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Cited by 34Ubiquitin and proteasome pathwaysGenomics and Chromatin DynamicsHeat shock proteins research

The 26S proteasome and initiation of gene transcription.

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Durairaj, Geetha, Kaiser, Peter·2014·Biomolecules
DOI 10.3390/biom4030827PMC PMC4192674
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Abstract

Transcription activation is the foremost step of gene expression and is modulated by various factors that act in synergy. Misregulation of this process and its associated factors has severe effects and hence requires strong regulatory control. In recent years, growing evidence has highlighted the 26S proteasome as an important contributor to the regulation of transcription initiation. Well known for its role in protein destruction, its contribution to protein synthesis was initially viewed with skepticism. However, studies over the past several years have established the proteasome as an important component of transcription initiation through proteolytic and non-proteolytic activities. In this review, we discuss findings made so far in understanding the connections between transcription initiation and the 26S proteasome complex.

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  • The 26S proteasome degrades polyubiquitinated proteins and plays an important role in many cellular processes, such as proteostasis and transcriptional control.

    “Also, the 26S proteasome has the capacity to degrade polyubiquitinated proteins and plays an important role in many cellular processes, such as proteostasis and transcriptional control (Durairaj and Kaiser, 2014; Gallagher et al., 2014).”

    From Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy (2020) · cites this paper as Durairaj and Kaiser, 2014

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Cited by

Sorted by citations

Authors
Durairaj, G., & Kaiser, P.
Affiliations
University of California, Irvine (US)
Corresponding author
Kaiser, Peter
ORCID
Kaiser, Peter
Venue
Biomolecules
Publisher
MDPI AG
Published
2014-09-10
Volume
4
Issue
3
Pages
827-847
ISSN
2218-273X (ISSN-L)
DOI
10.3390/biom4030827
PMC
PMC4192674
OpenAlex
W1974350858
Cited by
34
References
5
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 2 · 2017: 5 · 2016: 3 · 2015: 4
FWCI
0.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomolecules (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (CA-112560, R01CA112560)
  • National Institute of General Medical Sciences (R01GM066164, GM-066164, R56GM066164)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Keywords
26S proteasome, transcription initiation, transcriptional regulation, gene expression regulation, protein degradation
MeSH terms
Humans, Transcriptional Activation, Proteasome Endopeptidase Complex, Transcription Initiation, Genetic

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