SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2

Obesity and insulin resistance

Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,345

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884

Disruption of IRS-2 causes type 2 diabetes in mice

Withers, D. J., Gutierrez, J. S., Towery, H. H., Burks, D. J., Ren, J., Previs, S. F., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,775

Insulin resistance and cardiovascular disease

Ginsberg, H. N. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10762 · Cited by 1,372

Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action

Aguirre, V., Werner, E. D., Giraud, J., Lee, Y. H., Shoelson, S. E., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m101521200 · Cited by 1,010

Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

Shimomura, I., Matsuda, M., Hammer, R. E., Bashmakov, Y. K., Brown, M. S., & Goldstein, J. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00010-9 · Cited by 860

SOCS Proteins: Negative Regulators of Cytokine Signaling

Krebs, D. L., & Hilton, D. J. (2001) · Stem Cells · doi:10.1634/stemcells.19-5-378 · Cited by 826

New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes

Saltiel, A. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00239-2 · Cited by 688

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

Zhang, J., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., Moritz, R. L., Cary, D., Richardson, R. T., Hausmann, G., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2071 · Cited by 626

The Mechanisms of Insulin Action

White, M. F., & Copps, K. D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00033-0 · Cited by 12

Molecular characterization of nine suppressors of cytokine signaling (SOCS) genes from yellow catfish Pelteobagrus fulvidraco and their changes in mRNA expression to dietary carbohydrate levels

Ye, H.-M., Zhao, T., Wu, L., Cheng, J., & Tan, X.-Y. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.12.037 · Cited by 13

miRNA-Gene Regulatory Network in Gnotobiotic Mice Stimulated by Dysbiotic Gut Microbiota Transplanted From a Genetically Obese Child

Deng, L., Wang, R., Li, H., Zhang, C., Zhao, L., & Zhang, M. H. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01517 · Cited by 13

Centella asiatica (L.) extract attenuates inflammation and improve insulin sensitivity in a coculture of lipopolysaccharide (LPS)-induced 3T3-L1 adipocytes and RAW 264.7 macrophages

Kusumastuti, S. A., Nugrahaningsih, D. A. A., & Wahyuningsih, M. S. H. (2019) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2019.01052 · Cited by 13

Interleukin-1 antagonists for diabetes

Mandrup-Poulsen, T. R. (2013) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2013.804060 · Cited by 13

The role of microtubule‐associated protein 1S in SOCS3 regulation of IL‐6 signaling

Zou, T., Ouyang, L., Chen, L., Dong, W., Qiao, H., Liu, Y., & Qi, Y. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.10.055 · Cited by 13

Physiopathologie du syndrome métabolique

Jullien, D. (2008) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/s0151-9638(08)70542-8 · Cited by 15

[Cutaneous Histoplasmosis and AIDS].

Reyes, M., Arenas, L. R., Pichardo, P., Fragoso, R. V., Torres, A., & Zacarías, R. (2003) · PubMed · Cited by 13

Extrahepatic hepatitis C virus after transplantation: Diabetes and renal dysfunction

Sabharwal, S., Delgado‐Borrego, A., & Chung, R. T. (2008) · Liver Transplantation · doi:10.1002/lt.21613 · Cited by 13

Suppression of FoxO1 Activity by Long-Chain Fatty Acyl Analogs

Zatara, G., Hertz, R., Shaked, M., Mayorek, N., Morad, E., Grad, E., Cahan, A., Danenberg, H. D., Unterman, T. G., & Bar‐Tana, J. (2011) · Diabetes · doi:10.2337/db11-0248 · Cited by 13

Cross-talk das vias de sinalização de insulina e angiotensina II: implicações com a associação entre diabetes mellitus e hipertensão arterial e doença cardiovascular

Filho, C., Carvalheira, J. B. C., Velloso, L. A., & Saad, M. J. A. (2007) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302007000200008 · Cited by 20

Molecular Signatures of Obesity-Associated Infertility in Polycystic Ovary Syndrome: The Emerging Role of Exosomal microRNAs and Non-Coding RNAs

Voros, C., Papadimas, G. K., Mavrogianni, D., Koulakmanidis, A.-M., Athanasiou, D., Bananis, K., Athanasiou, A. I., Athanasiou, A. V., Papapanagiotou, I., Vaitsis, D., et al. (2025) · Genes · doi:10.3390/genes16091101 · Cited by 13

