SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2

Obesity and insulin resistance

Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,345

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884

Disruption of IRS-2 causes type 2 diabetes in mice

Withers, D. J., Gutierrez, J. S., Towery, H. H., Burks, D. J., Ren, J., Previs, S. F., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,775

Insulin resistance and cardiovascular disease

Ginsberg, H. N. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10762 · Cited by 1,372

Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action

Aguirre, V., Werner, E. D., Giraud, J., Lee, Y. H., Shoelson, S. E., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m101521200 · Cited by 1,010

Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

Shimomura, I., Matsuda, M., Hammer, R. E., Bashmakov, Y. K., Brown, M. S., & Goldstein, J. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00010-9 · Cited by 860

SOCS Proteins: Negative Regulators of Cytokine Signaling

Krebs, D. L., & Hilton, D. J. (2001) · Stem Cells · doi:10.1634/stemcells.19-5-378 · Cited by 826

New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes

Saltiel, A. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00239-2 · Cited by 688

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

Zhang, J., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., Moritz, R. L., Cary, D., Richardson, R. T., Hausmann, G., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2071 · Cited by 626

Molecular and Signaling Mechanisms of Atherosclerosis in Insulin Resistance

Schwartz, E. A., & Reaven, P. D. (2006) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2006.06.005 · Cited by 39

Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia

Lutz, S. Z., Hennige, A. M., Feil, S. C., Peter, A., Gerling, A., Machann, J., Kröber, S. M., Rath, M., Schürmann, A., Weigert, C., et al. (2011) · Diabetes · doi:10.2337/db10-0760 · Cited by 41

Immunometabolic role of long‐chain omega‐3 fatty acids in obesity‐induced inflammation

Flock, M. R., Rogers, C. J., Prabhu, K. S., & Kris‐Etherton, P. M. (2013) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2414 · Cited by 43

Chronic Kidney Disease-Induced Insulin Resistance: Current State of the Field

Dave, N., Wu, J., & Thomas, S. S. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1010-8 · Cited by 39

Cancer as a homeostatic challenge: the role of the hypothalamus

Francis, N., & Borniger, J. C. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.08.008 · Cited by 42

Short-term infusion of interleukin-6 does not induce insulin resistance in vivo or impair insulin signalling in rats

Sopasakis, V. R., Larsson, B.-M., Johansson, A., Holm�ng, A., & Smith, U. (2004) · Diabetologia · doi:10.1007/s00125-004-1544-y · Cited by 40

The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2

Warren, K. J., Fang, X., Gowda, N. M., Thompson, J. J., & Heller, N. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.756791 · Cited by 38

Identification of Novel Transcriptome Signature as a Potential Prognostic Biomarker for Anti-Angiogenic Therapy in Glioblastoma Multiforme

Zheng, S., & Tao, W. (2021) · Cancers · doi:10.3390/cancers13051013 · Cited by 38

Phosphorylation of Irs1 at SER-522 Inhibits Insulin Signaling

Giraud, J., Haas, M., Feener, E. P., Copps, K. D., Dong, X. C., Dunn, S. L., & White, M. F. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0159 · Cited by 38

The serine phosphorylations in the IRS-1 PIR domain abrogate IRS-1 and IR interaction

Woo, J. R., Bae, S.-H., Wales, T. E., Engen, J. R., Lee, J., Jang, H., & Park, S. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2401716121 · Cited by 41

Suppressor of cytokine signalling-3 inhibits tumor necrosis factor-alpha induced apoptosis and signalling in beta cells

Bruun, C., Heding, P. E., Rønn, S. G., Frobøse, H., Rhodes, C. J., Mandrup-Poulsen, T. R., & Billestrup, N. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.019 · Cited by 37

MicroRNA-494, Upregulated by Tumor Necrosis Factor-α, Desensitizes Insulin Effect in C2C12 Muscle Cells

Lee, H., Jee, Y., Hong, K., Hwang, G. S., & Chun, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083471 · Cited by 38

