Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways.

Sadar, Marianne D.

doi:10.1074/jbc.274.12.7777

Cited by 270Prostate Cancer Treatment and ResearchEstrogen and related hormone effectsSperm and Testicular Function

Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways.

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Sadar, Marianne D.·1999·Journal of Biological Chemistry

DOI 10.1074/jbc.274.12.7777

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Abstract

Transcription of the prostate-specific antigen (PSA) gene escapes regulation by androgens in advanced prostate cancer. To determine the molecular mechanism(s) of androgen-independent regulation of the PSA gene, the possibility that the androgen receptor (AR) is activated in the absence of androgen by stimulation of protein kinase A (PKA) was investigated. Activation of PKA by forskolin resulted in elevated expression of the PSA gene in androgen-depleted LNCaP cells, an effect that was blocked by the antiandrogen, bicalutamide. Further evidence that induction of PSA gene expression was dependent on AR was obtained from experiments using PC3 cells devoid of AR. Neither PSA, PB, nor ARR3 androgen-responsive reporters could be induced by activation of PKA in the absence of transfected AR. In addition, when nuclear AR from forskolin-treated LNCaP cells was incubated with oligonucleotides encoding an androgen response element of the PSA promoter and examined by electromobility shift assay, an increase in AR-androgen response element complex formation was observed. Lastly, cotransfection of an expression vector for a chimeric protein encoding the amino-terminal domain of the human AR linked to Gal4 and a 5xGal4UAS reporter gene construct resulted in activation of the amino-terminal domain of the AR by stimulation of PKA activity. These results demonstrate androgen-independent induction of PSA gene expression in prostate cancer cells by an AR-dependent pathway.

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When prostate cancer cells are treated with forskolin, AR-driven transcription is increased from AR-responsive promoters, an effect quenched by the addition of AR antagonists bicalutamide and flutamide.
“When prostate cancer cells are treated with the inhibitor forskolin (a naturally derived molecule that activates adenylyl cyclase, thus increasing the intracellular levels of cAMP and consequently protein kinase A), AR-driven transcription is increased from ARresponsive promoters, an effect that is quenched by the addition of AR antagonists bicalutamide and flutamide (55,56).”
From Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer (2011) · cites this paper as [56]

