The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Epidermal Growth Factor Receptor Regulates Interaction of the Human DF3/MUC1 Carcinoma Antigen with c-Src and β-Catenin
Open accessAbstract
The DF3/MUC1 mucin-like, transmembrane glycoprotein is aberrantly overexpressed in most human carcinomas. The MUC1 cytoplasmic domain interacts with the c-Src tyrosine kinase and thereby increases binding of MUC1 and beta-catenin. In the present work, coimmunoprecipitation studies demonstrate that MUC1 associates constitutively with the epidermal growth factor receptor (EGF-R) in human ZR-75-1 breast carcinoma cells. Immunofluorescence studies show that EGF-R and MUC1 associate at the cell membrane. We also show that the activated EGF-R phosphorylates the MUC1 cytoplasmic tail on tyrosine at a YEKV motif that functions as a binding site for the c-Src SH2 domain. The results demonstrate that EGF-R-mediated phosphorylation of MUC1 induces binding of MUC1 to c-Src in cells. Moreover, in vitro and in vivo studies demonstrate that EGF-R increases binding of MUC1 and beta-catenin. These findings support a novel role for EGF-R in regulating interactions of MUC1 with c-Src and beta-catenin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Yarden, Y., & Schlessinger, J. (1987) · Biochemistry · doi:10.1021/bi00379a035 · Cited by 627
Maa, M. C., Leu, T. H., McCarley, D. J., Schatzman, R. C., & Parsons, S. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6981 · Cited by 330
Research works printed but not linked: 18
- van der Geer, 1994, Annu. Rev. Cell Biol., 10, 251, 10.1146/annurev.cb.10.110194.001343 · DOI · Paper page
- Li, 1993, Nature, 363, 85, 10.1038/363085a0 · DOI · Paper page
- Egan, 1993, Nature, 363, 45, 10.1038/363045a0 · DOI · Paper page
- Rozakis-Adcock, 1992, Nature, 360, 689, 10.1038/360689a0 · DOI · Paper page
- Luttrell, 1994, Proc. Natl. Acad. Sci. U. S. A., 91, 83, 10.1073/pnas.91.1.83 · DOI · Paper page
- Di Fiore, 1987, Cell, 51, 1063, 10.1016/0092-8674(87)90592-7 · DOI · Paper page
- Velu, 1987, Science, 238, 1408, 10.1126/science.3500513 · DOI · Paper page
- Wilson, 1989, Mol. Cell. Biol., 9, 1536
- Kufe, 1984, Hybridoma, 3, 223, 10.1089/hyb.1984.3.223 · DOI · Paper page
- Gendler, 1988, J. Biol. Chem., 263, 12820, 10.1016/S0021-9258(18)37632-4 · DOI · Paper page
- Siddiqui, 1988, Proc. Natl. Acad. Sci. U. S. A., 85, 2320, 10.1073/pnas.85.7.2320 · DOI · Paper page
- Yamamoto, 1997, J. Biol. Chem., 272, 12492, 10.1074/jbc.272.19.12492 · DOI · Paper page
- Rubinfeld, 1993, Science, 262, 1731, 10.1126/science.8259518 · DOI · Paper page
- Su, 1993, Science, 262, 1734, 10.1126/science.8259519 · DOI · Paper page
- Rubinfeld, 1995, J. Biol. Chem., 270, 5549, 10.1074/jbc.270.10.5549 · DOI · Paper page
- Li, 1998, Mol. Cell. Biol., 18, 7216, 10.1128/MCB.18.12.7216 · DOI · Paper page
- Li, 2001, J. Biol. Chem., 276, 6061, 10.1074/jbc.C000754200 · DOI · Paper page
- Schroeder, 2001, J. Biol. Chem., 276, 13057, 10.1074/jbc.M011248200 · DOI · Paper page
Cited by
Src family kinases in tumor progression and metastasis
Summy, J. M., & Gallick, G. E. (2003) · Cancer and Metastasis Reviews · doi:10.1023/a:1023772912750 · Cited by 827
Kufe, D. W. (2013) · Oncogene · doi:10.1038/onc.2012.158 · Cited by 437
Self-citationCell surface-associated mucins in signal transduction
Singh, P. K., & Hollingsworth, M. A. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.07.006 · Cited by 422
Bafna, S., Kaur, S., & Batra, S. K. (2010) · Oncogene · doi:10.1038/onc.2010.87 · Cited by 360
Andrianifahanana, M., Moniaux, N., & Batra, S. K. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.01.002 · Cited by 314
Metadata
- Authors
- Li, Q., Kuwahara, H., Yin, L., Li, Y., Ren, J., Yu, W.-H., Carraway, K. L., & Kufe, D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-09
- Volume
- 276
- Issue
- 38
- Pages
- 35239-35242
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2076370383
- Cited by
- 257
- References
- 2
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- creativecommons.org/licenses/by/4.0/ (vor, 6973 d)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Epidermal Growth Factor Receptor Regulates Interaction of the Human DF3/MUC1 Carcinoma Antigen with c-Src and β-Catenin. https://app.cochat.ai/papers/10.1074/jbc.c100359200
- The paper
- Li, Q., Kuwahara, H., Yin, L., Li, Y., Ren, J., Yu, W.-H., Carraway, K. L., & Kufe, D. (2001). The Epidermal Growth Factor Receptor Regulates Interaction of the Human DF3/MUC1 Carcinoma Antigen with c-Src and β-Catenin. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.c100359200
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
