Cited by 1,168Mitochondrial Function and PathologyCell death mechanisms and regulationAutophagy in Disease and Therapy

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Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis

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Olichon, Aurélien, Baricault, Laurent, Gas, Nicole, Guillou, Emmanuelle, Valette, Annie, Belenguer, Pascale, Lenaers, Guy·2003·Journal of Biological Chemistry

DOI 10.1074/jbc.c200677200

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Abstract

OPA1 encodes a large GTPase related to dynamins, anchored to the mitochondrial cristae inner membrane, facing the intermembrane space. OPA1 haplo-insufficiency is responsible for the most common form of autosomal dominant optic atrophy (ADOA, MIM165500), a neuropathy resulting from degeneration of the retinal ganglion cells and optic nerve atrophy. Here we show that down-regulation of OPA1 in HeLa cells using specific small interfering RNA (siRNA) leads to fragmentation of the mitochondrial network concomitantly to the dissipation of the mitochondrial membrane potential and to a drastic disorganization of the cristae. These events are followed by cytochrome c release and caspase-dependent apoptotic nuclear events. Similarly, in NIH-OVCAR-3 cells, the OPA1 siRNA induces mitochondrial fragmentation and apoptosis, the latter being inhibited by Bcl2 overexpression. These results suggest that OPA1 is a major organizer of the mitochondrial inner membrane from which the maintenance of the cristae integrity depends. As loss of OPA1 commits cells to apoptosis without any other stimulus, we propose that OPA1 is involved in the cytochrome c sequestration and might be a target for mitochondrial apoptotic effectors. Our results also suggest that abnormal apoptosis is a possible pathophysiological process leading to the retinal ganglion cells degeneration in ADOA patients.

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Authors: Olichon, A., Baricault, L., Gas, N., Guillou, E., Valette, A., Belenguer, P., & Lenaers, G.
Affiliations: Université Toulouse III - Paul Sabatier (FR)
Corresponding author: Belenguer, Pascale
ORCID: Olichon, Aurélien
Guillou, Emmanuelle
Belenguer, Pascale
Lenaers, Guy
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2003-03
Volume: 278
Issue: 10
Pages: 7743-7746
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.c200677200
OpenAlex: W1986996580
Cited by: 1,168
References: 27
Citations by year: 2026: 29 · 2025: 46 · 2024: 38 · 2023: 55 · 2022: 47 · 2021: 64 · 2020: 59 · 2019: 61 · 2018: 50 · 2017: 60 · 2016: 78 · 2015: 61 · 2014: 57 · 2013: 39 · 2012: 61
FWCI: 12.90
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6443 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: OPA1, mitochondrial fission, mitochondrial cristae, inner mitochondrial membrane, cytochrome c release, apoptosis, mitochondrial membrane potential, autosomal dominant optic atrophy, Bcl-2, GTPase, retinal ganglion cell death
MeSH terms: Cytochrome c Group, Humans, Intracellular Membranes, Microscopy, Electron, Mitochondria, Tumor Cells, Cultured, Apoptosis, GTP Phosphohydrolases

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Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis

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