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Cited by 207

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Steroid Receptor Coactivator-1 Coactivates Activating Protein-1-mediated Transactivations through Interaction with the c-Jun and c-Fos Subunits

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Lee, Soo-Kyung, Kim, Han-Jong, Na, Soon-Young, Kim, Tae Sung, Choi, Hueng-Sik, Im, Suhn-Young, Lee, Jae Woon·1998·Journal of Biological Chemistry

Abstract

Steroid receptor coactivator-1 (SRC-1) specifically bound to the transcription factor AP-1 subunits c-Jun and c-Fos, as demonstrated by the yeast two-hybrid tests and glutathione S-transferase pull down assays. The c-Jun and c-Fos binding sites were localized to the C-terminal subregion of SRC-1 (amino acids 1101-1441) that encompasses the previously described histone acetyltransferase and receptor-binding domains. In mammalian cells, SRC-1, similar to the previous results with CBP-p300 (Arias, J., Alberts, A. S., Brindle, P., Claret, F. X., Smeal, T., Karin, M., Feramisco, J., and Montminy, M. (1994) Nature 370, 226-229; Bannister, A. J., and Kouzarides, T. (1995) EMBO J. 14, 4758-4762), potentiated the AP-1-mediated transactivations in a dose-dependent manner and derepressed the mutual inhibitions between nuclear receptors and AP-1. Furthermore, coexpression of p300 further enhanced this SRC-1-potentiated level of transactivations. Thus, we concluded that at least two distinct coactivator molecules may cooperate to regulate AP-1-dependent transactivations and mediate transrepression between AP-1 and nuclear receptors in vivo.

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Metadata

Authors
Lee, S.-K., Kim, H.-J., Na, S.-Y., Kim, T. S., Choi, H.-S., Im, S.-Y., & Lee, J. W.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1998-07
Volume
273
Issue
27
Pages
16651-16654
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1964456768
Cited by
207
References
8
FWCI
9.86
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Steroid Receptor Coactivator-1 Coactivates Activating Protein-1-mediated Transactivations through Interaction with the c-Jun and c-Fos Subunits. https://app.cochat.ai/papers/10.1074/jbc.273.27.16651
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Lee, S.-K., Kim, H.-J., Na, S.-Y., Kim, T. S., Choi, H.-S., Im, S.-Y., & Lee, J. W. (1998). Steroid Receptor Coactivator-1 Coactivates Activating Protein-1-mediated Transactivations through Interaction with the c-Jun and c-Fos Subunits. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.273.27.16651

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