Neuroendocrine and Behavioral Consequences of Hyperglycemia in Cancer

Vasquez, J. H., & Borniger, J. C. (2020) · Endocrinology · doi:10.1210/endocr/bqaa047 · Cited by 12

Oxidative stress, inflammation, dysfunctional redox homeostasis and autophagy cause age-associated diseases

Sobhon, P., Savedvanich, G., & Weerakiet, S. (2023) · Exploration of Medicine · doi:10.37349/emed.2023.00124 · Cited by 12

Modulation and Lack of Cross‐Talk between Signal Transducer and Activator of Transcription 5 and Suppressor of Cytokine Signaling‐3 in Insulin and Growth Hormone Signaling in 3T3‐L1 Adipocytes

Story, D. J., & Stephens, J. M. (2006) · Obesity · doi:10.1038/oby.2006.148 · Cited by 12

The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1

Yu, W., Singh, R., Wang, Z., O’Malley, B. W., & Yi, P. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100739 · Cited by 12

Effects of alkaloid-rich extracts obtained from Grifola frondosa on gut microbiota and glucose homeostasis in rats

Li, N., Gao, X., Pan, Y., Liu, B., Pang, J., Zhao, C., & Zeng, F. (2022) · Food & Function · doi:10.1039/d1fo04062f · Cited by 12

Obesidad, síndrome metabólico y su impacto en las enfermedades cardiovasculares

Contreras-Leal, E., & Santiago-Garcı́a, J. (2011) · Dialnet (Universidad de la Rioja) · doi:10.32776/revbiomed.v22i3.98 · Cited by 12

SOCS-1 ameliorates smoke inhalation-induced acute lung injury through inhibition of ASK-1 activity and DISC formation

Zhang, L., Xu, C., Ma, Y., Zhu, K., Chen, X., Shi, Q., Su, W., & Zhao, H. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.10.014 · Cited by 12

Structural insights into suppressor of cytokine signaling 1 protein‐ identification of new leads for type 2 diabetes mellitus

Dumpati, R., Ramatenki, V., Vadija, R., Vellanki, S., & Vuruputuri, U. (2018) · Journal of Molecular Recognition · doi:10.1002/jmr.2706 · Cited by 11

Development of low blood glucose readings in nine non-diabetic patients treated with tumor necrosis factor-alpha inhibitors: a case series

Czajkowska, J. B., Shutty, B. G., & Zito, S. (2012) · Journal of Medical Case Reports · doi:10.1186/1752-1947-6-5 · Cited by 12

Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-α signaling in the rMC-1 cell line.

Jiang, Y., Biswas, S. K., & Steinle, J. J. (2014) · Europe PMC (PubMed Central) · Cited by 12

Mechanisms of Insulin Action

White, M. F., & White, M. F. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1028-7_2 · Cited by 12

Pharmaceutical SH2 domain–containing protein tyrosine phosphatase 2 inhibition suppresses primary and metastasized liver tumors by provoking hepatic innate immunity

Liu, J. J., Xin, B., Du, L., Chen, L., Long, Y., & Feng, G. (2023) · Hepatology · doi:10.1002/hep.32555 · Cited by 11

Breast Cancer Risk and Management in the Endocrine Clinic: A Comprehensive Review

Hawazie, A., & Druce, M. R. (2025) · Clinical Endocrinology · doi:10.1111/cen.15209 · Cited by 11

Salicylate administration suppresses the inflammatory response to nutrients and improves ovarian function in polycystic ovary syndrome

González, F., Mather, K. J., Considine, R. V., Abdelhadi, O. A., & Acton, A. J. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00228.2020 · Cited by 12

Differential gene expression in liver of colored broiler chicken divergently selected for residual feed intake

Prakash, A., SAXENA, V. K., Kumar, R., Tomar, S., Singh, M. K., & Singh, G. (2021) · Tropical Animal Health and Production · doi:10.1007/s11250-021-02844-7 · Cited by 10

A Novel Domain Mediates Insulin-Induced Proteasomal Degradation of Insulin Receptor Substrate 1 (IRS-1)

Boura‐Halfon, S., Shuster-Meiseles, T., Beck, A., Petrovich, K., Gurevitch, D., Ronen, D., & Zick, Y. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0072 · Cited by 11

