Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works

A comprehensive set of sequence analysis programs for the VAX

Devereux, J., Haeberli, P. E., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222 · see citing works

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

Kozak, M. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.20.8125 · Cited by 5,090 · see citing works

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116 · see citing works

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

Brown, E. J., Albers, M. W., Bum Shin, T., ichikawa, K., Keith, C. T., Lane, W. S., & Schreiber, S. L. (1994) · Nature · doi:10.1038/369756a0 · Cited by 2,053 · see citing works

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

Heitman, J., Movva, N. R., & Hall, M. N. (1991) · Science · doi:10.1126/science.1715094 · Cited by 2,010 · see citing works

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

Clipstone, N. A., & Crabtree, G. R. (1992) · Nature · doi:10.1038/357695a0 · Cited by 1,635 · see citing works

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

Sabatini, D. M., Erdjument-Bromage, H., Lui, M., Tempst, P., & Snyder, S. H. (1994) · Cell · doi:10.1016/0092-8674(94)90570-3 · Cited by 1,509 · see citing works

In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis

Rosenfeld, J., Capdevielle, J., Guillemot, J. C., & Ferrara, P. (1992) · Analytical Biochemistry · doi:10.1016/0003-2697(92)90061-b · Cited by 1,239 · see citing works

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

Chung, J., Kuo, C. J., Crabtree, G. R., & Blenis, J. (1992) · Cell · doi:10.1016/0092-8674(92)90643-q · Cited by 1,151 · see citing works

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

Siekierka, J. J., Hung, S. H. Y., Poe, M., Lin, C. S., & SIGAL, N. H. (1989) · Nature · doi:10.1038/341755a0 · Cited by 1,007 · see citing works

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

O’Keefe, S. J., Tamura, J., Kincaid, R. L., Tocci, M. J., & O’Neill, E. A. (1992) · Nature · doi:10.1038/357692a0 · Cited by 841 · see citing works

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

Kunz, J., Henríquez, R., Schneider, U., Deuter‐Reinhard, M., Movva, N. R., & Hall, M. N. (1993) · Cell · doi:10.1016/0092-8674(93)90144-f · Cited by 838 · see citing works

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

Fruman, D. A., Klee, C. B., Bierer, B. E., & Burakoff, S. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.3686 · Cited by 823 · see citing works

Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

SIGAL, N. H., & Dumont, F. J. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.002511 · Cited by 674 · see citing works

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

Kuo, C. J., Chung, J., Fiorentino, D. F., Flanagan, W. M., Blenis, J., & Crabtree, G. R. (1992) · Nature · doi:10.1038/358070a0 · Cited by 594 · see citing works

PI 3‐kinase is a dual specificity enzyme: autoregulation by an intrinsic protein‐serine kinase activity.

Dhand, R., Hiles, I., Panayotou, G., Roche, S., Fry, M., Gout, I. T., Totty, N. F., Truong, O., Vicendo, P., & Yonezawa, K. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06290.x · Cited by 446 · see citing works

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

Helliwell, S. B., Wagner, P., Kunz, J., Deuter‐Reinhard, M., Henríquez, R., & Hall, M. N. (1994) · Molecular Biology of the Cell · doi:10.1091/mbc.5.1.105 · Cited by 390 · see citing works

The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

Dumont, F. J., Melino, M. R., Staruch, M. J., Koprak, S., Fischer, P. A., & SIGAL, N. H. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.4.1418 · Cited by 355 · see citing works

Molecular cloning and overexpression of the human FK506-binding protein FKBP

Standaert, R. F., Gałat, A., Verdine, G. L., & Schreiber, S. L. (1990) · Nature · doi:10.1038/346671a0 · Cited by 312 · see citing works

Dominant Missense Mutations in a Novel Yeast Protein related to Mammalian Phosphatidylinositol 3-Kinase and VPS34 Abrogate Rapamycin Cytotoxicity

Cafferkey, R., Young, P. R., McLaughlin, M. M., Bergsma, D. J., Koltin, Y., Sathe, G. M., Faucette, L. F., Eng, W.-K., Johnson, R. K., & Livi, G. P. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6012-6023.1993 · Cited by 309 · see citing works

Cyclosporin A, FK506 and rapamycin: more than just immunosuppression

Kunz, J., & Hall, M. N. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90069-y · Cited by 258 · see citing works

Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes.

