Cited by 721Cardiac Ischemia and ReperfusionCell death mechanisms and regulationMitochondrial Function and Pathology

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes

Open access

Vanden Hoek, Terry L., Becker, Lance B., Shao, Zuohui, Li, Changqing, Schumacker, Paul T.·1998·Journal of Biological Chemistry

DOI 10.1074/jbc.273.29.18092

Open this paper in CoChat — free account Open PDF

Abstract

Reactive oxygen species (ROS) have been proposed to participate in the induction of cardiac preconditioning. However, their source and mechanism of induction are unclear. We tested whether brief hypoxia induces preconditioning by augmenting mitochondrial generation of ROS in chick cardiomyocytes. Cells were preconditioned with 10 min of hypoxia, followed by 1 h of simulated ischemia and 3 h of reperfusion. Preconditioning decreased cell death from 47 +/- 3% to 14 +/- 2%. Return of contraction was observed in 3/3 preconditioned versus 0/6 non-preconditioned experiments. During induction, ROS oxidation of the probe dichlorofluorescin (sensitive to H2O2) increased approximately 2.5-fold. As a substitute for hypoxia, the addition of H2O2 (15 micromol/liter) during normoxia also induced preconditioning-like protection. Conversely, the ROS signal during hypoxia was attenuated with the thiol reductant 2-mercaptopropionyl glycine, the cytosolic Cu,Zn-superoxide dismutase inhibitor diethyldithiocarbamic acid, and the anion channel inhibitor 4,4'-diisothiocyanato-stilbene-2,2'-disulfonate, all of which also abrogated protection. ROS generation during hypoxia was attenuated by myxothiazol, but not by diphenyleneiodonium or the nitric-oxide synthase inhibitor L-nitroarginine. We conclude that hypoxia increases mitochondrial superoxide generation which initiates preconditioning protection. Furthermore, mitochondrial anion channels and cytosolic dismutation to H2O2 may be important steps for oxidant induction of hypoxic preconditioning.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1074/jbc.273.29.18092

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.
Murry, C. E., Jennings, R. B., & Reimer, K. A. (1986) · Circulation · doi:10.1161/01.cir.74.5.1124 · Cited by 7,813
Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria
Turrens, J. F., & Boveris, A. (1980) · Biochemical Journal · doi:10.1042/bj1910421 · Cited by 1,601
Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria
Turrens, J. F., Alexandre, A., & Lehninger, A. L. (1985) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(85)90293-0 · Cited by 1,214
Enzyme-independent formation of nitric oxide in biological tissues
Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788
Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.
Xia, Y., Dawson, V. L., Dawson, T. M., Snyder, S. H., & Zweier, J. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6770 · Cited by 717
Nitric Oxide and Cardiac Function
Kelly, R. A., Balligand, J., & Smith, T. W. (1996) · Circulation Research · doi:10.1161/01.res.79.3.363 · Cited by 715
Intracellular Signaling by Reactive Oxygen Species during Hypoxia in Cardiomyocytes
Duranteau, J., Chandel, N. S., Kulisz, A., Shao, Z., & Schumacker, P. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11619 · Cited by 679
Self-citation
Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells
Carter, W. O., Narayanan, P. K., & Robinson, J. P. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.2.253 · Cited by 640
Molecular oxygen: Friend and foe*The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury
HESS, M., & Manson, N. H. (1984) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(84)80011-5 · Cited by 542

Flagged first, then by citations

Show all 40 references

Research works printed but not linked: 6

Liang, 1996, Am. J. Physiol., 271, H1769
Vanden Hoek, 1996, Am. J. Physiol., 270, H1334
Bond, 1991, Res. Commun. Chem. Pathol. Pharm., 71, 195
Murry, 1988, Circulation, 78, 77
Pathak, 1995, Circulation, 92, I
Larsson, 1989, Cancer Res., 49, 5627