The Association between SOCS1−1656G>A Polymorphism, Insulin Resistance and Obesity in Nonalcoholic Fatty Liver Disease (NAFLD) Patients

Kempińska‐Podhorodecka, A., Wunsch, E., Milkiewicz, P., Stachowska, E., & Milkiewicz, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111912 · Cited by 11

Role of UPP pathway in amelioration of diabetes-associated complications

Gupta, A. K., Behl, T., Aleya, L., Rahman, M. H., Yadav, H. N., Pal, G., Kaur, I., & Arora, S. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-12781-5 · Cited by 11

Observations on the effects of Suppressor of Cytokine Signaling 7 (SOCS7) knockdown in breast cancer cells: their in vitro response to Insulin Like Growth Factor I (IGF-I)

Sasi, W., Ye, L., Jiang, W. G., Mokbel, K., & Sharma, A. K. (2013) · Clinical & Translational Oncology · doi:10.1007/s12094-013-1107-0 · Cited by 11

GLP-1 analogue recovers impaired insulin secretion from human islets treated with palmitate via down-regulation of SOCS2

Chowdhury, A. I., & Bergsten, P. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.034 · Cited by 11

Oligodendrocytes exhibit selective expression of suppressor of cytokine signaling genes and signal transducer and activator of transcription 1 independent inhibition of interferon-gamma-induced toxicity in response to leukemia inhibitory factor

Emery, B., Butzkueven, H., Snell, C. E., Binder, M. D., & Kilpatrick, T. J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.022 · Cited by 11

Imbalance of T cell subsets: a core event that mediates the progression of T2DM and its complications

Xie, X., Fan, L., Wu, Q., Zeng, C., Chen, X., Wang, W., Zhang, C., & Chen, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1688392 · Cited by 11

LncRNA MEG3: Targeting the Molecular Mechanisms and Pathogenic causes of Metabolic Diseases

Luo, Y., Wang, H., Wang, L., Wu, W. L., Zhao, J., Li, X., Xiong, R., Ding, X., Yuan, D., & Yuan, C. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673268051231009075027 · Cited by 10

Discovering therapeutic possibilities for polycystic ovary syndrome by targeting XIST and its associated ceRNA network through the analysis of transcriptome data

Berenji, E., Motlagh, A. V., Fathi, M., Esmaeili, M., Izadi, T., Rezvanian, P., Zanjirband, M., Safaeinejad, Z., & Nasr‐Esfahani, M. H. (2024) · Scientific Reports · doi:10.1038/s41598-024-56524-1 · Cited by 12

Combined effects of progesterone and SOCS3 DNA methylation on T2DM: a case–control study

Wang, L., Mao, Z., Liu, X., Wei, D., Liu, P., Nie, L., Fan, K., Kang, N., Song, Y., Xu, Q., et al. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01172-9 · Cited by 10

Antidiabetic and Antioxidative Effects of Jatropha curcas Extracts in Streptozotocin-induced Diabetic Rats

Asuk, A. A., Dasofunjo, K., Okafor, A., & Mbina, F. (2014) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2015/11766 · Cited by 10

Postprandial activation of metabolic and inflammatory signalling pathways in human peripheral mononuclear cells

Ehlers, K., Brand, T., Bangert, A., Hauner, H., & Laumen, H. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514000208 · Cited by 11

Testosterone interacts with the feedback mechanisms engaged by Tyr985 of the leptin receptor and diet-induced obesity

Johnson, J. A., Calo, S., Nair, L. T., IglayReger, H. B., Greenwald-Yarnell, M. L., Skorupski, J. C., Myers, M. G., & Bodary, P. F. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.06.002 · Cited by 10

Establishment of a Mammary Stromal Fibroblastic Cell Line for In Vitro Studies in Mice of Mammary Adipocyte Differentiation1

Nakatani, H., Aoki, N., Okajima, T., Nadano, D., Flint, D., & Matsuda, T. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.109.077958 · Cited by 10

Effect of pioglitazone on metabolic features in endotoxemia model in obese diabeticdb/dbmice

Sharma, M., Mohapatra, J., Malik, U., Nagar, J., Chatterjee, A., Ramachandran, B., & Jain, M. R. (2016) · Journal of Diabetes · doi:10.1111/1753-0407.12450 · Cited by 10

Small heterodimer partner (SHP) contributes to insulin resistance in cardiomyocytes

Rodríguez‐Calvo, R., Chanda, D., Oligschlaeger, Y., Miglianico, M., Coumans, W. A., Barroso, E., Tajes, M., Luiken, J. J. F. P., Glatz, J. F. C., Vázquez‐Carrera, M., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.02.006 · Cited by 10

TRIM32 regulates insulin sensitivity by controlling insulin receptor degradation in the liver

Thakur, S., Rawat, P., Dehury, B., & Mondal, P. (2025) · EMBO Reports · doi:10.1038/s44319-024-00348-7 · Cited by 9

Burn injury-induced IRS-1 degradation in mouse skeletal muscle.

