Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis

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Mitochondrial respiration is sensitive to cytoarchitectural breakdown

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Relationship Between β-Amyloid and Mitochondrial Dynamics

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Mitochondrial transplantation reduces lower limb ischemia-reperfusion injury by increasing skeletal muscle energy and adipocyte browning

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In vivo time-lapse imaging of mitochondria in healthy and diseased peripheral myelin sheath

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Small molecule OPA1 inhibitors amplify cytochrome c release and reverse cancer cells resistance to Bcl-2 inhibitors

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The first direct activity assay for the mitochondrial protease OMA1

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Cardiac-specific PFKFB3 overexpression prevents diabetic cardiomyopathy via enhancing OPA1 stabilization mediated by K6-linked ubiquitination

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Subcellular Localization of Class I Histone Deacetylases in the Developing Xenopus tectum

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Mitochondrial prohibitin and its ubiquitination during spermatogenesis of the swimming crab Charybdis japonica

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HSF-1 promotes longevity through ubiquilin-1-dependent mitochondrial network remodelling

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Saccharomyces cerevisiae as a Tool for Studying Mutations in Nuclear Genes Involved in Diseases Caused by Mitochondrial DNA Instability

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Astragaloside IV Alleviates Infarction Induced Cardiomyocyte Injury by Improving Mitochondrial Morphology and Function

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Non-Coding RNA-Dependent Regulation of Mitochondrial Dynamics in Cancer Pathophysiology

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Ferroptosis in Glaucoma: A Promising Avenue for Therapy

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A zebrafish model to study small-fiber neuropathy reveals a potential role for GDAP1

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Chronic hypoxia alters cardiac mitochondrial complex protein expression and activity in fetal guinea pigs in a sex-selective manner

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A Molecular Perspective on Mitochondrial Membrane Fusion: From the Key Players to Oligomerization and Tethering of Mitofusin

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HIGD‑1B inhibits hypoxia‑induced mitochondrial fragmentation by regulating OPA1 cleavage in cardiomyocytes

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OPA1 , a molecular regulator of dilated cardiomyopathy

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MeHg Causes Ultrastructural Changes in Mitochondria and Autophagy in the Spinal Cord Cells of Chicken Embryo

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Hemagglutinin-neuraminidase and fusion proteins of virulent Newcastle disease virus cooperatively disturb fusion–fission homeostasis to enhance mitochondrial function by activating the unfolded protein response of endoplasmic reticulum and mitochondrial stress

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Humic substances from composted fennel residues control the inflammation induced by Helicobacter pylori infection in AGS cells

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Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling

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Loss of function of Ywhah in mice induces deafness and cochlear outer hair cells' degeneration

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The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling

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Effects of Different Doses of Calcium on the Mitochondrial Apoptotic Pathway and Rho/ROCK Signaling Pathway in the Bone of Fluorosis Rats

Yang, J., Zhu, Y., Zhang, D., Yan, Z., Zhao, Y., Manthari, R. K., Cheng, X., Wang, J., & Wang, J. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02305-6 · Cited by 16

Mitofusin 2 but not mitofusin 1 mediates Bcl-XL-induced mitochondrial aggregation

Du, M., Si, Y., Su, W., Zhao, M., Yang, F., Liu, Y., Mai, Z., Wang, Y., Wang, X., & Chen, T. (2020) · Journal of Cell Science · doi:10.1242/jcs.245001 · Cited by 16

Protein-dependent membrane remodeling in mitochondrial morphology and clathrin-mediated endocytosis

Tarasenko, D., & Meinecke, M. (2021) · European Biophysics Journal · doi:10.1007/s00249-021-01501-z · Cited by 16

Drug-induced Optic Neuropathy—TB or Not TB

Pradhan, M. A., Sharp, D. M., Best, S. J., Vincent, A. L., & Vaphiades, M. S. (2010) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2009.10.005 · Cited by 16

Mitofusin 1 inhibits an apoptosis-associated amino-terminal conformational change in Bax, but not its mitochondrial translocation, in a GTPase-dependent manner

Ryu, S., Choi, K., Park, J., Park, Y., Kim, S., & Choi, C. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.03.038 · Cited by 16

Status epilepticus triggers early mitochondrial fusion in the rat hippocampus in a lithium-pilocarpine model

Córdova-Dávalos, L. E., Carrera-Calvo, D., Solís-Navarrete, J., Mercado-Gómez, O. F., Arriaga-Ávila, V. S., Agredano‐Moreno, L. T., Jiménez‐García, L. F., & Guevara‐Guzmán, R. (2016) · Epilepsy Research · doi:10.1016/j.eplepsyres.2016.03.007 · Cited by 16

Antiapoptotic and mitochondrial biogenetic effects of exercise training on ovariectomized hypertensive rat hearts

Lin, Y.-Y., Hong, Y., Yu, S., Wu, X., Shyu, W., Chen, J., Ting, H., Yang, A., & Lee, S. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00038.2019 · Cited by 18

