The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
Correlation between Sustained c-Jun N-terminal Protein Kinase Activation and Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells
Open accessAbstract
Rat mesangial cells are normally resistant to tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis. In this report we show that the cells can be made susceptible to the apoptotic effect of TNF-alpha when pretreated with actinomycin D, cycloheximide, or vanadate. c-Jun N-terminal protein kinase (JNK) has been thought to mediate apoptotic processes elicited by some stimuli, but its involvement in TNF-alpha-induced apoptosis has been controversial. JNK activation was investigated under conditions where the mesangial cells were either resistant or susceptible to TNF-alpha-induced apoptosis. TNF-alpha alone stimulated a single transient JNK activity peak. However, when the cells were pretreated with actinomycin D or cycloheximide, TNF-alpha stimulated a second sustained JNK activity peak. When the cells were pretreated with the phosphatase inhibitor vanadate, TNF-alpha-induced JNK activation was greatly prolonged. In all three cases, a sustained JNK activation was associated with the initiation of apoptosis. Our data suggest that a sustained activation of JNK induced by these reagents may be associated with blocking the expression of a phosphatase that inactivates JNK. Further studies reveal that the expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) was induced by TNF-alpha, indicating that MKP-1 may be involved in protecting the cells from apoptosis by preventing a prolonged activation of JNK under normal conditions. Additional studies showed that extracellular signal-regulated protein kinase activation stimulated by TNF-alpha was unlikely to contribute to the resistance of mesangial cells to TNF-alpha cytotoxicity.
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“Although the SAPKs can also mediate proliferative responses, prolonged activation of these SAPK can lead to apoptosis (80, 162).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [162]
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Tumor necrosis factor signaling
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Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis
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Metadata
- Authors
- Guo, Y.-L., Baysal, K., Kang, B., Yang, L.-J., & Williamson, J. R.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Williamson, John R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-02
- Volume
- 273
- Issue
- 7
- Pages
- 4027-4034
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1993170284
- Cited by
- 249
- References
- 51
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2014: 6 · 2013: 7 · 2012: 8
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health (5r01dk048493-04, 5r01dk015120-25)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 15120, DK-48493, DK-07314)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- JNK activation, TNF-α, apoptosis, mesangial cells, MKP-1, protein phosphatase, actinomycin D, cycloheximide, vanadate, ERK activation, apoptosis resistance
- MeSH terms
- Animals, Cell Survival, Cells, Cultured, Cycloheximide, Dactinomycin, Enzyme Activation, Glomerular Mesangium, Phosphoprotein Phosphatases, Tumor Necrosis Factor-alpha, Vanadates, NF-kappa B, Protein Tyrosine Phosphatases, Rats, Sprague-Dawley, Apoptosis, Calcium-Calmodulin-Dependent Protein Kinases, Immediate-Early Proteins, Cell Cycle Proteins, Okadaic Acid, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, JNK Mitogen-Activated Protein Kinases, Rats, Dual Specificity Phosphatase 1, Protein Phosphatase 1
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