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Differential Reactivity of a Novel Monoclonal Antibody (DF3) with Human Malignant versus Benign Breast Tumors
Abstract
We have defined a human breast tumor associated antigen using a murine monoclonal antibody (MAb DF3) prepared against a membrane-enriched fraction of a human breast carcinoma. This antigen has a MW of 290 kD and is detectable on the cell surface of human breast carcinoma cells using a live cell radioimmunoassay and fluorescence flow cytometry. More important, immunoperoxidase staining with MAb DF3 clearly distinguishes malignant and benign breast lesions. A cytoplasmic staining pattern has been observed with 40 of 51 (78%) breast carcinomas, but only one of 13 fibroadenoma or fibrocystic disease specimens. In contrast, reactivity of benign breast lesions with MAb DF3 primarily occurs along apical borders on ductules. These results demonstrate that the DF3 antigen is present on apical borders of more differentiated secretory mammary epithelial cells and in the cytosol of less differentiated cells.
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Cited by
Ligtenberg, M. J., Vos, H. L., Gennissen, A. M., & Hilkens, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39399-8 · Cited by 369
Stubbs, J. D., Lekutis, C., Singer, K. L., Bui, A., Yuzuki, D., Srinivasan, U., & Parry, G. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8417 · Cited by 313
Band, V, & Sager, R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.4.1249 · Cited by 194
Dhanisha, S. S., Guruvayoorappan, C., Drishya, S., & Abeesh, P. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.12.006 · Cited by 194
MUC1 (CD227): a multi-tasked molecule
Apostolopoulos, V., Stojanovska, L., & Gargosky, S. E. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2014-z · Cited by 138
Metadata
- Authors
- KUFE, D., INGHIRAMI, G., ABE, M., HAYES, D., JUSTI-WHEELER, H., & SCHLOM, J.
- Venue
- Hybridoma
- Publisher
- SAGE Publications
- Published
- 1984-01
- Volume
- 3
- Issue
- 3
- Pages
- 223-232
- ISSN
- 0272-457X (ISSN-L)
- OpenAlex
- W2023761151
- Cited by
- 573
- References
- 0
- FWCI
- 18.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- KUFE, D., INGHIRAMI, G., ABE, M., HAYES, D., JUSTI-WHEELER, H., & SCHLOM, J. (1984). Differential Reactivity of a Novel Monoclonal Antibody (DF3) with Human Malignant versus Benign Breast Tumors. Hybridoma. https://doi.org/10.1089/hyb.1984.3.223
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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