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells
Schreiber, E. H., Matthias, P., Müller, M. M., & Schaffner, W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.15.6419 · Cited by 4,179 · see citing works
A mutation in the ligand binding domain of the androgen receptor of human INCaP cells affects steroid binding characteristics and response to anti-androgens
Veldscholte, J., Ris‐Stalpers, C., Kuiper, G. G. J. M., Jenster, G. W., Berrevoets, C., Claassen, E., van Rooij, H. C. J., Trapman, J., Brinkmann, A. O., & Mulder, E. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80067-1 · Cited by 945 · see citing works
Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor.
Čulig, Z., Hobisch, A., Cronauer, M. V., Radmayr, C., Trapman, J., Hittmair, A., Bartsch, G., & Klocker, H. (1994) · PubMed · Cited by 938 · see citing works
Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization
Jenster, G., van der Korput, H. A. G. M., van Vroonhoven, C., van der Kwast, T. H., Trapman, J., & Brinkmann, A. O. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-10-1396 · Cited by 523 · see citing works
Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I
Aronica, S. M., & Katzenellenbogen, B. S. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.6.7689695 · Cited by 455 · see citing works
The Promoter of the Prostate-Specific Antigen Gene Contains a Functional Androgen Responsive Element
Riegman, P. H. J., Vlietstra, R. J., van der Korput, J. A. G. M., Brinkmann, A. O., & Trapman, J. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-12-1921 · Cited by 448 · see citing works
The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens
Veldscholte, J., Berrevoets, C., Ris‐Stalpers, C., Kuiper, G. G. J. M., Jenster, G. W., Trapman, J., Brinkmann, A. O., & Mulder, E. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90401-4 · Cited by 442 · see citing works
Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones.
Kemppainen, J., Lane, M. V., Sar, M., & Wilson, E. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48380-9 · Cited by 430 · see citing works
Activation of the human androgen receptor through a protein kinase A signaling pathway.
Nazareth, L. V., & Weigel, N. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.33.19900 · Cited by 429 · see citing works
Identification of two transcription activation units in the N-terminal domain of the human androgen receptor
Jenster, G., van der Korput, H. A. G. M., Trapman, J., & Brinkmann, A. O. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7341 · Cited by 419 · see citing works
Two Androgen Response Regions Cooperate in Steroid Hormone Regulated Activity of the Prostate-specific Antigen Promoter
Cleutjens, K. B. J. M., Eekelen, C. C. E.-V., van der Korput, H. A. G. M., Brinkmann, A. O., & Trapman, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6379 · Cited by 408 · see citing works
Steroid hormone receptors and their regulation by phosphorylation
Weigel, N. L. (1996) · Biochemical Journal · doi:10.1042/bj3190657 · Cited by 351 · see citing works
Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element
Ignar-Trowbridge, D. M., Teng, C. T., Ross, K. A., Parker, M. G., Korach, K. S., & McLachlan, J. A. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.8.8232319 · Cited by 325 · see citing works
Binding properties of androgen receptors. Evidence for identical receptors in rat testis, epididymis, and prostate.
Wilson, E. M., & French, F. S. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33103-4 · Cited by 312 · see citing works
Prostate-specific Antigen Expression Is Regulated by an Upstream Enhancer
Schuur, E. R., Henderson, G. A., Kmetec, L. A., Miller, J. D., Lamparski, H., & Henderson, D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.12.7043 · Cited by 302 · see citing works
Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation
Veldscholte, J., Berrevoets, C., Brinkmann, A. O., Grootegoed, J. A., & Mulder, E. (1992) · Biochemistry · doi:10.1021/bi00123a026 · Cited by 278 · see citing works
Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol
Ignar-Trowbridge, D. M., Pimentel, M. A., Parker, M. G., McLachlan, J. A., & Korach, K. S. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612509 · Cited by 230 · see citing works
Progesterone Receptor Regulation in Uterine Cells:Stimulation by Estrogen, Cyclic Adenosine 3′,5′-Monophosphate, and Insulin-Like Growth Factor I andSuppression by Antiestrogens and Protein KinaseInhibitors*
Aronica, S. M., & Katzenellenbogen, B. S. (1991) · Endocrinology · doi:10.1210/endo-128-4-2045 · Cited by 203 · see citing works
Androgenic Induction of Prostate-specific Antigen Gene Is Repressed by Protein-Protein Interaction between the Androgen Receptor and AP-1/c-Jun in the Human Prostate Cancer Cell Line LNCaP
Sato, N., Sadar, M. D., Bruchovsky, N., Saatcioglu, F., Rennie, P. S., Sato, S., Lange, P. H., & Gleave, M. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17485 · Cited by 202 · see citing works
Self-citation
Structural determinants of DNA-binding specificity by steroid receptors
Zilliacus, J., Wright, A. P. H., Carlstedt‐Duke, J., & Gustafsson, J. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.4.7659083 · Cited by 199 · see citing works
Stimulation of androgen-regulated transactivation by modulators of protein phosphorylation
Ikonen, T., Palvimo, J. J., Kallio, P. J., Reinikainen, P., & Jänne, O. A. (1994) · Endocrinology · doi:10.1210/endo.135.4.7925097 · Cited by 187 · see citing works
Identification of three proline-directed phosphorylation sites in the human androgen receptor
Zhou, Z. X., Kemppainen, J., & Wilson, E. M. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.5.7565807 · Cited by 186 · see citing works