Egr2 enhances insulin resistance via JAK2/STAT3/SOCS-1 pathway in HepG2 cells treated with palmitate

Lü, L., Ye, X., Yao, Q., Lu, A., Zhao, Z., Ding, Y., Meng, C., Yu, W., Du, Y., & Cheng, J. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.08.023 · Cited by 37

Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression

Williams, J. J. L., Munro, K. M., & Palmer, T. M. (2014) · Cells · doi:10.3390/cells3020546 · Cited by 38

Sepsis-induced SOCS-3 expression is immunologically restricted to phagocytes

Grutkoski, P. S., Chen, Y., Chung, C., & Ayala, A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0303108 · Cited by 37

Interleukin-Targeted Therapy for Metabolic Syndrome and Type 2 Diabetes

Maedler, K., Dharmadhikari, G., Schumann, D., & Størling, J. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17214-4_11 · Cited by 37

Overview of Genomic Insights into Chicken Growth Traits Based on Genome- Wide Association Study and microRNA Regulation

Xu, Z., Nie, Q., & Zhang, X. (2013) · Current Genomics · doi:10.2174/1389202911314020006 · Cited by 36

Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice

Inagaki-Ohara, K., Sasaki, A., Matsuzaki, G., Ikeda, T., Hotokezaka, M., Chijiiwa, K., Kubo, M., Yoshida, H., Nawa, Y., & Yoshimura, A. (2005) · Gut · doi:10.1136/gut.2004.062653 · Cited by 36

Aging and calorie restriction regulate the expression of miR-125a-5p and its target genes Stat3, Casp2 and Stard13

Makwana, K., Patel, S. A., Velingkaar, N., Ebron, J. S., Shukla, G. C., & Kondratov, R. V. (2017) · Aging · doi:10.18632/aging.101270 · Cited by 37

PM2.5 aggravates diabetes via the systemically activated IL-6-mediated STAT3/SOCS3 pathway in rats’ liver

Long, M., Zhang, C., Xu, D., Fu, W., Gan, X., Li, F., Wang, Q., Xia, W., & Xu, D. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113342 · Cited by 35

Causal network inference from gene transcriptional time-series response to glucocorticoids

Lu, J., Dumitrascu, B., McDowell, I. C., Jo, B., Barrera, A., Hong, L. K., Leichter, S. M., Reddy, T. E., & Engelhardt, B. E. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008223 · Cited by 35

The Insulin Receptor: An Important Target for the Development of Novel Medicines and Pesticides

Zhang, X., Zhu, X.-Z., Bi, X., Huang, J., & Zhou, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147793 · Cited by 40

Expression of Inflammatory and Insulin Signaling Genes in Adipose Tissue in Response to Elective Surgery

Witasp, A., Nordfors, L., Schalling, M., Nygren, J., Ljungqvist, O. H., & Thorell, A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2588 · Cited by 35

The E3 ubiquitin ligase HOIL‐1 induces the polyubiquitination and degradation of SOCS6 associated proteins

Bayle, J., Lopez, S., Iwaï, K., Dubreuil, P. C., & Sepulveda, P. D. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.03.093 · Cited by 35

Pathophysiology of insulin resistance and steatosis in patients with chronic viral hepatitis

Başaranoğlu, M. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i36.4055 · Cited by 35

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs

Yoshihara, H., Fukushima, T., Hakuno, F., Saeki, Y., Tanaka, K., Ito, A., Yoshida, M., Iemura, S., Natsume, T., Asano, T., et al. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.05.093 · Cited by 35

Associations of GlycA and high-sensitivity C-reactive protein with measures of lipolysis in adults with obesity

Levine, J. A., Han, J. M., Wolska, A. T., Wilson, S. R., Patel, T. P., Remaley, A. T., Periwal, V., Yanovski, J. A., & Demidowich, A. P. (2020) · Journal of clinical lipidology · doi:10.1016/j.jacl.2020.07.012 · Cited by 35

Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling

Scheufele, F., Wolf, B., Kruse, M., Hartmann, T., Lempart, J., Muehlich, S., Pfeiffer, A. F. H., Field, L. J., Charron, M. J., Pan, Z., et al. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.11.005 · Cited by 35

Tuberous Sclerosis and Insulin Resistance: Unlikely Bedfellows Reveal A TORrid Affair

Shah, O. J., & Hunter, T. R. (2004) · Cell Cycle · doi:10.4161/cc.4.1.1343 · Cited by 34

Targeting endoplasmic reticulum stress as a potential therapeutic strategy for diabetic cardiomyopathy

Congur, I., Mingrone, G., & Guan, K. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156062 · Cited by 33

Diabetic cardiomyopathy: role of the E3 ubiquitin ligase

Bai, T., Wang, F., Mellen, N. M., Zheng, Y., & Cai, L. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00467.2015 · Cited by 33

Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis

Balaji, V., Pokrzywa, W., & Hoppe, T. (2018) · BioEssays · doi:10.1002/bies.201700223 · Cited by 33

Expression Pattern of microRNAs, miR-21, miR-155 and miR-338 in Patients with Type 1 Diabetes

Mostahfezian, M., Azhir, Z., Dehghanian, F., & Hojati, Z. (2019) · Archives of Medical Research · doi:10.1016/j.arcmed.2019.07.002 · Cited by 32

Hypothalamic Leptin Receptor and Signaling Molecule Expressions in Cafeteria Diet-Fed Rats

Plut, C., Ribière, C., Giudicelli, Y., & Dausse, J. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054726 · Cited by 33

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

Parnell, E., McElroy, S. P., Wiejak, J., Baillie, G. L., Porter, A., Adams, D. R., Rehmann, H., Smith, B. O., & Yarwood, S. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-00455-7 · Cited by 32

Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation

Zhao, H., Lu, J., He, F., Wang, M., Yan, Y., Chen, B., Xie, D., Xu, C., Wang, Q., Liu, W., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.931087 · Cited by 31

Cullin RING Ligase 5 (CRL-5): Neddylation Activation and Biological Functions

Zhang, S., & Sun, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1025-0_16 · Cited by 31

Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3‐mediated IRS1 degradation

Xu, T., Xu, L., Meng, P., Ma, X., Yang, X., Zhou, Y., & Feng, M. (2020) · The FASEB Journal · doi:10.1096/fj.202000246rr · Cited by 32

REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-κB activation

Lee, D., Kim, T., Byeon, J., Park, M., Kim, S., Kim, J., Choi, S., Lee, G., Park, C., Lee, K. W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34110-1 · Cited by 35

Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo

Pereira, S., Park, E., Moore, J., Faubert, B., Breen, D. M., Oprescu, A. I., Nahle, A., Kwan, D., Giacca, A., & Tsiani, E. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0075 · Cited by 34

Identification of the Degradation Determinants of Insulin Receptor Substrate 1 for Signaling Cullin-RING E3 Ubiquitin Ligase 7-mediated Ubiquitination

Xu, X., Keshwani, M. M., Meyer, K. R., Sarikas, A., Taylor, S. S., & Pan, Z. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.405209 · Cited by 33

Suppressor of Cytokine Signaling 3 Inhibits Breast Tumor Kinase Activation of STAT3

Gao, Y., Cimica, V., & Reich, N. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.334144 · Cited by 33

Linking obesity with type 2 diabetes: the role of T-bet

Sutherland, A. P. R., Wali, J. A., & Thomas, H. (2014) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s51432 · Cited by 34

Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity

Zhang, L. R., Xu, J., Song, H., Yao, Z., & Ji, G. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0236-8 · Cited by 31

Chemical Genetic Identification of the IGF-Linked Pathway that Is Mediated by STAT6 and MFP2

