Cited by 249Cell death mechanisms and regulationProtein Tyrosine PhosphatasesNF-κB Signaling Pathways

The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.

Correlation between Sustained c-Jun N-terminal Protein Kinase Activation and Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells

Open access

Guo, Yan-Lin, Baysal, Kemal, Kang, Baobin, Yang, Li-Jun, Williamson, John R.·1998·Journal of Biological Chemistry

Open this paper in CoChat — free account Open PDF

Abstract

Rat mesangial cells are normally resistant to tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis. In this report we show that the cells can be made susceptible to the apoptotic effect of TNF-alpha when pretreated with actinomycin D, cycloheximide, or vanadate. c-Jun N-terminal protein kinase (JNK) has been thought to mediate apoptotic processes elicited by some stimuli, but its involvement in TNF-alpha-induced apoptosis has been controversial. JNK activation was investigated under conditions where the mesangial cells were either resistant or susceptible to TNF-alpha-induced apoptosis. TNF-alpha alone stimulated a single transient JNK activity peak. However, when the cells were pretreated with actinomycin D or cycloheximide, TNF-alpha stimulated a second sustained JNK activity peak. When the cells were pretreated with the phosphatase inhibitor vanadate, TNF-alpha-induced JNK activation was greatly prolonged. In all three cases, a sustained JNK activation was associated with the initiation of apoptosis. Our data suggest that a sustained activation of JNK induced by these reagents may be associated with blocking the expression of a phosphatase that inactivates JNK. Further studies reveal that the expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) was induced by TNF-alpha, indicating that MKP-1 may be involved in protecting the cells from apoptosis by preventing a prolonged activation of JNK under normal conditions. Additional studies showed that extracellular signal-regulated protein kinase activation stimulated by TNF-alpha was unlikely to contribute to the resistance of mesangial cells to TNF-alpha cytotoxicity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1074/jbc.273.7.4027

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273
Apoptosis by Death Factor
Nagata, S. (1997) · Cell · doi:10.1016/s0092-8674(00)81874-7 · Cited by 4,934
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo
Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27489 · Cited by 3,374
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
The stress-activated protein kinase subfamily of c-Jun kinases
Kyriakis, J. M., Banerjee, P. T., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., & Woodgett, J. R. (1994) · Nature · doi:10.1038/369156a0 · Cited by 2,601
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581
Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death
Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937

Flagged first, then by citations

Show all 51 references

1 of the 51 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Gines, 1995, Hepatology, 22, 1296