Intermittent androgen suppression delays progression to androgen-independent regulation of prostate-specific antigen gene in the LNCaP prostate tumour model
Sato, N., Gleave, M. E., Bruchovsky, N., Rennie, P. S., Goldenberg, S. L., Lange, P. H., & Sullivan, L. D. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(96)00018-0 · Cited by 183 · see citing works
Two Separate Mechanisms for Ligand-Independent Activation of the Estrogen Receptor
El‐Tanani, M., & Green, C. D. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.7.9939 · Cited by 165 · see citing works
Ligand-induced Conformational Alterations of the Androgen Receptor Analyzed by Limited Trypsinization
Kuil, C. W., Berrevoets, C., & Mulder, E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27569 · Cited by 130 · see citing works
Characterization of the gene for prostate-specific antigen, a human glandular kallikrein
Lundwall, Å. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91362-4 · Cited by 114 · see citing works
Delineation of Two Distinct Type 1 Activation Functions in the Androgen Receptor Amino-terminal Domain
Chamberlain, N. L., Whitacre, D. C., & Miesfeld, R. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.43.26772 · Cited by 113 · see citing works
The unliganded estrogen receptor (ER) transduces growth factor signals
Newton, C. J., Buric, R., Trapp, T., Brockmeier, S. J., Pagotto, U., & Stalla, G. K. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90197-x · Cited by 111 · see citing works
Dominant negative regulation of trans-activation by the rat androgen receptor: roles of the N-terminal domain and heterodimer formation
Palvimo, J. J., Kallio, P. J., Ikonen, T., Mehto, M., & Jänne, O. A. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.11.8114755 · Cited by 92 · see citing works
Activation of the progesterone receptor by the gonadotropin-releasing hormone self-priming signaling pathway.
TURGEON, J. L., & Waring, D. W. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.7.7984148 · Cited by 92 · see citing works
Complete testicular feminization caused by an amino-terminal truncation of the androgen receptor with downstream initiation.
ZOPPI, S., Wilson, C. M., Harbison, M. D., Griffin, J. E., Wilson, J. D., McPhaul, M. J., & Marcelli, M. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116269 · Cited by 91 · see citing works
Forskolin-Induced Dephosphorylation of the Androgen Receptor Impairs Ligand Binding
Blok, L. J., de Ruiter, P. E., & Brinkmann, A. O. (1998) · Biochemistry · doi:10.1021/bi9724422 · Cited by 86 · see citing works
Adipsin gene expression in 3T3-F442A adipocytes is posttranscriptionally down-regulated by retinoic acid.
Antras, J., Lasnier, F., & Pairault, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35296-1 · Cited by 85 · see citing works
Hormone-dependent androgen receptor phosphorylation is accompanied by receptor transformation in human lymph node carcinoma of the prostate cells
van Laar, J. H., Berrevoets, C., Trapman, J., Zegers, N. D., & Brinkmann, A. O. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67856-7 · Cited by 83 · see citing works
Acrosin biosynthesis in meiotic and postmelotic spermatogenic cells
Kashiwabara, S., Arai, Y., Kodaira, K., & Baba, T. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81047-2 · Cited by 80 · see citing works
Localization and hormonal stimulation of phosphorylation sites in the LNCaP-cell androgen receptor
Kuiper, G. G. J. M., de Ruiter, P. E., Trapman, J., Boersma, W. J. A., Grootegoed, J. A., & Brinkmann, A. O. (1993) · Biochemical Journal · doi:10.1042/bj2910095 · Cited by 65 · see citing works
Effects of antiandrogens on transformation and transcription activation of wild-type and mutated (LNCaP) androgen receptors
Berrevoets, C., Veldscholte, J., & Mulder, E. A. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90313-l · Cited by 63 · see citing works
Androgen Receptor Phosphorylation
Blok, L. J., de Ruiter, P. E., & Brinkmann, A. O. (1996) · Endocrine Research · doi:10.3109/07435809609030508 · Cited by 62 · see citing works
Phosphotryptic Peptide Analysis of the Human Androgen Receptor: Detection of a Hormone-Induced Phosphopeptide
Kuiper, G. G. J. M., & Brinkmann, A. O. (1995) · Biochemistry · doi:10.1021/bi00006a005 · Cited by 59 · see citing works
Tumor-promoting phorbol ester down-regulates the androgen induction of prostate-specific antigen in a human prostatic adenocarcinoma cell line.
Andrews, P. E., Young, C. Y. F., Montgomery, B. T., & Tindall, D. J. (1992) · PubMed · Cited by 51 · see citing works
Differential transactivation by the androgen receptor in prostate cancer cells
Snoek, R., Bruchovsky, N., Kasper, S., Matusik, R. J., Gleave, M. E., Sato, N., Mawji, N. R., & Rennie, P. S. (1998) · The Prostate · doi:10.1002/(sici)1097-0045(19980901)36:4 · Cited by 50 · see citing works
Phosphorylation of the androgen receptor by a nuclear cAMP-independent protein kinase
Goueli, S. A., Holtzman, J. L., & Ahmed, K. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)90297-3 · Cited by 44 · see citing works
Induction of cell-free, in vitro transcription by recombinant androgen receptor peptides
Snoek, R., Rennie, P. S., Kasper, S., Matusik, R. J., & Bruchovsky, N. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(96)00116-1 · Cited by 41 · see citing works
Steroid-independent activation of steroid receptors in mammalian and yeast cells and in breast cancer
Picard, D., Bunone, G., Liu, J. W., & Donzé, O. (1997) · Biochemical Society Transactions · doi:10.1042/bst0250597 · Cited by 30 · see citing works
Androgen receptor heterogeneity in LNCaP cells is caused by a hormone independent phosphorylation step
Kuiper, G. G. J. M., de Ruiter, P. E., & Brinkmann, A. O. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90407-a · Cited by 19 · see citing works

