The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
Correlation between Sustained c-Jun N-terminal Protein Kinase Activation and Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells
Open accessAbstract
Rat mesangial cells are normally resistant to tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis. In this report we show that the cells can be made susceptible to the apoptotic effect of TNF-alpha when pretreated with actinomycin D, cycloheximide, or vanadate. c-Jun N-terminal protein kinase (JNK) has been thought to mediate apoptotic processes elicited by some stimuli, but its involvement in TNF-alpha-induced apoptosis has been controversial. JNK activation was investigated under conditions where the mesangial cells were either resistant or susceptible to TNF-alpha-induced apoptosis. TNF-alpha alone stimulated a single transient JNK activity peak. However, when the cells were pretreated with actinomycin D or cycloheximide, TNF-alpha stimulated a second sustained JNK activity peak. When the cells were pretreated with the phosphatase inhibitor vanadate, TNF-alpha-induced JNK activation was greatly prolonged. In all three cases, a sustained JNK activation was associated with the initiation of apoptosis. Our data suggest that a sustained activation of JNK induced by these reagents may be associated with blocking the expression of a phosphatase that inactivates JNK. Further studies reveal that the expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) was induced by TNF-alpha, indicating that MKP-1 may be involved in protecting the cells from apoptosis by preventing a prolonged activation of JNK under normal conditions. Additional studies showed that extracellular signal-regulated protein kinase activation stimulated by TNF-alpha was unlikely to contribute to the resistance of mesangial cells to TNF-alpha cytotoxicity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although the SAPKs can also mediate proliferative responses, prolonged activation of these SAPK can lead to apoptosis (80, 162).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [162]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273
Nagata, S. (1997) · Cell · doi:10.1016/s0092-8674(00)81874-7 · Cited by 4,934
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27489 · Cited by 3,374
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
The stress-activated protein kinase subfamily of c-Jun kinases
Kyriakis, J. M., Banerjee, P. T., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., & Woodgett, J. R. (1994) · Nature · doi:10.1038/369156a0 · Cited by 2,601
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581
Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
Verheij, M., Bose, R., Lin, X. H., Yao, B., Jarvis, W. D., Grant, S., Birrer, M. J., Szabo, E. M., Zon, L. I., Kyriakis, J. M., et al. (1996) · Nature · doi:10.1038/380075a0 · Cited by 1,767
Sugarman, B. J., Aggarwal, B. B., Hass, P. E., Figari, I. S., Palladino, M. A., & Shepard, H. M. (1985) · Science · doi:10.1126/science.3933111 · Cited by 1,572
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
Kauffmann-Zeh, A., Rodriguez‐Viciana, P., Ulrich, E., Gilbert, C. S., Coffer, P. J., Downward, J., & Evan, G. I. (1997) · Nature · doi:10.1038/385544a0 · Cited by 1,144
Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation
Kyriakis, J. M., & Avruch, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24313 · Cited by 1,083
Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK
Minden, A., Lin, A., McMahon, M., Lange, C. A., Dérijard, B., Davis, R. J., Johnson, G. L., & Karin, M. (1994) · Science · doi:10.1126/science.7992057 · Cited by 1,069
The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation
Chen, Y.-R., Wang, X., Templeton, D., Davis, R. J., & Tan, T.-H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.31929 · Cited by 867
Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis
Yang, X., Khosravi‐Far, R., Chang, H. Y., & Baltimore, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80294-9 · Cited by 838
Karin, M., & Hunter, T. R. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00151-5 · Cited by 747
Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway
Lee, F. S., Hagler, J., Chen, Z. J., & Maniatis, T. (1997) · Cell · doi:10.1016/s0092-8674(00)81842-5 · Cited by 710
Protein kinase cascades activated by stress and inflammatory cytokines
Kyriakis, J. M., & Avruch, J. (1996) · BioEssays · doi:10.1002/bies.950180708 · Cited by 709
Apoptosis: Activate NF-κB or die?
