SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2

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Regulating insulin signaling and β-cell function through IRS proteinsThis paper is one of a selection of papers published in this Special Issue, entitled Second Messengers and Phosphoproteins—12th International Conference.

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Negative regulation of cytokine signaling and immune responses by SOCS proteins.

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Human biliverdin reductase: A member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity

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The SCF-Fbxo40 Complex Induces IRS1 Ubiquitination in Skeletal Muscle, Limiting IGF1 Signaling

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Suppressors of Cytokine Signaling 4 and 5 Regulate Epidermal Growth Factor Receptor Signaling

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Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity

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SOCS2 Can Enhance Interleukin-2 (IL-2) and IL-3 Signaling by Accelerating SOCS3 Degradation

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The SOCS Box Encodes a Hierarchy of Affinities for Cullin5: Implications for Ubiquitin Ligase Formation and Cytokine Signalling Suppression

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JAK/STAT3 Pathway Is Involved in Survival of Neurons in Response to Insulin-like Growth Factor and Negatively Regulated by Suppressor of Cytokine Signaling-3

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Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation

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Disruption of the SH2-B Gene Causes Age-Dependent Insulin Resistance and Glucose Intolerance

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Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle

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IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro

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Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans

Banks, A. S., Li, J., McKeag, L., Hribal, M. L., Kashiwada, M., Accili, D., & Rothman, P. B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23853 · Cited by 104

Hepatitis C, insulin resistance and diabetes: clinical and pathogenic data

Serfaty, L., & Capeau, J. (2009) · Liver International · doi:10.1111/j.1478-3231.2008.01952.x · Cited by 108

Acute insulin resistance following injury

Li, L., & Messina, J. L. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.06.004 · Cited by 109

SOCS Proteins as Regulators of Inflammatory Responses Induced by Bacterial Infections: A Review

Duncan, S. A., Baganizi, D. R., Sahu, R., Singh, S. R., & Dennis, V. A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02431 · Cited by 104

Macronutrient-Mediated Inflammation and Oxidative Stress: Relevance to Insulin Resistance, Obesity, and Atherogenesis

Biobaku, F., Ghanim, H., Batra, M., & Dandona, P. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01833 · Cited by 104

The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase

Babon, J. J., Sabo, J. K., Soetopo, A., Yao, S., Bailey, M. F., Zhang, J., Nicola, N. A., & Norton, R. S. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.06.038 · Cited by 107

Insulin-Like Peptides

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Liver-Specific Suppressor of Cytokine Signaling-3 Deletion in Mice Enhances Hepatic Insulin Sensitivity and Lipogenesis Resulting in Fatty Liver and Obesity

Sachithanandan, N., Fam, B. C., Fynch, S., Dzamko, N. L., Watt, M. J., Wormald, S., Honeyman, J. E., Galić, S., Proietto, J., Andrikopoulos, S., et al. (2010) · Hepatology · doi:10.1002/hep.23861 · Cited by 107

SOCS3 as a future target to treat metabolic disorders

Pedroso, J. A. B., Ramos-Lobo, A. M., & Donato, J. (2018) · HORMONES · doi:10.1007/s42000-018-0078-5 · Cited by 106

Negative Regulation of Cytokine and TLR Signalings by SOCS and Others

Naka, T., Fujimoto, M., Tsutsui, H., & Yoshimura, A. (2005) · Advances in immunology · doi:10.1016/s0065-2776(05)87003-8 · Cited by 101

Insulin‐like growth factor‐I receptor signal transduction and the Janus Kinase/Signal Transducer and Activator of Transcription (JAK‐STAT) pathway

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Genomic aspects of NAFLD pathogenesis

Naik, A., Košir, R., & Rozman, D. (2013) · Genomics · doi:10.1016/j.ygeno.2013.03.007 · Cited by 108

The Emerging Role of the COP9 Signalosome in Cancer

Richardson, K. S., & Zundel, W. (2005) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0233 · Cited by 101

The role of cullin 5-containing ubiquitin ligases

Okumura, F., Akiko, J.-O., Nakatsukasa, K., & Kamura, T. (2016) · Cell Division · doi:10.1186/s13008-016-0016-3 · Cited by 99

Nutrient-dependent and Insulin-stimulated Phosphorylation of Insulin Receptor Substrate-1 on Serine 302 Correlates with Increased Insulin Signaling

Giraud, J., Leshan, R. L., Lee, Y.-H., & White, M. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308631200 · Cited by 100

Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis

Ahmad, A., & Álvarez, F. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0304197 · Cited by 100

IRS Depleted by Dirty SOCS

(2002) · Science Signaling · doi:10.1126/scisignal.1572002tw402

Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity

Galić, S., Sachithanandan, N., Kay, T. W. H., & Steinberg, G. R. (2014) · Biochemical Journal · doi:10.1042/bj20140143 · Cited by 100

Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms

Ueki, K., Kondo, T., & Kahn, C. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5434-5446.2004 · Cited by 686

A New Role for SOCS in Insulin Action

Krebs, D. L., & Hilton, D. J. (2003) · Science Signaling · doi:10.1126/stke.2003.169.pe6 · Cited by 78

Induction of SOCS-3 is insufficient to confer IRS-1 protein degradation in 3T3-L1 adipocytes

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