The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Lysophospholipids Open the Two-pore Domain Mechano-gated K+ Channels TREK-1 and TRAAK
Open accessAbstract
The two-pore (2P) domain K(+) channels TREK-1 and TRAAK are opened by membrane stretch as well as arachidonic acid (AA) (Patel, A. J., Honoré, E., Maingret, F., Lesage, F., Fink, M., Duprat, F., and Lazdunski, M. (1998) EMBO J. 17, 4283-4290; Maingret, F., Patel, A. J., Lesage, F., Lazdunski, M., and Honoré, E. (1999) J. Biol. Chem. 274, 26691-26696; Maingret, F., Fosset, M., Lesage, F., Lazdunski, M. , and Honoré, E. (1999) J. Biol. Chem. 274, 1381-1387. We demonstrate that lysophospholipids (LPs) and platelet-activating factor also produce large specific and reversible activations of TREK-1 and TRAAK. LPs activation is a function of the size of the polar head and length of the acyl chain but is independent of the charge of the molecule. Bath application of lysophosphatidylcholine (LPC) immediately opens TREK-1 and TRAAK in the cell-attached patch configuration. In excised patches, LPC activation is lost, whereas AA still produces maximal opening. The carboxyl-terminal region of TREK-1, but not the amino terminus and the extracellular loop M1P1, is critically required for LPC activation. LPC activation is indirect and may possibly involve a cytosolic factor, whereas AA directly interacts with either the channel proteins or the bilayer and mimics stretch. Opening of TREK-1 and TRAAK by fatty acids and LPs may be an important switch in the regulation of synaptic function and may also play a protective role during ischemia and inflammation.
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Cites
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Inhalational anesthetics activate two-pore-domain background K+ channels
Patel, A. J., Honoré, E., Lesage, F., Fink, M., Romey, G., & Lazdunski, M. (1999) · Nature Neuroscience · doi:10.1038/8084 · Cited by 655
Self-citationA mammalian two pore domain mechano-gated S-like K+ channel
Patel, A. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4283 · Cited by 641
Self-citationTASK, a human background K+ channel to sense external pH variations near physiological pH
Duprat, F. (1997) · The EMBO Journal · doi:10.1093/emboj/16.17.5464 · Cited by 636
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A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids
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Cited by
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
TREK-1, a K+ channel involved in neuroprotection and general anesthesia
Heurteaux, C., Guy, N., Laigle, C., Blondeau, N., Duprat, F., Mazzuca, M., Lang‐Lazdunski, L., Widmann, C., Zanzouri, M., Romey, G., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600234 · Cited by 534
Self-citationMembranes: A meeting point for lipids, proteins and therapies
Escribá, P. V., González‐Ros, J. M., Goñi, F. M., Kinnunen, P. K. J., Vigh, L., Sánchez‐Magraner, L., Fernández, A. M., Busquets, X., Horváth, I., & Barceló‐Coblijn, G. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00281.x · Cited by 454
Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K + channels
Brohawn, S. G., Su, Z., & MacKinnon, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320768111 · Cited by 403
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
Metadata
- Authors
- Maingret, F., Patel, A. J., Lesage, F., Lazdunski, M., & Honoré, E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 275
- Issue
- 14
- Pages
- 10128-10133
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2077365895
- Cited by
- 391
- References
- 30
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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