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Cell Permeable Iron Chelators as Potential Cancer Chemotherapeutic Agents

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Advancing glioblastoma treatment through iron metabolism: A focus on TfR1 and Ferroptosis innovations

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Transferrin receptor 1 mRNA is downregulated in placenta of hepcidin transgenic embryos

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EPAS1 Is Required for Spermatogenesis in the Postnatal Mouse Testis1

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Therapeutic Potential of Iron Chelators in Cancer Therapy

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Anemia in patients receiving anticancer treatments: focus on novel therapeutic approaches

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Quantitative imaging of receptor-ligand engagement in intact live animals

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Investigational hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHI) for the treatment of anemia associated with chronic kidney disease

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Effects of Cell Proliferation on the Uptake of Transferrin–Bound Iron by Human Hepatoma Cells

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Prolyl hydroxylase domain enzymes and their role in cell signaling and cancer metabolism

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The biochemical and molecular mechanisms involved in the role of tumor micro-environment stress in development of drug resistance

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Association of serum transferrin receptor concentration with markers of inflammation in Zimbabwean children

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When less is more: novel mechanisms of iron conservation

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Hypoxia-Mediated Mechanism of MUC5AC Production in Human Nasal Epithelia and Its Implication in Rhinosinusitis

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Transgenic rescue of erythroid 5‐aminolevulinate synthase‐deficient mice results in the formation of ring sideroblasts and siderocytes

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Serum soluble transferrin receptor concentrations are increased in central obesity. Results from a screening programme for hereditary hemochromatosis in men with hyperferritinemia

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Current Understanding of HIF in Renal Disease

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Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer’s Disease Is Associated with Activation of HIF-1 Signaling Pathway

Petralla, S., Saveleva, L., Kanninen, K. M., Oster, J. S., Panayotova, M., Fricker, G., & Puris, E. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03990-3 · Cited by 39

Increasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular Ascorbate

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Triad role of hepcidin, ferroportin, and Nrf2 in cardiac iron metabolism: From health to disease

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N-myc downstream regulated 1 gene and its place in the cellular machinery.

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Reticulocyte transferrin receptor (TfR) expression and contribution to soluble TfR levels.

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Role of Ets-1 in transcriptional regulation of transferrin receptor and erythroid differentiation

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Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins

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Trasferrin receptor 2 gene regulation by microRNA 221 in SH-SY5Y cells treated with MPP+ as Parkinson's disease cellular model

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Heme-mediated cell activation: the inflammatory puzzle of sickle cell anemia

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Oxygen matters: hypoxia as a pathogenic mechanism in rhinosinusitis

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Iron‐Sulfur Clusters: A Key Factor of Regulated Cell Death in Cancer

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Developmental Regulation of Oxygen Sensing and Ion Channels in the Pulmonary Vasculature

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T-cell activation without proliferation in juvenile idiopathic arthritis

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(Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells

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Strategies to Interfere with Tumor Metabolism through the Interplay of Innate and Adaptive Immunity

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A Hypoxia-Inducible Factor Stabilizer Improves Hematopoiesis and Iron Metabolism Early after Administration to Treat Anemia in Hemodialysis Patients

Ogawa, C., Tsuchiya, K., Tomosugi, N., & Maeda, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197153 · Cited by 29

Supplementation with a synthetic polyphenol limits oxidative stress and enhances neuronal cell viability in response to hypoxia–re-oxygenation injury

Duong, T. T. H., Antao, S., Ellis, N. A., Myers, S. J., & Witting, P. K. (2008) · Brain Research · doi:10.1016/j.brainres.2008.04.044 · Cited by 28

Iron metabolism in mammalian cells

Walker, B., Tiong, J., & Jefferies, W. A. (2001) · International review of cytology · doi:10.1016/s0074-7696(01)11020-x · Cited by 27

A novel hypoxia-response element in the lactate dehydrogenase-B gene of the killifish Fundulus heteroclitus