Indole-3-propionic acid promotes hepatic stellate cells inactivation

Ilha, M., Sehgal, R., Matilainen, J., Rilla, K. J., Kamińska, D., Gandhi, S., Männistö, V., Ling, C., Romeo, S., Pajukanta, P., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06266-z · Cited by 16

PGAM5 aggravated doxorubicin-induced cardiotoxicity by disturbing mitochondrial dynamics and exacerbating cardiomyocytes apoptosis

He, W., Wang, J., He, W., Ling, Z., Zhao, R., Qiu, K., Tong, G., Zhongchan, S., & He, P. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.04.037 · Cited by 15

Mitochondrial organization and structure are compromised in fibroblasts from patients with Huntington’s disease

Vanišová, M., Štufková, H., Kohoutová, M., Daňhelovská, T., Křížová, J., Klempíř, J., Ryšánková, I., Roth, J., Zeman, J., & Hansíková, H. (2022) · Ultrastructural Pathology · doi:10.1080/01913123.2022.2100951 · Cited by 15

Melatonin protects oocytes from cadmium exposure-induced meiosis defects by changing epigenetic modification and enhancing mitochondrial morphology in the mouse

Qu, J., Wang, Q., Niu, H., Sun, X., Ji, D., & Li, Y. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114311 · Cited by 15

Mitochondrial fusion in Chlamydomonas reinhardtii zygotes

Scholz, D., & Westermann, B. (2012) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2012.10.004 · Cited by 15

Cardiac Mitochondrial PTEN-L determines cell fate between apoptosis and survival during chronic alcohol consumption

Sivakumar, A., Shanmugarajan, S., Ramasamy, S., & Balakrishnan, R. (2020) · APOPTOSIS · doi:10.1007/s10495-020-01616-2 · Cited by 15

Analysis of opa1 isoforms expression and apoptosis regulation in autosomal dominant optic atrophy (ADOA) patients with mutations in the opa1 gene

Formichi, P., Radi, E., Giorgi, E., Gallus, G. N., Brunetti, J., Battisti, C., Rufa, A., Dotti, M. T., Franceschini, R., Bracci, L., et al. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.02.047 · Cited by 15

Mitochondrial retention of Opa1 is required for mouse embryogenesis

Moore‐Scott, B. A., Aviles, G. D. G., Larkins, C. E., Hillman, M. J., & Caspary, T. (2010) · Mammalian Genome · doi:10.1007/s00335-010-9272-8 · Cited by 15

Alterations of mitochondrial dynamics allow retrograde propagation of locally initiated axonal insults

Lassus, B., Magnifico, S., Pignon, S., Belenguer, P., Miquel, M., & Peyrin, J. (2016) · Scientific Reports · doi:10.1038/srep32777 · Cited by 16

Autosomal dominant optic atrophy and cataract “plus” phenotype including axonal neuropathy

Horga, A., Bugiardini, E., Manole, A., Bremner, F., Jaunmuktane, Z., Dankwa, L., Rebelo, A. P., Woodward, C. E., Hargreaves, I. P., Cortese, A., et al. (2019) · Neurology Genetics · doi:10.1212/nxg.0000000000000322 · Cited by 15

Proteolytic regulation of mitochondrial dynamics

Dietz, J. V., Bohovych, I., Viana, M. P., & Khalimonchuk, O. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.04.008 · Cited by 15

CARD19 Interacts with Mitochondrial Contact Site and Cristae Organizing System Constituent Proteins and Regulates Cristae Morphology

Rios, K. E., Zhou, M., Lott, N. M., Beauregard, C. R., McDaniel, D. P., Conrads, T. P., & Schaefer, B. C. (2022) · Cells · doi:10.3390/cells11071175 · Cited by 13

Spatiotemporal Distribution and Function of Mitochondria in Oocytes

Kang, X., Yan, L., & Wang, J. (2023) · Reproductive Sciences · doi:10.1007/s43032-023-01331-8 · Cited by 14

OPA 1 and Its Clinical Implications

Trevisson, E., Salviati, L., & Scorrano, L. (2009) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0021785 · Cited by 1

OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

Frezza, C., Cipolat, S., Martins de Brito, O., Micaroni, M., Beznoussenko, G. V., Rudka, T., Bartoli, D., Polishuck, R. S., Danial, N. N., De Strooper, B., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.025 · Cited by 1,673

OPA1-dependent cristae remodeling disassembles respiratory chain supercomplexes, triggering apoptotic mitochondrial dysfunction

Cogliati, S. (2011) · Padua Research Archive (University of Padova) · Cited by 1

Identification and functional characterization of components of the OPA1 complexes targeted during apoptotic cristae remodeling

Glytsou, C. (2016) · Padua@research (University of Padova)

Release of OPA1 during Apoptosis Participates in the Rapid and Complete Release of Cytochrome c and Subsequent Mitochondrial Fragmentation

Arnoult, D., Grodet, A., Lee, Y.-J., Estaquier, J., & Blackstone, C. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505970200 · Cited by 265