Regulatory Factor-2 Directs Transcription from the gp91 Promoter
Open accessAbstract
Repressor elements in the gp91(phox) promoter are necessary to restrict tissue-specific transcription to mature phagocytes. Deletion of these elements leads to significant promoter activity in cell lines such as HEL and K562 that do not normally express gp91(phox). The -100 to +12 base pair gp91(phox) promoter region is sufficient to direct maximal de-repressed transcription in these cells. However, promoter activity is dramatically decreased following a 16-base pair truncation that deletes an interferon-stimulated response element. This element interacts with IRF-1 and IRF-2, members of the interferon regulatory factor family of transcription factors. In addition, this promoter region is bound by a factor with properties similar to BID, a DNA-binding protein that also interacts with three upstream sites within the gp91(phox) promoter. Transient transfection studies using mutated promoters indicate that both the IRF and BID binding sites are required for maximal gp91(phox) promoter activity. Overexpression of IRF-1 or IRF-2 in K562 cells leads to transactivation of gp91(phox) promoter constructs, which is dependent on the presence of an intact IRF binding site. IRF-2 predominates in macrophages that express the gp91(phox) gene as well as in HEL and K562 cells. We conclude that IRF-2 and BID activate gp91(phox) promoter activity in the absence of transcriptional repression.
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Previous studies found IRF2 activates transcription of some genes involved in the innate immune response.
“Previous studies found IRF2 activates transcription of some genes involved in the innate immune response (23, 44 -46).”
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- Authors
- Luo, W., & Skalnik, D. G.
- Affiliations
- Indiana University Indianapolis (US)
- Corresponding author
- Skalnik, David G.
- ORCID
- Luo, Wen
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-09
- Volume
- 271
- Issue
- 38
- Pages
- 23445-23451
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1971688493
- Cited by
- 67
- References
- 51
- Citations by year
- 2021: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2012: 3
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (CA58947)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- IRF2, IRF1, NADPH oxidase, interferon-stimulated response element, Bid, transcriptional activation, transcriptional repression, macrophages, K562 cells, HEL cells
- MeSH terms
- NADPH Oxidase 2, Binding Sites, Cell Differentiation, DNA-Binding Proteins, Humans, Membrane Glycoproteins, Models, Genetic, Phosphoproteins, Promoter Regions, Genetic, Protein Binding, Recombinant Proteins, Repressor Proteins, Transcription Factors, Transcription, Genetic, Tumor Cells, Cultured, DNA Probes, Transcriptional Activation, Trans-Activators, Sequence Deletion, NADPH Oxidases, Interferon Regulatory Factor-2, Interferon Regulatory Factor-1
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