Choi, Y., Shimogawa, H., Murakami, K., Ramdas, L., Zhang, W., Qin, J., & Uesugi, M. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.12.011 · Cited by 31

Amino acid-induced impairment of insulin sensitivity in healthy and obese rats is reversible

Jeganathan, S., Abdullahi, A., Zargar, S., Maeda, N., Riddell, M. C., & Adegoke, O. A. J. (2014) · Physiological Reports · doi:10.14814/phy2.12067 · Cited by 29

Macrophage CGI-58 deficiency promotes IL-1β transcription by activating the SOCS3–FOXO1 pathway

Miao, H., Ou, J., Zhang, X., Chen, Y., Xue, B., Shi, H., Gan, L., Yu, L., & Liang, H. (2014) · Clinical Science · doi:10.1042/cs20140414 · Cited by 31

Effects of periodontitis on aortic insulin resistance in an obese rat model

Ekuni, D., Tomofuji, T., Irie, K., Kasuyama, K., Umakoshi, M., Azuma, T., Tamaki, N., Sanbe, T., Endo, Y., Yamamoto, T., et al. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2009.141 · Cited by 31

The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin

Martens, N., Wéry, M., Wang, P., Braet, F., Gertler, A., Hooghe, R. J., Vandenhaute, J., & Hooghe-Peters, E. L. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.002 · Cited by 32

Reduced insulin receptor signaling in retinal Müller cells cultured in high glucose.

Jiang, Y., Pagadala, J., Miller, D. D., & Steinle, J. J. (2013) · Europe PMC (PubMed Central) · Cited by 31

Type 2 Diabetes Mellitus

Mandrup-Poulsen, T. R. (2013) · Dermatologic Clinics · doi:10.1016/j.det.2013.04.006 · Cited by 31

Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance

Morel, C., Standen, C. L., Jung, D. Y., Gray, S., Ong, H., Flavell, R. A., Kim, J. K., & Davis, R. J. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00585-10 · Cited by 30

Constitutive expression of suppressor of cytokine signalling-3 in skeletal muscle leads to reduced mobility and overweight in mice

Lebrun, P., Cognard, E., Paul, R., Gontard, P., Filloux, C., Jehl-Piétri, C., Grimaldi, P. A., Samson, M., Pénicaud, L., Ruberte, J., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1474-9 · Cited by 31

Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma

Khan, M. G. M., Ghosh, A., Variya, B. C., Santharam, M. A., Ihsan, A. U., Ramanathan, S., & Ilangumaran, S. (2020) · BMC Cancer · doi:10.1186/s12885-020-07285-3 · Cited by 31

Aronia melanocarpa anthocyanin extracts are an effective regulator of suppressor of cytokine signaling 3-dependent insulin resistance in HepG2 and C2C12 cells

Chen, J., Zhu, J., & Meng, X. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104258 · Cited by 30

Increased expression of SOCS3 in monocytes and SOCS1 in lymphocytes correlates with progressive loss of renal function and cardiovascular risk factors in chronic kidney disease

Rastmanesh, M. M., Bluyssen, H. A. R., Joles, J. A., de Boer, P., Willekes-Koolschijn, N., & Braam, B. G. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.07.013 · Cited by 30

Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function

van de Loo, F. A. J., Veenbergen, S., van den Brand, B. T., Bennink, M. B., Blaney‐Davidson, E., Arntz, O. J., van Beuningen, H. M., van der Kraan, P. M., & van den Berg, W. B. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34529 · Cited by 30

Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-α-induced hepatic insulin resistance

Zhao, H., Huang, X., Jiao, J., Zhang, H., Liu, J., Qin, W., Meng, X., Shen, T., Lin, Y., Chu, J., et al. (2015) · Scientific Reports · doi:10.1038/srep18093 · Cited by 30

Akyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity

Li, J.-Y., Chai, B.-X., Zhang, W., Liu, Y.-Q., Ammori, J. B., & Mulholland, M. W. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2006.12.010 · Cited by 30