Sorted by citations

Signaling to NF-κB
Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842
Tumor necrosis factor signaling
Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401189 · Cited by 2,422
Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis
Sinha, K., Das, J., Pal, P. B., & Sil, P. C. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1034-4 · Cited by 1,643
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
Wallach, D., Varfolomeev, E. E., Malinin, N. L., Goltsev, Y. V., Kovalenko, A. V., & Boldin, M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.331 · Cited by 1,299
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T., & Ichijo, H. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve046 · Cited by 1,211
A Family of Stress-Inducible GADD45-like Proteins Mediate Activation of the Stress-Responsive MTK1/MEKK4 MAPKKK
Takekawa, M., & Saito, H. (1998) · Cell · doi:10.1016/s0092-8674(00)81619-0 · Cited by 746
Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling
De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D. U., Jin, R., Jones, J., Cong, R., & Franzoso, G. (2001) · Nature · doi:10.1038/35104560 · Cited by 732
Inhibition of JNK activation through NF-κB target genes
Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., & Lin, A. (2001) · Nature · doi:10.1038/35104568 · Cited by 721
Redox regulation of mitochondrial function
Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588
Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling
Matsuzawa, A., & Ichijo, H. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.12.011 · Cited by 507
NF‐κB inhibits TNF‐induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death
Sakon, S., Xue, X., Takekawa, M., Sasazuki, T., Okazaki, T., Kojima, Y., Piao, J., Yagita, H., Okumura, K., Doi, T., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg379 · Cited by 497
TNF-Induced Signaling in Apoptosis
Rath, P., & Aggarwal, B. (1999) · Journal of Clinical Immunology · doi:10.1023/a:1020546615229 · Cited by 454
Protective effect of curcumin against heavy metals-induced liver damage
García‐Niño, W. R., & Pedraza‐Chaverrí, J. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.04.016 · Cited by 395
Reactive oxygen species mediate crosstalk between NF-κB and JNK
Nakano, H., Nakajima, A., Sakon-Komazawa, S., Piao, J.-H., Xue, X., & Okumura, K. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401830 · Cited by 370
Chemical Genetic Analysis of the Time Course of Signal Transduction by JNK
Ventura, J., Hübner, A., Zhang, C., Flavell, R. A., Shokat, K. M., & Davis, R. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.018 · Cited by 329
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species
Ventura, J.-J., Cogswell, P., Flavell, R. A., Baldwin, A. S., & Davis, R. J. (2004) · Genes & Development · doi:10.1101/gad.1223004 · Cited by 303
An Inhibitor of p38 Mitogen-activated Protein Kinase Protects Neonatal Cardiac Myocytes from Ischemia
Mackay, K., & Mochly‐Rosen, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6272 · Cited by 296
Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress
Morita, K., Saitoh, M., Tobiume, K., Matsuura, H., Enomoto, S., Nishitoh, H., & Ichijo, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.6028 · Cited by 289
Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.
Manna, S. K., Mukhopadhyay, A., Van, N. T., & Aggarwal, B. B. (1999) · PubMed · Cited by 293
Homocysteine Induces Programmed Cell Death in Human Vascular Endothelial Cells through Activation of the Unfolded Protein Response
Zhang, C., Cai, Y., Adachi, M. T., Oshiro, S., Aso, T., Kaufman, R. J., & Kitajima, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100747200 · Cited by 288
The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs)
Barr, R. K., & Bogoyevitch, M. A. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00093-0 · Cited by 285
Stress-Responsive Protein Kinases in Redox-Regulated Apoptosis Signaling
Matsuzawa, A., & Ichijo, H. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.472 · Cited by 284
Silymarin Suppresses TNF-Induced Activation of NF-κB, c-Jun N-Terminal Kinase, and Apoptosis
Manna, S. K., Mukhopadhyay, A., Van, N. T., & Aggarwal, B. B. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6800 · Cited by 277
Protein Kinase C δ Is Essential for Etoposide-induced Apoptosis in Salivary Gland Acinar Cells
Reyland, M. E., Anderson, S. M., Matassa, A. A., Barzen, K. A., & Quissell, D. O. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19115 · Cited by 269