Lu, X.-M., Tompkins, R., & Fischman, A. J. (2013) · Europe PMC (PubMed Central) · Cited by 9

Chlorpromazine attenuates pancreatic β-cell function and mass through IRS2 degradation, while exercise partially reverses the attenuation

Park, S., Sm, H., Lee, J., Sung, S., & Kim, S. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881106081529 · Cited by 9

Suppressor of cytokine signaling and accelerated atherosclerosis in kidney disease.

Wesoły, J., Sikorski, K., Lee, C., & Bluyssen, H. A. R. (2010) · Acta Biochimica Polonica · doi:10.18388/abp.2010_2402 · Cited by 9

Obesity and Diabetes

Karanastasis, G., & Mantzoros, C. S. (2006) · Humana Press eBooks · doi:10.1007/978-1-59259-985-1_1 · Cited by 9

Chapter 4 Role of Prolactin in Autoimmune Diseases

Bellis, A. D., Bizzarro, A., & Bellastella, A. (2008) · Technical report · doi:10.1016/s1571-5078(07)00204-8 · Cited by 9

Differential regulation of insulin receptor substrate-1 degradation during mannitol and okadaic acid induced apoptosis in human neuroblastoma cells

Kim, B., Oh, S., van Golen, C. M., & Feldman, E. L. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.11.001 · Cited by 9

Mechanisms of Insulin Signal Transduction

Garvey, W. T. (2004) · Wiley eBooks · doi:10.1002/0470862092.d0301 · Cited by 10

TLR4 and prostaglandin pathways at the crossroads of endotoxemia-induced lipolysis

Chirivi, M., Abou-Rjeileh, U., Myers, M. N., Parales-Girón, J., Worden, L. C., Lock, A. L., & Contreras, G. A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1591210 · Cited by 8

Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance

Cruz, A. M., & Beall, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.567378 · Cited by 8

Suppressor of Cytokine Signaling, Skeletal Muscle, and Chronic Health Conditions

Spangenburg, E. E. (2007) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3180a02fe6 · Cited by 8

Obesity and gut microbiota - what do we know so far?

da Silva-Junior, V. L., Lopes, F. D. A. M., Albano, R. M., de Souza, M. D. G. C., Barbosa, C. M. D. L., Maranhao, P. A., Bouskela, E., & Kraemer‐Aguiar, L. G. (2017) · Medical Express · doi:10.5935/medicalexpress.2017.04.01 · Cited by 10

DYRK1A aggravates β cell dysfunction and apoptosis by promoting the phosphorylation and degradation of IRS2

Lü, M., Ma, L., Shan, P., Liu, A., Yu, X., Jiang, W., Wang, X., Zhao, X., Ye, X., & Wang, T. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110659 · Cited by 8

Nano Chromium Picolinate Improves Gene Expression Associated with Insulin Signaling in Porcine Skeletal Muscle and Adipose Tissue

Hung, A., Leury, B. J., Sabin, M. A., Fahri, F., DiGiacomo, K., Lien, T., & Dunshea, F. R. (2020) · Animals · doi:10.3390/ani10091685 · Cited by 8

Insulin-Like Peptides

Antonova‐Koch, Y., Riehle, M. A., Arik, A. J., & Brown, M. R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385095-9.00038-5 · Cited by 8

Underlying Pathways for Interferon Risk to Type II Diabetes Mellitus

Abdel‐Hamid, N. M., Jubori, T., Farhan, A., Mahrous, M., Gouri, A., Awad, E. M., & Breuss, J. M. (2013) · Current Diabetes Reviews · doi:10.2174/15733998113096660080 · Cited by 8

Hepatitis C virus infection in vitro triggers endoplasmic reticulum stress and downregulates insulin receptor substrates 1 and 2 through upregulation of cytokine signaling suppressor 3