The role of lnc-DC long non-coding RNA and SOCS1 in the regulation of STAT3 in coronary artery disease and type 2 diabetes mellitus

Alikhah, A., Kakhki, M. P., Ahmadi, A., Dehghanzad, R., Boroumand, M. A., & Behmanesh, M. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.12.001 · Cited by 29

Quercetin Mitigates Hepatic Insulin Resistance in Rats with Bile Duct Ligation Through Modulation of the STAT3/SOCS3/IRS1 Signaling Pathway

Khodarahmi, A., Eshaghian‐dorcheh, A., Safari, F., & Moradi, A. (2019) · Journal of Food Science · doi:10.1111/1750-3841.14793 · Cited by 29

Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization

Chen, C., Gu, L., Matye, D. J., Clayton, Y., Hasan, M. N., Wang, Y., Friedman, J. E., & Li, T. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111737119 · Cited by 29

Transcription factor AP-2β: A negative regulator of IRS-1 gene expression

Meng, X., Kondo, M., Morino, K., Fuke, T., Obata, T., Yoshizaki, T., Ugi, S., Nishio, Y., Maeda, S., Araki, E., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.01.056 · Cited by 29

Temporal Relationship between Diet-Induced Steatosis and Onset of Insulin/Leptin Resistance in Male Wistar Rats

Zhang, L., Song, H., Ying-li, G. E., Ji, G., & Yao, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117008 · Cited by 33

Insulin induces the low density lipoprotein receptor‐related protein 1 (LRP1) degradation by the proteasomal system in J774 macrophage‐derived cells

Ceschin, D. G., Sanchez, M. C., & Chiabrando, G. A. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22014 · Cited by 29

JAK-STAT signaling and myocardial glucose metabolism

Frias, M. A., & Montessuit, C. (2013) · JAK-STAT · doi:10.4161/jkst.26458 · Cited by 30

A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue

de Almeida-Faria, J., Duque-Guimaraes, D. E., Carpenter, A. A. M., Loche, E., & Ozanne, S. E. (2017) · Scientific Reports · doi:10.1038/srep44949 · Cited by 32

Lipocalin 13 regulation of glucose and lipid metabolism in obesity

Zhou, Y., & Rui, L. (2013) · Vitamins & Hormones · doi:10.1016/b978-0-12-407766-9.00015-8 · Cited by 28

Muscle wasting: An overview of recent developments in basic research

Palus, S., von Haehling, S., & Springer, J. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.08.086 · Cited by 29

Insulin Resistance and Insulin Handling in Chronic Kidney Disease

Parvathareddy, V. P., Wu, J., & Thomas, S. S. (2023) · Comprehensive physiology · doi:10.1002/j.2040-4603.2023.tb00281.x · Cited by 28

Tumor Necrosis Factor (TNF)-α-induced Repression of GKAP42 Protein Levels through cGMP-dependent Kinase (cGK)-Iα Causes Insulin Resistance in 3T3-L1 Adipocytes

Ando, Y., Shinozawa, Y., Iijima, Y., Yu, B., Sone, M., Ooi, Y., Watanaka, Y., Chida, K., Hakuno, F., & Takahashi, S. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.624759 · Cited by 28

Suppressors of cytokine signaling (SOCS) and type 2 diabetes

Feng, X., Tang, H., Leng, J., & Jiang, Q. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3079-8 · Cited by 28

Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

Gylvin, T., Nolsöe, R. L. M., Hansen, T. F., Nielsen, E., Bergholdt, R., Karlsen, A. E., Billestrup, N., Borch‐Johnsen, K., Pedersen, O. B., Mandrup-Poulsen, T. R., et al. (2004) · Diabetologia · doi:10.1007/s00125-004-1440-5 · Cited by 28

The expression of suppressor of cytokine signaling 1 and 3 in fat and placental tissue from women with gestational diabetes

