The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Intracerebroventricular Leptin Regulates Hepatic but Not Peripheral Glucose Fluxes
Open accessAbstract
Acute intravenous infusions of leptin markedly alter hepatic glucose fluxes (Rossetti, L., Massillon, D., Barzilai, N., Vuguin, P., Chen, W., Hawkins, M., Wu, J., and Wang, J. (1997) J. Biol. Chem. 272, 27758-22763). Here we examine whether intracerebroventricular (ICV) leptin administration regulates peripheral and hepatic insulin action. Recombinant mouse leptin (n = 14; 0.02 or 1 microgram/kg.h) or vehicle (n = 9) were administered ICV for 6 h to conscious rats, and insulin action was determined by insulin (3 milliunits/kg.min) clamp and tracer dilution techniques. During physiologic hyperinsulinemia (approximately 65 microunits/ml), the rates of glucose uptake (Rd, 20.1 +/- 0.6 and 23.1 +/- 0.7 versus 21.7 +/- 0.6 mg/kg.min; p = NS), glycolysis and glycogen synthesis were similar in rats receiving low- and high-dose leptin versus vehicle. ICV leptin resulted in a 2-3-fold increase in hepatic phosphoenolpyruvate carboxykinase mRNA levels. Glycogenolysis and PEP-gluconeogenesis (2.1 +/- 0.3 mg/kg. min) contributed similarly to endogenous glucose production (GP) in the vehicle-infused group. However, gluconeogenesis accounted for approximately 80% of GP in both groups receiving ICV leptin, while hepatic glycogenolysis was markedly suppressed (0.7 +/- 0.3 and 1.2 +/- 0.3 versus 2.2 +/- 0.4 mg/kg.min, in rats receiving low- and high-dose leptin versus vehicle, respectively; p < 0.01). In summary, short-term ICV leptin administration: 1) failed to affect peripheral insulin action, but 2) induced a striking re-distribution of intrahepatic glucose fluxes. The latter effect largely reproduced that of leptin given systemically at much higher doses. Thus, the regulation of hepatic glucose fluxes by leptin is largely mediated via its central receptors.
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“the effect is similar whether leptin is administered i.v. or via i.c.v. infusion (at much lower doses) in both rats (106) and mice (91).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [106]
In the citing paper
“In normal rats, i.c.v. leptin administration stimulates hepatic gluconeogenesis, but fails to affect overall hepatic glucose production owing to a simultaneous decrease of glycogenolysis (106).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [106]
In the citing paper
“This leptin action is distinct from its previously reported effect to increase insulin sensitivity in the liver and offers compelling evidence that the brain has the capacity to normalize diabetic hyperglycemia in the presence of sufficient amounts of central nervous system leptin.”
From Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia (2011) · cites this paper as [10]
In the citing paper
“Although accumulating evidence suggests that leptin (10 -13), insulin (14,15), and nutrient-related signals (16 -18) in the CNS improve hepatic insulin sensitivity”
From Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia (2011) · cites this paper as [10]
Citations
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Items 201–222 of 222
Cailotto, C. (2006) · UvA-DARE (University of Amsterdam)
Central and peripheral mechanisms regulating energy and glucose homeostasis
Tom, R. Z. (2013) · Figshare
Leptin in the perinatal period
Hytinantti, T. K. (2001) · Työväentutkimus Vuosikirja
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Mitsuyama, M. (2009) · Journal of molecular medicine · doi:10.1007/s00109-009-0487-7
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LEPTIN— MUC HMOR ETHA N ASATIET YSIGNAL
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Senior Author Correspondence Information
(2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.1-v
The Role of Brain in Glucose Metabolism
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The Role of Brain in Glucose Metabolism
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Participação da via da STAT3 em neurônios POMC do hipotálamo na homeostase energética
Volpi, R. E. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2020.tde-30092022-095827
Metadata
- Authors
- Liu, L., Karkanias, G. B., Morales, J. C., Hawkins, M., Barzilai, N., Wang, J., & Rossetti, L.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Rossetti, Luciano
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 273
- Issue
- 47
- Pages
- 31160-31167
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2001716823
- Cited by
- 222
- References
- 41
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 7 · 2019: 1 · 2018: 3 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 3 · 2013: 5 · 2012: 7
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK-45024, R01DK045024, R01-DK 48321, R01DK048321, DK20541)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- leptin, intracerebroventricular administration, insulin action, gluconeogenesis, glycogenolysis, endogenous glucose production, phosphoenolpyruvate carboxykinase, hepatic glucose uptake, hyperinsulinemia
- MeSH terms
- Animals, Blood Glucose, Carboxy-Lyases, Cerebral Ventricles, Drug Administration Routes, Glucose, Glycogen, Glycolysis, Infusions, Intra-Arterial, Infusions, Parenteral, Insulin, Liver, Male, Proteins, Glucose Clamp Technique, Rats, Sprague-Dawley, Leptin, Mice, Rats
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