E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators
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IRF-3 functionally interacts with CBP/p300 proteins.
“IRF-3 joins a growing list of cellular and viral proteins that functionally interact with CBP/p300 proteins”
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The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
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“IRF-3 joins a growing list of cellular and viral proteins that functionally interact with CBP/p300 proteins, highly homologous proteins originally identified through their interactions with adenovirus E1A and CREB proteins ( 1 , 13).”
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“1 b and Table 2 ), a region which is highly conserved in its homologue CREB-binding protein (CBP; ref”
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BackgroundStructure and function of transcriptional activation domains
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“C2C12 cells were transfected with either 4RE-CAT(shadedbars)orMCK-CAT(blackbars)reporterconstructswith(1) or without ( 2 ) an expression vector for p300.”
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“Immunoprecipitation and indirect immunofluorescence with anti-p300 antibodies were also per-tially involved in additional protein–protein interactions (Rikitake and Moran, 1992; Arany et al., 1994, 1995; formed using C2C12 cells at different times during differentiation.”
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Large-scale discovery of enhancers from human heart tissue
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“We performed chromatin immunoprecipitation with a pan-specific antibody that recognizes both p300 and the closely related CBP coactivator protei”
MethodTranscriptional regulation by steroid hormones
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Hijacking of the AP-1 Signaling Pathway during Development of ATL
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“Although E1A induces c-jun transcription (Van Dam et al., 1993), it concomitantly represses AP-1 activity through competition for CREB-binding protein (CBP) in a similar manner to the competitive effect of E1A binding on p300 (Offringa et al., 1990; Arany et al., 1994).”
BackgroundTriggering the Interferon Response: The Role of IRF-3 Transcription Factor
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Association of p300 and CBP with Simian Virus 40 Large T Antigen
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“p300 displays striking homology (2) to another large nuclear protein, CBP, which was cloned as part of a search for proteins capable of binding to the transcription factor CREB after its phosphorylation by protein kinase A (9, 35).”
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“These proteins are well conserved amongst mammals and homologs of CBP/p300 have been found in Drosophila, Caenorhabditis elegans, and Arabidopsis thaliana [105].”
BackgroundTranscriptional regulation by cyclic AMP-responsive factors
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“…function as transcriptional coactivators or adapter proteins that are recruited to target promoters by sequence-speci®c DNA-binding proteins. p300/CBP interact with CREB, jun, MyoD, the STATs, p53, nuclear hormone receptors and other transcriptional factors (Giles et al., 1998: Arany et al., 1994).”
BackgroundInteraction of melittin with a human lymphoblastoid cell line, HMy2
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“The receptor interaction domain (RID), the three cysteine-plus histidine-rich domains (CH1, CH2, and CH3), the CREB binding KIX domain (KIX), and the bromodomain (Br) are shown (6, 19, 22, 36, 58).”
BackgroundDifferential Use of CREB Binding Protein-Coactivator Complexes
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Lineage-specific Signaling in Melanocytes
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“…the inhibition by the viral oncoprotein E1A of transcriptional activation mediated by a variety of DNA-bound transcription factors (Eckner et al., 1994, 1996a,b; Arany et al., 1994; Lundblad et al., 1995; Chakravati et al., 1996; Gerritsen et al., 1997; Aarnisalo et al., 1998; Blobel et al., 1998).”
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The Role of Bromodomain Proteins in Regulating Gene Expression
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“CBP and p300 belong to the same class of HATs and are very similar in structure [107].”
BackgroundCoupling cAMP Signaling to Transcription in the Liver: Pivotal Role of CREB and CREM
Servillo, G., Fazia, M. A. D., & Sassone‐Corsi, P. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5491 · Cited by 173 · see citing works
p300 Functions as a Coactivator for the Peroxisome Proliferator-activated Receptor α
Dowell, P., Ishmael, J. E., Avram, D., Peterson, V. J., Nevrivy, D. J., & Leid, M. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.33435 · Cited by 174 · see citing works
EP300 Selectively Controls the Enhancer Landscape of MYCN -Amplified Neuroblastoma
Durbin, A. D., Wang, T., Wimalasena, V. K., Zimmerman, M. W., Li, D., Dharia, N. V., Mariani, L., Shendy, N. A. M., Nance, S., Patel, A. G., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0385 · Cited by 174 · see citing works
“These two enzymes share a 95 large degree of sequence homology, and both contain multiple homologous domains, including 96 kinase-inducible domain interacting (KIX) domains, histone acetyltransferases (HAT) and 97 bromodomains (14).”