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Sun, S., Sprenger, C. C. T., Vessella, R. L., Haugk, K., Soriano, K., Mostaghel, E. A., Page, S. T., Coleman, I. M., Nguyen, H. M., Sun, H., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41824 · Cited by 748 · see citing works
The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions
Heinlein, C. A., & Chang, C. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0070 · Cited by 568 · see citing works
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Grossmann, M. E., Huang, H., & Tindall, D. J. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.22.1687 · Cited by 548 · see citing works
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Tindall, D. J., & Lonergan, P. E. (2011) · Journal of Carcinogenesis · doi:10.4103/1477-3163.83937 · Cited by 544 · see citing works
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor.
Andersen, R. J., Mawji, N. R., Wang, J., Wang, G., Haile, S., Myung, J.-K., Watt, K., Tam, T., Yang, Y. C., Bañuelos, C. A., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.04.027 · Cited by 503 · see citing works
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Non-genomic actions of androgens
Foradori, C. D., Weiser, M. J., & Handa, R. J. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.10.005 · Cited by 493 · see citing works
Her-2-neu Expression and Progression Toward Androgen Independence in Human Prostate Cancer
Signoretti, S. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.23.1918 · Cited by 397 · see citing works
Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells.
Zegarra-Moro, O. L., Schmidt, L. J., Huang, H., & Tindall, D. J. (2002) · PubMed · Cited by 395 · see citing works
Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways.
Ueda, T., Bruchovsky, N., & Sadar, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108255200 · Cited by 381 · see citing works
Self-citation
Androgen Receptor Phosphorylation
Gioeli, D. G., Ficarro, S. B., Kwiek, J. J., Aaronson, D. S., Hancock, M., Catling, A. D., White, F. M., Christian, R. E., Settlage, R. E., Shabanowitz, J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204131200 · Cited by 355 · see citing works
Human Tissue Kallikreins: Physiologic Roles and Applications in Cancer
Borgoño, C. A., Michael, I. P., & Diamandis, E. P. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.257.2.5 · Cited by 340 · see citing works
Mechanisms of the androgen receptor splicing in prostate cancer cells
Liu, L. L., Xie, N., Sun, S., Plymate, S. R., Mostaghel, E. A., & Dong, X. (2013) · Oncogene · doi:10.1038/onc.2013.284 · Cited by 313 · see citing works
Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells.
Ueda, T., Mawji, N. R., Bruchovsky, N., & Sadar, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203313200 · Cited by 311 · see citing works
Self-citation
An androgen receptor N-terminal domain antagonist for treating prostate cancer
Myung, J., Banuelos, C. A., Fernandez, J. G., Mawji, N. R., Wang, J., Tien, A. H., Yang, Y. C., Tavakoli, I., Haile, S., Watt, K., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66398 · Cited by 307 · see citing works
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PDEF, a Novel Prostate Epithelium-specific Ets Transcription Factor, Interacts with the Androgen Receptor and Activates Prostate-specific Antigen Gene Expression
Oettgen, P., Finger, E., Sun, Z., Akbarali, Y., Thamrongsak, U., Boltax, J., Grall, F., Dube, A., Weiss, A., Brown, L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1216 · Cited by 268 · see citing works
Androgen receptor as a target in androgen-independent prostate cancer
Balk, S. P. (2002) · Urology · doi:10.1016/s0090-4295(02)01593-5 · Cited by 264 · see citing works
Androgen receptor coregulators and their involvement in the development and progression of prostate cancer
Chmelar, R. S., Buchanan, G., Need, E. F., Tilley, W. D., & Greenberg, N. M. (2006) · International Journal of Cancer · doi:10.1002/ijc.22365 · Cited by 256 · see citing works
Androgen Receptor Structural and Functional Elements: Role and Regulation in Prostate Cancer
Dehm, S. M., & Tindall, D. J. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0223 · Cited by 252 · see citing works
Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases
Zhang, X., Morrissey, C. M., Sun, S., Ketchandji, M., Nelson, P. S., True, L. D., Vakar‐Lopez, F., Vessella, R. L., & Plymate, S. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027970 · Cited by 240 · see citing works
Caveolin-1 Interacts with Androgen Receptor
Lu, M. L., Schneider, M. C., Zheng, Y., Zhang, X., & Richie, J. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006598200 · Cited by 239 · see citing works
Epinephrine Protects Cancer Cells from Apoptosis via Activation of cAMP-dependent Protein Kinase and BAD Phosphorylation
Sastry, K. S., Karpova, Y., Prokopovich, S., Smith, A. J., Essau, B., Gersappe, A., Carson, J. P., Weber, M. J., Register, T. C., Chen, Y. Q., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611370200 · Cited by 225 · see citing works
Behavioral stress accelerates prostate cancer development in mice
Hassan, S., Karpova, Y., Baiz, D., Yancey, D., Pullikuth, A., Flores, A., Register, T. C., Cline, J. M., D’Agostino, R., Danial, N. N., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci63324 · Cited by 231 · see citing works
Activation of Peroxisome Proliferator-Activated Receptors (PPARs) by Their Ligands and Protein Kinase A Activators
Lazennec, G., Canaple, L., Saugy, D., & Wahli, W. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.12.0575 · Cited by 220 · see citing works
Is the Achilles’ Heel for Prostate Cancer Therapy a Gain of Function in Androgen Receptor Signaling?
Litvinov, I. V., Marzo, A. M. D., & Isaacs, J. T. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-022038 · Cited by 215 · see citing works
Mechanisms mediating androgen receptor reactivation after castration
Yuan, X., & Balk, S. P. (2008) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2008.03.021 · Cited by 204 · see citing works
Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1
Chen, S., Xu, Y., Yuan, X., Bubley, G. J., & Balk, S. P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604193103 · Cited by 202 · see citing works
Role of SRC-1 in the Promotion of Prostate Cancer Cell Growth and Tumor Progression