JunD Mediates Survival Signaling by the JNK Signal Transduction Pathway
Lamb, J. A., Ventura, J., Hess, P., Flavell, R. A., & Davis, R. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00203-x · Cited by 261
Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium
Chuang, S., Wang, I., & Yang, J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.7.1423 · Cited by 252
Physiological Roles of ASK1-Mediated Signal Transduction in Oxidative Stress- and Endoplasmic Reticulum Stress-Induced Apoptosis: Advanced Findings from ASK1 Knockout Mice
Matsuzawa, A., Nishitoh, H., Tobiume, K., Takeda, K., & Ichijo, H. (2002) · Antioxidants and Redox Signaling · doi:10.1089/15230860260196218 · Cited by 249
Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation
Nakagawa, H., Maeda, S., Hikiba, Y., Ohmae, T., Shibata, W., Yanai, A., Sakamoto, K., Ogura, K., Noguchi, T., Karin, M., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.006 · Cited by 255
Role of Hsp70 in regulation of stress‐kinase JNK: implications in apoptosis and aging
Gabai, V. L., Meriin, A. B., Yaglom, J. A., Volloch, V., & Sherman, M. Y. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01242-3 · Cited by 240
Preconditioning with erythropoietin protects against subsequent ischemia‐reperfusion injury in rat kidney
Yang, C. W., Li, C., Jung, J., Shin, S. J., Choi, B. S., Lim, S. W., Sun, B., Kim, Y., Kim, J., Chang, Y. S., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-1191fje · Cited by 237
Roles of MAPKKK ASK1 in Stress-Induced Cell Death.
Takeda, K., Matsuzawa, A., Nishitoh, H., & Ichijo, H. (2003) · Cell Structure and Function · doi:10.1247/csf.28.23 · Cited by 224
Extracellular Signal-regulated Protein Kinase/Jun Kinase Cross-talk Underlies Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation
Pedram, A., Razandi, M., & Levin, E. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26722 · Cited by 216
NF-κB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun
Liu, H., Lo, C. R., & Czaja, M. J. (2002) · Hepatology · doi:10.1053/jhep.2002.32534 · Cited by 199
Role of Gadd45 in apoptosis
Sheikh, M. S., Hollander, M. C., & Fornace, A. J. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00291-9 · Cited by 196
MAPK activation determines renal epithelial cell survival during oxidative injury
Mari, J. F. D., Davis, R. J., & Safirstein, R. L. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.277.2.f195 · Cited by 195
Role of 4-hydroxynonenal in stress-mediated apoptosis signaling
Awasthi, S., Sharma, R., Cheng, J. Z., Yang, Y., Sharma, A., Singhal, S. S., & Awasthi, S. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(03)00017-7 · Cited by 198
IL-4, but not vitamin D3, induces monoblastic cell line UG3 to differentiate into multinucleated giant cells on osteoclast lineage
Kaji, Y., Ikeda, K., Ikeda, T., Kawakami, K., Sasaki, K., Shindo, M., Hatake, K., Harada, M., Motoyoshi, K., Mori, S., et al. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200002)182:2 · Cited by 10
Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH2-terminal kinase and promoter response element
Cai, Y., Zhang, C., Nawa, T., Aso, T., Tanaka, M. R., Oshiro, S., Ichijo, H., & Kitajima, S. (2000) · Blood · doi:10.1182/blood.v96.6.2140 · Cited by 181
Identification of NF-κB-regulated genes induced by TNFα utilizing expression profiling and RNA interference
Zhou, A., Scoggin, S. O., Gaynor, R. B., & Williams, N. S. (2003) · Oncogene · doi:10.1038/sj.onc.1206262 · Cited by 177
MAPK signaling and the kidney
Tian, W., Zhang, Z., & Cohen, D. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.279.4.f593 · Cited by 174
Molecular Mechanisms of the Decision between Life and Death: Regulation of Apoptosis by Apoptosis Signal-Regulating Kinase 1
Matsuzawa, A., & Ichijo, H. (2001) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a002947 · Cited by 171
c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells
Gururajan, M., Chui, R., Karuppannan, A. K., Ke, J., JENNINGS, C. D., & Bondada, S. (2005) · Blood · doi:10.1182/blood-2004-10-3819 · Cited by 156
Negative Regulation of JNK Signaling by the Tumor Suppressor CYLD
Reiley, W. W., Zhang, M., & Sun, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411049200 · Cited by 148
Ectopic Expression of Hepatitis C Virus Core Protein Differentially Regulates Nuclear Transcription Factors
Shrivastava, A., Manna, S. K., Ray, R., & Aggarwal, B. B. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9722-9728.1998 · Cited by 145