Sorted by citations

Items 301–400 of 714

Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells
Gebremedhin, D., Yamaura, K., & Harder, D. R. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01416.2006 · Cited by 54
Boranil dye based “turn-on” fluorescent probes for detection of hydrogen peroxide and their cell imaging application
Shanmugapriya, J., Rajaguru, K., Sivaraman, G., Muthusubramanian, S., & Bhuvanesh, N. S. P. (2016) · RSC Advances · doi:10.1039/c6ra17863d · Cited by 54
Inhibition of the pentose phosphate pathway decreases ischemia–reperfusion-induced creatine kinase release in the heart
Zuurbier, C. J. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.01.010 · Cited by 54
Cardioprotective effect of chronic hypoxia is blunted by concomitant hypercapnia
Neckář, J., Szárszoi, O., Herget, J., Ošťádal, B., & Kolář, F. (2003) · Physiological Research · doi:10.33549/physiolres.930303 · Cited by 54
Cardioprotection initiated by reactive oxygen species is dependent on activation of PKCepsilon.
Kabir, A. M. N., Clark, J. E., Tanno, M., Cao, X.-B., Hothersall, J., Dashnyam, S., Gorog, D. A., Bellahcene, M., Shattock, M., & Marber, M. (2006) · American Journal of Physiology. Heart and Circulatory Physiology · doi:10.1152/ajpheart.00798.2005 · Cited by 54
Genetic redox preconditioning differentially modulates AP-1 and NFκB responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis
Yang, J., Marden, J. J., Fan, C., Şanlıoğlu, S., Weiss, R. M., Ritchie, T. C., Davisson, R. L., & Engelhardt, J. F. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(02)00061-8 · Cited by 53
Cardiac Ischemic Preconditioning Promotes MG53 Secretion Through H 2 O 2 -Activated Protein Kinase C-δ Signaling
Shan, D., Guo, S., Wu, H., Lv, F., Jin, L., Zhang, M., Xie, P., Wang, Y., Song, Y., Wu, F., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.044998 · Cited by 52
Propofol limits rat myocardial ischemia and reperfusion injury with an associated reduction in apoptotic cell death in vivo
Jin, Y. C., Kim, W., Ha, Y. M., Shin, I.-W., Sohn, J. T., Kim, H. J., Seo, H. G., Lee, J. H., & Chang, K. C. (2008) · Vascular Pharmacology · doi:10.1016/j.vph.2008.10.002 · Cited by 53
Hibernation induces glutathione redox imbalance in ground squirrel intestine
Carey, H. V., Rhoads, C. A., & Aw, T. Y. (2003) · Journal of Comparative Physiology B · doi:10.1007/s00360-003-0330-3 · Cited by 51
Nitric oxide during ischemia attenuates oxidant stress and cell death during ischemia and reperfusion in cardiomyocytes
Iwase, H., Robin, E., Guzy, R. D., Mungai, P. T., Hoek, T. L. V., Chandel, N. S., Levraut, J., & Schumacker, P. T. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.017 · Cited by 51
Self-citation
Ischemic Preconditioning in Isolated Cells
Marber, M. S. (2000) · Circulation Research · doi:10.1161/01.res.86.9.926 · Cited by 51
Ischemic Preconditioning Improves Oxygen Saturation and Attenuates Hypoxic Pulmonary Vasoconstriction at High Altitude
Foster, G. P., Giri, P. C., Rogers, D. M., Larson, S. R., & Anholm, J. D. (2014) · High Altitude Medicine & Biology · doi:10.1089/ham.2013.1137 · Cited by 50
Label-free imaging of metabolism and oxidative stress in human induced pluripotent stem cell-derived cardiomyocytes
Datta, R., Heylman, C. M., George, S. C., & Gratton, E. (2016) · Biomedical Optics Express · doi:10.1364/boe.7.001690 · Cited by 50
An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals
Détaille, D., Pasdois, P., Sémont, A., Santos, P. D. D., & Diolez, P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216385 · Cited by 53
NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1α signal transduction
Kim, K. H., Kim, D., Park, J. Y., Jung, H. J., Cho, Y., Kim, H. K., Han, J., Choi, K., & Kwon, H. J. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1235-1 · Cited by 52
Diazoxide-induced respiratory inhibition – a putative mitochondrial KATP channel independent mechanism of pharmacological preconditioning
Minners, J., Lacerda, L., Yellon, D. M., Opie, L. H., McLeod, C. J., & Sack, M. N. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-9066-6 · Cited by 49
Protection Against Renal Ischemia-Reperfusion Injury by Ischemic Postconditioning
