Degradation of HER2 by Cbl-Based Chimeric Ubiquitin Ligases

THE UBIQUITIN SYSTEM

Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840 · see citing works

Untangling the ErbB signalling network

Yarden, Y., & Sliwkowski, M. X. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052073 · Cited by 6,974 · see citing works

The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction

Glickman, M. H., & Ciechanover, A. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00027.2001 · Cited by 4,216 · see citing works

ERBB receptors and cancer: the complexity of targeted inhibitors

Hynes, N. E., & Lane, H. A. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1609 · Cited by 3,313 · see citing works

The ErbB signaling network: receptor heterodimerization in development and cancer

Olayioye, M. A., Neve, R. M., Lane, H. A., & Hynes, N. E. (2000) · The EMBO Journal · doi:10.1093/emboj/19.13.3159 · Cited by 2,438 · see citing works

Protein modules and signalling networks

Pawson, T. (1995) · Nature · doi:10.1038/373573a0 · Cited by 2,420 · see citing works

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.Preprint

Polyak, K., Kato, J., Solomon, M., Sherr, C., Massagué, J., Roberts, J., & Koff, A. (1994) · Genes & Development · doi:10.1101/gad.8.1.9 · Cited by 1,949 · see citing works

Tyrosine Kinases as Targets for Cancer Therapy

Krause, D. S., & Etten, R. A. V. (2005) · New England Journal of Medicine · doi:10.1056/nejmra044389 · Cited by 1,376 · see citing works

Status of Epidermal Growth Factor Receptor Antagonists in the Biology and Treatment of Cancer

Mendelsohn, J. M., & Baselga, J. M. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.01.504 · Cited by 1,257 · see citing works

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene.

Muller, W., Sinn, E., Pattengale, P., Wallace, R., & Leder, P. (1988) · Cell · doi:10.1016/0092-8674(88)90184-5 · Cited by 1,246 · see citing works

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

Guy, C. T., Webster, M. A., Schaller, M. D., Parsons, T. J., Cardiff, R. D., & Muller, W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10578 · Cited by 1,193 · see citing works

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

Joazeiro, C. A. P., Wing, S. S., Huang, H.-K., Leverson, J. D., Hunter, T. R., & Liu, Y. (1999) · Science · doi:10.1126/science.286.5438.309 · Cited by 1,036 · see citing works

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

Haglund, K., Sigismund, S., Polo, S., Szymkiewicz, I., Fiore, P. P. D., & Đikić, I. (2003) · Nature Cell Biology · doi:10.1038/ncb983 · Cited by 813 · see citing works

Cbl: many adaptations to regulate protein tyrosine kinases

Thien, C. B. F., & Langdon, W. Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35067100 · Cited by 628 · see citing works

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

Matsui, Y., Halter, S. A., Holt, J. T., Hogan, B. L. M., & Coffey, R. J. (1990) · Cell · doi:10.1016/0092-8674(90)90077-r · Cited by 440 · see citing works

Biologic and therapeutic role of HER2 in cancer

Ménard, S., Pupa, S. M., Campiglio, M., & Tagliabue, E. (2003) · Oncogene · doi:10.1038/sj.onc.1206779 · Cited by 433 · see citing works

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

Xu, W., Marcu, M. G., Yuan, X., Mimnaugh, E. G., Patterson, C., & Neckers, L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202365899 · Cited by 431 · see citing works

Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation

Sakamoto, K. M., Kim, K. B., Verma, R., Ransick, A., Stein, B., Crews, C. M., & Deshaies, R. J. (2003) · Molecular & Cellular Proteomics · doi:10.1074/mcp.t300009-mcp200 · Cited by 425 · see citing works

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

Marmor, M. D., & Yarden, Y. (2004) · Oncogene · doi:10.1038/sj.onc.1207390 · Cited by 382 · see citing works

Phosphotyrosine-binding domains in signal transduction

Yaffe, M. B. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm759 · Cited by 366 · see citing works

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

Murphy, M. A., Schnall, R., Venter, D. J., Barnett, L. D., Bertoncello, I., Thien, C. B. F., Langdon, W. Y., & Bowtell, D. D. L. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4872 · Cited by 361 · see citing works

Sensitivity of Mature ErbB2 to Geldanamycin Is Conferred by Its Kinase Domain and Is Mediated by the Chaperone Protein Hsp90

Xu, W., Mimnaugh, E. G., Rosser, M. F. N., Nicchitta, C. V., Marcu, M. G., Yarden, Y., & Neckers, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006864200 · Cited by 350 · see citing works

Negative receptor signalling.

Dikič, I., & Giordano, S. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00004-8 · Cited by 342 · see citing works

Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

Mosesson, Y., Shtiegman, K., Katz, M., Zwang, Y., Vereb, G., Szöllõsi, J., & Yarden, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300096200 · Cited by 338 · see citing works

Interaction of Phosphatidylinositol 3-Kinase-Associated p85 with Epidermal Growth Factor and Platelet-Derived Growth Factor Receptors

Hu, P. J., Margolis, B. L., Skolnik, E. Y., Lammers, R., Ullrich, A., & Schlessinger, J. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.3.981 · Cited by 322 · see citing works

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

Meng, W., Sawasdikosol, S., Burakoff, S. J., & Eck, M. J. (1999) · Nature · doi:10.1038/18050 · Cited by 306 · see citing works

The Cbl family proteins: Ring leaders in regulation of cell signaling

Swaminathan, G., & Tsygankov, A. Y. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20694 · Cited by 289 · see citing works

Therapeutic and diagnostic implications of Hsp90 activation

Kamal, A., Boehm, M. F., & Burrows, F. J. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.04.006 · Cited by 280 · see citing works

Ubiquitin‐dependent internalization and down‐regulation of plasma membrane proteins

Hicke, L. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.14.9409540 · Cited by 271 · see citing works

Involvement of pp60c-src with two major signaling pathways in human breast cancer.

Luttrell, D. K., Lee, A., Lansing, T. J., Crosby, R. M., Jung, K., Willard, D., Luther, M., Rodriguez, M., Berman, J., & Gilmer, T. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.83 · Cited by 271 · see citing works

ErbB-1 and ErbB-2 Acquire Distinct Signaling Properties Dependent upon Their Dimerization Partner

Olayioye, M. A., Graus-Porta, D., Beerli, R. R., Rohrer, J., Gay, B., & Hynes, N. E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5042 · Cited by 262 · see citing works

Epidermal Growth Factor Receptors Harboring Kinase Domain Mutations Associate with the Heat Shock Protein 90 Chaperone and Are Destabilized following Exposure to Geldanamycins

Shimamura, T., Lowell, A. M., Engelman, J. A., & Shapiro, G. I. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0933 · Cited by 259 · see citing works

Escape from Cbl-mediated downregulation

Peschard, P., & Park, M. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00136-3 · Cited by 235 · see citing works

The erbB Family: Targets for Therapeutic Development Against Cancer and Therapeutic Strategies Using Monoclonal Antibodies and Tyrosine Kinase Inhibitors

Rowinsky, E. K. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.55.091902.104433 · Cited by 210 · see citing works

ErbB2 Degradation Mediated by the Co-chaperone Protein CHIP

Zhou, P., Fernandes, N. D., Dodge, I. L., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209640200 · Cited by 201 · see citing works

Heregulin-dependent Activation of Phosphoinositide 3-Kinase and Akt via the ErbB2/ErbB3 Co-receptor

Hellyer, N. J., Kim, M.-S., & Koland, J. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102079200 · Cited by 154 · see citing works

Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins.

Levkowitz, G., Klapper, L. N., Tzahar, E., Freywald, A., Sela, M., & Yarden, Y. (1996) · PubMed · Cited by 154 · see citing works

The Evolutionarily Conserved N-terminal Region of Cbl Is Sufficient to Enhance Down-regulation of the Epidermal Growth Factor Receptor

Lill, N. L., Douillard, P., Awwad, R. A., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.367 · Cited by 142 · see citing works

Beyond the RING: CBL proteins as multivalent adapters

Tsygankov, A. Y., Teckchandani, A. M., Feshchenko, E. A., & Swaminathan, G. (2001) · Oncogene · doi:10.1038/sj.onc.1204781 · Cited by 124 · see citing works

Inhibition of Breast and Ovarian Tumor Growth through Multiple Signaling Pathways by Using Retrovirus-mediated Small Interfering RNA against Her-2/neu Gene Expression

Yang, G. S., Cai, K. Q., Thompson-Lanza, J. A., Bast, R. C., & Liu, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311153200 · Cited by 114 · see citing works

Epidermal Growth Factor Receptor Activation under Oxidative Stress Fails to Promote c-Cbl Mediated Down-regulation

Ravid, T., Sweeney, C. A., Gee, P., Carraway, K. L., & Goldkorn, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204677200 · Cited by 106 · see citing works

Interaction of Phosphatidylinositol 3-Kinase-Associated p85 with Epidermal Growth Factor and Platelet-Derived Growth Factor Receptors

Hu, P. J., Margolis, B. L., Skolnik, E. Y., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.3.981-990.1992 · Cited by 94 · see citing works

Antitumor activity of HER-2 inhibitors

Rabindran, S. K. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.11.015 · Cited by 87 · see citing works

Aberrations of the G1- and G1/S-regulating genes in human cancer

Bártková, J., Lukas, J., & Bártek, J. (1997) · Springer eBooks · doi:10.1007/978-1-4615-5371-7_16 · Cited by 84 · see citing works

Structural Determinants of the Interaction between the erbB2 Receptor and the Src Homology 2 Domain of Grb7

Janes, P. W., Lackmann, M., Church, W. B., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8490 · Cited by 81 · see citing works

Using Natural Product Inhibitors to Validate Hsp90 as a Molecular Target in Cancer

Neckers, L. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/156802606777811979 · Cited by 75 · see citing works

Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1

Zsebik, B., Citri, A., Isola, J. J., Yarden, Y., Szöllõsi, J., & Vereb, G. (2005) · Immunology Letters · doi:10.1016/j.imlet.2005.11.018 · Cited by 75 · see citing works

Mini ReviewNegative regulation of PTK signalling by Cbl proteins

Thien, C. B. F., & Langdon, W. Y. (2005) · Growth Factors · doi:10.1080/08977190500153763 · Cited by 67 · see citing works

Eradication of pathogenic β-catenin by Skp1/Cullin/F box ubiquitination machinery

Su, Y., Ishikawa, S., Kojima, M., & Liu, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2133261100 · Cited by 58 · see citing works

Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase.

Ricci, A. L., Lanfrancone, L., Chiari, R., et al. (1995) · PubMed · Cited by 58 · see citing works

Geldanamycins Trigger a Novel Ron Degradative Pathway, Hampering Oncogenic Signaling

Germano, S., Barberis, D., Santoro, M. M., Penengo, L., Citri, A., Yarden, Y., & Gaudino, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602014200 · Cited by 32 · see citing works

PROTAC targeted protein degraders: the past is prologue

Békés, M., Langley, D. R., & Crews, C. M. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00371-6 · Cited by 3,395 · see citing works

Targeted Degradation of KRAS by an Engineered Ubiquitin Ligase Suppresses Pancreatic Cancer Cell Growth <i>In Vitro</i> and <i>In Vivo</i>

Ma, Y., Gu, Y., Zhang, Q., Han, Y., Yu, S., Lu, Z., & Chen, J. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0650 · Cited by 55 · see citing works

A recombinant chimeric protein specifically induces mutant KRAS degradation and potently inhibits pancreatic tumor growth

Pan, T., Zhang, Y., Zhou, N., He, X., Chen, C., Liang, L., Duan, X., Lin, Y., Wu, K., & Zhang, H. (2016) · Oncotarget · doi:10.18632/oncotarget.9996 · Cited by 21 · see citing works

Herpes Simplex Virus Type 1 Immediate-Early Protein ICP0 and Its Isolated RING Finger Domain Act as Ubiquitin E3 Ligases In Vitro

Boutell, C., Sadis, S., & Everett, R. D. (2002) · Journal of Virology · doi:10.1128/jvi.76.2.841-850.2002 · Cited by 386 · see citing works

Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation

Han, Y., Li, R., Gao, J., Miao, S., & Wang, L. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.10.109 · Cited by 21 · see citing works

Alphaherpesvirus Proteins Related to Herpes Simplex Virus Type 1 ICP0 Induce the Formation of Colocalizing, Conjugated Ubiquitin

Parkinson, J., & Everett, R. D. (2001) · Journal of Virology · doi:10.1128/jvi.75.11.5357-5362.2001 · Cited by 27 · see citing works

Structure of LNX1:Ubc13 ~ Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1

Nayak, D., & Sivaraman, J. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.02.016 · Cited by 13 · see citing works

A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125

Bijlmakers, M.-J., Teixeira, J. M. C., Boer, R., Mayzel, M., Puig-Sàrries, P., Karlsson, G., Coll, M., Pons, M., & Crosas, B. (2016) · Scientific Reports · doi:10.1038/srep29232 · Cited by 28 · see citing works