Overexpression of γ-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1
Manna, S. K., Kuo, M. T., & Aggarwal, B. B. (1999) · Oncogene · doi:10.1038/sj.onc.1202811 · Cited by 143
Cellular and molecular mechanisms of sex differences in renal ischemia–reperfusion injury
Kher, A., Meldrum, K. K., Wang, M., Tsai, B. M., Pitcher, J. M., & Meldrum, D. R. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.05.005 · Cited by 136
Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: Involvement of p38 mitogen-activated protein kinase
Weng, M., Ho, Y., & Lin, J.-K. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.03.011 · Cited by 131
Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells
Reardon, D., Contessa, J., Mikkelsen, R., Valerie, K., Amir, C., Dent, P., & Schmidt-Ullrich, R. (1999) · Oncogene · doi:10.1038/sj.onc.1202849 · Cited by 143
Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) Expression Is Induced by Low Oxygen Conditions Found in Solid Tumor Microenvironments
Laderoute, K. R., Mendonca, H. L., Calaoagan, J. M., Knapp, A. M., Giaccia, A. J., & Stork, P. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12890 · Cited by 127
NF-κB activation results in rapid inactivation of JNK in TNFα-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-κB
Javelaud, D., & Besançon, F. (2001) · Oncogene · doi:10.1038/sj.onc.1204570 · Cited by 124
Regulation of c-Jun-NH2 Terminal Kinase and Extracellular-Signal Regulated Kinase in Human Platelets
Bugaud, F., Nadal-Wollbold, F., Levy-Toledano, S., Rosa, J., & Bryckaert, M. (1999) · Blood · doi:10.1182/blood.v94.11.3800 · Cited by 123
Transfection of mGSTA4 in HL-60 Cells Protects against 4-Hydroxynonenal-Induced Apoptosis by Inhibiting JNK-Mediated Signaling
Cheng, J., Singhal, S. S., Sharma, A., Saini, M. K., Yang, Y., Awasthi, S., Zimniak, P., & Awasthi, S. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2452 · Cited by 121
Cross-Talk between Phosphatidylinositol 3-Kinase/AKT and c-Jun NH2-Terminal Kinase Mediates Survival of Isolated Human Islets
Aikin, R. A., Maysinger, D., & Rosenberg, L. C. (2004) · Endocrinology · doi:10.1210/en.2004-0488 · Cited by 119
Inhibition of C-Jun N-Terminal Kinase 1, but Not c-Jun N-Terminal Kinase 2, Suppresses Apoptosis Induced by Ischemia/Reoxygenation in Rat Cardiac Myocytes
Hreniuk, D., Garay, M., Gaarde, W. A., Monia, B. P., McKay, R. A., & Cioffi, C. L. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.867 · Cited by 119
Suppressed NF- B and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF- -induced apoptosis in human cancer cells
Zhang, S. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh234 · Cited by 113
Activation of JNK and Transcriptional Repressor ATF3/LRF1 through the IRE1/TRAF2 Pathway Is Implicated in Human Vascular Endothelial Cell Death by Homocysteine
Zhang, C., Kawauchi, J., Adachi, M. T., Hashimoto, Y., Oshiro, S., Aso, T., & Kitajima, S. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6044 · Cited by 111
Lipopolysaccharide Signals an Endothelial Apoptosis Pathway Through TNF Receptor-Associated Factor 6-Mediated Activation of c-Jun NH2-Terminal Kinase
Hull, C. M., McLean, G. W., Wong, F., Duriez, P. J., & Karsan, A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2611 · Cited by 107
Akt, MAPK (Erk1/2), and p38 Act in Concert to Promote Apoptosis in Response to ErbB Receptor Family Inhibition
Nelson, J. M., & Fry, D. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008786200 · Cited by 102
Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase–dependent manner
Graf, D., Kurz, A. K., Fischer, R., Reinehr, R., & Häussinger, D. (2002) · Gastroenterology · doi:10.1053/gast.2002.32976 · Cited by 97
JNK and p38 are activated by erythropoietin (EPO) but are not induced in apoptosis following EPO withdrawal in EPO-dependent HCD57 cells
Jacobs-Helber, S. M., Ryan, J. J., & Sawyer, S. T. (2000) · Blood · doi:10.1182/blood.v96.3.933 · Cited by 96
An antiapoptotic protein, c‐FLIPL, directly binds to MKK7 and inhibits the JNK pathway
Nakajima, A., Komazawa‐Sakon, S., Takekawa, M., Sasazuki, T., Yeh, W., Yagita∥, H., Okumura, K., & Nakano, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601423 · Cited by 94
Squamous cell carcinoma antigen suppresses radiation-induced cell death
Murakami, A., Suminami, Y., Hirakawa, H., Nawata, S., Numa, F., & Kato, H. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2000.1683 · Cited by 95
