The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Endostatin Induces Endothelial Cell Apoptosis
Open accessAbstract
Endostatin, a carboxyl-terminal fragment of collagen XVIII, has been shown to regress tumors in mice. In this study, we have analyzed the mechanism of endostatin action on endothelial cells and nonendothelial cells. Endostatin treatment of cow pulmonary artery endothelial cells caused apoptosis, as demonstrated by three methods, annexin V-fluorescein isothiocyanate staining, caspase 3, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling assay. Moreover, addition of endostatin led to a marked reduction of the Bcl-2 and Bcl-XL anti-apoptotic protein, whereas Bax protein levels were unaffected. These effects were not seen in several nonendothelial cells. Collectively, these findings provide important mechanistic insight into endostatin action.
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Cites
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Cited by
Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
Jiménez, B., Volpert, O. V., Crawford, S. E., Febbraio, M., Silverstein, R. L., & Bouck, N. (2000) · Nature Medicine · doi:10.1038/71517 · Cited by 1,020
Wang, Y., Zhou, K., Huang, G., Hensley, C., Huang, X., Ma, X., Zhao, T., Sumer, B. D., DeBerardinis, R. J., & Gao, J. (2014) · Nature Materials · doi:10.1038/nmat3819 · Cited by 773
Endogenous Inhibitors of Angiogenesis
Nyberg, P., Xie, L., & Kalluri, R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2427 · Cited by 553
Extracellular matrix remodelling and cellular differentiation
Streuli, C. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00026-5 · Cited by 512
Endothelial Cell Apoptosis in Angiogenesis and Vessel Regression
Dimmeler, S., & Zeiher, A. M. (2000) · Circulation Research · doi:10.1161/01.res.87.6.434 · Cited by 425
Metadata
- Authors
- Dhanabal, M., Ramchandran, R., Waterman, M. J. F., Lu, H., Knebelmann, B., Segal, M., & Sukhatme, V. P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-04
- Volume
- 274
- Issue
- 17
- Pages
- 11721-11726
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1968431199
- Cited by
- 584
- References
- 27
- FWCI
- 17.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dhanabal, M., Ramchandran, R., Waterman, M. J. F., Lu, H., Knebelmann, B., Segal, M., & Sukhatme, V. P. (1999). Endostatin Induces Endothelial Cell Apoptosis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.17.11721
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
