Cited by 53Cholesterol and Lipid MetabolismCancer, Lipids, and MetabolismLipoproteins and Cardiovascular Health

Cholesterol: From Feeding to Gene Regulation

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Martini, C., Pallottini, V.·2007·Genes & Nutrition

Abstract

We present here a brief description of the path that cholesterol covers from its intestinal absorption to its effects exerted on gene regulation. In particular, the relationship between cholesterol and the protein complexes involved in the intricate gene regulation mechanism implicated in cholesterol homeostasis will be discussed. In addition, a new target role for the pharmacological interventions of one of these factors, the insulin-induced gene (Insig) protein, will be introduced.

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Crossref · 10.1007/s12263-007-0049-y

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  • 80% of the cholesterol present in the mammal body is endogenously synthesized, mainly in the liver.

    “although 80% of the cholesterol present in the mammal body is endogenously synthesized, mainly in the liver [42].”

    From Brain Cholesterol Biosynthetic Pathway Is Altered in a Preclinical Model of Fragile X Syndrome (2022) · cites this paper as [42]

    The Introduction (page unavailable) says cholesterol is both synthesized by cells and obtained from food. “From enterocytes to limph and liver” (page unavailable) says de novo synthesis occurs mainly in the liver when cholesterol supply is low. Neither passage supports the claim that 80% of cholesterol in a mammal’s body is endogenously synthesized. (LLM, conf=0.87)

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Research works printed but not linked: 1

  1. Luong A (2000) Identification of three novel SREBP-activated target genes: acetyl CoA synthetase, 3-b-hydroxysterol dehy- drogenase, and CL-6/INSIG1. PhD dissertation. University of Texas Southwestern Medical Center at Dallas, Dallas, pp 1-137

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Authors
Martini, C., & Pallottini, V.
Affiliations
Roma Tre University (IT)
Corresponding author
Pallottini, V.
Venue
Genes & Nutrition
Published
2007-09-27
Volume
2
Issue
2
Pages
181-193
ISSN
  • 1555-8932 (ISSN-L)
  • 1865-3499
OpenAlex
W2093708379
Cited by
53
References
139
Citations by year
2025: 4 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 10 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 2 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 5
FWCI
3.33
Type
journal article
Language
en
Open access
Locations
  • Genes & Nutrition (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
cholesterol, intestinal cholesterol absorption, gene expression regulation, cholesterol homeostasis, protein complexes, dietary cholesterol

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