An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response
Brown, M., Strudwick, N., Suwara, M., Sutcliffe, L. K., Mihai, A. D., Ali, A. A., Watson, J. N., & Schröder, M. (2016) · Journal of Cell Science · doi:10.1242/jcs.179127 · Cited by 97
Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity
Chuang, S., Liou, G., & Yang, J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.491 · Cited by 93
JNK Activation Is Required for JB6 Cell Transformation Induced by Tumor Necrosis Factor-α but Not by 12-O-Tetradecanoylphorbol-13-Acetate
Huang, C., Li, J., Ma, W., & Dong, Z. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.29672 · Cited by 93
Hepatitis B Virus X Protein Differentially Activates RAS-RAF-MAPK and JNK Pathways in X-transforming Versus Non-transforming AML12 Hepatocytes
Tarn, C., Lee, S., Hu, Y., Ashendel, C. L., & ANDRISANI, O. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104105200 · Cited by 92
The Novel Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) Potently Enhances Apoptosis Induced by Tumor Necrosis Factor in Human Leukemia Cells
Stadheim, T. A., Suh, N., Ganju, N., Sporn, M. B., & Eastman, A. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108974200 · Cited by 91
COX-2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer
Sui, H. X., Zhou, S., Wang, Y., Liu, X., Zhou, L., Yin, P., Fan, Z., & Li, Q. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr016 · Cited by 91
Signal transduction pathways regulated by arsenate and arsenite
Porter, A. C., Fanger, G. R., & Vaillancourt, R. R. (1999) · Oncogene · doi:10.1038/sj.onc.1203214 · Cited by 89
Role of MAPK pathways in light chain-induced cytokine production in human proximal tubule cells
Şengül, Ş., Zwizinski, C. W., & Batuman, V. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00350.2002 · Cited by 88
Hyperosmolality activates Akt and regulates apoptosis in renal tubular cells
Terada, Y., Inoshita, S., Hanada, S., Shimamura, H., Kuwahara, M., Ogawa, W., Kasuga, M., Sasaki, S., & Marumo, F. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.060002553.x · Cited by 87
Increased cytochromeP-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-α
Liu, H., Jones, B., Bradham, C. A., & Czaja, M. J. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00304.2001 · Cited by 87
Lipopolysaccharide Inhibits TNF-Induced Apoptosis: Role of Nuclear Factor-κB Activation and Reactive Oxygen Intermediates
Manna, S. K., & Aggarwal, B. B. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1510 · Cited by 104
Microglia-derived IGF-2 prevents TNFα induced death of mature oligodendrocytes in vitro
Nicholas, R. S., Stevens, S. C. W., Wing, M. G., & Compston, D. A. S. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00011-5 · Cited by 86
Lipopolysaccharide inhibits TNF-induced apoptosis: role of nuclear factor-kappaB activation and reactive oxygen intermediates.
Manna, S. K., & Aggarwal, B. B. (1999) · PubMed · Cited by 86
PP2C family members play key roles in regulation of cell survival and apoptosis
Tamura, S., Toriumi, S., Saito, J., Awano, K., Kudo, T., & Kobayashi, T. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00219.x · Cited by 85
Apoptotic regulatory proteins in renal injury
Ortíz, A. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00188.x · Cited by 84
Inhibition of the Expression of Mitogen-activated Protein Phosphatase-1 Potentiates Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells
Guo, Y., Kang, B., & WILLIAMSON, J. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10362 · Cited by 83
Self-citation
Hyperosmolarity triggers CD95 membrane trafficking and sensitizes rat hepatocytes toward CD95L-induced apoptosis
Reinehr, R., Graf, D., Fischer, R., Schliess, F., & Häussinger, D. (2002) · Hepatology · doi:10.1053/jhep.2002.35447 · Cited by 80
Apoptosis and extracellular matrix–cell interactions in kidney disease
Makino, H., Sugiyama, H., & Kashihara, N. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.07711.x · Cited by 73
Differential MAP kinase activation and Na+/H+exchanger phosphorylation by H2O2 in rat cardiac myocytes
Wei, S., Rothstein, E. C., Fliegel, L., Dell’Italia, L. J., & Lucchesi, P. A. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.5.c1542 · Cited by 74
Signaling crosstalk between NF-κB and JNK
Nakano, H. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.05.007 · Cited by 74
Genipin Induced Apoptosis Associated with Activation of the c-Jun NH2-Terminal Kinase and p53 Protein in HeLa Cells
