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The Role of Iron in Oxygen-Mediated Toxicities
Abstract
The transition metal iron is capable of catalyzing redox reactions between biomolecules and oxygen that would not occur if catalytically active iron were not present. Although these biological oxidations (which are known collectively as "oxidative stress") have been implicated in numerous toxicities, the exact role of the iron catalyst remains to be elucidated. This review focuses on our current understanding of the role of iron in oxidative stress, discussing biologically relevant sources, biochemical forms, and reaction mechanisms of iron as a catalyst of biomolecular oxidations. Specific toxicities in which alterations in normal iron metabolism is thought to overwhelm the body's antioxidant defense system are presented, and future treatment regimens involving novel antioxidant drugs are discussed.
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Cites
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Cited by
Toxicity, mechanism and health effects of some heavy metals
Jaishankar, M., Tseten, T., Anbalagan, N., Mathew, B. B., & Beeregowda, K. N. (2014) · Interdisciplinary Toxicology · doi:10.2478/intox-2014-0009 · Cited by 6,402
Oxidative mechanisms in the toxicity of metal ions
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Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury
Farina, M., Avila, D. S., da Rocha, J. B. T., & Aschner, M. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2012.12.006 · Cited by 553
Coordinate Transcriptional and Translational Regulation of Ferritin in Response to Oxidative Stress
Tsuji, Y., Ayaki, H., Whitman, S. P., Morrow, C. S., Torti, S. V., & Torti, F. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5818-5827.2000 · Cited by 285
Early Embryonic Lethality of H Ferritin Gene Deletion in Mice
Ferreira, C., Bucchini, D., Martin, M.-E., Levi, S., Arosio, P., Grandchamp, B., & Beaumont, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3021 · Cited by 276
Metadata
- Authors
- Ryan, T. P., & Aust, S. D.
- Venue
- Critical Reviews in Toxicology
- Publisher
- Informa UK Limited
- Published
- 1992-01
- Volume
- 22
- Issue
- 2
- Pages
- 119-141
- ISSN
- 0045-6446 (ISSN-L)
- 1040-8444
- 1547-6898
- OpenAlex
- W2146682670
- Cited by
- 249
- References
- 6
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
