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Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule
Open accessAbstract
We previously reported a new type of signal-transducing adaptor molecule, STAM, which was shown to be involved in cytokine-mediated intracellular signal transduction. In this study, we molecularly cloned a 110-kDa phosphotyrosine protein inducible by stimulation with interleukin 2 (IL-2). The 110-kDa molecule was found to be a human counterpart of mouse Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and to be associated with STAM. Tyrosine phosphorylation of Hrs is induced rapidly after stimulation with IL-2 and granulocyte-macrophage colony-stimulating factor as well as hepatocyte growth factor. The mutual association sites of Hrs and STAM include highly conserved coiled-coil sequences, suggesting that their association is mediated by the coiled-coil structures. Exogenous introduction of the wild-type Hrs significantly suppressed DNA synthesis upon stimulation with IL-2 and granulocyte-macrophage colony-stimulating factor, while the Hrs mutant deleted of the STAM-binding site lost such suppressive ability. These results suggest that Hrs counteracts the STAM function which is critical for cell growth signaling mediated by the cytokines.
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Predicting coiled coils from protein sequences.
Lupas, A., Van Dyke, M., & Stock, J. (1991) · Science · doi:10.1126/science.252.5009.1162 · Cited by 3,953
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THE ESCRT COMPLEXES: Structure and Mechanism of a Membrane-Trafficking Network
Hurley, J. H., & Emr, S. D. (2006) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.040405.102126 · Cited by 546
Hofmann, K., & Falquet, L. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01835-7 · Cited by 444
Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila
Lloyd, T. E., Atkinson, R., Wu, M. N., Zhou, Y., Pennetta, G., & Bellen, H. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00611-6 · Cited by 401
Dell'Angelica, E. C., Puertollano, R., Mullins, C., Aguilar, R. C., Vargas, J. D., Hartnell, L. M., & Bonifacino, J. S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.1.81 · Cited by 363
Metadata
- Authors
- Asao, H., Sasaki, Y., Arita, T., Tanaka, N., Endo, K., Kasai, H., Takeshita, T., Endo, Y., Fujita, T., & Sugamura, K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 272
- Issue
- 52
- Pages
- 32785-32791
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2036673687
- Cited by
- 188
- References
- 1
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Asao, H., Sasaki, Y., Arita, T., Tanaka, N., Endo, K., Kasai, H., Takeshita, T., Endo, Y., Fujita, T., & Sugamura, K. (1997). Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.52.32785
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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