Cao, H., Feng, Q., Xu, W., Li, X., Kang, Z., Ren, Y., & Du, L. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.1343 · Cited by 73
Roles of p38 and JNK mitogen-activated protein kinase pathways during cantharidin-induced apoptosis in U937 cells
Huh, J., Kang, K., Chae, C., Kim, H., Ahn, K.-S., & Kim, S. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.12.025 · Cited by 72
TNF‐induced death of adult human oligodendrocytes is mediated by c‐jun NH2‐terminal kinase‐3
Jurewicz, A., Matysiak, M., Tybor, K., & Selmaj, K. (2003) · Brain · doi:10.1093/brain/awg146 · Cited by 70
TNF-α AND IL-1α INDUCE APOPTOSIS IN SUBCONFLUENT RAT MESANGIAL CELLS. EVIDENCE FOR THE INVOLVEMENT OF HYDROGEN PEROXIDE AND LIPID PEROXIDATION AS SECOND MESSENGERS
Böhler, T., Waiser, J., Hepburn, H., Gaedeke, J., Lehmann, C., Hambach, P., Budde, K., & Neumayer, H. (2000) · Cytokine · doi:10.1006/cyto.1999.0633 · Cited by 68
Sequential Activation of ERK and Repression of JNK by Scatter Factor/Hepatocyte Growth Factor in Madin-Darby Canine Kidney Epithelial Cells
Paumelle, R., Tulasne, D., Leroy, C., Coll, J., Vandenbunder, B., & Fafeur, V. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.11.3751 · Cited by 67
Biglycan, a Nitric Oxide-regulated Gene, Affects Adhesion, Growth, and Survival of Mesangial Cells
Schaefer, L., Beck, K., Raslik, I., Walpen, S., Mihálik, D., Micegova, M., Mačáková, K., Schönherr, E., Seidler, D. G., Varga, G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210574200 · Cited by 66
Preparation andin vitrocharacterization of vascular endothelial growth factor (VEGF)-loaded poly( D,L -lactic-co-glycolic acid) microspheres using a double emulsion/solvent evaporation technique
Karal‐Yılmaz, O., Serhatlı, M., Baysal, K., & Baysal, B. M. (2010) · Journal of Microencapsulation · doi:10.3109/02652048.2010.523795 · Cited by 68
Self-citation
Bcl-w is expressed in a majority of infiltrative gastric adenocarcinomas and suppresses the cancer cell death by blocking stress-activated protein kinase/c-Jun NH2-terminal kinase activation.
Lee, H. W., Lee, S., Lee, S. J., & Um, H. (2003) · PubMed · Cited by 65
Cellular N-Ras Promotes Cell Survival by Downregulation of Jun N-Terminal Protein Kinase and p38
Wolfman, J. C., Palmby, T. R., Der, C. J., & Wolfman, A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.5.1589-1606.2002 · Cited by 66
Antioxidants Differentially Regulate Activation of Nuclear Factor- κ B, Activator Protein-1, c-Jun Amino-Terminal Kinases, and Apoptosis Induced by Tumor Necrosis Factor: Evidence that JNK and NF- κ B Activation Are Not Linked to Apoptosis
Shrivastava, A., & Aggarwal, B. B. (1999) · Antioxidants and Redox Signaling · doi:10.1089/ars.1999.1.2-181 · Cited by 65
Coordination of MAPK and p53 dynamics in the cellular responses to DNA damage and oxidative stress
Hanson, R. L., & Batchelor, E. (2022) · Molecular Systems Biology · doi:10.15252/msb.202211401 · Cited by 60
Apoptosis-inducing Agents Cause Rapid Shedding of Tumor Necrosis Factor Receptor 1 (TNFR1)
Madge, L. A., Sierra-Honigmann, M. R., & Pober, J. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13643 · Cited by 64
p38 Mitogen-Activated Protein Kinase Mediates Tumor Necrosis Factor-α-Induced Apoptosis in Rat Fetal Brown Adipocytes*
Valladares, A., Alvarez, A. M., Ventura, J., Roncero, C., Benito, M., & Porrás, A. (2000) · Endocrinology · doi:10.1210/endo.141.12.7843 · Cited by 64
Regulation of glomerular cell number by apoptosis
Savill, J. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00707.x · Cited by 65
Tumor necrosis factor–induced signal transduction and left ventricular remodeling
Mann, D. L. (2002) · Journal of Cardiac Failure · doi:10.1054/jcaf.2002.129253 · Cited by 62
Increased Expression and Activation of c-Jun Contributes to Human Amylin-induced Apoptosis in Pancreatic Islet β-Cells
Zhang, S., Liu, J., MacGibbon, G. A., Dragunow, M., & Cooper, G. J. S. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)01044-6 · Cited by 62
Lead exposure activates nuclear factor kappa B, activator protein-1, c-Jun N-terminal kinase and caspases in the rat brain
Ramesh, G. T., Manna, S. K., Aggarwal, B. B., & Jadhav, A. L. (2001) · Toxicology Letters · doi:10.1016/s0378-4274(01)00395-2 · Cited by 57
Kininostatin, an Angiogenic Inhibitor, Inhibits Proliferation and Induces Apoptosis of Human Endothelial Cells
Guo, Y., Wang, S., & Colman, R. W. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0901.095277 · Cited by 55
Self-citation