Rees, B. B., Figueroa, Y. G., Wiese, T. E., Beckman, B. S., & Schulte, P. M. (2009) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2009.05.001 · Cited by 27

Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice

Chiabrando, D., Fiorito, V., Marro, S., Silengo, L., Altruda, F., & Tolosano, E. (2013) · Blood Cells, Molecules, and Diseases · doi:10.1016/j.bcmd.2012.08.002 · Cited by 24

Transient Ureteral Obstruction Prevents against Kidney Ischemia/Reperfusion Injury via Hypoxia-Inducible Factor (HIF)-2α Activation

Zhang, S., Han, C., Chen, X., Zhang, M., Xu, L., Zhang, J., & Xia, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029876 · Cited by 24

Immunohistochemical Study of Transferrin Receptor Expression in the Placenta of Pre-eclamptic Pregnancy

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Influence of the availability of iron during hypoxia on the genes associated with apoptotic activity and local iron metabolism in rat H9C2 cardiomyocytes and L6G8C5 skeletal myocytes

Dzięgała, M., Kasztura, M., Kobak, K. A., Bania, J., Banasiak, W., Ponikowski, P. P., & Jankowska, E. A. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5705 · Cited by 25

Different effects of long noncoding RNANDRG1-OT1fragments onNDRG1transcription in breast cancer cells under hypoxia

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HIF1α-Dependent Induction of TFRC by a Combination of Intestinal Inflammation and Systemic Iron Deficiency in Inflammatory Bowel Disease

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Ferroptosis in the Lacrimal Gland Is Involved in Dry Eye Syndrome Induced by Corneal Nerve Severing

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Local and Systemic Hypoxia as Inductors of Increased Aluminum and Iron Brain Accumulation Promoting the Onset of Alzheimer’s Disease

Ćirović, A., Cirovic, A., Orisakwe, O. E., & Lima, R. R. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03599-y · Cited by 22

Catecholamine Stress Hormones Regulate Cellular Iron Homeostasis by a Posttranscriptional Mechanism Mediated by Iron Regulatory Protein

Tapryal, N., Vishnu Vivek, G., & Mukhopadhyay, C. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.592519 · Cited by 22

Distinct TP53 Mutation Subtypes Differentially Influence Cellular Iron Metabolism

Clarke, S. L., Thompson, L. R., Dandekar, E., Srinivasan, A., & Montgomery, M. R. (2019) · Nutrients · doi:10.3390/nu11092144 · Cited by 21

Iron Regulatory Protein 1 Suppresses Hypoxia‐Induced Iron Uptake Proteins Expression and Decreases Iron Levels in HepG2 Cells

Cheng, C., Wang, D., Cao, X., Luo, Q., Lu, Y., & Zhu, L. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25147 · Cited by 19

From iron-driven cell death to clot formation: The emerging role of ferroptosis in thrombogenesis

Ravari, F. K., Gorji, M. G., & Rafiei, A. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118328 · Cited by 19

Effects of hypoxia-inducible factor prolyl hydroxylase inhibitors versus erythropoiesis-stimulating agents on iron metabolism and inflammation in patients undergoing dialysis: A systematic review and meta-analysis

Zheng, Q., Zhang, P., Yang, H., Geng, Y., Tang, J., Kang, Y., Qi, A., & Li, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15310 · Cited by 19

Exploring Potential Mechanisms Accounting for Iron Accumulation in the Central Nervous System of Patients with Alzheimer’s Disease

LeVine, S. M. (2024) · Cells · doi:10.3390/cells13080689 · Cited by 20

The Effect of Altitude Change on Anemia Treatment Response in Hemodialysis Patients

Brookhart, M. A., Bradbury, B. D., Avorn, J., Schneeweiß, S., & Winkelmayer­, W. C. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwq423 · Cited by 18

Moonlighting Protein Glyceraldehyde-3-Phosphate Dehydrogenase: A Cellular Rapid-Response Molecule for Maintenance of Iron Homeostasis in Hypoxia

