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Intracerebroventricular Leptin Regulates Hepatic but Not Peripheral Glucose Fluxes
Open accessAbstract
Acute intravenous infusions of leptin markedly alter hepatic glucose fluxes (Rossetti, L., Massillon, D., Barzilai, N., Vuguin, P., Chen, W., Hawkins, M., Wu, J., and Wang, J. (1997) J. Biol. Chem. 272, 27758-22763). Here we examine whether intracerebroventricular (ICV) leptin administration regulates peripheral and hepatic insulin action. Recombinant mouse leptin (n = 14; 0.02 or 1 microgram/kg.h) or vehicle (n = 9) were administered ICV for 6 h to conscious rats, and insulin action was determined by insulin (3 milliunits/kg.min) clamp and tracer dilution techniques. During physiologic hyperinsulinemia (approximately 65 microunits/ml), the rates of glucose uptake (Rd, 20.1 +/- 0.6 and 23.1 +/- 0.7 versus 21.7 +/- 0.6 mg/kg.min; p = NS), glycolysis and glycogen synthesis were similar in rats receiving low- and high-dose leptin versus vehicle. ICV leptin resulted in a 2-3-fold increase in hepatic phosphoenolpyruvate carboxykinase mRNA levels. Glycogenolysis and PEP-gluconeogenesis (2.1 +/- 0.3 mg/kg. min) contributed similarly to endogenous glucose production (GP) in the vehicle-infused group. However, gluconeogenesis accounted for approximately 80% of GP in both groups receiving ICV leptin, while hepatic glycogenolysis was markedly suppressed (0.7 +/- 0.3 and 1.2 +/- 0.3 versus 2.2 +/- 0.4 mg/kg.min, in rats receiving low- and high-dose leptin versus vehicle, respectively; p < 0.01). In summary, short-term ICV leptin administration: 1) failed to affect peripheral insulin action, but 2) induced a striking re-distribution of intrahepatic glucose fluxes. The latter effect largely reproduced that of leptin given systemically at much higher doses. Thus, the regulation of hepatic glucose fluxes by leptin is largely mediated via its central receptors.
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“the effect is similar whether leptin is administered i.v. or via i.c.v. infusion (at much lower doses) in both rats (106) and mice (91).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [106]
In the citing paper
“In normal rats, i.c.v. leptin administration stimulates hepatic gluconeogenesis, but fails to affect overall hepatic glucose production owing to a simultaneous decrease of glycogenolysis (106).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [106]
In the citing paper
“This leptin action is distinct from its previously reported effect to increase insulin sensitivity in the liver and offers compelling evidence that the brain has the capacity to normalize diabetic hyperglycemia in the presence of sufficient amounts of central nervous system leptin.”
From Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia (2011) · cites this paper as [10]
In the citing paper
“Although accumulating evidence suggests that leptin (10 -13), insulin (14,15), and nutrient-related signals (16 -18) in the CNS improve hepatic insulin sensitivity”
From Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia (2011) · cites this paper as [10]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660
Identification of targets of leptin action in rat hypothalamus.
Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,499
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
Schwartz, M. W., Peskind, E., Raskind, M., Boyko, E. J., & Porte, D. (1996) · Nature Medicine · doi:10.1038/nm0596-589 · Cited by 1,014
Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte, D., Woods, S. C., Seeley, R. J., et al. (1996) · Diabetes · doi:10.2337/diab.45.4.531 · Cited by 904
Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis.
Pilkis, S. J., & Granner, D. K. (1992) · Annual Review of Physiology · doi:10.1146/annurev.ph.54.030192.004321 · Cited by 865
Flagged first, then by citations
Research works printed but not linked: 2
- Hill, 1984, Am. J. Physiol., 247, R318
- Himms-Hagen, 1994, Am. J. Physiol., 266, R1371
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Ahima, R. S., & Flier, J. S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00301-5 · Cited by 1,608
Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus
Shepherd, P. R., & Kahn, B. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410406 · Cited by 1,295
High‐fat Diets: Modeling the Metabolic Disorders of Human Obesity in Rodents
Buettner, R., Schölmerich, J., & Bollheimer, L. C. (2007) · Obesity · doi:10.1038/oby.2007.608 · Cited by 1,284
Mechanisms of leptin action and leptin resistance.
Myers, M. G., Cowley, M. A., & Münzberg, H. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100707 · Cited by 1,074
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
Combs, T. P., Berg, A. H., Obici, S., Scherer, P. E., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14120 · Cited by 955
Self-citationHypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904
Self-citationDecreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
Obici, S., Feng, Z., Karkanias, G., Baskin, D. G., & Rossetti, L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-861 · Cited by 719
Self-citationCentral Administration of Oleic Acid Inhibits Glucose Production and Food Intake
Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G., & Rossetti, L. (2002) · Diabetes · doi:10.2337/diabetes.51.2.271 · Cited by 654
Self-citationAdipose Tissue as an Endocrine Organ
Ahima, R. S. (2006) · Obesity · doi:10.1038/oby.2006.317 · Cited by 646
Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat
Kishi, T., Aschkenasi, C. J., Lee, C. E., Mountjoy, K. G., Saper, C. B., & Elmquist, J. K. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10454 · Cited by 581
New insights into sympathetic regulation of glucose and fat metabolism
Nonogaki, K. (2000) · Diabetologia · doi:10.1007/s001250051341 · Cited by 589
Molecular and anatomical determinants of central leptin resistance
Münzberg, H., & Myers, M. G. (2005) · Nature Neuroscience · doi:10.1038/nn1454 · Cited by 550
Obici, S., Feng, Z., Arduini, A., Conti, R., & Rossetti, L. (2003) · Nature Medicine · doi:10.1038/nm873 · Cited by 548
Self-citationHuang, W., Metlakunta, A., Dedousis, N., Zhang, P., Sipula, I., Dube, J. J., Scott, D. K., & O'Doherty, R. M. (2010) · Diabetes · doi:10.2337/db09-0016 · Cited by 520
Leptin Receptor Signaling and the Regulation of Mammalian Physiology
Myers, M. G. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.287 · Cited by 463
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Self-citationBerglund, E. D., Vianna, C. R., Donato, J., Kim, M. H., Chuang, J.-C., Lee, C. E., Lauzon, D. A., Lin, P., Brule, L. J., Scott, M. M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59816 · Cited by 352
Leptin and the Central Nervous System Control of Glucose Metabolism
Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338
“Among several lines of evidence implicating the brain in the actions of leptin on glucose metabolism is the observation that the effect is similar whether leptin is administered intravenously or via intracerebroventricular infusion (at much lower doses) in both rats (106) and mice (91).”
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Leptin receptor signaling and the regulation of mammalian physiology
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The role of the autonomic nervous liver innervation in the control of energy metabolism
Yi, C., la Fleur, S. E., Fliers, E., & Kalsbeek, A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.01.006 · Cited by 240
Critical role of STAT3 in leptin's metabolic actions
Buettner, C., Pocai, A., Muse, E. D., Etgen, A. M., Myers, M. G., & Rossetti, L. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.014 · Cited by 228
Self-citationLeptin—Much More Than a Satiety Signal
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Self-citationThe glucoregulatory actions of leptin
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Jitrapakdee, S. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.10.001 · Cited by 202
Selective interaction between leptin and insulin signaling pathways in a hepatic cell line
Szántó, I., & Kahn, C. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050580497 · Cited by 187
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Self-citationFunctional identification of a neurocircuit regulating blood glucose
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The Integrative Role of CNS Fuel-Sensing Mechanisms in Energy Balance and Glucose Regulation
Sandoval, D., Cota, D., & Seeley, R. J. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.120806.095256 · Cited by 178
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Flak, J. N., & Myers, M. G. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1232 · Cited by 179
Bates, S. H., Kulkarni, R. N., Seifert, M., & Myers, M. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.02.001 · Cited by 173
German, J. P., Thaler, J. P., Wisse, B. E., Oh-I, S., Sarruf, D. A., Matsen, M. E., Fischer, J. D., Taborsky, G. J., Schwartz, M. W., & Morton, G. J. (2011) · Endocrinology · doi:10.1210/en.2010-0890 · Cited by 169
German, J., Kim, F., Schwartz, G. J., Havel, P. J., Rhodes, C. J., Schwartz, M. W., & Morton, G. J. (2009) · Endocrinology · doi:10.1210/en.2009-0445 · Cited by 164
Leptin and its metabolic interactions – an update
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Central Leptin Acutely Reverses Diet-Induced Hepatic Insulin Resistance
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Self-citationHypothalamic control of energy metabolism via the autonomic nervous system
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The role of leptin in glucose homeostasis
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Perspective: Hexosamines and Nutrient Sensing
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Self-citationNew lessons in the regulation of glucose metabolism taught by the glucose 6‐phosphatase system
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Relation between leptin and the regulation of glucose metabolism
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Role of adipocytokines in obesity-associated insulin resistance
Zou, C., & Shao, J. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.06.006 · Cited by 143
Purnell, J. Q., Selzer, F., Wahed, A. S., Pender, J. R., Pories, W. J., Pomp, A., Dakin, G. F., Mitchell, J. E., Garcia, L., Staten, M. A., et al. (2016) · Diabetes Care · doi:10.2337/dc15-2138 · Cited by 136
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Wired on sugar: the role of the CNS in the regulation of glucose homeostasis
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Central insulin and leptin-mediated autonomic control of glucose homeostasis
Marino, J. S., Xu, Y., & Hill, J. W. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.03.001 · Cited by 129
Integrative neurobiology of energy homeostasis-neurocircuits, signals and mediators
Sánchez-Lasheras, C., Könner, A. C., & Brüning, J. C. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.08.002 · Cited by 127
JULLIARD, A., CHAPUT, M., APELBAUM, A., AIME, P., MAHFOUZ, M., & DUCHAMPVIRET, P. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.05.033 · Cited by 119
Melanocortin-independent Effects of Leptin on Hepatic Glucose Fluxes
Gutiérrez-Juárez, R., Obici, S., & Rossetti, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408665200 · Cited by 115
Self-citationLiver Triglyceride Secretion and Lipid Oxidative Metabolism Are Rapidly Altered by Leptin in Vivo
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Hidaka, S., Yoshimatsu, H., Kondou, S., Tsuruta, Y., Oka, K., Noguchi, H., Okamoto, K., Sakino, H., Teshima, Y., Okeda, T., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0164com · Cited by 108
The hypothalamic clock and its control of glucose homeostasis
Kalsbeek, A., Yi, C., la Fleur, S. E., & Fliers, E. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.02.005 · Cited by 112
Leptin: obesity, diabetes and other peripheral effects - a review
Moran, O., & Phillip, M. (2003) · Pediatric Diabetes · doi:10.1034/j.1399-5448.2003.00017.x · Cited by 110
Sandoval, D. A., & Davis, S. N. (2003) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(02)00167-8 · Cited by 107
Leptin Improves Insulin Resistance and Hyperglycemia in a Mouse Model of Type 2 Diabetes
Toyoshima, Y., Gavrilova, O., Yakar, S., Jou, W., Pack, S., Shyr, Z. A., Wheeler, M. B., & LeRoith, D. (2005) · Endocrinology · doi:10.1210/en.2005-0087 · Cited by 108
Targeting the CNS to treat type 2 diabetes
Sandoval, D. A., Obici, S., & Seeley, R. J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2874 · Cited by 101
Zhang, Y., Li, Y., Niepel, M. W., Kawano, Y., Han, S., Liu, S., Marsili, A., Larsen, P. R., Lee, C., & Cohen, D. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116011109 · Cited by 98
Hepatic leptin signaling in obesity
Brabant, G. E., Müller, G. A., Horn, R., Anderwald, C. H., Roden, M., & Nave, H. (2005) · The FASEB Journal · doi:10.1096/fj.04-2846fje · Cited by 101
Coutinho, E. A., Okamoto, S., Ishikawa, A. W., Yokota, S., Wada, N., Hirabayashi, T., Saito, K., Sato, T., Takagi, K., Wang, C.-C., et al. (2017) · Diabetes · doi:10.2337/db16-1344 · Cited by 96
Carvalheira, J. B. C., Ribeiro, E. B., Folli, F. B., Velloso, L. A., & Saad, M. J. A. (2003) · Biological Chemistry · doi:10.1515/bc.2003.016 · Cited by 92
Mingrone, G., Greco, A., Giancaterini, A., Scarfone, A., Castagneto, M., & Pugeat, M. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00667-0 · Cited by 96
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Prodi, E., & Obici, S. (2006) · Endocrinology · doi:10.1210/en.2006-0143 · Cited by 88
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Perrin, C., Knauf, C., & Burcelin, R. (2004) · Endocrinology · doi:10.1210/en.2004-0270 · Cited by 79
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Wang, J., Liu, R., Liu, L., Chowdhury, R., Barzilai, N., Tan, J., & Rossetti, L. (1999) · Nature Medicine · doi:10.1038/11335 · Cited by 75
Self-citationHanusch‐Enserer, U., Cauza, E., Brabant, G. E., Dunky, A., Rosén, H., Pacini, G., Tüchler, H., Prager, R., & Roden, M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031438 · Cited by 78
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Güemes, A., & Georgiou, P. (2018) · Bioelectronic Medicine · doi:10.1186/s42234-018-0009-4 · Cited by 79
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Knauf, C., Rieusset, J., Foretz, M., Cani, P. D., Uldry, M., Hosokawa, M., Martinez, E., Bringart, M., Waget, A., Kersten, S., et al. (2006) · Endocrinology · doi:10.1210/en.2005-1536 · Cited by 75
Roman, E. A. F. R., Reis, D., Romanatto, T., Maimoni, D., Ferreira, E. A., Santos, G. A., Torsoni, A. S., Velloso, L. A., & Torsoni, M. A. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.007 · Cited by 71
Anderwald, C. H., Müller, G. A., Koca, G., Fürnsinn, C., Waldhäusl, W. K., & Roden, M. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.7.0867 · Cited by 73
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Scherer, T., Lindtner, C., Zieliński, E., O’Hare, J., Filatova, N., & Buettner, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.307348 · Cited by 72
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Self-citationElevated bound leptin correlates with energy expenditure in cirrhotics
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Muzumdar, R. H., Ma, X., Yang, X., Atzmon, G., Bernstein, J., Karkanias, G. B., & Barzilai, N. (2003) · The FASEB Journal · doi:10.1096/fj.02-0991fje · Cited by 69
Self-citation
Metadata
- Authors
- Liu, L., Karkanias, G. B., Morales, J. C., Hawkins, M., Barzilai, N., Wang, J., & Rossetti, L.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Rossetti, Luciano
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 273
- Issue
- 47
- Pages
- 31160-31167
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2001716823
- Cited by
- 222
- References
- 41
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 7 · 2019: 1 · 2018: 3 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 3 · 2013: 5 · 2012: 7
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK-45024, R01DK045024, R01-DK 48321, R01DK048321, DK20541)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- leptin, intracerebroventricular administration, insulin action, gluconeogenesis, glycogenolysis, endogenous glucose production, phosphoenolpyruvate carboxykinase, hepatic glucose uptake, hyperinsulinemia
- MeSH terms
- Animals, Blood Glucose, Carboxy-Lyases, Cerebral Ventricles, Drug Administration Routes, Glucose, Glycogen, Glycolysis, Infusions, Intra-Arterial, Infusions, Parenteral, Insulin, Liver, Male, Proteins, Glucose Clamp Technique, Rats, Sprague-Dawley, Leptin, Mice, Rats
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