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Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation
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Upon ligand stimulation, RTKs undergo ubiquitin-mediated internalization leading to degradation via the endosomal-lysosomal pathway.
“It is well documented that upon ligand stimulation RTKs undergo ubiquitin-mediated internalization leading to degradation via the endosomal-lysosomal pathway (13,39).”
From Essential Role of Ubiquitin-Specific Protease 8 for Receptor Tyrosine Kinase Stability and Endocytic Trafficking In Vivo (2007) · cites this paper as [39]
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Research works printed but not linked: 22
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Metadata
- Authors
- Mosesson, Y., Shtiegman, K., Katz, M., Zwang, Y., Vereb, G., Szollosi, J., & Yarden, Y.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 278
- Issue
- 24
- Pages
- 21323-21326
- ISSN
- 0021-9258
- Cited by
- 286
- References
- 0
- Language
- en
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