Malhotra, H., Kumar, M., Chauhan, A. S., Dhiman, A., Chaudhary, S., Patidar, A., Jaiswal, P., Sharma, K., Sheokand, N., Raje, C. I., et al. (2019) · Cellular Physiology and Biochemistry · doi:10.33594/000000037 · Cited by 17

TfR1 Extensively Regulates the Expression of Genes Associated with Ion Transport and Immunity

Huang, N. J., Zhan, L., Cheng, Y., Wang, X., Wei, Y., Wang, Q., & Li, W. (2020) · Current Medical Science · doi:10.1007/s11596-020-2208-y · Cited by 17

Oxidative stress, NO and smooth muscle cell extracellular superoxide dismutase expression

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Subcellular distribution of S100A4 and its transcriptional regulation under hypoxic conditions in gastric cancer cell line BGC823

Zhang, R., Fu, H., Chen, D., Hua, J., Hu, Y., Sun, K., & Sun, X. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01533.x · Cited by 17

Deregulation of iron homeostasis and cold-preservation injury to rat liver stored in University of Wisconsin solution

Wyllie, S., Seu, P., Gao, F. Q., & Goss, J. A. (2003) · Liver Transplantation · doi:10.1053/jlts.2003.50065 · Cited by 17

Induction of Gastrin Expression in Gastrointestinal Cells by Hypoxia or Cobalt Is Independent of Hypoxia-Inducible Factor (HIF)

Xiao, L., Kovac, S., Chang, M. S. S., Shulkes, A., Baldwin, G. S., & Patel, O. (2012) · Endocrinology · doi:10.1210/en.2011-2069 · Cited by 17

Inhibition of transferrin receptor 1 transcription by a cell density response element

Wang, J., Chen, G., & Pantopoulos, K. (2005) · Biochemical Journal · doi:10.1042/bj20050492 · Cited by 17

ASC modulates HIF-1α stability and induces cell mobility in OSCC

Wu, C., Chang, I. Y., Hung, J.-L., Liao, W., Lai, Y.-R., Chang, K., Li, H., & Chang, Y. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02927-7 · Cited by 19

Roquin is a major mediator of iron-regulated changes to transferrin receptor-1 mRNA stability

Corral, V. M., Schultz, E. R., Eisenstein, R. S., & Connell, G. J. (2021) · iScience · doi:10.1016/j.isci.2021.102360 · Cited by 16

New perspectives on the molecular basis of the interaction between oxygen homeostasis and iron metabolism

Cairo, G., Recalcati, S., & Gammella, E. (2015) · Hypoxia · doi:10.2147/hp.s83537 · Cited by 17

HIF‑1α: Its notable role in the maintenance of oxygen, bone and iron homeostasis (Review)

Huang, X., Zhang, Y., Qi, B., Sun, K., Liu, N., Tang, B., Fang, S., Zhu, L., & Wei, X. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5197 · Cited by 17

Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone

Bae, D.-H., Lane, D. J. R., Siafakas, A. R., Šuťák, R., Paluncic, J., Huang, M., Jansson, P. J., Rahmanto, Y. S., & Richardson, D. R. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165844 · Cited by 15

Induction of Transferrin Receptor by Ethanol in Rat Primary Hepatocyte Culture

Suzuki, M., Fujimoto, Y., Suzuki, Y., Hosoki, Y., Saito, H., Nakayama, K., Ohtake, T., & Kohgo, Y. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2004.tb03225.x · Cited by 15

Ischemia‐reperfusion of rat liver modulates hepcidin in vivo expression

Goss, J. A., Seu, P., Gao, F. Q., & Wyllie, S. (2005) · Liver Transplantation · doi:10.1002/lt.20436 · Cited by 15

Induction of Transferrin Receptor by Ethanol in Rat Primary Hepatocyte Culture

Suzuki, M., Fujimoto, Y., Suzuki, Y., Hosoki, Y., Saito, H., Nakayama, K., Ohtake, T., & Kohgo, Y. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000133584.61304.19 · Cited by 15

