Cholesterol: From Feeding to Gene Regulation
Open accessAbstract
We present here a brief description of the path that cholesterol covers from its intestinal absorption to its effects exerted on gene regulation. In particular, the relationship between cholesterol and the protein complexes involved in the intricate gene regulation mechanism implicated in cholesterol homeostasis will be discussed. In addition, a new target role for the pharmacological interventions of one of these factors, the insulin-induced gene (Insig) protein, will be introduced.
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80% of the cholesterol present in the mammal body is endogenously synthesized, mainly in the liver.
“although 80% of the cholesterol present in the mammal body is endogenously synthesized, mainly in the liver [42].”
From Brain Cholesterol Biosynthetic Pathway Is Altered in a Preclinical Model of Fragile X Syndrome (2022) · cites this paper as [42]
The Introduction (page unavailable) says cholesterol is both synthesized by cells and obtained from food. “From enterocytes to limph and liver” (page unavailable) says de novo synthesis occurs mainly in the liver when cholesterol supply is low. Neither passage supports the claim that 80% of cholesterol in a mammal’s body is endogenously synthesized. (LLM, conf=0.87)
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- Luong A (2000) Identification of three novel SREBP-activated target genes: acetyl CoA synthetase, 3-b-hydroxysterol dehy- drogenase, and CL-6/INSIG1. PhD dissertation. University of Texas Southwestern Medical Center at Dallas, Dallas, pp 1-137
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- Authors
- Martini, C., & Pallottini, V.
- Affiliations
- Roma Tre University (IT)
- Corresponding author
- Pallottini, V.
- Venue
- Genes & Nutrition
- Published
- 2007-09-27
- Volume
- 2
- Issue
- 2
- Pages
- 181-193
- ISSN
- 1555-8932 (ISSN-L)
- 1865-3499
- PMC
- PMC2474947
- OpenAlex
- W2093708379
- Cited by
- 53
- References
- 139
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 10 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 2 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 5
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Genes & Nutrition (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- cholesterol, intestinal cholesterol absorption, gene expression regulation, cholesterol homeostasis, protein complexes, dietary cholesterol
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