van den Akker, E. K., Manintveld, O. C., Hesselink, D. A., de Bruin, R. W. F., IJzermans, J. N. M., & Dor, F. J. M. F. (2013) · Transplantation · doi:10.1097/tp.0b013e318281b934 · Cited by 48
Grape Seed Proanthocyanidins Ameliorate Doxorubicin-Induced Cardiotoxicity
Li, J., Liu, H., Ramachandran, S., Waypa, G. B., Yin, J., Li, C., Han, M., Huang, H., Sharp, W. W., Hoek, T. L. V., et al. (2010) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x10008068 · Cited by 48
Self-citation
Effect of diazoxide on flavoprotein oxidation and reactive oxygen species generation during ischemia-reperfusion: a study on Langendorff-perfused rat hearts using optic fibers
Pasdois, P., Beauvoit, B. P., Tariosse, L., Jaspard‐Vinassa, B., Bonoron‐Adèle, S., & Santos, P. D. D. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01345.2007 · Cited by 49
Hypoxic induction of hypoxia-inducible factor-1α and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells
Enomoto, N., Koshikawa, N., Gassmann, M., Hayashi, J., & Takenaga, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02186-1 · Cited by 49
Respiratory Chain-Generated Oxidative Stress Following Treatment of Leukemic Blasts with DNA-Damaging Agents
Pham, N., & Hedley, D. W. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5148 · Cited by 48
Mitochondrial Therapeutics for Cardioprotection
Carreira, R., Lee, P. P. W., & Gottlieb, R. A. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211796904777 · Cited by 48
Role of Reactive Oxygen Species in Ischemic Preconditioning of Subcellular Organelles in the Heart
Saini, H. K., Macháčková, J., & Dhalla, N. (2004) · Antioxidants and Redox Signaling · doi:10.1089/152308604322899468 · Cited by 51
Effect of Coenzyme Q10 Supplementation on Mitochondrial Function after Myocardial Ischemia Reperfusion
Crestanello, J. A., Doliba, N. M., Doliba, N. M., Babsky, A. M., Niibori, K., Osbakken, M. D., & Whitman, G. J. R. (2002) · Journal of Surgical Research · doi:10.1006/jsre.2001.6324 · Cited by 47
Calpain-mediated proteolytic cleavage of troponin I induced by hypoxia or metabolic inhibition in cultured neonatal cardiomyocytes
Kositprapa, C., Zhang, B., Berger, S. B., Canty, J. M., & Lee, T. (2000) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007160702275 · Cited by 46
Sarcolemmal K ATP Channel Triggers Opioid-Induced Delayed Cardioprotection in the Rat
Patel, H. H., Hsu, A. K., Peart, J. N., & Gross, G. J. (2002) · Circulation Research · doi:10.1161/01.res.0000029085.69891.f2 · Cited by 46
Free radicals upregulate complement expression in rabbit isolated heart
Tanhehco, E. J., Yasojima, K., McGeer, P. L., Washington, R. A., & Lucchesi, B. R. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.1.h195 · Cited by 46
Jun Kinase Delays Caspase-9 Activation by Interaction with the Apoptosome
Tran, T., Andreka, P. G., Rodrigues, C. O., Webster, K. A., & Bishopric, N. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702210200 · Cited by 45
Skeletal muscle alterations and exercise performance decrease in erythropoietin-deficient mice: a comparative study
Mille-Hamard, L., Billat, V. L., Henry, E., Bonnamy, B., Joly, F., Benech, P. D., & Barrey, É. (2012) · BMC Medical Genomics · doi:10.1186/1755-8794-5-29 · Cited by 45
Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition
Batthish, M. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00454-6 · Cited by 45
Past and present course of cardioprotection against ischemia- reperfusion injury
Liem, D. A., Honda, H. M., Zhang, J., Woo, D. D. L., & Ping, P. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00383.2007 · Cited by 46
Reduction of acute photodamage in skin by topical application of a novel PARP inhibitor
Farkas, B., Magyarlaki, M., Csete, B., Németh, J., Rabloczky, G., Bernath, S., Nagy, P., & Sümegi, B. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00929-7 · Cited by 45
Contribution of epoxyeicosatrienoic acids to the hypoxia-induced activation of Ca2+-activated K+ channel current in cultured rat hippocampal astrocytes
Yamaura, K., Gebremedhin, D., Zhang, C., Narayanan, J., Hoefert, K., Jacobs, E. R., Koehler, R. C., & Harder, D. R. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.021 · Cited by 45
Protective Effects of Hydrogen Peroxide Against Ischemia/Reperfusion Injury in Perfused Rat Hearts.