Kuźmicki, M., Telejko, B., Wawrusiewicz‐Kurylonek, N., Citko, A., Lipińska, D., Pliszka, J., Wilk, J., Kalejta, K., Lemancewicz, A., Grabiec, M., et al. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2012.683055 · Cited by 28

Phosphorylation of Serine 1137/1138 of Mouse Insulin Receptor Substrate (IRS) 2 Regulates cAMP-dependent Binding to 14-3-3 Proteins and IRS2 Protein Degradation

Neukamm, S. S., Ott, J., Dammeier, S., Lehmann, R., Häring, H., Schleicher, E. D., & Weigert, C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.474593 · Cited by 28

SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases

Elliott, J., Suessmuth, Y., Scott, L. M., Nahlik, K., McMullin, M. F., Constantinescu, S. N., Green, A. R., & Johnston, J. A. (2009) · Haematologica · doi:10.3324/haematol.2008.002352 · Cited by 28

Unveil the transcriptional landscape at the Cryptococcus-host axis in mice and nonhuman primates

Li, H., Li, Y., Sun, T., Du, W., Li, C., Suo, C., Meng, Y., Liang, Q., Lan, T., Zhong, M., et al. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007566 · Cited by 29

Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma

Eichner, R., Fernández‐Sáiz, V., Targosz, B., & Bassermann, F. C. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.06.001 · Cited by 27

Conditional ablation of HDAC3 in islet beta cells results in glucose intolerance and enhanced susceptibility to STZ-induced diabetes

Chen, W.-B., Gao, L., Wang, J., Wang, Y.-G., Dong, Z., Zhao, J., Mi, Q., & Zhou, L. (2016) · Oncotarget · doi:10.18632/oncotarget.11295 · Cited by 27

Baicalein improves insulin resistance via regulating SOCS3 and enhances the effect of acarbose on diabetes prevention

Sun, W., Sun, J., Zhang, B., Xing, Y., Yu, X., Li, X., Xiu, Z., & Dong, Y. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.08.005 · Cited by 27

PPARγ alleviated hepatocyte steatosis through reducing SOCS3 by inhibiting JAK2/STAT3 pathway

Bi, J., Sun, K., Wu, H., Chen, X., Tang, H., & Mao, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.110 · Cited by 28

The role of small adaptor proteins in the control of oncogenic signaling driven by tyrosine kinases in human cancer

Naudin, C., Chevalier, C., & Roche, S. (2016) · Oncotarget · doi:10.18632/oncotarget.6929 · Cited by 33

Interleukin-6 deficiency modulates testicular function by increasing the expression of suppressor of cytokine signaling 3 (SOCS3) in mice

Alves-Silva, T., Freitas, G., Húngaro, T., Arruda, A., Oyama, L., Avellar, M. C. W., & Araújo, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-90872-6 · Cited by 24

Therapeutic Effects of Suppressors of Cytokine Signaling in Diabetic Nephropathy

Liu, Q., Xing, L., Wang, L., Yao, F., Liu, S., Hao, J., Liu, W., & Duan, H. (2013) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155413512493 · Cited by 26

Protein kinase C-δ is involved in the inflammatory effect of IL-6 in mouse adipose cells

Wallerstedt, E., Smith, U., & Andersson, C. X. (2010) · Diabetologia · doi:10.1007/s00125-010-1668-1 · Cited by 27

Insulin receptor and IRS-1 co-immunoprecipitation with SOCS-3, and IKKα/β phosphorylation are increased in obese Zucker rat skeletal muscle

Zolotnik, I. A., Figueroa, T. Y., & Yaspelkis, B. B. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.08.038 · Cited by 26

Suppressors of Cytokine Signaling Promote Fas-Induced Apoptosis through Downregulation of NF-κB and Mitochondrial Bfl-1 in Leukemic T Cells

Oh, J., Kim, S.-H., Ahn, S., & Lee, C. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103415 · Cited by 27

Navigating Between the Scylla and Charybdis of Prescribing Dietary Protein for Chronic Kidney Diseases