Hypoxia induces erythroid‐specific 5‐aminolevulinate synthase expression in human erythroid cells through transforming growth factor‐β signaling

Kaneko, K., Furuyama, K., Aburatani, H., & Shibahara, S. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.06878.x · Cited by 14

Structure-based drug design for hypoxia-inducible factor prolyl-hydroxylase inhibitors and its therapeutic potential for the treatment of erythropoiesis-stimulating agent-resistant anemia: raising expectations for exploratory clinical trials

Higashijima, Y., Tanaka, T., & Nangaku, M. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.796358 · Cited by 14

Therapeutics of managing reduced red cell mass associated with chronic kidney disease – Is there a case for earlier intervention?

Elliott, J. (2023) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/jvp.13127 · Cited by 15

Methionine sulfoxide reductase A deficiency aggravated ferroptosis in LPS-induced acute kidney injury by inhibiting the AMPK/NRF2 axis and activating the CaMKII/HIF-1α pathway

Yang, L., Xiao, J., Zhang, L., Lu, Q., Hu, B.-B., Liu, Y., Jun-xing, P., Hu, J., Yu, H. J., Yu, H. J., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.04.040 · Cited by 17

Glycosylation Profile of the Transferrin Receptor in Gestational Iron Deficiency and Early-Onset Severe Preeclampsia

Gómez-Gutiérrez, A. M., Parra-Sosa, B. E., & Bueno-Sánchez, J. C. (2019) · Journal of Pregnancy · doi:10.1155/2019/9514546 · Cited by 13

Ferroptosis: An Energetic Villain of Age-Related Macular Degeneration

Zhao, N. R., Li, S., Wu, H., Dong, W., Pu, N., Wang, K., Liu, Y., Tao, Y., & Song, Z. (2025) · Biomedicines · doi:10.3390/biomedicines13040986 · Cited by 14

Iron homeostasis and post-hemorrhagic hydrocephalus: a review

Pan, S., Hale, A. T., Lemieux, M., Raval, D. K., Garton, T. P., Sadler, B. E., Mahaney, K. B., & Strahle, J. M. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2023.1287559 · Cited by 11

Pseudorabies virus induces ferroptosis by disrupting iron homeostasis through activation of TfR1 and ferritinophagy

Ma, Z., Guo, L., Ji, R., Sun, Z., Wang, J., Yang, Y., Liu, K., Zhang, H., Wang, X., Wu, C., et al. (2025) · Journal of Virology · doi:10.1128/jvi.00974-25 · Cited by 11

Early-Life Iron Deficiency Alters Glucose Transporter-1 Expression in the Adult Rodent Hippocampus

Ennis, K., Felt, B. T., Georgieff, M., & Rao, R. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz100 · Cited by 11

Are Hippocampal Hypoperfusion and ATP Depletion Prime Movers in the Genesis of Alzheimer’s Disease? A Review of Recent Pertinent Observations from Molecular Biology

Walker, V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157328 · Cited by 11

Beneficial effect of roxadustat on early posttransplant anemia and iron utilization in kidney transplant recipients: a retrospective comparative cohort study

Li, H., Hu, S.-M., Li, Y., Ciancio, G., Tadros, N. N., Tao, Y., Bai, Y.-J., & Shi, Y. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5897 · Cited by 11

Effects of hypoxic preconditioning on the expression of iron influx and efflux proteins in primary neuron culture

Du, F., Fan, M., Gong, Q., Zhu, L., Zhu, Z.-J., Lü, L., & Ke, Y. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.01.008 · Cited by 10

Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy

Sofer, T., Li, R., Joehanes, R., Lin, H., Gower, A. C., Wang, H., Kurniansyah, N., Cade, B. E., Lee, J., Williams, S., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102803 · Cited by 12

Hypoxia and cytoplasmic alkalinization upregulate growth hormone expression in lymphocytes

Weigent, D. A. (2013) · Cellular Immunology · doi:10.1016/j.cellimm.2013.03.007 · Cited by 10

Hypoxia-inducible factor-1α as prognostic marker

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