Schumacker, Paul T.

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia

Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., & Schumacker, P. T. (2000) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 2,000

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 1,926

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

Guzy, R. D., Hoyos, B., Robin, E., Chen, H., Liu, L., Mansfield, K. D., Simon, M. C., Hammerling, U., & Schumacker, P. T. (2005) · Cell Metabolism

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 1,545

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

Murphy, M. P., Bayir, H., Belousov, V., Chang, C. J., Davies, K. J. A., Davies, M. J., Dick, T. P., Finkel, T., Forman, H. J., Janssen-Heininger, Y., et al. (2022) · Nature Metabolism

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 1,514

Mitochondria are required for antigen-specific t cell activation through reactive oxygen species signaling

Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C.-R., Schumacker, P. T., Licht, J. D., Perlman, H., et al. (2013) · Immunity

T-cell and B-cell ImmunologyMitochondrial Function and Pathology

Cited by 1,338

Reactive oxygen species in cancer cells: Live by the sword, die by the sword

Schumacker, P. T. (2006) · Cancer Cell

Redox biology and oxidative stressCancer and biochemical research

Cited by 1,242

Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia

Guzy, R. D., & Schumacker, P. T. (2006) · Experimental Physiology

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 881

Unraveling the biological roles of reactive oxygen species

Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., et al. (2011) · Cell Metabolism

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 836

Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes

Vanden Hoek, T. L., Becker, L. B., Shao, Z., Li, C., & Schumacker, P. T. (1998) · Journal of Biological Chemistry

Cardiac Ischemia and ReperfusionCell death mechanisms and regulation

Cited by 721

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

Mansfield, K. D., Guzy, R. D., Pan, Y., Young, R. M., Cash, T. P., Schumacker, P. T., & Simon, M. C. (2005) · Cell Metabolism

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 606

Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange

Heiden, M. G. V., Chandel, N. S., Schumacker, P. T., & Thompson, C. B. (1999) · Molecular Cell

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 505

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N. S., et al. (2019) · Cell Metabolism

Phagocytosis and Immune RegulationSirtuins and Resveratrol in Medicine

Cited by 485

Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells

Wang, W., Wang, Y., Long, J., Wang, J., Haudek, S. B., Overbeek, P., Chang, B. H. J., Schumacker, P. T., & Danesh, F. R. (2012) · Cell Metabolism

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 476

Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis

Guzy, R. D., Sharma, B., Bell, E., Chandel, N. S., & Schumacker, P. T. (2008) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismCancer and biochemical research

Cited by 427

Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels

Mungai, P. T., Waypa, G. B., Jairaman, A., Prakriya, M., Dokic, D., Ball, M. K., & Schumacker, P. T. (2011) · Molecular and Cellular Biology

Metabolism, Diabetes, and CancerCalcium signaling and nucleotide metabolism

Cited by 385

BNIP3 Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy

Tracy, K., Dibling, B. C., Spike, B. T., Knabb, J. R., Schumacker, P., & Macleod, K. F. (2007) · Molecular and Cellular Biology

Autophagy in Disease and TherapyCell death mechanisms and regulation

Cited by 369

Model for Hypoxic Pulmonary Vasoconstriction Involving Mitochondrial Oxygen Sensing

Waypa, G. B., Chandel, N. S., & Schumacker, P. T. (2001) · Circulation Research

Pulmonary Hypertension Research and TreatmentsMitochondrial Function and Pathology

Cited by 367

Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia

Bell, E. L., Klimova, T. A., Eisenbart, J., Schumacker, P. T., & Chandel, N. S. (2007) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceCancer, Hypoxia, and Metabolism

Cited by 237

The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease

Surmeier, D. J., Guzman, J. N., Sanchez-Padilla, J., & Schumacker, P. T. (2011) · Neuroscience

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 236

ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel

Lebuffe, G., Schumacker, P. T., Shao, Z.-H., Anderson, T., Iwase, H., & Vanden Hoek, T. L. (2003) · American Journal of Physiology-Heart and Circulatory Physiology

Cardiac Ischemia and ReperfusionCell death mechanisms and regulation

Cited by 227

Reactive oxygen species are downstream products of TRAF-mediated signal transduction

Chandel, N. S., Schumacker, P. T., & Arch, R. H. (2001) · Journal of Biological Chemistry

NF-κB Signaling PathwaysRedox biology and oxidative stress

Cited by 203

Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells

Waypa, G. B., Guzy, R., Mungai, P. T., Mack, M. M., Marks, J. D., Roe, M. W., & Schumacker, P. T. (2006) · Circulation Research

Pulmonary Hypertension Research and TreatmentsRedox biology and oxidative stress

Cited by 191

Mitochondrial Electron Transport can Become a Significant Source of Oxidative Injury in Cardiomyocytes

Vanden Hoek, T. L., Shao, Z., Li, C., Schumacker, P. T., & Becker, L. B. (1997) · Journal of Molecular and Cellular Cardiology

Cardiac Ischemia and ReperfusionMitochondrial Function and Pathology

Cited by 161

Roles of HIF1 and HIF2 in pulmonary hypertension: it all depends on the context

Waypa, G. B., & Schumacker, P. T. (2019) · European Respiratory Journal

Pulmonary Hypertension Research and TreatmentsCancer, Hypoxia, and Metabolism

Cited by 26