Ahmed, Q. L., Manzoor, S., TARIQ, M., Khalid, M., Ashraf, W., Parvaiz, F., & Imran, M. (2014) · Acta Virologica · doi:10.4149/av_2014_03_238 · Cited by 8

Scallop mantle extract inhibits insulin signaling in HepG2 cells

Kariya, T., Takahashi, K., Itagaki, D., & Hasegawa, Y. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1061 · Cited by 7

Latent M. tuberculosis infection is associated with increased inflammatory cytokine and decreased suppressor of cytokine signalling (SOCS)‐3 in the diabetic host

Masood, K. I., Irfan, M., Masood, Q., Yameen, M., Jamil, B., Ram, N., Rao, S., Rottenberg, M. E., & Hasan, Z. (2021) · Scandinavian Journal of Immunology · doi:10.1111/sji.13134 · Cited by 9

Prediabetes uncovers differential gene expression at fasting and in response to oral glucose load in immune cells

Mallu, A. C. T., Vasudevan, M., Allanki, S., Nathan, A. A., Ravi, M. M., Ramanathan, G. S., Pradeepa, R., Mohan, V., & Dixit, M. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.08.007 · Cited by 8

Genetic contributions to Type 2 diabetes: recent insights

Sale, M. M., & Rich, S. S. (2007) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.7.2.207 · Cited by 8

Mechanisms of insulin signal transduction

Langlais, P. R., Mandarino, L. J., & Garvey, W. T. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch12 · Cited by 8

The Complex Relation of Branched‐Chain Amino Acids and Inflammation in the Obesity and Diabetes Context

Starling-Soares, B., Coelho, M. M., Campolina, B. G., Duarte, C. K., & Maioli, T. U. (2026) · Obesity Reviews · doi:10.1111/obr.70092 · Cited by 7

Alterations of SOCS1 and SOCS3 transcript levels, but not promoter methylation levels in subcutaneous adipose tissues in obese women

Emamgholipour, S., Esmaeili, F., Shabani, M., Hasanpour, S. Z., Pilehvari, M., Mahmoudabadi, H. Z., Motevasseli, M., & Shanaki, M. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-022-01247-5 · Cited by 8

The Effect of Hormones Insulin and Glucagon on Ubiquitin Modifications Elucidated by Proteomics in Liver Cells

Vemana, H. P., & Dukhande, V. V. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121935 · Cited by 6

Sarcopenia in Diabetes Mellitus

Sugimoto, K., Wang, C.-C., & Rakugi, H. (2016) · Springer eBooks · doi:10.1007/978-4-431-55720-3_16 · Cited by 7

Sarcopenia in patients with chronic kidney disease: prevalence, pathogenesis and clinical significance

Гасанов, М. З. (2021) · Nephrology (Saint-Petersburg) · doi:10.36485/1561-6274-2021-25-1-47-58 · Cited by 7

Regulation of cytokine-inducible SH2-containing protein (CIS) by ubiquitination and Elongin B/C interaction

Jensik, P. J., & Arbogast, L. A. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.10.017 · Cited by 7

Síndrome metabólico: Bases clínicas y fisiopatológicas para un enfoque terapéutico racional

Gonzalo Martínez, R., Rodrigo Alonso, K., & Victoria Novik, A. (2009) · Revista médica de Chile · doi:10.4067/s0034-98872009000500014 · Cited by 7

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase

Ishimoto, K., Hayase, A., Kumagai, F., Kawai, M., Okuno, H., Hino, N., Okada, Y., Kawamura, T., Tanaka, T., Hamakubo, T., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.04.159 · Cited by 7

Dose threshold for radiation induced fetal programming in a mouse model at 4 months of age: Hepatic expression of genes and proteins involved in glucose metabolism and glucose uptake in brown adipose tissue

Davidson, C., Tharmalingam, S., Niccoli, S., Nemec-Bakk, A. S., Khurana, S., Murray, A., Tai, T. C., Boreham, D. R., Khaper, N., & Lees, S. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231650 · Cited by 9

Mechanism of Insulin Action

White, M. F. (2016) · Wiley eBooks · doi:10.1002/9781118924853.ch8 · Cited by 8

Emerging perspectives in proteostasis: bridging mechanisms and therapeutics for human diseases

