The FKBP12-Rapamycin-binding Domain Is Required for FKBP12-Rapamycin-associated Protein Kinase Activity and G1 Progression

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Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

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Structure of the FKBP12-Rapamycin Complex Interacting with Binding Domain of Human FRAP

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Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

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4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathwayPreprint

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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Osmotic Stress Signaling and Osmoadaptation in Yeasts

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

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mTOR kinase structure, mechanism and regulation

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Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

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mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E

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Regulation of cellular growth by the Drosophila target of rapamycin dTORPreprint

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Chemotherapy resistance in osteosarcoma: current challenges and future directions

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mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

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The TOR Kinases Link Nutrient Sensing to Cell Growth

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TOR Deficiency in C. elegans Causes Developmental Arrest and Intestinal Atrophy by Inhibition of mRNA Translation

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Therapy for Osteosarcoma

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Roles of Glutamate Receptors and the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Activity-dependent Dendritic Protein Synthesis in Hippocampal Neurons

Gong, R., Park, C. S., Abbassi, N. R., & Tang, S.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512524200 · Cited by 249

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

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Current Therapeutic Strategies and Novel Approaches in Osteosarcoma

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TOR Signaling

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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

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BMPs signal alternately through a SMAD or FRAP–STAT pathway to regulate fate choice in CNS stem cells

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Cytoplasmic–nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation

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FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse

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mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

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Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

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Cloning of a Novel Phosphatidylinositol Kinase-related Kinase

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Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages

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The Mammalian Target of Rapamycin Regulates C2C12 Myogenesis via a Kinase-independent Mechanism

Erbay, E., & Chen, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100406200 · Cited by 158

Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity

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mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR

Yin, Y., Hua, H. M., Li, M., Liu, S., Kong, Q., Shao, T., Wang, J., Luo, Y., Wang, Q., Luo, T. L., et al. (2015) · Cell Research · doi:10.1038/cr.2015.133 · Cited by 147

Large FK506-binding proteins shape the pharmacology of rapamycin

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Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect

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The Rapamycin-binding Domain of the Protein Kinase Mammalian Target of Rapamycin Is a Destabilizing Domain

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mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle Progression

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Review of the proliferation inhibitor everolimus

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From Beach to Bedside: History of the Development of Sirolimus

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Current Status and Perspectives Regarding the Treatment of Osteosarcoma: Chemotherapy

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A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling

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The Rapamycin-Binding Domain Governs Substrate Selectivity by the Mammalian Target of Rapamycin

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Human exercise-mediated skeletal muscle hypertrophy is an intrinsic process

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Integrated Computational Approaches and Tools for Allosteric Drug Discovery

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Rapid Mitogenic Regulation of the mTORC1 Inhibitor, DEPTOR, by Phosphatidic Acid

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Control of Translation by the Target of Rapamycin Proteins

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Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila

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TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals

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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

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Mechanical Stimulation Induces mTOR Signaling via an ERK-Independent Mechanism: Implications for a Direct Activation of mTOR by Phosphatidic Acid

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Regulation of Ribosomal S6 Kinase 2 by Mammalian Target of Rapamycin

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Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity

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Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton

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Uptake and cellular actions of mycolactone, a virulence determinant for Mycobacterium ulcerans

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A Nuclear Transport Signal in Mammalian Target of Rapamycin Is Critical for Its Cytoplasmic Signaling to S6 Kinase 1

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Drosophila Target of Rapamycin Kinase Functions as a Multimer

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Salicylate-induced Growth Arrest Is Associated with Inhibition of p70s6k and Down-regulation of c-Myc, Cyclin D1, Cyclin A, and Proliferating Cell Nuclear Antigen

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Immunosuppressants: Neuroprotection and promoting neurological recovery following peripheral nerve and spinal cord lesions

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TOR Action in Mammalian Cells and in Caenorhabditis elegans

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Molecular actions of sirolimus: sirolimus and mTor

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Rapamycin inhibits oxidative/nitrosative stress and enhances angiogenesis in high glucose-treated human umbilical vein endothelial cells: Role of autophagy

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The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways

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MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1

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Sirolimus-FKBP12.6 Impairs Endothelial Barrier Function Through Protein Kinase C-α Activation and Disruption of the p120–Vascular Endothelial Cadherin Interaction

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The evolving experience using everolimus in clinical transplantation

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Sirolimus: Continuing the Evolution of Transplant Immunosuppression

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Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a*

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Mds3 Regulates Morphogenesis in Candida albicans through the TOR Pathway

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The osmotic stress response of Saccharomyces cerevisiae

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The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2–3

Stover, C. M., Endo, Y., Takahashi, M., Lynch, N. J., Constantinescu, C. S., Vorup‐Jensen, T., Thiel, S., Friedl, H., Hankeln, T., Hall, R. E., et al. (2001) · Genes and Immunity · doi:10.1038/sj.gene.6363745 · Cited by 45

