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Ca2+-dependent Gene Expression Mediated by MEF2 Transcription Factors
Open accessAbstract
Ca(2+) induction of a subset of cellular and viral immediate-early activation genes in lymphocytes has been previously mapped to response elements recognized by the MEF2 family of transcription factors. Here, we demonstrate that Ca(2+) activation of MEF2 response elements in T lymphocytes is mediated in synergy by two Ca(2+)/calmodulin-dependent enzymes, the phosphatase calcineurin, and the kinase type IV/Gr (CaMKIV/Gr), which promote transcription by the MEF2 family members MEF2A and MEF2D. Calcineurin up-regulates the activity of both factors by an NFAT-dependent mechanism, while CaMKIV/Gr selectively and independently activates MEF2D. These results identify MEF2 proteins as effectors of a pathway of gene induction in T lymphocytes which integrates diverse Ca(2+) activation signals and may be broadly operative in several tissues.
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Cites
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116
Cited by
Mitogen-activated protein kinases in apoptosis regulation
Wada, T., & Penninger, J. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207556 · Cited by 1,432
Crabtree, G. R., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00699-2 · Cited by 1,323
Class II histone deacetylases: versatile regulators
Verdin, E., Dequiedt, F., & Kasler, H. G. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00073-8 · Cited by 664
Ca2+/CaM-Dependent Kinases: From Activation to Function
Hook, S. S., & Means, A. R. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.471 · Cited by 482
Molecular mechanisms regulating myogenic determination and differentiation
Perry, R. (2000) · Frontiers in Bioscience · doi:10.2741/perry · Cited by 369
Metadata
- Authors
- Blaeser, F., Ho, N., Prywes, R., & Chatila, T. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 275
- Issue
- 1
- Pages
- 197-209
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2070145205
- Cited by
- 203
- References
- 1
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Blaeser, F., Ho, N., Prywes, R., & Chatila, T. A. (2000). Ca2+-dependent Gene Expression Mediated by MEF2 Transcription Factors. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.275.1.197
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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