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Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila

Lloyd, Thomas E., Atkinson, Richard, Wu, Mark N., Zhou, Yi, Pennetta, Giuseppa, Bellen, Hugo J.·2002·Cell
DOI 10.1016/s0092-8674(02)00611-6
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Abstract

Signaling through tyrosine kinase receptors (TKRs) is thought to be modulated by receptor-mediated endocytosis and degradation of the receptor in the lysosome. However, factors that regulate endosomal sorting of TKRs are largely unknown. Here, we demonstrate that Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) is one such factor. Electron microscopy studies of hrs mutant larvae reveal an impairment in endosome membrane invagination and formation of multivesicular bodies (MVBs). hrs mutant animals fail to degrade active epidermal growth factor (EGF) and Torso TKRs, leading to enhanced signaling and altered embryonic patterning. These data suggest that Hrs and MVB formation function to downregulate TKR signaling.

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Metadata

Authors
Lloyd, T. E., Atkinson, R., Wu, M. N., Zhou, Y., Pennetta, G., & Bellen, H. J.
Venue
Cell
Publisher
Elsevier BV
Published
2002-01
Volume
108
Issue
2
Pages
261-269
ISSN
0092-8674
DOI
10.1016/s0092-8674(02)00611-6
Cited by
401
References
1
Language
en
Licence
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health
  • National Institute of Mental Health

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