Goldstein, Lawrence S.B.

Comparative Genomics of the Eukaryotes

Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science

Genomics and Phylogenetic StudiesBioinformatics and Genomic Networks

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Somatic coding mutations in human induced pluripotent stem cells

Gore, A., Li, Z., Fung, H.-L., Young, J. E., Agarwal, S., Antosiewicz-Bourget, J., Canto, I., Giorgetti, A., Israel, M. A., Kiskinis, E., et al. (2011) · Nature

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

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Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

Israel, M. A., Yuan, S. H., Bardy, C., Reyna, S. M., Mu, Y., Herrera, C., Hefferan, M. P., Van Gorp, S., Nazor, K. L., Boscolo, F. S., et al. (2012) · Nature

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

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Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease

Stokin, G. B., Lillo, C., Falzone, T. L., Brusch, R. G., Rockenstein, E., Mount, S. L., Raman, R., Davies, P., Masliah, E., Williams, D. S., et al. (2005) · Science

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,214

Bead movement by single kinesin molecules studied with optical tweezers

Block, S. M., Goldstein, L. S. B., & Schnapp, B. J. (1990) · Nature

Microtubule and mitosis dynamicsOrbital Angular Momentum in Optics

Cited by 1,038

Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

Kamal, A., Almenar-Queralt, A., LeBlanc, J. F., Roberts, E. A., & Goldstein, L. S. B. (2001) · Nature

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 583

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

van der Kant, R., Goldstein, L. S. B., & Ossenkoppele, R. (2020) · Nature reviews. Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 580

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

Kamal, A., Stokin, G. B., Yang, Z., Xia, C.-H., & Goldstein, L. S. B. (2000) · Neuron

Alzheimer's disease research and treatmentsMicrotubule and mitosis dynamics

Cited by 544

Increased App expression in a mouse model of Down’s syndrome disrupts NGF transport and causes cholinergic neuron degeneration

Salehi, A., Delcroix, J.-D., Belichenko, P. V., Zhan, K., Wu, C., Valletta, J. S., Takimoto-Kimura, R., Kleschevnikov, A. M., Sambamurti, K., Chung, P. P., et al. (2006) · Neuron

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 543

CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment

Wood, K. W., Sakowicz, R., Goldstein, L. S. B., & Cleveland, D. W. (1997) · Cell

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 431

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila

Gunawardena, S., & Goldstein, L. S. B. (2001) · Neuron

Alzheimer's disease research and treatmentsMicrotubule and mitosis dynamics

Cited by 428

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

van der Kant, R., Langness, V. F., Herrera, C. M., Williams, D. A., Fong, L. K., Leestemaker, Y., Steenvoorden, E., Rynearson, K. D., Brouwers, J. F., Helms, J. B., et al. (2019) · Cell Stem Cell

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 350

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice

Yamanaka, K., Boillee, S., Roberts, E. A., Garcia, M. L., McAlonis-Downes, M., Mikse, O. R., Cleveland, D. W., & Goldstein, L. S. B. (2008) · Proceedings of the National Academy of Sciences

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 309

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Mertens, J., Herdy, J. R., Traxler, L., Schafer, S. T., Schlachetzki, J. C. M., Böhnke, L., Reid, D. A., Lee, H., Zangwill, D., Fernandes, D. P., et al. (2021) · Cell Stem Cell

Pluripotent Stem Cells ResearchAlzheimer's disease research and treatments

Cited by 240

Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles

Encalada, S. E., Szpankowski, L., Xia, C.-H., & Goldstein, L. S. B. (2011) · Cell

Microtubule and mitosis dynamicsCellular transport and secretion

Cited by 206

Kinesin heavy chain is essential for viability and neuromuscular functions in Drosophila, but mutants show no defects in mitosis

Saxton, W. M., Hicks, J., Goldstein, L. S. B., & Raff, E. C. (1991) · Cell

Microtubule and mitosis dynamicsNeurobiology and Insect Physiology Research

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Kinesin Light Chains Are Essential for Axonal Transport in Drosophila

Gindhart, J. G., Desai, C. J., Beushausen, S., Zinn, K., & Goldstein, L. S. B. (1998) · The Journal of Cell Biology

Microtubule and mitosis dynamicsHereditary Neurological Disorders

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The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells

Woodruff, G., Young, J. E., Martinez, F. J., Buen, F., Gore, A., Kinaga, J., Li, Z., Yuan, S. H., Zhang, K., & Goldstein, L. S. B. (2013) · Cell Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 177

Direction of microtubule movement is an intrinsic property of the motor domains of kinesin heavy chain and Drosophila ncd protein.

Stewart, R. J., Thaler, J. P., & Goldstein, L. S. (1993) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsGenetic and Kidney Cyst Diseases

Cited by 145

Two Kinesin Light Chain Genes in Mice

Rahman, A., Friedman, D. S., & Goldstein, L. S. B. (1998) · Journal of Biological Chemistry

Microtubule and mitosis dynamicsHereditary Neurological Disorders

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The Drosophila kinesin light chain. Primary structure and interaction with kinesin heavy chain

Gauger, A. K., & Goldstein, L. S. (1993) · Journal of Biological Chemistry

Microtubule and mitosis dynamicsCellular transport and secretion

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Defective kinesin heavy chain behavior in mouse kinesin light chain mutants

Rahman, A., Kamal, A., Roberts, E. A., & Goldstein, L. S. B. (1999) · The Journal of Cell Biology

Microtubule and mitosis dynamicsCellular transport and secretion

Cited by 102

Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila

Reis, G. F., Yang, G., Szpankowski, L., Weaver, C., Shah, S. B., Robinson, J. T., Hays, T. S., Danuser, G., & Goldstein, L. S. B. (2012) · Molecular Biology of the Cell

Microtubule and mitosis dynamicsCellular transport and secretion

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Tetratrico peptide repeats are present in the kinesin light chain

Gindhart, J. G., & Goldstein, L. S. B. (1996) · Trends in Biochemical Sciences

Microtubule and mitosis dynamicsCardiovascular and exercise physiology

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