Agoulnik, I. U., Vaid, A., Bingman, W. E., Erdeme, H., Frolov, A., Smith, C. S., Ayala, G., Ittmann, M., & Weigel, N. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3541 · Cited by 201 · see citing works
Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells.
Bakin, R. E., Gioeli, D. G., Sikes, R. A., Bissonette, E. A., & Weber, M. J. (2003) · PubMed · Cited by 201 · see citing works
Rapid actions of androgens
Michels, G., & Hoppe, U. C. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.08.004 · Cited by 198 · see citing works
Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions
Dubois, V., Laurent, M., Boonen, S., Vanderschueren, D., & Claessens, F. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0883-3 · Cited by 197 · see citing works
Interaction of IGF signaling and the androgen receptor in prostate cancer progression.
Wu, J. D., Haugk, K., Woodke, L., Nelson, P., Coleman, I., & Plymate, S. R. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20929 · Cited by 188 · see citing works
Neuropeptide-Induced Androgen Independence in Prostate Cancer Cells: Roles of Nonreceptor Tyrosine Kinases Etk/Bmx, Src, and Focal Adhesion Kinase
Lee, L., Guan, J., Qiu, Y., & Kung, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.24.8385-8397.2001 · Cited by 184 · see citing works
Androgen action and metabolism in prostate cancer
Green, S. M., Mostaghel, E. A., & Nelson, P. S. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.046 · Cited by 182 · see citing works
Establishment and characterization of androgen-independent human prostate cancer LNCaP cell model
Igawa, T., Lin, F., Lee, M., Karan, D., Batra, S. K., & Lin, M. (2002) · The Prostate · doi:10.1002/pros.10054 · Cited by 181 · see citing works
Stress Kinase Signaling Regulates Androgen Receptor Phosphorylation, Transcription, and Localization
Gioeli, D. G., Black, B. E., Gordon, V. L., Spencer, A., Kesler, C. T., Eblen, S. T., Paschal, B. M., & Weber, M. J. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0351 · Cited by 175 · see citing works
Peroxisome Proliferator-activated Receptor δ (PPARδ)-mediated Regulation of Preadipocyte Proliferation and Gene Expression Is Dependent on cAMP Signaling*
Hansen, J., Zhang, H., Rasmussen, T. H., Petersen, R., Flindt, E., & Kristiansen, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005567200 · Cited by 187 · see citing works
Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression.
Lin, D., Whitney, M. C., Yao, Z., & Keller, E. T. (2001) · PubMed · Cited by 169 · see citing works
In vitro evidence for complex modes of nuclear β-catenin signaling during prostate growth and tumorigenesis
Chesire, D. R., Ewing, C. M., Gage, W. R., & Isaacs, W. B. (2002) · Oncogene · doi:10.1038/sj.onc.1205352 · Cited by 160 · see citing works
Essential role for co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology
Yong, W., Yang, Z., Periyasamy, S., Chen, H., Yucel, S., Li, W., Lin, L. Y., Wolf, I. M., Cohn, M. J., Baskin, L. S., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609360200 · Cited by 156 · see citing works
Alterations of androgen receptor in prostate cancer
Linja, M. J., & Visakorpi, T. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.10.012 · Cited by 151 · see citing works
Non-Genomic Actions of the Androgen Receptor in Prostate Cancer
Leung, J. K., & Sadar, M. D. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00002 · Cited by 152 · see citing works
Self-citation
Testosterone, sex hormone-binding globulin, and body composition in young adult African American and Caucasian men
Winters, S. J., Brufsky, A., Weissfeld, J. L., Trump, D. L., Dyky, M. A., & Hadeed, V. (2001) · Metabolism · doi:10.1053/meta.2001.26714 · Cited by 152 · see citing works
Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer
Lamont, K. R., & Tindall, D. J. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0469 · Cited by 150 · see citing works
Ras signaling in prostate cancer progression
Weber, M. J., & Gioeli, D. G. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10683 · Cited by 148 · see citing works
Small Molecule Inhibitors Targeting the “Achilles' Heel” of Androgen Receptor Activity
Sadar, M. D. (2011) · Cancer Research · doi:10.1158/0008-5472.can_10-3398 · Cited by 147 · see citing works
Self-citation
The Amino Terminus of the Human AR Is Target for Corepressor Action and Antihormone Agonism
Dotzlaw, H., Moehren, U., Mink, S., Cato, A. C. B., Iñiguez-Lluhı́, J. A., & Baniahmad, A. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.4.0798 · Cited by 143 · see citing works
Heregulin-Induced Activation of HER2 and HER3 Increases Androgen Receptor Transactivation and CWR-R1 Human Recurrent Prostate Cancer Cell Growth
Gregory, C. W., Whang, Y. E., McCall, W., Fei, X., Liu, Y., Ponguta, L. A., French, F. S., Wilson, E. M., & Earp, H. S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1158 · Cited by 140 · see citing works
Androgen Receptor Cross-talk with Cell Signalling Pathways
Čulig, Z. (2004) · Growth Factors · doi:10.1080/08977190412331279908 · Cited by 137 · see citing works
Dissociation between androgen responsiveness for malignant growth vs. expression of prostate specific differentiation markers PSA, hK2, and PSMA in human prostate cancer models
Denmeade, S. R., Sokoll, L. J., Dalrymple, S. L., Rosen, D. M., Gady, A. M., Bruzek, D. J., Ricklis, R. M., & Isaacs, J. T. (2003) · The Prostate · doi:10.1002/pros.10199 · Cited by 136 · see citing works
The Endocrinology of Prostate Cancer
Taplin, M. E., & Ho, S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7782 · Cited by 130 · see citing works
Short Hairpin RNA Knockdown of the Androgen Receptor Attenuates Ligand-Independent Activation and Delays Tumor Progression
Cheng, H., Snoek, R., Ghaidi, F., Cox, M., & Rennie, P. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0028 · Cited by 127 · see citing works
A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells
Flowers, L. O., Subramaniam, P. S., & Johnson, H. M. (2005) · Oncogene · doi:10.1038/sj.onc.1208437 · Cited by 125 · see citing works
Molecular Biology of the Androgen Receptor: From Molecular Understanding to the Clinic
Eder, I. E., Čulig, Z., Putz, T., Nessler‐Menardi, C., Bartsch, G. H., & Klocker, H. (2001) · European Urology · doi:10.1159/000049782 · Cited by 122 · see citing works