Yaguchi, Y., Satoh, H., Wakahara, N., Katoh, H., Uehara, A., Terada, H., Fujise, Y., & Hayashi, H. (2003) · Circulation Journal · doi:10.1253/circj.67.253 · Cited by 45
Phosphate Increases Mitochondrial Reactive Oxygen Species Release
de Oliveira, G. A., & Kowaltowski, A. J. (2004) · Free Radical Research · doi:10.1080/10715760400009258 · Cited by 44
HPLC Analysis of Phenolics Compounds and Antioxidant Capacity of Leaves of Vitex megapotamica (Sprengel) Moldenke
de Brum, T. F., Zadra, M., Piana, M., Boligon, A. A., Frohlich, J. K., Freitas, R. D., Stefanello, S. T., Froeder, A. L. F., Belke, B. V., Nunes, L., et al. (2013) · Molecules · doi:10.3390/molecules18078342 · Cited by 44
Cytotoxic activity of genistein-8-C-glucoside form Lupinus luteus L. and genistein against human SK-OV-3 ovarian carcinoma cell line
Antosiak, A., Miłowska, K., Maczynska, K., Różalska, S., & Gabryelak, T. (2016) · Medicinal Chemistry Research · doi:10.1007/s00044-016-1725-5 · Cited by 44
Mitochondria play a critical role in cardioprotection
Marı́n-Garcı́a, J., & Goldenthal, M. J. (2004) · Journal of Cardiac Failure · doi:10.1016/s1071-9164(03)00129-5 · Cited by 45
Anti-oxidant effects of estrogen reduce [Ca2+]i during metabolic inhibition
Sugishita, K. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00017-8 · Cited by 44
Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species
Przygodzki, T., Sokal, A., & Bryszewska, M. J. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.03.009 · Cited by 44
Mitochondrial ATP production is necessary for activation of the extracellular-signal-regulated kinases during ischaemia/reperfusion in rat myocyte-derived H9c2 cells
Abas, L., Bogoyevitch, M. A., & Guppy, M. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490119 · Cited by 43
Hyperbaric oxygen: a new drug in myocardial revascularization and protection?
Yogaratnam, J. Z., Laden, G., Madden, L. A., Seymour, A.-M., Guvendik, L., Cowen, M., Greenman, J., Cale, A. R. J., & Griffin, S. C. (2006) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2006.04.006 · Cited by 43
Regulation of AMPA Receptor Currents by Mitochondrial ATP-Sensitive K+Channels in Anoxic Turtle Neurons
Zivkovic, G., & Buck, L. T. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00506.2010 · Cited by 43
Comparison of volatile anesthetic-induced preconditioning in cardiac and cerebral system: molecular mechanisms and clinical aspects
Chen, S., Lotz, C., Roewer, N., & Broscheit, J. (2018) · European journal of medical research · doi:10.1186/s40001-018-0308-y · Cited by 43
In Vivo Hyperoxic Preconditioning Prevents Myocardial Infarction by Expressing Bcl-2
Choi, H., Kim, S., Chun, Y., Cho, Y., Park, J., & Kim, M.-S. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623100412 · Cited by 42
Temperature Dependence of the Mitochondrial Inner Membrane Anion Channel
Beavis, A. D., & Powers, M. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310475200 · Cited by 42
Extracellular signal-regulated kinase 1/2 activation is involved in intermedin1–53 attenuating myocardial oxidative stress injury induced by ischemia/reperfusion
Zhao, L., Peng, D.-Q., Zhang, J., Song, J.-Q., Teng, X., Yu, Y.-R., Tang, C., & Qi, Y. (2012) · Peptides · doi:10.1016/j.peptides.2011.12.016 · Cited by 41
Interaction between Sensory C-fibers and Cardiac Mast Cells in Ischemia/Reperfusion: Activation of a Local Renin-Angiotensin System Culminating in Severe Arrhythmic Dysfunction
Morrey, C., Brazin, J. A., Seyedi, N., Corti, F., Silver, R. B., & Levi, R. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.172262 · Cited by 41
Reactive Oxygen Species Mediate Sevoflurane- and Desflurane-Induced Preconditioning in Isolated Human Right Atria In Vitro
Hanouz, J., Zhu, L., Lemoine, S., Durand, C., Lepage, O., Massetti, M., Khayat, A. S., Plaud, B., & Gérard, J.-L. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000286170.22307.1a · Cited by 41
Effects of Mitochondrial Potassium Channel and Membrane Potential on Hypoxic Human Pulmonary Artery Smooth Muscle Cells
Hu, H., Zhang, Z., Chen, C., Cai, C., Zhao, J., & Wang, X. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0017oc · Cited by 41
Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells
Vasilaki, A., CSETE, M. E., Pye, D., Lee, S., Palomero, J., McArdle, F., Remmen, H. V., Richardson, A. G., McArdle, A., Faulkner, J. A., et al. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.09.008 · Cited by 41
Dual Involvement of Coenzyme Q 10 in Redox Signaling and Inhibition of Death Signaling in the Rat Heart Mitochondria
Yamamura, T., Otani, H., Nakao, Y., Hattori, R., Osako, M., Imamura, H., & Das, D. K. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601750100588 · Cited by 41
Ischemic Preconditioning Protects Astrocytes against Oxygen Glucose Deprivation Via the Nuclear Erythroid 2-Related Factor 2 Pathway
Narayanan, S., Dave, K. R., & Pérez‐Pinzón, M. A. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0574-y · Cited by 40
Functioning of the mitochondrial ATP-dependent potassium channel in rats varying in their resistance to hypoxia. Involvement of the channel in the process of animal’s adaptation to hypoxia
Mironova, G. D., Shigaeva, M. I., Gritsenko, E. N., Murzaeva, S. V., Горбачева, О. С., Germanova, E. L., & Lukyanova, L. D. (2010) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-010-9316-5 · Cited by 40
Reduced tolerance of exercise in fibromyalgia may be a consequence of impaired microcirculation initiated by deficient action of nitric oxide
Kaşıkçıoğlu, E., Dinler, M., & Berker, E. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2005.11.028 · Cited by 39
Opening of Mitochondrial K+ Channels Increases Ischemic ATP Levels by Preventing Hydrolysis
Belisle, E., & Kowaltowski, A. J. (2002) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1020256502583 · Cited by 40
Oxidant Preconditioning Protects Human Proximal Tubular Cells against Lethal Oxidant Injury via p38 MAPK and Heme Oxygenase-1
Lee, H. T., Xu, H. X., Ota‐Setlik, A., & Emala, C. W. (2003) · American Journal of Nephrology · doi:10.1159/000072914 · Cited by 40
Signaling pathways targeting mitochondrial potassium channels
Rotko, D., Kunz, W. S., Szewczyk, A. M., & Kulawiak, B. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105792 · Cited by 40
Uridine treatment prevents myocardial injury in rat models of acute ischemia and ischemia/reperfusion by activating the mitochondrial ATP-dependent potassium channel
Крылова, И. Б., Selina, E. N., Bulion, V. V., Rodionova, O. M., Evdokimova, N. R., Belosludtseva, N. V., Shigaeva, M. I., & Mironova, G. D. (2021) · Scientific Reports · doi:10.1038/s41598-021-96562-7 · Cited by 41
Contribution of peroxynitrite to the beneficial effects of preconditioning on ischaemia-induced arrhythmias in rat isolated hearts
Altup, S., Demiryürek, A. T., Doğrukol‐Ak, D., Tungel, M., & Kanzık, ⋖. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00843-3 · Cited by 37
Attenuation of Isoflurane-Induced Preconditioning and Reactive Oxygen Species Production in the Senescent Rat Heart
Nguyen, L., Rebecchi, M. J., Moore, L. C., Glass, P. S. A., Brink, P. R., & Liu, L. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318180419d · Cited by 39
In situ fabricated MOF–cellulose composite as an advanced ROS deactivator-convertor: fluoroswitchable bi-phasic tweezers for free chlorine detoxification and size-exclusive catalytic insertion of aqueous H 2 O 2
Goswami, R., Bankar, B. D., Rajput, S., Seal, N., Pillai, R. S., Biradar, A. V., & Neogi, S. (2022) · Journal of Materials Chemistry A · doi:10.1039/d1ta10504c · Cited by 37
Melatonin does not prevent the protection of ischemic preconditioning in vivo despite its antioxidant effect against oxidative stress
Andreadou, I., Iliodromitis, E. K., Mikros, E., Bofilis, E., Ζώγα, Α., Constantinou, M. A., Tsantili‐Kakoulidou, A., & Kremastinos, D. T. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.005 · Cited by 38
Cardiac mitochondrial network excitability: insights from computational analysis
Zhou, L., & O'Rourke, B. P. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01073.2011 · Cited by 37
Baicalein Preconditioning Protects Cardiomyocytes from Ischemia-Reperfusion Injury via Mitochondrial Oxidant Signaling
Chang, W., Li, J., Hoek, M. S. V., Zhu, X., Li, C., Huang, H., Hsu, C.-W., Zhong, Q., Li, J., Chen, S., et al. (2013) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x13500237 · Cited by 36
Self-citation
Real-Time Measurement of Intracellular Reactive Oxygen Species Using Mito Tracker Orange (CMH2TMRos)
Kweon, S.-M., Kim, H., Lee, Z., Kim, S., Kim, S.-I., Paik, S., & Ha, K. (2001) · Bioscience Reports · doi:10.1023/a:1013290316939 · Cited by 36
Brain preconditioning and obstructive sleep apnea syndrome
Brzecka, A. (2005) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2005-1558 · Cited by 36
Role of Vitamin C in Cardioprotection of Ischemia/Reperfusion Injury by Activation of Mitochondrial KATP Channel
Hao, J., Li, W., Du, H., Zhao, Z., Liu, F., Lu, J., Yang, X., & Cui, W. (2016) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c15-00693 · Cited by 36
Opening of Mitochondrial K ATP Channels Triggers Cardioprotection
Liu, Y., & O'Rourke, B. P. (2001) · Circulation Research · doi:10.1161/hh0801.090537 · Cited by 35
A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel
Wojtovich, A. P., Nadtochiy, S. M., Urciuoli, W. R., Smith, C. O., Grunnet, M., Nehrke, K. W., & Brookes, P. S. (2013) · PeerJ · doi:10.7717/peerj.48 · Cited by 35
Neuron specific metabolic adaptations following multi-day exposures to oxygen glucose deprivation
Zeiger, S. L. H., McKenzie, J. R., Stankowski, J. N., Martin, J. A., Cliffel, D. E., & McLaughlin, B. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.07.013 · Cited by 35
Physiology and Pharmacology of Myocardial Preconditioning and Postconditioning
Huffmyer, J. L., & Raphael, J. (2009) · Seminars in Cardiothoracic and Vascular Anesthesia · doi:10.1177/1089253208330709 · Cited by 35
Nuclear ferritin‐mediated protection of corneal epithelial cells from oxidative damage to DNA
Cai, C. X., Ching, A., Lagace, C. J., & Linsenmayer, T. F. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21494 · Cited by 35
Effect of reduced oxygen tension on reactive oxygen species production and activity of antioxidant enzymes in swine granulosa cells
Basini, G., Grasselli, F., Bianco, F., Tirelli, M., & Tamanini, C. (2004) · BioFactors · doi:10.1002/biof.5520200201 · Cited by 35
A confocal microscopy study of the very early cellular response to oxidative stress induced by zinc phthalocyanine sensitization
Alexandratou, E., Yova, D. M., & Loukas, S. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.006 · Cited by 34
Reduction of Ischemic, Pharmacological and Remote Preconditioning Effects by an Antioxidant N-Acetyl Cysteine Pretreatment in Isolated Rat Heart
Khanna, G., Diwan, V., Singh, M., Singh, N., & Jaggi, A. S. (2008) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.128.469 · Cited by 34
Plant Inner Membrane Anion Channel (PIMAC) Function in Plant Mitochondria
Laus, M. N., Soccio, M., Trono, D., Cattivelli, L., & Pastore, D. (2008) · Plant and Cell Physiology · doi:10.1093/pcp/pcn082 · Cited by 34
Akt activates NOS3 and separately restores barrier integrity in H2O2-stressed human cardiac microvascular endothelium
Dossumbekova, A., Berdyshev, E. V., Gorshkova, I. A., Shao, Z., Li, C., Long, P., Joshi, A., Natarajan, V., & Hoek, T. L. V. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00501.2008 · Cited by 32
Self-citation
Influence of Heme and Heme Oxygenase-1 Transfection of Pulmonary Microvascular Endothelium on Oxidant Generation and cGMP
Mingone, C. J., Gupte, S. A., Quan, S., Abraham, N. G., & Wolin, M. S. (2003) · Experimental Biology and Medicine · doi:10.1177/15353702-0322805-22 · Cited by 34
Role of energy metabolism in the preconditioned heart – a possible contribution of mitochondria
Takeo, S. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00079-6 · Cited by 34
Ischemic and hypoxic preconditioning protect cardiac muscles via intracellular ROS signaling
Zuo, L., Roberts, W. J., Tolomello, R. C., & Goins, A. T. (2012) · Frontiers in Biology · doi:10.1007/s11515-012-1225-z · Cited by 33
Balance of Nitric Oxide and Reactive Oxygen Species in Myocardial Reperfusion Injury and Protection
Folino, A., Losano, G., & Rastaldo, R. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3182a50c45 · Cited by 32
Reactive Oxygen Species and Mitochondrial Adenosine Triphosphate–Regulated Potassium Channels Mediate Helium-Induced Preconditioning Against Myocardial Infarction In Vivo
Pagel, P. S., Krolikowski, J. G., Pratt, P. F., Shim, Y. H., Amour, J., Warltier, D. C., & Weihrauch, D. (2008) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2008.04.005 · Cited by 33
Sources for Superoxide Release: Lessons from Blockade of Electron Transport, NADPH Oxidase, and Anion Channels in Diaphragm
Zuo, L., Pasniciuc, S., Wright, V. P., Merola, A. J., & Clanton, T. L. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770310347 · Cited by 32
Mitochondrial KATP channels-derived reactive oxygen species activate pro-survival pathway in pravastatin-induced cardioprotection
Thuc, L. C., Teshima, Y., Takahashi, N., Torigoe, Y., Ezaki, K., Yufu, K., Nakagawa, M., Hara, M., & Saikawa, T. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0473-0 · Cited by 32
NADPH oxidase mediated maneb- and paraquat-induced oxidative stress in rat polymorphs: Crosstalk with mitochondrial dysfunction
Shukla, S., Singh, D., Kumar, V., Chauhan, A. K., Singh, S., Ahmad, I., Pandey, H. P., & Singh, C. (2015) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2015.03.007 · Cited by 32
N -Acetylcysteine Restores Isoflurane-induced Preconditioning against Myocardial Infarction during Hyperglycemia
Kehl, F., Krolikowski, J. G., Weihrauch, D., Pagel, P. S., Warltier, D. C., & Kersten, J. R. (2003) · Anesthesiology · doi:10.1097/00000542-200306000-00013 · Cited by 32
The Mitochondrial Translocator Protein and Arrhythmogenesis in Ischemic Heart Disease
Motloch, L. J., Hu, J., & Akar, F. G. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/234104 · Cited by 32
Effect of Calcium on Reactive Oxygen Species in Isolated Rat Cardiomyocytes During Hypoxia and Reoxygenation
Sharikabad, M. N., Hagelin, E. M. V., Hagberg, I. A., Lyberg, T., & Brørs, O. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1999.1092 · Cited by 32
Pseudopterosin A: Protection of Synaptic Function and Potential as a Neuromodulatory Agent
Caplan, S. L., Zheng, B., Dawson-Scully, K. D., White, C. A., & West, L. M. (2016) · Marine Drugs · doi:10.3390/md14030055 · Cited by 32
Caveolins in cardioprotection – translatability and mechanisms
Schilling, J. M., Roth, D. M., & Patel, H. H. (2014) · British Journal of Pharmacology · doi:10.1111/bph.13009 · Cited by 31
Cyclic stretch attenuates effects of hyperoxia on cell proliferation and viability in human alveolar epithelial cells
McAdams, R. M., Mustafa, S. B., Shenberger, J. S., Dixon, P. S., Henson, B. M., & DiGeronimo, R. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00160.2005 · Cited by 31
Epicatechin regulation of mitochondrial structure and function is opioid receptor dependent
Panneerselvam, M., Ali, S. S., Finley, J. C., Kellerhals, S. E., Migita, M. Y., Head, B. P., Patel, P. M., Roth, D. M., & Patel, H. H. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300026 · Cited by 31
Preconditioning improves function and recovery of single muscle fibers during severe hypoxia and reoxygenation
Kohin, S., Stary, C. M., Howlett, R. A., & Hogan, M. C. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.1.c142 · Cited by 31
TNFα-induced cytoprotection requires the production of free radicals within mitochondria in C2C12 myotubes
Lacerda, L., Smith, R. M., Opie, L. H., & Lecour, S. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.07.020 · Cited by 31
Stimulation of NOX2 in isolated hearts reversibly sensitizes RyR2 channels to activation by cytoplasmic calcium
Donoso, P., Finkelstein, J. P., Montecinos, L., Said, M., Sánchez, G., Vittone, L., & Bull, R. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.12.028 · Cited by 30
Complex I syndrome in myocardial stunning and the effect of adenosine
Valdez, L. B., Zaobornyj, T., Bombicino, S. S., Iglesias, D. E., Boveris, A., Donato, M., D’Annunzio, V., Buchholz, B., & Gelpi, R. J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.007 · Cited by 32
Cardioprotection by Noble Gases
Pagel, P. S. (2009) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2009.03.016 · Cited by 30
Ultrastructural Modifications in the Mitochondria of Hypoxia-Adapted Drosophila melanogaster
Perkins, G. A., Hsiao, Y., Yin, S., Tjong, J., Tran, M. T., Lau, J., Xue, J., Liu, S., Ellisman, M. H., & Zhou, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045344 · Cited by 30
Mitochondrial plasticity in classical ischemic preconditioning—moving beyond the mitochondrial KATP channel
Minners, J. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00337-7 · Cited by 30

