Cited by 123Microtubule and mitosis dynamicsHereditary Neurological DisordersGenetic and Kidney Cyst Diseases

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Two Kinesin Light Chain Genes in Mice

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Rahman, Amena, Friedman, Dara S., Goldstein, Lawrence S.B.·1998·Journal of Biological Chemistry

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Abstract

Native kinesin consists of two light chains and two heavy chains in a 1:1 stoichiometric ratio. To date, only one gene for kinesin light chain has been characterized, while a second gene was identified in a genomic sequencing study but not analyzed biochemically. Here we describe new genes encoding kinesin light chains in mouse. One of these light chains is neuronally enriched, while another shows ubiquitous expression. The presence of multiple kinesin light chain genes in mice is especially interesting, since there are two kinesin heavy chain genes in humans (Niclas, J., Navone, F., Hom-Booher, N., and Vale, R. D. (1994) Neuron 12, 1059-1072). To assess the selectivity of kinesin light chain interaction with the heavy chains, we performed immunoprecipitation experiments. The data suggested that the light chains form homodimers with no specificity in their interaction with the two heavy chains. Immunofluorescence and biochemical subfractionation suggested differences in the subcellular localization of the two kinesin light chain gene products. Although both kinesin light chains are distributed throughout the central and peripheral nervous systems, there is enrichment of one in sciatic nerve axons, while the other shows elevated levels in olfactory bulb glomeruli. These results indicate that the mammalian nervous system contains multiple kinesin light chain gene products with potentially distinct functions.

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Authors: Rahman, A., Friedman, D. S., & Goldstein, L. S. B.
Affiliations: Howard Hughes Medical Institute (US)
University of California, San Francisco (US)
Corresponding author: Goldstein, Lawrence S.B.
ORCID: Goldstein, Lawrence S.B.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1998-06
Volume: 273
Issue: 25
Pages: 15395-15403
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.273.25.15395
OpenAlex: W1983362841
Cited by: 123
References: 55
Citations by year: 2026: 2 · 2025: 4 · 2024: 1 · 2023: 8 · 2022: 3 · 2021: 6 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 1 · 2012: 4
FWCI: 2.16
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8177 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: University of California, San Francisco
Lawrence Livermore National Laboratory
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords: kinesin light chain, kinesin heavy chain, gene duplication, neuronal expression, subcellular localization, olfactory bulb glomeruli
MeSH terms: Amino Acid Sequence, Animals, Brain Chemistry, Chromosome Mapping, Cloning, Molecular, Humans, Microtubule-Associated Proteins, Microtubules, Molecular Sequence Data, Sciatic Nerve, Kinesins, Sequence Analysis, DNA, Mice

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Two Kinesin Light Chain Genes in Mice

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