Baichwal, V. R., & Baeuerle, P. A. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00046-7 · Cited by 528
Leist, M., Gantner, F., Bohlinger, I., Germann, P., Tiegs, G., & Wendel, A. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.4.1778 · Cited by 490
Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway
Natoli, G., Costanzo, A., Ianni, A., Templeton, D. J., Woodgett, J. R., Balsano, C., & Levrero, M. (1997) · Science · doi:10.1126/science.275.5297.200 · Cited by 452
Zanke, B. W., Boudreau, K., Rubie, E. A., Winnett, E., Tibbles, L. A., Zon, L. I., Kyriakis, J. M., Liu, F., & Woodgett, J. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)00547-x · Cited by 442
Muda, M., Theodosiou, A. M., Rodrigues, N. R., Boschert, U., Camps, M., Gilliéron, C., Davies, K. E., Ashworth, A., & Arkinstall, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27205 · Cited by 375
Ceramide Activates the Stress-activated Protein Kinases
Westwick, J. K., Bielawska, A. E., Dbaibo, G., Hannun, Y. A., & Brenner, D. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.39.22689 · Cited by 303
Liu, Y., Gorospe, M., Yang, C., & Holbrook, N. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.15.8377 · Cited by 283
Tumor necrosis factor α‐induced activation of c‐jun N‐terminal kinase is mediated by TRAF2
Reinhard, C., Shamoon, B., Shyamala, V., & Williams, L. T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.5.1080 · Cited by 277
Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway
Goillot, E., Raingeaud, J., Ranger, A. M., Tepper, R. I., Davis, R. J., Harlow, E., & Sánchez, I. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3302 · Cited by 260
An emerging family of dual specificity MAP kinase phosphatases
Keyse, S. M. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(94)00211-v · Cited by 249
Molecular mechanisms of tumor necrosis factor‐induced cytotoxicity
Beyaert, R., & Fiers, W. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80163-0 · Cited by 235
Gardner, A. M., & Johnson, G. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14560 · Cited by 215
Isolation and characterization of rat glomerular epithelial cells in vitro
Kreisberg, J. I., Hoover, R. L., & Karnovsky, M. J. (1978) · Kidney International · doi:10.1038/ki.1978.86 · Cited by 210
Peng, M., Huang, L., Xie, Z., Huang, W.-H., & Askari, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.10372 · Cited by 194
Wolf, B. A., Wertkin, A. M., Jolly, Y. C., Yasuda, R. P., Wolfe, B. B., Konrad, R. J., Manning, D. R., Ravi, S., WILLIAMSON, J. R., & Lee, V. M. ‐. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4916 · Cited by 190
Self-citationSchievella, A. R., Chen, J. H., Graham, J. R., & Lin, L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.12069 · Cited by 170
Bokemeyer, D., Sorokin, A., Yan, M., Ahn, N. G., Templeton, D. J., & Dunn, M. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.2.639 · Cited by 157
Butterfield, L., Storey, B., Maas, L., & Heasley, L. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.10110 · Cited by 146
Activation of c-Jun N-terminal Kinase Antagonizes an Anti-apoptotic Action of Bcl-2
Park, J., Kim, I. J., Oh, Y. J., Lee, K.-W., Han, P., & Choi, E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.16725 · Cited by 130
MacMARCKS, a novel member of the MARCKS family of protein kinase C substrates
Li, J., & Aderem, A. A. (1992) · Cell · doi:10.1016/0092-8674(92)90312-z · Cited by 117
Nuclear Factor-κB Is Activated by Hyperoxia but Does Not Protect from Cell Death
Li, Y., Zhang, W., Mantell, L. L., Kazzaz, J. A., Fein, A. M., & Horowitz, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20646 · Cited by 104
Han, Y., & Brasier, A. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9825 · Cited by 101
Cell growth and apoptosis: a practical approach
(1997) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(97)84212-7 · Cited by 93
The mesangial cell: A tissue culture view
Davies, M. (1994) · Kidney International · doi:10.1038/ki.1994.41 · Cited by 90
[35] Methods for analyzing c-Jun kinase
Westwick, J. K., & Brenner, D. A. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(95)55037-2 · Cited by 51
Lubinus, M., Meier, K. E., Smith, E. A., Gause, K. C., LeRoy, E. C., & Trojanowska, M. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36957-0 · Cited by 47
Liu, Z., Striker, G. E., Stetler-Stevenson, M. A., Fukushima, P. I., Patel, A. D., & Striker, L. J. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.270.6.c1595 · Cited by 45
Cosulich, S. C., & Clarke, P. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70779-3 · Cited by 44
Guo, Y., & Roux, S. J. (1990) · PLANT PHYSIOLOGY · doi:10.1104/pp.94.1.143 · Cited by 39
Self-citationGinès, P., Li, X., Zamarripa, J., Brown, S. E., Wieder, E., Nakamura, T., Guzelian, P. S., Schrier, R. W., Heasley, L. E., & Nemenoff, R. A. (1995) · Hepatology · doi:10.1002/hep.1840220440 · Cited by 32
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Gines, 1995, Hepatology, 22, 1296
Cited by
Sorted by citations
Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842
Tumor necrosis factor signaling
Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401189 · Cited by 2,422
Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis
Sinha, K., Das, J., Pal, P. B., & Sil, P. C. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1034-4 · Cited by 1,643
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
Wallach, D., Varfolomeev, E. E., Malinin, N. L., Goltsev, Y. V., Kovalenko, A. V., & Boldin, M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.331 · Cited by 1,299
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T., & Ichijo, H. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve046 · Cited by 1,211
Metadata
- Authors
- Guo, Y.-L., Baysal, K., Kang, B., Yang, L.-J., & Williamson, J. R.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Williamson, John R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-02
- Volume
- 273
- Issue
- 7
- Pages
- 4027-4034
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1993170284
- Cited by
- 249
- References
- 51
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2014: 6 · 2013: 7 · 2012: 8
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health (5r01dk048493-04, 5r01dk015120-25)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 15120, DK-48493, DK-07314)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- JNK activation, TNF-α, apoptosis, mesangial cells, MKP-1, protein phosphatase, actinomycin D, cycloheximide, vanadate, ERK activation, apoptosis resistance
- MeSH terms
- Animals, Cell Survival, Cells, Cultured, Cycloheximide, Dactinomycin, Enzyme Activation, Glomerular Mesangium, Phosphoprotein Phosphatases, Tumor Necrosis Factor-alpha, Vanadates, NF-kappa B, Protein Tyrosine Phosphatases, Rats, Sprague-Dawley, Apoptosis, Calcium-Calmodulin-Dependent Protein Kinases, Immediate-Early Proteins, Cell Cycle Proteins, Okadaic Acid, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, JNK Mitogen-Activated Protein Kinases, Rats, Dual Specificity Phosphatase 1, Protein Phosphatase 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