Molecular Engineering of a Two-Step Transcription Amplification (TSTA) System for Transgene Delivery in Prostate Cancer
Zhang, L., Adams, J. Y., Billick, E., Ilagan, R., Iyer, M. R., Le, K., Smallwood, A., Gambhir, S. S., Carey, M., & Wu, L. (2002) · Molecular Therapy · doi:10.1006/mthe.2002.0551 · Cited by 117 · see citing works
Signal transduction in prostate cancer progression
Gioeli, D. G. (2005) · Clinical Science · doi:10.1042/cs20040329 · Cited by 116 · see citing works
The androgen receptor and signal‐transduction pathways in hormone‐refractory prostate cancer. Part 2: androgen‐receptor cofactors and bypass pathways
Edwards, J., & Bartlett, J. M. S. (2005) · British Journal of Urology · doi:10.1111/j.1464-410x.2005.05527.x · Cited by 118 · see citing works
G Proteins in Cancer: The Prostate Cancer Paradigm
Daaka, Y. (2004) · Science s STKE · doi:10.1126/stke.2162004re2 · Cited by 117 · see citing works
Androgen receptor and its splice variants in prostate cancer
Haile, S., & Sadar, M. D. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0766-7 · Cited by 113 · see citing works
Self-citation
Aberrant activation of the androgen receptor by NF-κB2/p52 in prostate cancer cells.
Nadiminty, N., Lou, W., Sun, M., Chen, J., Yue, J., Kung, H.-J., Evans, C. P., Zhou, Q., & Gao, A. C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3703 · Cited by 113 · see citing works
Targeting Androgen Receptor Activation Function-1 with EPI to Overcome Resistance Mechanisms in Castration-Resistant Prostate Cancer
Yang, Y. C., Banuelos, C. A., Mawji, N. R., Wang, J., Kato, M., Haile, S., McEwan, I. J., Plymate, S. R., & Sadar, M. D. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2901 · Cited by 108 · see citing works
Self-citation
Inhibition of LNCaP prostate tumor growth in vivo by an antisense oligonucleotide directed against the human androgen receptor
Eder, I. E., Hoffmann, J., Rogatsch, H., Schäfer, G., Zopf, D., Bartsch, G. H., & Klocker, H. (2002) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700416 · Cited by 107 · see citing works
Pathophysiologic interactions in skeletal metastasis
Orr, F. W., Lee, J., Duivenvoorden, W., & Singh, G. (2000) · Cancer · doi:10.1002/1097-0142(20000615)88:12+ · Cited by 79 · see citing works
Roles of cAMP and cAMP-dependent protein kinase in the progression of prostate cancer: Cross-talk with the androgen receptor
Merkle, D., & Hoffmann, R. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.08.017 · Cited by 104 · see citing works
Chimeric PSA enhancers exhibit augmented activity in prostate cancer gene therapy vectors
Wu, L., Matherly, J., Smallwood, A., Adams, J. Y., Billick, E., Belldegrun, A. S., & Carey, M. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301549 · Cited by 104 · see citing works
Src kinase potentiates androgen receptor transactivation function and invasion of androgen-independent prostate cancer C4-2 cells.
Asim, M., Siddiqui, I. A., Hafeez, B. B., Baniahmad, A., & Mukhtar, H. (2008) · Oncogene · doi:10.1038/sj.onc.1211016 · Cited by 101 · see citing works
LEF1 in Androgen-Independent Prostate Cancer: Regulation of Androgen Receptor Expression, Prostate Cancer Growth, and Invasion
Li, Y., Wang, L., Zhang, M., Melamed, J., Liu, X., Reiter, R. E., Wei, J., Peng, Y., Zou, X., Pellicer, À., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3380 · Cited by 101 · see citing works
An evaluation of bicalutamide in the treatment of prostate cancer
Schellhammer, P. F. (2002) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.3.9.1313 · Cited by 100 · see citing works
Suppression of Androgen Receptor-mediated Transactivation and Cell Growth by the Glycogen Synthase Kinase 3β in Prostate Cells
Wang, L., Lin, H.-K., Hu, Y., Xie, S., Yang, L., & Chang, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313963200 · Cited by 95 · see citing works
Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer
Ponnusamy, S., Coss, C. C., Thiyagarajan, T., Watts, K., Hwang, D., He, Y., Selth, L. A., McEwan, I. J., Duke, C. B., Pagadala, J., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0976 · Cited by 95 · see citing works
Dutasteride, the dual 5α–reductase inhibitor, inhibits androgen action and promotes cell death in the LNCaP prostate cancer cell line
Lazier, C. B., Thomas, L. N., Douglas, R. C., Vessey, J. P., & Rittmaster, R. S. (2003) · The Prostate · doi:10.1002/pros.10340 · Cited by 94 · see citing works
X chromosome gene expression in human tissues: Male and female comparisons
Talebizadeh, Z., Simon, S. D., & Butler, M. G. (2006) · Genomics · doi:10.1016/j.ygeno.2006.07.016 · Cited by 92 · see citing works
A magic drug target: Androgen receptor
Li, D., Zhou, W., Pang, J., Tang, Q., Zhong, B., Shen, C., Li, X., & Hou, T. (2018) · Medicinal Research Reviews · doi:10.1002/med.21558 · Cited by 87 · see citing works
Identification of novel androgen-responsive genes by sequencing of LongSAGE libraries
Romanuik, T. L., Wang, G., Holt, R. A., Jones, S. J. M., Marra, M. A., & Sadar, M. D. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-476 · Cited by 88 · see citing works
Self-citation
Human PIRH2 Enhances Androgen Receptor Signaling through Inhibition of Histone Deacetylase 1 and Is Overexpressed in Prostate Cancer
Logan, I. R., Gaughan, L., McCracken, S. R., Sapountzi, V., Leung, H. Y., & Robson, C. N. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00147-06 · Cited by 88 · see citing works
Androgen receptor targeted therapies in castration‐resistant prostate cancer: Bench to clinic
Imamura, Y., & Sadar, M. D. (2016) · International Journal of Urology · doi:10.1111/iju.13137 · Cited by 86 · see citing works
Self-citation
Amplification of the androgen receptor gene in bone metastases from hormone‐refractory prostate cancer
Brown, R. S. D., Edwards, J., Doǧan, A., Payne, H. A., Harland, S. J., Bartlett, J. M. S., & Masters, J. R. (2002) · The Journal of Pathology · doi:10.1002/path.1206 · Cited by 87 · see citing works
Androgen receptor decoy molecules block the growth of prostate cancer.
Quayle, S. N., Mawji, N. R., Wang, J., & Sadar, M. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606718104 · Cited by 84 · see citing works
Self-citation
The Androgen Receptor Acetylation Site Regulates cAMP and AKT but Not ERK-induced Activity