Morice, W. G., Brunn, G. J., Wiederrecht, G., Siekierka, J. J., & Abraham, R. T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53755-8 · Cited by 180 · see citing works

Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.

Calvo, V., Crews, C. M., Vik, T. A., & Bierer, B. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7571 · Cited by 163 · see citing works

Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G1 phase of the cycle

Terada, N., Lucas, J. J., Szepesi, Á., Franklin, R. A., Domenico, J. M., & Gelfand, E. W. (1993) · Journal of Cellular Physiology · doi:10.1002/jcp.1041540103 · Cited by 156 · see citing works

The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase.

Siekierka, J. J., Wiederrecht, G., Greulich, H. E., Boulton, D. A., Hung, S. H., Cryan, J. G., Hodges, P. J., & SIGAL, N. H. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45319-1 · Cited by 134 · see citing works

Relationship between multiple biologic effects of rapamycin and the inhibition of pp70S6 protein kinase activity. Analysis in mutant clones of a T cell lymphoma.

Dumont, F. J., Altmeyer, A., Kastner, C. A., Fischer, P. A., Lemon, K. P., Chung, J., Blenis, J., & Staruch, M. J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.3.992 · Cited by 33 · see citing works

Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T cell lymphoma

Altmeyer, A., & Dumont, F. J. (1993) · Cytokine · doi:10.1016/1043-4666(93)90052-7 · Cited by 20 · see citing works

Multiple cytokine interactions regulate Ly-6E antigen expression: Cooperative Ly-6E induction by IFNs, TNF, and IL-1 in a T cell lymphoma and in its induction-deficient variants

Altmeyer, A., Staruch, M. J., Cofano, F., Landolfo, S., & Dumont, F. J. (1991) · Cellular Immunology · doi:10.1016/0008-8749(91)90135-x · Cited by 4 · see citing works

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works

mTOR Signaling in Growth, Metabolism, and Disease

Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works

Upstream and downstream of mTOR

Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181 · see citing works

mTOR: from growth signal integration to cancer, diabetes and ageing

Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941 · see citing works

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 2,974 · see citing works

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785 · see citing works

mTOR at the nexus of nutrition, growth, ageing and disease

Liu, G. Y., & Sabatini, D. M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0199-y · Cited by 2,737 · see citing works

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,645 · see citing works

MTOR: a pharmacologic target for autophagy regulation

Kim, Y. C., & Guan, K.-L. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73939 · Cited by 2,126 · see citing works

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works

TOR, a Central Controller of Cell Growth

Schmelzle, T., & Hall, M. N. (2000) · Cell · doi:10.1016/s0092-8674(00)00117-3 · Cited by 1,914 · see citing works

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

Hara, K., Maruki, Y., Long, X., Yoshino, K.-I., Oshiro, N., Sujuti, H., Tokunaga, C., Avruch, J., & Yonezawa, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00833-4 · Cited by 1,810 · see citing works

Growing roles for the mTOR pathway

Sarbassov, D. D., Ali, S. M., & Sabatini, D. M. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.009 · Cited by 1,556 · see citing works

Regulation of translation initiation by FRAP/mTOR

Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545 · see citing works

Hypothalamic mTOR Signaling Regulates Food Intake

Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278 · see citing works

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

Fingar, D. C., & Blenis, J. (2004) · Oncogene · doi:10.1038/sj.onc.1207542 · Cited by 1,250 · see citing works

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H., & Sabatini, D. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1432 · Cited by 1,130 · see citing works

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

Boland, B., Kumar, A., Lee, S., Platt, F. M., Wegiel, J., Yu, W. H., & Nixon, R. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0800-08.2008 · Cited by 1,119 · see citing works

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

Fingar, D. C., Salama, S., Tsou, C., Harlow, E., & Blenis, J. (2002) · Genes & Development · doi:10.1101/gad.995802 · Cited by 1,093 · see citing works

mTOR as a central hub of nutrient signalling and cell growth

Kim, J., & Guan, K. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0205-1 · Cited by 1,067 · see citing works

Targeting metabolic transformation for cancer therapy

Tennant, D. A., Durán, R. V., & Gottlieb, E. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2817 · Cited by 1,057 · see citing works

Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., & Chen, J. (2001) · Science · doi:10.1126/science.1066015 · Cited by 1,055 · see citing works

A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046 · see citing works

Rapamycin passes the torch: a new generation of mTOR inhibitors

Benjamin, D., Colombi, M., Moroni, C., & Hall, M. N. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3531 · Cited by 981 · see citing works

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

Neshat, M. S., Mellinghoff, I. K., Tran, C., Stiles, B. L., THOMAS, G. V., Petersen, R., Frost, P., Gibbons, J. J., Wu, H., & Sawyers, C. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171076798 · Cited by 968 · see citing works

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

Brunn, G. J., Hudson, C. C., Sekulić, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C., & Abraham, R. T. (1997) · Science · doi:10.1126/science.277.5322.99 · Cited by 959 · see citing works

GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

Kim, D., Sarbassov, D. D., Ali, S. M., Latek, R. R., Guntur, K., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00114-x · Cited by 955 · see citing works

Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k

Jefferies, H. B. J., Fumagalli, S., Dennis, P. B., Reinhard, C., Pearson, R. B., & Thomas, G. (1997) · The EMBO Journal · doi:10.1093/emboj/16.12.3693 · Cited by 934 · see citing works

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

NAVÉ, B. T., Ouwens, D. M., Withers, D. J., Alessi, D. R., & Shepherd, P. R. (1999) · Biochemical Journal · doi:10.1042/bj3440427 · Cited by 926 · see citing works

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

Loewith, R., & Hall, M. N. (2011) · Genetics · doi:10.1534/genetics.111.133363 · Cited by 900 · see citing works

The mTOR Signalling Pathway in Human Cancer

Pópulo, H., Lopes, J. M., & Soares, P. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13021886 · Cited by 830 · see citing works

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

Shillingford, J. M., Murcia, N. S., Larson, C. H., Low, S. H., Hedgepeth, R. C., Brown, N. E., Flask, C. A., Novick, A. C., Goldfarb, D. A., Kramer-Zucker, A. G., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509694103 · Cited by 808 · see citing works

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

González, A., Hall, M. N., Lin, S.-C., & Hardie, D. G. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.015 · Cited by 797 · see citing works

Sirolimus: its discovery, biological properties, and mechanism of action

Sehgal, S. N. (2003) · Transplantation Proceedings · doi:10.1016/s0041-1345(03)00211-2 · Cited by 784 · see citing works

Nutrient sensing and TOR signaling in yeast and mammals

González, A., & Hall, M. N. (2017) · The EMBO Journal · doi:10.15252/embj.201696010 · Cited by 725 · see citing works

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002.

Brunn, G. J., Williams, J. M., Sabers, C. J., Wiederrecht, G., Lawrence, J. C., & Abraham, R. T. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00911.x · Cited by 715 · see citing works

TOR controls translation initiation and early G1 progression in yeast.

Barbet, N., Schneider, U., Helliwell, S. B., Stansfield, I., Tuite, M. F., & Hall, M. N. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.1.25 · Cited by 710 · see citing works

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

Sekulić, A., Hudson, C. C., Homme, J. L., Yin, P., Otterness, D. M., Karnitz, L. M., & Abraham, R. T. (2000) · PubMed · Cited by 708 · see citing works

IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis

Jung, Y., Isaacs, J. S., Lee, S., Trepel, J. B., & Neckers, L. (2003) · The FASEB Journal · doi:10.1096/fj.03-0329fje · Cited by 681 · see citing works

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

Wymann, M. P., Bulgarelli-Leva, G., Zvelebil, M., Pirola, L., Vanhaesebroeck, B., Waterfield, M. D., & Panayotou, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1722 · Cited by 679 · see citing works

Rapamycin blocks the phosphorylation of 4E‐BP1 and inhibits cap‐dependent initiation of translation.