Farnesyltransferase Inhibitor Induces Rapid Growth Arrest and Blocks p70s6k Activation by Multiple Stimuli

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Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor

Nicastro, R., Brohée, L., Alba, J., Nüchel, J., Figlia, G., Kipschull, S., Gollwitzer, P., Romero‐Pozuelo, J., Fernandes, S., Lamprakis, A. A., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01198-6 · Cited by 48

Distant N- and C-terminal Domains Are Required for Intrinsic Kinase Activity of SMG-1, a Critical Component of Nonsense-mediated mRNA Decay

Morita, T., Yamashita, A., Kashima, I., Ogata, K., Ishiura, S., & Ohno, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610159200 · Cited by 48

Rhein Suppresses Colorectal Cancer Cell Growth by Inhibiting the mTOR Pathway In Vitro and In Vivo

Zhang, H., Yi, J. K., Huang, H., Park, S., Park, S., Kwon, W., Kim, E., Jang, S., Kim, S., Choi, S., et al. (2021) · Cancers · doi:10.3390/cancers13092176 · Cited by 43

A homologue of the cell cycle check point TOR2 fromSaccharomyces cerevisiae exists in the arbuscular mycorrrhizal fungusGlomus mosseae

Requena, N., Mann, P., & Franken, P. (2000) · Protoplasma · doi:10.1007/bf01279350 · Cited by 28

Identification of functional FKB protein in Echinococcus granulosus: Its involvement in the protoscolicidal action of rapamycin derivates and in calcium homeostasis

Cumino, A. C., Lamenza, P., & Denegri, G. M. (2009) · International Journal for Parasitology · doi:10.1016/j.ijpara.2009.11.011 · Cited by 38

Characterization of the cloned full-length and a truncated human target of rapamycin: Activity, specificity, and enzyme inhibition as studied by a high capacity assay

Toral‐Barza, L., Zhang, W., Lamison, C., LaRocque, J., Gibbons, J. J., & Yu, K. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.04.117 · Cited by 38

FRAP-Dependent Serine Phosphorylation of IRS-1 Inhibits IRS-1 Tyrosine Phosphorylation

Hartman, M. E., Villela-Bach, M., Chen, J., & Freund, G. G. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4214 · Cited by 37

mTOR: A Mediator of Intracellular Homeostasis

Jaeschke, A., Dennis, P. B., & Thomas, G. (2004) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-18930-2_17 · Cited by 36

mTOR Inhibitors in Advanced Biliary Tract Cancers

Wu, C., Chen, M., & Yeh, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030500 · Cited by 35

VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma

Ganner, A., Gehrke, C., Klein, M., Thegtmeier, L., Matulenski, T., Wingendorf, L., Wang, L., Pilz, F., Greidl, L., Meid, L., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94132-5 · Cited by 39

Novel Regulatory Mechanisms of mTOR Signaling

Chen, J. (2004) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-18930-2_14 · Cited by 34

Bone Morphogenetic Protein-Mediated Modulation of Lineage Diversification During Neural Differentiation of Embryonic Stem Cells

Goßrau, G., Thiele, J., Konang, R., Schmandt, T., & Brüstle, O. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0299 · Cited by 35

Antiproliferative Drugs for Restenosis Prevention

Habib, A., & Finn, A. V. (2016) · Interventional Cardiology Clinics · doi:10.1016/j.iccl.2016.02.002 · Cited by 34

Annexin A1 Preferentially Predicts Poor Prognosis of Basal-Like Breast Cancer Patients by Activating mTOR-S6 Signaling

Bhardwaj, A., Ganesan, N., Tachibana, K., Rajapakshe, K., Albarracin, C. T., Gunaratne, P. H., Coarfa, C., & Bedrosian, I. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127678 · Cited by 34

Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT

Ayala, S., Pigazzini, M. L., Richter, Y., Özel, M., Grothaus, I. L., Protze, J., Ziege, K., Kulke, M., ElBediwi, M., Vermaas, J. V., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32370-5 · Cited by 35

The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest

Moustafa-Kamal, M., Kucharski, T. J., El-Assaad, W., Abbas, Y. M., Gandin, V., Nagar, B., Pelletier, J., Topisirovic, I., & Teodoro, J. G. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108230 · Cited by 31

Acquired Resistance to Third-Generation EGFR Tyrosine Kinase Inhibitors in Patients With De Novo EGFRT790M-Mutant NSCLC

Park, H.-R., Kim, T. M., Lee, Y., Kim, S., Park, S., Ju, Y. S., Kim, M., Keam, B., Jeon, Y. K., Kim, D., et al. (2021) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2021.06.013 · Cited by 32

Target of rapamycin (TOR) controls vitellogenesis via activation of the S6 kinase in the fat body of the tick, Haemaphysalis longicornis

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Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition

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