BackgroundHarrod, R., Tang, Y., Nicot, C., Lu, H. S., Vassilev, A. P., Nakatani, Y., & Giam, C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5052 · Cited by 173 · see citing works
Naqvi, S., Martin, K. J., & Arthur, J. S. C. (2014) · Biochemical Journal · doi:10.1042/bj20131115 · Cited by 171 · see citing works
CREB-binding Protein Activates Transcription through Multiple Domains
Swope, D. L., Mueller, C. L., & Chrivia, J. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.45.28138 · Cited by 170 · see citing works
A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegansPreprint
Shi, Y., & Mello, C. C. (1998) · Genes & Development · doi:10.1101/gad.12.7.943 · Cited by 166 · see citing works
“CBP-1 is a C. elegans protein that shares significant sequence homology with mammalian p300 and CBP proteins (Chrivia et al. 1993; Arany et al. 1994; Eckner et al. 3Corresponding author.”
BackgroundGenetic syndromes caused by mutations in epigenetic genes
Berdasco, M., & Esteller, M. (2013) · Human Genetics · doi:10.1007/s00439-013-1271-x · Cited by 165 · see citing works
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53
Shi, D., Pop, M. S., Kulikov, R., Love, I. M., Kung, A. L., & Grossman, S. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904305106 · Cited by 161 · see citing works
“The N terminus of p300 harbors its E3/E4 activity (14), and the same region of CBP encodes its E3/E4 activity and shares significant areas of sequence conservation (18, 30).”
BackgroundImhof, M. O., & McDonnell, D. P. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2594 · Cited by 160 · see citing works
Expression of HDAC1 and CBP/p300 in human colorectal carcinomas
Ishihama, K., Yamakawa, M., Semba, S., Takeda, H., Kawata, S., Kimura, S., & Kimura, W. (2007) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.029165 · Cited by 157 · see citing works
Lee, J.-S., See, R. H., Deng, T., & Shi, Y. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4312 · Cited by 153 · see citing works
“p300 shares significant homology with the transcriptional cofactor CBP (4).”
BackgroundBillon, N., Carlisi, D., Datto, M., van Grunsven, L. A., Watt, A. J., Wang, X., & Rudkin, B. B. (1999) · Oncogene · doi:10.1038/sj.onc.1202712 · Cited by 151 · see citing works
“Indeed, p300/ CBP have been shown to interact functionally with a number of transcriptional activators including CREB (Chrivia et al., 1993; Arany et al., 1994; Kwok et al., 1994), bHLH factors (Eckner et al., 1996; Puri et al., 1997), pp90RSK (Nakajima et al., 1996; Xing et al., 1996), nuclear…”
Backgroundp300 Modulates the BRCA1 inhibition of estrogen receptor activity.
Fan, S., Ma, Y. X., Wang, C., Yuan, R., Meng, Q., Wang, J., Erdos, M. R., Goldberg, I. D., Webb, P., Kushner, P. J., et al. (2002) · PubMed · Cited by 148 · see citing works
Ko, L., Cardona, G. R., & Chin, W. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6212 · Cited by 144 · see citing works
Heinlein, C. A., Ting, H., Yeh, S., & Chang, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16147 · Cited by 134 · see citing works
Li, P., Black, T. A., Shi, Q., Jones, C. A., Petrovic, N., Loudon, J. A., Kane, C. M., Sigmund, C. D., & Gross, K. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103010200 · Cited by 133 · see citing works
Molecular Mechanisms of Transforming Growth Factor-β Signaling
Hu, P. P.-C., Datto, M., & Wang, X. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0333 · Cited by 134 · see citing works
KATs in cancer: functions and therapies
Farria, A. T., Li, W., & Dent, S. (2015) · Oncogene · doi:10.1038/onc.2014.453 · Cited by 132 · see citing works
- Authors
- Arany, Z.
- Affiliations
- Harvard University (US)
- Corresponding author
- Arany, Z
- ORCID
- Arany, Z
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1994-06-17
- Volume
- 77
- Issue
- 6
- Pages
- 799-800
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2087880580
- Cited by
- 444
- References
- 10
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 7 · 2023: 9 · 2022: 2 · 2021: 11 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 7 · 2012: 7
- FWCI
- 13.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- P300, CREB-binding protein, CBP, transcriptional coactivator, CREB
- MeSH terms
- Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Nuclear Proteins, Transcription Factors, Trans-Activators, Conserved Sequence, Cyclic AMP Response Element-Binding Protein, Sequence Homology, Amino Acid, Adenovirus E1A Proteins, E1A-Associated p300 Protein, CREB-Binding Protein
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