Beretta, L., Gingras, A., Svitkin, Y. V., Hall, M. N., & Sonenberg, N. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00398.x · Cited by 673 · see citing works

Regulation of mTORC1 and its impact on gene expression at a glance

Laplante, M., & Sabatini, D. M. (2013) · Journal of Cell Science · doi:10.1242/jcs.125773 · Cited by 665 · see citing works

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

Kwiatkowski, D. J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.5.525 · Cited by 663 · see citing works

Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression

Sehgal, S. N. (1998) · Clinical Biochemistry · doi:10.1016/s0009-9120(98)00045-9 · Cited by 660 · see citing works

IMMUNOPHARMACOLOGY OF RAPAMYCIN

Abraham, R. T., & Wiederrecht, G. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.483 · Cited by 653 · see citing works

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics

Zhang, L. J., Pitcher, L. E., Prahalad, V., Niedernhofer, L. J., & Robbins, P. D. (2022) · FEBS Journal · doi:10.1111/febs.16350 · Cited by 648 · see citing works

THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA

Lavin, M. F., & Shiloh, Y. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.177 · Cited by 642 · see citing works

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

Ostrem, J. M. L., & Shokat, K. M. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.139 · Cited by 641 · see citing works

mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells

Murakami, M., Ichisaka, T., Maeda, M., Oshiro, N., Hara, K., Edenhofer, F., Kiyama, H., Yonezawa, K., & Yamanaka, S. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.15.6710-6718.2004 · Cited by 620 · see citing works

A WORLDWIDE, PHASE III, RANDOMIZED, CONTROLLED, SAFETY AND EFFICACY STUDY OF A SIROLIMUS/CYCLOSPORINE REGIMEN FOR PREVENTION OF ACUTE REJECTION IN RECIPIENTS OF PRIMARY MISMATCHED RENAL ALLOGRAFTS

MacDonald, A. S. (2001) · Transplantation · doi:10.1097/00007890-200101270-00019 · Cited by 616 · see citing works

mTOR-targeted therapy of cancer with rapamycin derivatives

Vignot, S., Faivre, S. J., de Aguirre, & Raymond, É. (2005) · Annals of Oncology · doi:10.1093/annonc/mdi113 · Cited by 613 · see citing works

The target of rapamycin (TOR) proteins

Raught, B., Gingras, A., & Sonenberg, N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121145898 · Cited by 603 · see citing works

The TOR signaling cascade regulates gene expression in response to nutrientsPreprint

Cardenas, M. E., Cutler, N. S., Lorenz, M. C., Como, C. J. D., & Heitman, J. (1999) · Genes & Development · doi:10.1101/gad.13.24.3271 · Cited by 580 · see citing works

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

Hidalgo, M. M., & Rowinsky, E. K. (2000) · Oncogene · doi:10.1038/sj.onc.1204091 · Cited by 577 · see citing works

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten +/− mice

Podsypanina, K., Lee, R. T., Politis, C., Hennessy, I., Crane, A., Puc, J., Neshat, M. S., Wang, H., Yang, L., Gibbons, J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171060098 · Cited by 568 · see citing works

Expanding mTOR signaling

Yang, Q., & Guan, K. (2007) · Cell Research · doi:10.1038/cr.2007.64 · Cited by 540 · see citing works

Rapalogs and mTOR inhibitors as anti-aging therapeutics

Lamming, D. W., Ye, L., Sabatini, D. M., & Baur, J. A. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64099 · Cited by 531 · see citing works

Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity

Johnson, D. I. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.1.54-105.1999 · Cited by 530 · see citing works

A humanized system for pharmacologic control of gene expression

Rivera, V. M., Clackson, T., Natesan, S., Pollock, R. M., Amara, J. F., Keenan, T. P., Magari, S. R., Phillips, T., Courage, N. L., Cerasoli, F., et al. (1996) · Nature Medicine · doi:10.1038/nm0996-1028 · Cited by 528 · see citing works

Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression

Hou, L., & Klann, E. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0995-04.2004 · Cited by 527 · see citing works

Issues and progress with protein kinase inhibitors for cancer treatment

Dancey, J. E., & Sausville, E. A. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1066 · Cited by 524 · see citing works

Regulation of eIF-4E BP1 Phosphorylation by mTOR

Hara, K., Yonezawa, K., Kozlowski, M. T., Sugimoto, T., Andrabi, K. I., Weng, Q.-P., Kasuga, M., Nishimoto, I., & Avruch, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.42.26457 · Cited by 522 · see citing works

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

Ui, M., Okada, T., Hazeki, K., & Hazeki, O. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89056-8 · Cited by 519 · see citing works

Calcineurin is required for virulence of Cryptococcus neoformans

Odom, A., Muir, S., Lim, E., Toffaletti, D. L., Perfect, J., & Heitman, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2576 · Cited by 516 · see citing works

TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function

Schalm, S. S., Fingar, D. C., Sabatini, D. M., & Blenis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00329-4 · Cited by 513 · see citing works

Safety and Pharmacokinetics of Escalated Doses of Weekly Intravenous Infusion of CCI-779, a Novel mTOR Inhibitor, in Patients With Cancer

Raymond, É., Alexandre, J., Faivre, S. J., Vera, K., Materman, E., Boni, J. P., Leister, C. A., Korth-Bradley, J. M., Hanauske, A.-R., & Armand, J. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.08.116 · Cited by 499 · see citing works

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

Sabatini, D. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716173114 · Cited by 499 · see citing works

PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding

Wang, L., Harris, T. E., Roth, R. A., & Lawrence, J. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702376200 · Cited by 491 · see citing works

New Insights Into the Role of mTOR Signaling in the Cardiovascular System

Sciarretta, S., Forte, M., Frati, G., & Sadoshima, J. (2018) · Circulation Research · doi:10.1161/circresaha.117.311147 · Cited by 489 · see citing works

mTOR: Role in cancer, metastasis and drug resistance

Murugan, A. K. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.003 · Cited by 483 · see citing works

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

Scott, P., Brunn, G. J., Kohn, A. D., Roth, R. A., & Lawrence, J. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7772 · Cited by 476 · see citing works

PI3K/Akt/mTOR pathway as a target for cancer therapy

Morgensztern, D., & McLeod, H. L. (2005) · Anti-Cancer Drugs · doi:10.1097/01.cad.0000173476.67239.3b · Cited by 467 · see citing works

Rapamycin in transplantation: A review of the evidence

Saunders, R. N., Metcalfe, M. S., & Nicholson, M. L. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00460.x · Cited by 460 · see citing works

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

Caramés, B., Hasegawa, A., Taniguchi, N., Miyaki, S., Blanco, F. J., & Lotz, M. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200557 · Cited by 460 · see citing works

Rapamycin Protects against Neuron Death inIn VitroandIn VivoModels of Parkinson's Disease

Malagelada, C., Jin, Z. H., Jackson-Lewis, V. R., Przedborski, S., & Greene, L. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3944-09.2010 · Cited by 458 · see citing works

Mammalian Target of Rapamycin Signaling in Cardiac Physiology and Disease

Sciarretta, S., Volpe, M., & Sadoshima, J. (2014) · Circulation Research · doi:10.1161/circresaha.114.302022 · Cited by 451 · see citing works

PI 3-kinase related kinases: ?big? players in stress-induced signaling pathways

Abraham, R. T. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.04.002 · Cited by 445 · see citing works

mTOR substrate phosphorylation in growth control

Battaglioni, S., Benjamin, D., Wälchli, M., Maier, T., & Hall, M. N. (2022) · Cell · doi:10.1016/j.cell.2022.04.013 · Cited by 437 · see citing works

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

Kang, S. A., Pacold, M. E., Cervantes, C., Lim, D., Lou, H. J., Ottina, K. A., Gray, N. S., Turk, B. E., Yaffe, M. B., & Sabatini, D. M. (2013) · Science · doi:10.1126/science.1236566 · Cited by 420 · see citing works

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer.

Yu, K., Toral‐Barza, L., Discafani, C. M., Zhang, W. G., Skotnicki, J. S., Frost, P., & Gibbons, J. J. (2001) · Endocrine Related Cancer · doi:10.1677/erc.0.0080249 · Cited by 420 · see citing works

Nutrient signaling to mTOR and cell growth

Jewell, J. L., & Guan, K. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.01.004 · Cited by 407 · see citing works

The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation

Peng, T., Golub, T. R., & Sabatini, D. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5575-5584.2002 · Cited by 393 · see citing works

Autophagy as a molecular target for cancer treatment

Kocatürk, N. M., Akkoç, Y., Kığ, C., Bayraktar, O., Gözüaçık, D., & Kutlu, Ö. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.04.011 · Cited by 388 · see citing works

Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

Corradetti, M. N., & Guan, K.-L. (2006) · Oncogene · doi:10.1038/sj.onc.1209885 · Cited by 387 · see citing works

Separation and detection of large phosphoproteins using Phos-tag SDS-PAGE

Kinoshita, E., Kinoshita‐Kikuta, E., & Koike, T. (2009) · Nature Protocols · doi:10.1038/nprot.2009.154 · Cited by 385 · see citing works

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

Costa-Mattioli, M., & Monteggia, L. M. (2013) · Nature Neuroscience · doi:10.1038/nn.3546 · Cited by 367 · see citing works

The Schizosaccharomyces pombe rad3 checkpoint gene.

Bentley, N. J., Holtzman, D. A., Flaggs, G., Keegan, K. S., DeMaggio, A. J., Ford, J. C., Hoekstra, M. F., & Carr, A. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01054.x · Cited by 366 · see citing works

Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae

Crespo, J. L., & Hall, M. N. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.4.579-591.2002 · Cited by 361 · see citing works

Mechanism of action of the immunosuppressant rapamycin

Dumont, F. J., & Su, Q. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02233-3 · Cited by 356 · see citing works

Vascular Smooth Muscle Cell Proliferation in Restenosis

Marx, S. O., Totary-Jain, H., & Marks, A. R. (2011) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.110.957332 · Cited by 350 · see citing works

The TOR Kinases Link Nutrient Sensing to Cell Growth

Rohde, J. R., Heitman, J., & Cardenas, M. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r000034200 · Cited by 350 · see citing works

Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis

Takiar, V., Nishio, S., Seo-Mayer, P., King, J. D., Li, H., Zhang, L., Karihaloo, A., Hallows, K. R., Somlo, S., & Caplan, M. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011498108 · Cited by 345 · see citing works

PI3 Kinase Regulation of Skeletal Muscle Hypertrophy and Atrophy

Glass, D. J. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_78 · Cited by 333 · see citing works

Thr2446 Is a Novel Mammalian Target of Rapamycin (mTOR) Phosphorylation Site Regulated by Nutrient Status

Cheng, S., Fryer, L. G. D., Carling, D., & Shepherd, P. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300534200 · Cited by 328 · see citing works

Common corruption of the mTOR signaling network in human tumors

Menon, S., & Manning, B. D. (2008) · Oncogene · doi:10.1038/onc.2009.352 · Cited by 328 · see citing works

Targeted protein degradation: advances in drug discovery and clinical practice

Zhong, G., Chang, X., Xie, W., & Zhou, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02004-x · Cited by 326 · see citing works

Nutrient-Sensing Mechanisms across Evolution

Chantranupong, L., Wolfson, R. L., & Sabatini, D. M. (2015) · Cell · doi:10.1016/j.cell.2015.02.041 · Cited by 320 · see citing works

Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells.

Hosoi, H., Dilling, M. B., Shikata, T., Liu, L. N., Shu, L., Ashmun, R. A., Germain, G. S., Abraham, R. T., & Houghton, P. J. (1999) · PubMed · Cited by 310 · see citing works

A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt

Aoki, M., Blazek, E., & Vogt, P. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.136 · Cited by 306 · see citing works

Growing knowledge of the mTOR signaling network

Huang, K., & Fingar, D. C. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.09.011 · Cited by 301 · see citing works

Mechanism of action of rapamycin: New insights into the regulation of G1-phase progression in eukaryotic cells

Wiederrecht, G., Sabers, C. J., Brunn, G. J., Martin, M. M., Dumont, F. J., & Abraham, R. T. (1995) · Springer eBooks · doi:10.1007/978-1-4615-1809-9_5 · Cited by 164 · see citing works

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

Chiu, M. I., Katz, H., & Berlin, V (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12574 · Cited by 481 · see citing works

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

Sabatini, D. M., Erdjument-Bromage, H., Lui, M., Tempst, P., & Snyder, S. H. (1994) · Cell · doi:10.1016/0092-8674(94)90570-3 · Cited by 1,509 · see citing works

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

Brown, E. J., Albers, M. W., Bum Shin, T., ichikawa, K., Keith, C. T., Lane, W. S., & Schreiber, S. L. (1994) · Nature · doi:10.1038/369756a0 · Cited by 2,053 · see citing works

IMMUNOPHARMACOLOGY OF RAPAMYCIN

Abraham, R. T., & Wiederrecht, G. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.483 · Cited by 653 · see citing works