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Integrin-associated Protein Is a Ligand for the P84 Neural Adhesion Molecule
Open accessAbstract
P84 (also known as SHPS-1, BIT, and SIRP) is a heterophilic adhesive membrane protein involved in receptor tyrosine kinase signaling that is found at synapses in the mammalian central nervous system and in non-neural tissues. We have identified a binding partner for P84 using an expression cloning strategy. Here we report that integrin-associated protein (IAP/CD47) is a predominant binding partner of P84. Immunohistochemistry reveals a virtually identical distribution of P84 and IAP in a variety of adult brain regions. Because IAP has been implicated in cell signaling in cells of the immune system, P84 and IAP represent a heterophilic binding pair that is likely to be involved in bi-directional signaling at the synapse and in other tissues.
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Cited by
The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
Neel, B. G., Gu, H., & Pao, L. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00091-4 · Cited by 1,249
Barclay, A. N., & van den Berg, T. K. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120142 · Cited by 841
Chao, M. P., Jaiswal, S., Weissman-Tsukamoto, R., Alizadeh, A. A., Gentles, A. J., Volkmer, J., Weiskopf, K., Willingham, S. B., Raveh, T., Park, C. Y., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001375 · Cited by 776
Tsai, R. K., & Discher, D. E. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708043 · Cited by 486
Indentation and Adhesive Probing of a Cell Membrane with AFM: Theoretical Model and Experiments
Sen, S., Subramanian, S., & Discher, D. E. (2005) · Biophysical Journal · doi:10.1529/biophysj.105.063826 · Cited by 304
Metadata
- Authors
- Jiang, P., Lagenaur, C. F., & Narayanan, V.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 274
- Issue
- 2
- Pages
- 559-562
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2083359402
- Cited by
- 351
- References
- 0
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Jiang, P., Lagenaur, C. F., & Narayanan, V. (1999). Integrin-associated Protein Is a Ligand for the P84 Neural Adhesion Molecule. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.2.559
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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