Borlepawar, A., Neu, M., Ma, Z., Deshpande, A., Bühringer, H., Hajieva, P., Frey, N., & Rangrez, A. Y. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02714-4 · Cited by 7

Obesity and chronic leptin resistance foster insulin resistance

Dey, S., Murmu, N., Böse, M., Ghosh, S., & Giri, B. (2021) · BLDE University Journal of Health Sciences · doi:10.4103/bjhs.bjhs_29_20 · Cited by 9

Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice

Mathew, D., Barillas, J., Nedeljkovic-Kurepa, A., Abraham, M. N., Taylor, M. D., & Deutschman, C. S. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00703-9 · Cited by 6

Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling

Ghosh, A., Leung, Y. H., Yu, J. C., SLADEK, R. M., Chénier, I., Oppong, A. K., Peyot, M., Madiraju, S. R. M., Al‐Khairi, I., Thanaraj, T. A., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2024.159461 · Cited by 5

Cycloheximide stimulates suppressor of cytokine signaling-3 gene expression in 3T3-L1 adipocytes via the extracellular signal-regulated kinase pathway

Chang, H.-H., Tsai, P.-H., Liu, C.-W., Ku, H., Kao, C.-C., & Kao, Y.-H. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.12.002 · Cited by 6

Tuberculosis and host metabolism: ancient associations, fresh insights

Blumenthal, A., Isovski, F., & Rhee, K. Y. (2009) · Translational research · doi:10.1016/j.trsl.2009.04.004 · Cited by 6

Using Integrative Analysis of DNA Methylation and Gene Expression Data in Multiple Tissue Types to Prioritize Candidate Genes for Drug Development in Obesity

Guo, Q., Zheng, R., Huang, J., He, M. X., Wang, Y., Guo, Z., Sun, L., & Chen, P. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00663 · Cited by 6

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From obesity through immunity to type 2 diabetes mellitus

Szablewski, L. (2016) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-016-0531-4 · Cited by 5

Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle

Yaspelkis, B. B., Kvasha, I. A., Lessard, S. J., Rivas, D. A., & Hawley, J. A. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1559-7 · Cited by 6

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Mieulet, V., & Lamb, R. F. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.05.010 · Cited by 6

Correction: Biologically anchored knowledge expansion approach uncovers KLF4 as a novel insulin signaling regulator

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Nelson, D. A., Thompson, K. J., Wang, L., Wang, Z., Eberts, P. M., Azarin, S. M., Kalari, K. R., & Kandimalla, K. K. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230907 · Cited by 6

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Pilling, C., & Cooper, J. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-11040-3 · Cited by 5

Effects of dietary adjustment of n-3:n-6 fatty-acid ratio to 1:2 on anti-inflammatory and insulin-signaling pathways in ovariectomized mice with high fat diet-induced obesity

Tung, Y., Chen, Y., Fan, T.-Y., Fong, T.-H., & Chiu, W. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20451 · Cited by 5

Proteomics and PUGNA city will overcome questioning of insulin resistance induction by nonselective inhibition of O‐ G lc NA case

Dehennaut, V., & Lefebvre, T. (2013) · PROTEOMICS · doi:10.1002/pmic.201300363 · Cited by 5

Association of the suppressor of cytokine signaling 1 (SOCS1) gene polymorphisms with acute coronary syndrome in Mexican patients

Vargas‐Alarcón, G., Posadas‐Sánchez, R., Posadas‐Romero, C., González-Salazar, C., Cardoso-Saldaña, G. C., Martínez‐Ríos, M. A., Peña‐Duque, M. A., Obil-Chavarría, C. A., Pérez-Méndez, O. A., & Fragoso, J. M. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.06.019 · Cited by 5

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May, A. K., Mukherjee, K., Albaugh, V. L., Richards, J. E., & Rumbaugh, K. A. (2015) · Open Access Surgery · doi:10.2147/oas.s50416 · Cited by 5

Adipocyte-hepatocyte crosstalk and the pathogenesis of nonalcoholic fatty liver disease #

Smith, B. W., George, J., Kowdley, K. V., McCaughan, G. W., & Trautwein, C. (2009) · Hepatology · doi:10.1002/hep.22937 · Cited by 5

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Insulin signaling in the aging nervous system

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Pathogenesis of Type 2 Diabetes

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IRS Depleted by Dirty SOCS

(2002) · Science Signaling · doi:10.1126/scisignal.1572002tw402

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