Fu, M., Rao, M., Wu, K., Wang, C., Zhang, X., Hessien, M., Yeung, Y.-G., Gioeli, D. G., Weber, M. J., & Pestell, R. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313466200 · Cited by 83 · see citing works
Vav3 Oncogene Is Overexpressed and Regulates Cell Growth and Androgen Receptor Activity in Human Prostate Cancer
Dong, Z., Liu, Y., Lu, S., Wang, A. Y., Lee, K., Wang, L., Revelo, M. P., & Lu, S. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0048 · Cited by 82 · see citing works
Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells
Wang, G., Jones, S. J. M., Marra, M. A., & Sadar, M. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209715 · Cited by 81 · see citing works
Self-citation
Examination of Selected Food Additives and Organochlorine Food Contaminants for Androgenic Activity in Vitro
SCHRADER, T. J. (2000) · Toxicological Sciences · doi:10.1093/toxsci/53.2.278 · Cited by 81 · see citing works
Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival
Rokhlin, O. W., Taghiyev, A. F., Bayer, K. U., Bumcrot, D. A., Koteliansky, V., Glover, R. A., & Cohen, M. B. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.5.3975 · Cited by 79 · see citing works
Targeting the BAF57 SWI/SNF Subunit in Prostate Cancer: A Novel Platform to Control Androgen Receptor Activity
Link, K. A., Balasubramaniam, S., Sharma, A. M., Comstock, C. E. S., Godoy‐Tundidor, S., Powers, N., Cao, K. H., Haelens, A., Claessens, F., Revelo, M. P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6392 · Cited by 79 · see citing works
Molecular effects of the herbal compound PC-SPES: identification of activity pathways in prostate carcinoma.
Bonham, M. J., Arnold, H., Montgomery, B., & Nelson, P. S. (2002) · PubMed · Cited by 79 · see citing works
Regions of Prostate-specific Antigen (PSA) Promoter Confer Androgen-independent Expression of PSA in Prostate Cancer Cells
Yeung, F., Li, X., Ellett, J. D., Trapman, J., Kao, C. H., & Chung, L. W. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002755200 · Cited by 78 · see citing works
Expression of prostate‐specific antigen is transcriptionally regulated by genistein in prostate cancer cells
Davis, J. N., Küçük, Ö., & Sarkar, F. H. (2002) · Molecular Carcinogenesis · doi:10.1002/mc.10053 · Cited by 76 · see citing works
Ligand-independent activation of the androgen receptor by the differentiation agent butyrate in human prostate cancer cells.
Sadar, M. D., & Gleave, M. E. (2000) · PubMed · Cited by 74 · see citing works
Self-citation
Niphatenones, Glycerol Ethers from the Sponge Niphates digitalis Block Androgen Receptor Transcriptional Activity in Prostate Cancer Cells: Structure Elucidation, Synthesis, and Biological Activity
Meimetis, L. G., Williams, D. E., Mawji, N. R., Banuelos, C. A., Lal, A., Park, J. J., Tien, A. H., Fernandez, J. G., de Voogd, N. J., Sadar, M. D., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2014056 · Cited by 71 · see citing works
Self-citation
Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway
Lee, S. O., Lou, W., Hou, M., Oñate, S. A., & Gao, A. C. (2003) · Oncogene · doi:10.1038/sj.onc.1206735 · Cited by 71 · see citing works
Androgen Receptor Expression and Cellular Proliferation During Transition from Androgen-Dependent to Recurrent Growth after Castration in the CWR22 Prostate Cancer Xenograft
Kim, D., Gregory, C. W., French, F. S., Smith, G. J., & Mohler, J. L. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64365-9 · Cited by 71 · see citing works
Specificity of cyclin D1 for androgen receptor regulation.
Petre, C. E., Cook, S. L., Burd, C. J., Marshall, T. W., Wetherill, Y. B., & Knudsen, K. E. (2003) · PubMed · Cited by 71 · see citing works
Androgen receptor mediates the reduced tumor growth, enhanced androgen responsiveness, and selected target gene transactivation in a human prostate cancer cell line.
Cinar, B., Koeneman, K. S., Edlund, M., Prins, G. S., Zhau, H. E., & Chung, L. W. K. (2001) · PubMed · Cited by 69 · see citing works
Osteoblast-derived factors induce androgen-independent proliferation and expression of prostate-specific antigen in human prostate cancer cells.
Blaszczyk, N., Masri, B. A., Mawji, N. R., Ueda, T., McAlinden, G., Duncan, C. P., Bruchovsky, N., Schweikert, H.-U., Schnabel, D., Jones, E. C., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0974-3 · Cited by 66 · see citing works
Self-citation
Beyond the Ligand-Binding Pocket: Targeting Alternate Sites in Nuclear Receptors
Caboni, L., & Lloyd, D. G. (2012) · Medicinal Research Reviews · doi:10.1002/med.21275 · Cited by 64 · see citing works
The Scaffolding Protein RACK1 Interacts with Androgen Receptor and Promotes Cross-talk through a Protein Kinase C Signaling Pathway
Rigas, A. C., Ozanne, D. M., Neal, D. E., & Robson, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306219200 · Cited by 64 · see citing works
Sintokamide A Is a Novel Antagonist of Androgen Receptor That Uniquely Binds Activation Function-1 in Its Amino-terminal Domain
Banuelos, C. A., Tavakoli, I., Tien, A. H., Caley, D. P., Mawji, N. R., Li, Z., Wang, J., Yang, Y. C., Imamura, Y., Yan, L., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.734475 · Cited by 61 · see citing works
Self-citation
Quantitative profiling of LNCaP prostate cancer cells using isotope‐coded affinity tags and mass spectrometry
Meehan, K. L., & Sadar, M. D. (2004) · PROTEOMICS · doi:10.1002/pmic.200300649 · Cited by 61 · see citing works
Self-citation
Ligand-independent activation of the androgen receptor in prostate cancer by growth factors and cytokines
Jenster, G. W. (2000) · The Journal of Pathology · doi:10.1002/1096-9896(200007)191:3 · Cited by 61 · see citing works
Suppressor of Cytokine Signaling-3 Antagonizes cAMP Effects on Proliferation and Apoptosis and Is Expressed in Human Prostate Cancer
Bellezza, I., Neuwirt, H., Nemes, C., Cavarretta, I. T. R., Puhr, M., Steiner, H., Minelli, A., Bartsch, G. C., Offner, F. A., Hobisch, A., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060171 · Cited by 59 · see citing works
Heparin-Binding Epidermal Growth Factor-Like Growth Factor Stimulates Androgen-Independent Prostate Tumor Growth and Antagonizes Androgen Receptor Function
Adam, R. M., Kim, J., Lin, J., Anna Orsola, A., Zhuang, L., Rice, D. C., & Freeman, M. R. (2002) · Endocrinology · doi:10.1210/en.2002-220561 · Cited by 56 · see citing works