Authors: Guo, Y.-L., Baysal, K., Kang, B., Yang, L.-J., & Williamson, J. R.
Affiliations: University of Pennsylvania (US)
Corresponding author: Williamson, John R.
ORCID: Guo, Yan-Lin
Baysal, Kemal
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1998-02
Volume: 273
Issue: 7
Pages: 4027-4034
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.273.7.4027
OpenAlex: W1993170284
Cited by: 249
References: 51
Citations by year: 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2014: 6 · 2013: 7 · 2012: 8
FWCI: 10.26
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8309 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: American Diabetes Association
National Institutes of Health (5r01dk048493-04, 5r01dk015120-25)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 15120, DK-48493, DK-07314)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: JNK activation, TNF-α, apoptosis, mesangial cells, MKP-1, protein phosphatase, actinomycin D, cycloheximide, vanadate, ERK activation, apoptosis resistance
MeSH terms: Animals, Cell Survival, Cells, Cultured, Cycloheximide, Dactinomycin, Enzyme Activation, Glomerular Mesangium, Phosphoprotein Phosphatases, Tumor Necrosis Factor-alpha, Vanadates, NF-kappa B, Protein Tyrosine Phosphatases, Rats, Sprague-Dawley, Apoptosis, Calcium-Calmodulin-Dependent Protein Kinases, Immediate-Early Proteins, Cell Cycle Proteins, Okadaic Acid, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, JNK Mitogen-Activated Protein Kinases, Rats, Dual Specificity Phosphatase 1, Protein Phosphatase 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Correlation between Sustained c-Jun N-terminal Protein Kinase Activation and Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks