The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Early Embryonic Lethality of H Ferritin Gene Deletion in Mice
Open accessAbstract
Ferritin molecules play an important role in the control of intracellular iron distribution and in the constitution of long term iron stores. In vitro studies on recombinant ferritin subunits have shown that the ferroxidase activity associated with the H subunit is necessary for iron uptake by the ferritin molecule, whereas the L subunit facilitates iron core formation inside the protein shell. However, plant and bacterial ferritins have only a single type of subunit which probably fulfills both functions. To assess the biological significance of the ferroxidase activity associated with the H subunit, we disrupted the H ferritin gene (Fth) in mice by homologous recombination. Fth(+/-) mice are healthy, fertile, and do not differ significantly from their control littermates. However, Fth(-/-) embryos die between 3.5 and 9.5 days of development, suggesting that there is no functional redundancy between the two ferritin subunits and that, in the absence of H subunits, L ferritin homopolymers are not able to maintain iron in a bioavailable and nontoxic form. The pattern of expression of the wild type Fth gene in 9.5-day embryos is suggestive of an important function of the H ferritin gene in the heart.
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The ferritins: molecular properties, iron storage function and cellular regulation
Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667
Self-citationHentze, M. W., & Kühn, L. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8175 · Cited by 1,292
Transferrin receptor is necessary for development of erythrocytes and the nervous system
Levy, J. E., Jin, O., Fujiwara, Y., Kuo, F., & Andrews, N. (1999) · Nature Genetics · doi:10.1038/7727 · Cited by 574
Ferritin: structure, biosynthesis, and role in iron metabolism.
Munro, H. N., & Linder, M. C. (1978) · Physiological Reviews · doi:10.1152/physrev.1978.58.2.317 · Cited by 396
Levi, S., Luzzago, A., Cesareni, G., Cozzi, A., Franceschinelli, F., Albertini, A., & Arosio, P. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81326-1 · Cited by 380
Self-citationCoordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2 , by c-MYC
Wu, K.-J., Polack, A., & Dalla-Favera, R. (1999) · Science · doi:10.1126/science.283.5402.676 · Cited by 326
Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.
Mountford, P., Zevnik, B., Düwel, A., Nichols, J., Li, M., Dani, C., Robertson, M., Chambers, I., & Smith, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4303 · Cited by 312
The Role of Iron in Oxygen-Mediated Toxicities
Ryan, T. P., & Aust, S. D. (1992) · Critical Reviews in Toxicology · doi:10.3109/10408449209146308 · Cited by 249
The Role of the L-Chain in Ferritin Iron Incorporation
Levi, S., Santambrogio, P., Cozzi, A., Rovida, E., Corsi, B., Tamborini, E., Spada, S., Albertini, A., & Arosio, P. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1325 · Cited by 180
Self-citationProduction and characterization of recombinant heteropolymers of human ferritin H and L chains
Santambrogio, P., Levi, S., Cozzi, A., Rovida, E., Albertini, A., & Arosio, P. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31451-0 · Cited by 161
Self-citation
Cited by
Two to tango: Regulation of Mammalian iron metabolism
Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120
Regulation of ferritin genes and protein
Torti, F. M., & Torti, S. V. (2002) · Blood · doi:10.1182/blood.v99.10.3505 · Cited by 1,173
Regulation of cellular iron metabolism
Wang, J., & Pantopoulos, K. (2011) · Biochemical Journal · doi:10.1042/bj20101825 · Cited by 986
Ferritins: A family of molecules for iron storage, antioxidation and more
Arosio, P., Ingrassia, R., & Cavadini, P. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.09.004 · Cited by 886
Self-citationChemistry and biology of eukaryotic iron metabolism
Aisen, P. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00063-2 · Cited by 804
Metadata
- Authors
- Ferreira, C., Bucchini, D., Martin, M.-E., Levi, S., Arosio, P., Grandchamp, B., & Beaumont, C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 275
- Issue
- 5
- Pages
- 3021-3024
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1999236279
- Cited by
- 276
- References
- 24
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ferreira, C., Bucchini, D., Martin, M.-E., Levi, S., Arosio, P., Grandchamp, B., & Beaumont, C. (2000). Early Embryonic Lethality of H Ferritin Gene Deletion in Mice. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.275.5.3021
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