The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus
Kim, J. Y., Jia, L., Stallcup, M. R., & Coetzee, G. A. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01701 · Cited by 59 · see citing works
Protein kinase A (PKA) pathway is functionally linked to androgen receptor (AR) in the progression of prostate cancer
Sarwar, M., Sandberg, S., Abrahamsson, P., & Persson, J. L. (2013) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2012.08.019 · Cited by 38 · see citing works
An AKT activity threshold regulates androgen-dependent and androgen-independent PSA expression in prostate cancer cell lines
Paliouras, M., & Diamandis, E. P. (2008) · Biological Chemistry · doi:10.1515/bc.2008.072 · Cited by 19 · see citing works
Activation of Androgen Receptor in Prostate Cancer: Role of Protein Kinase A and Extracellular Signal-regulated Kinases
Daaka, Y., Kasbohm, E. A., & Yowell, C. W. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-387-23761-5_57
Androgens Transduce the Gαs-Mediated Activation of Protein Kinase A in Prostate Cells
Bagchi, G., Wu, J., French, J. E., Kim, J. I., Moniri, N. H., & Daaka, Y. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5026 · Cited by 31 · see citing works

Authors: Sadar, M. D.
Affiliations: BC Cancer Agency (CA)
Corresponding author: Sadar, Marianne D.
ORCID: Sadar, Marianne D.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1999-03
Volume: 274
Issue: 12
Pages: 7777-7783
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.274.12.7777
OpenAlex: W2043236550
Cited by: 270
References: 46
Citations by year: 2024: 3 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 4 · 2014: 2 · 2013: 10 · 2012: 10
FWCI: 19.80
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 7891 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p50dk047656-07)
National Institute of Diabetes and Digestive and Kidney Diseases (P50 DK47656)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: prostate-specific antigen, androgen receptor, protein kinase A, prostate cancer, forskolin, bicalutamide, androgen response element, LNCaP cells, PC-3 cells, transcriptional activation
MeSH terms: Androgen Antagonists, Androgens, Anilides, Colforsin, Humans, Nitriles, Receptors, Androgen, RNA, Messenger, Tosyl Compounds, Tumor Cells, Cultured, Signal Transduction, Gene Expression Regulation, Neoplastic, Prostate-Specific Antigen, Cyclic AMP-Dependent Protein Kinases

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Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways.

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