Franch, H. A., & Mitch, W. E. (2009) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-080508-141051 · Cited by 26

SOCS1 negatively regulates the production of Foxp3+ CD4+ T cells in the thymus

Zhan, Y., Davey, G. M., Graham, K. L., Kiu, H., Dudek, N. L., Kay, T. W. H., & Lew, A. M. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2009.23 · Cited by 25

Curcumin attenuates hepatic fibrosis and insulin resistance induced by bile duct ligation in rats

Eshaghian‐dorcheh, A., Khodarahmi, A., Safari, F., Binesh, F., & Moradi, A. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518001095 · Cited by 26

SOCS-1 Suppresses Inflammation Through Inhibition of NALP3 Inflammasome Formation in Smoke Inhalation-Induced Acute Lung Injury

Zhang, L., Xu, C., Chen, X., Shi, Q., Su, W., & Zhao, H. (2018) · Inflammation · doi:10.1007/s10753-018-0802-y · Cited by 26

The suppressor of cytokine signaling SOCS1 promotes apoptosis of intestinal epithelial cells via p53 signaling in Crohn's disease

Cui, X., Shan, X., Qian, J., Ji, Q., Wang, L., Wang, X., Li, M., Ding, H., Liu, Q., Chen, L., et al. (2016) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2016.05.011 · Cited by 27

Dietary calcium regulates the insulin sensitivity by altering the adipokine secretion in high fat diet induced obese rats

Das, S. R., & Choudhuri, D. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117560 · Cited by 27

MG53 is not a critical regulator of insulin signaling pathway in skeletal muscle

Philouze, C., Turban, S., Cremers, B., Caliez, A., Lamarche, G., Bernard, C., Provost, N., & Delerive, P. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245179 · Cited by 24

SOCS3 and SOCS6 are required for the risperidone-mediated inhibition of insulin and leptin signaling in neuroblastoma cells

Piao, L., Park, J., Li, Y., Shin, S., Shin, S., Kong, G., SHRESTHA, R., Tran, Q., Hur, G. M., Kim, J. L., et al. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1693 · Cited by 27

SOCS and diabetes—ups and downs of a turbulent relationship

Suchy, D., Łabuzek, K., Machnik, G., Kozłowski, M., & Okopień, B. (2013) · Cell Biochemistry and Function · doi:10.1002/cbf.2940 · Cited by 27

Resistin induces insulin resistance, but does not affect glucose output in rat-derived hepatocytes

Liu, F., Yang, T., Wang, B., Zhang, M., Gu, N., Qiu, J., Fan, H., Zhang, C., Li, F., Pan, X.-Q., et al. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00709.x · Cited by 25

Insulin Resistance and Insulin Handling in Chronic Kidney Disease

Parvathareddy, V. P., Wu, J., & Thomas, S. S. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220019 · Cited by 54

Purple sweet potato color improves hippocampal insulin resistance via down-regulating SOCS3 and galectin-3 in high-fat diet mice

Qin, S., Sun, D., Mu, J., Ma, D., Tang, R., & Zheng, Y. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.025 · Cited by 24

IRS Depleted by Dirty SOCS

(2002) · Science Signaling · doi:10.1126/scisignal.1572002tw402

Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity

Galić, S., Sachithanandan, N., Kay, T. W. H., & Steinberg, G. R. (2014) · Biochemical Journal · doi:10.1042/bj20140143 · Cited by 100

Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms

Ueki, K., Kondo, T., & Kahn, C. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5434-5446.2004 · Cited by 686

A New Role for SOCS in Insulin Action

Krebs, D. L., & Hilton, D. J. (2003) · Science Signaling · doi:10.1126/stke.2003.169.pe6 · Cited by 78

Induction of SOCS-3 is insufficient to confer IRS-1 protein degradation in 3T3-L1 adipocytes

He, F., & Stephens, J. M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.142 · Cited by 15