The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The c-Src Tyrosine Kinase Regulates Signaling of the Human DF3/MUC1 Carcinoma-associated Antigen with GSK3β and β-Catenin
Open accessAbstract
The DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed in most human carcinomas. The cytoplasmic domain of MUC1 interacts with glycogen synthase kinase 3 beta (GSK3 beta) and thereby decreases binding of MUC1 and beta-catenin. The present studies demonstrate that MUC1 associates with the c-Src tyrosine kinase. c-Src phosphorylates the MUC1 cytoplasmic domain at a YEKV motif located between sites involved in interactions with GSK3 beta and beta-catenin. The results demonstrate that the c-Src SH2 domain binds directly to pYEKV and inhibits the interaction between MUC1 and GSK3 beta. Moreover and in contrast to GSK3 beta, in vitro and in vivo studies demonstrate that c-Src-mediated phosphorylation of MUC1 increases binding of MUC1 and beta-catenin. The findings support a novel role for c-Src in regulating interactions of MUC1 with GSK3 beta and beta-catenin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Maa, M. C., Leu, T. H., McCarley, D. J., Schatzman, R. C., & Parsons, S. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6981 · Cited by 330
Research works printed but not linked: 32
- Takeichi, 1990, Annu. Rev. Biochem., 59, 237, 10.1146/annurev.bi.59.070190.001321 · DOI · Paper page
- Jou, 1995, Proc. Natl. Acad. Sci. U. S. A., 92, 5067, 10.1073/pnas.92.11.5067 · DOI · Paper page
- Kawanishi, 1995, Mol. Cell. Biol., 15, 1175, 10.1128/MCB.15.3.1175 · DOI · Paper page
- Rubinfield, 1993, Science, 262, 1731, 10.1126/science.8259518 · DOI · Paper page
- Rubinfield, 1995, J. Biol. Chem., 270, 5549, 10.1074/jbc.270.10.5549 · DOI · Paper page
- Su, 1993, Science, 262, 1734, 10.1126/science.8259519 · DOI · Paper page
- Rubinfield, 1996, Science, 272, 1023, 10.1126/science.272.5264.1023 · DOI · Paper page
- Aberie, 1997, EMBO J., 16, 3797, 10.1093/emboj/16.13.3797 · DOI · Paper page
- Orford, 1997, J. Biol. Chem., 272, 24735, 10.1074/jbc.272.40.24735 · DOI · Paper page
- Solomon, 1997, J. Cell Biol., 139, 1325, 10.1083/jcb.139.5.1325 · DOI
- Munemitsu, 1995, Proc. Natl. Acad. Sci. U. S. A., 92, 3046, 10.1073/pnas.92.7.3046 · DOI · Paper page
- Huber, 1996, Mech. Dev., 59, 3, 10.1016/0925-4773(96)00597-7 · DOI · Paper page
- Molenaar, 1996, Cell, 86, 391, 10.1016/S0092-8674(00)80112-9 · DOI · Paper page
- Brunner, 1997, Nature, 385, 829, 10.1038/385829a0 · DOI · Paper page
- Yamamoto, 1997, J. Biol. Chem., 272, 12492, 10.1074/jbc.272.19.12492 · DOI · Paper page
- Li, 1998, Mol. Cell. Biol., 18, 7216, 10.1128/MCB.18.12.7216 · DOI · Paper page
- Kufe, 1984, Hybridoma, 3, 223, 10.1089/hyb.1984.3.223 · DOI · Paper page
- Friedman, 1986, Cancer Res., 46, 5189
- Perey, 1992, Cancer Res., 52, 2563
- Gendler, 1988, J. Biol. Chem., 263, 12820, 10.1016/S0021-9258(18)37632-4 · DOI · Paper page
- Siddiqui, 1988, Proc. Natl. Acad. Sci. U. S. A., 85, 2320, 10.1073/pnas.85.7.2320 · DOI · Paper page
- Ligtenberg, 1992, Cancer Res., 52, 223
- Kamps, 1986, Mol. Cell. Biol., 6, 751
- Shiue, 1995, J. Biol. Chem., 270, 10498, 10.1074/jbc.270.18.10498 · DOI · Paper page
- Weng, 1995, Mol. Cell. Biol., 15, 5627, 10.1128/MCB.15.10.5627 · DOI
- Songyang, 1993, Cell, 72, 767, 10.1016/0092-8674(93)90404-E · DOI · Paper page
- Malarkey, 1995, Biochem. J., 309, 361, 10.1042/bj3090361 · DOI · Paper page
- Holmes, 1996, J. Neurosci., 16, 581, 10.1523/JNEUROSCI.16-05-01581.1996 · DOI · Paper page
- Yu, 1997, Science, 278, 114, 10.1126/science.278.5335.114 · DOI · Paper page
- van Hoek, 1997, Biochem. J., 326, 271, 10.1042/bj3260271 · doi:10.1042/bj3260271
- Biscardi, 1999, Adv. Cancer Res., 76, 61, 10.1016/S0065-230X(08)60774-5 · DOI · Paper page
- Hansen, 1996, EMBO J., 15, 5299, 10.1002/j.1460-2075.1996.tb00915.x · DOI
Cited by
Kufe, D. W. (2013) · Oncogene · doi:10.1038/onc.2012.158 · Cited by 437
Self-citationCell surface-associated mucins in signal transduction
Singh, P. K., & Hollingsworth, M. A. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.07.006 · Cited by 422
Andrianifahanana, M., Moniaux, N., & Batra, S. K. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.01.002 · Cited by 314
Lipid rafts: signaling and sorting platforms of cells and their roles in cancer
Staubach, S., & Hanisch, F.-G. (2011) · Expert Review of Proteomics · doi:10.1586/epr.11.2 · Cited by 284
β-Catenin and Tcfs in Mammary Development and Cancer
Hatsell, S., Rowlands, T., Hiremath, M., & Cowin, P. (2003) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1025944723047 · Cited by 209
Metadata
- Authors
- Li, Y., Kuwahara, H., Ren, J., Wen, G., & Kufe, D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 276
- Issue
- 9
- Pages
- 6061-6064
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2007121859
- Cited by
- 226
- References
- 2
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- creativecommons.org/licenses/by/4.0/ (vor, 7154 d)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The c-Src Tyrosine Kinase Regulates Signaling of the Human DF3/MUC1 Carcinoma-associated Antigen with GSK3β and β-Catenin. https://app.cochat.ai/papers/10.1074/jbc.c000754200
- The paper
- Li, Y., Kuwahara, H., Ren, J., Wen, G., & Kufe, D. (2001). The c-Src Tyrosine Kinase Regulates Signaling of the Human DF3/MUC1 Carcinoma-associated Antigen with GSK3β and β-Catenin. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.c000754200
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
