The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Slow Degradation of Aggregates of the Alzheimer's Disease Amyloid β-Protein by Microglial Cells
Open accessAbstract
Microglia are immune system cells associated with senile plaques containing beta-amyloid (Abeta) in Alzheimer's disease. Although microglia are an integral part of senile plaques, their role in the development of Alzheimer's disease is not known. Because microglia are phagocytic cells, it has been suggested that microglia may function as plaque-attacking scavenger cells. Microglia bind and internalize microaggregates of Abeta that resemble those present in dense Alzheimer's disease plaques. In this study, we compared the degradation by microglia of Abeta microaggregates with the degradation of two other proteins, acetylated low density lipoprotein and alpha2-macroglobulin. We found that the majority of the internalized Abeta in microaggregates was undegraded 72 h after uptake, whereas 70-80% of internalized acetylated low density lipoprotein or alpha2-macroglobulin was degraded and released from cells in trichloroacetic acid-soluble form after 4 h. In the continued presence of fluorescent Abeta microaggregates for 4 days, microglia took up huge amounts of Abeta and became engorged with undigested material. These data suggest that microglia can slowly degrade limited amounts of Abeta plaque material, but the degradation mechanisms can be overwhelmed by larger amounts of Abeta.
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Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
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Metadata
- Authors
- Paresce, D. M., Chung, H., & Maxfield, F. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-11
- Volume
- 272
- Issue
- 46
- Pages
- 29390-29397
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2009639401
- Cited by
- 271
- References
- 78
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Paresce, D. M., Chung, H., & Maxfield, F. R. (1997). Slow Degradation of Aggregates of the Alzheimer's Disease Amyloid β-Protein by Microglial Cells. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.46.29390
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