Authors: Vanden Hoek, T. L., Becker, L. B., Shao, Z., Li, C., & Schumacker, P. T.
Affiliations: University of Chicago (US)
Corresponding author: Schumacker, Paul T.
ORCID: Becker, Lance B.
Li, Changqing
Schumacker, Paul T.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1998-07
Volume: 273
Issue: 29
Pages: 18092-18098
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.273.29.18092
OpenAlex: W2145047965
Cited by: 721
References: 40
Citations by year: 2026: 5 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 4 · 2021: 15 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 8 · 2016: 29 · 2015: 16 · 2014: 31 · 2013: 33 · 2012: 26
FWCI: 20.19
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8147 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k08hl003779-02, HL35440)
National Heart, Lung, and Blood Institute (HL 32646, HL-03779, R01HL035440, HL35440)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: reactive oxygen species, mitochondrial superoxide, hypoxia, cardioprotection, preconditioning, cardiomyocytes, ischemia-reperfusion injury, hydrogen peroxide, superoxide dismutase, DIDS, myxothiazol, nitric oxide synthase, cell death
MeSH terms: Animals, Cells, Cultured, Chick Embryo, Cytosol, Ditiocarb, Enzyme Inhibitors, Hydrogen Peroxide, Tiopronin, Methacrylates, Mitochondria, Heart, Myocardial Contraction, Onium Compounds, Superoxide Dismutase, Thiazoles, Cell Hypoxia, Cell Death, Reactive Oxygen Species, Nitric Oxide Synthase, Ischemic Preconditioning, Myocardial

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks