The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB
Open accessAbstract
We report here that the Shigella invasion plasmid antigen (Ipa)B, which is sufficient to induce apoptosis in macrophages, binds to caspase (Casp)-1, but not to Casp-2 or Casp-3. Casp-1 is activated and its specific substrate interleukin-1beta is cleaved shortly after Shigella infection. Macrophages isolated from Casp-1 knock-out mice are not susceptible to Shigella-induced apoptosis, although they respond normally to other apoptotic stimuli. Shigella kills macrophages from casp-3, casp-11, and p53 knock-out mice as well as macrophages overexpressing Bcl-2. We propose that Shigella induces apoptosis by directly activating Casp-1 through IpaB, bypassing signal transduction events and caspases upstream of Casp-1. Taken together these data indicate that Shigella-induced apoptosis is distinct from other forms of apoptosis and seems uniquely dependent on Casp-1.
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Cites
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Cited by
Pyroptosis: host cell death and inflammation
Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,183
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
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The Inflammasomes: Guardians of the Body
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NLRP3 inflammasome activation and cell death
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Pathogenicity Islands and the Evolution of Microbes
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Metadata
- Authors
- Hilbi, H., Moss, J. E., Hersh, D., Chen, Y., Arondel, J., Banerjee, S., Flavell, R. A., Yuan, J., Sansonetti, P. J., & Zychlinsky, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 273
- Issue
- 49
- Pages
- 32895-32900
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2048215059
- Cited by
- 428
- References
- 43
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB. https://app.cochat.ai/papers/10.1074/jbc.273.49.32895
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- Hilbi, H., Moss, J. E., Hersh, D., Chen, Y., Arondel, J., Banerjee, S., Flavell, R. A., Yuan, J., Sansonetti, P. J., & Zychlinsky, A. (1998). Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.273.49.32895
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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