Rheb Binds Tuberous Sclerosis Complex 2 (TSC2) and Promotes S6 Kinase Activation in a Rapamycin- and Farnesylation-dependent Manner

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Identification of the Tuberous Sclerosis Gene TSC1 on Chromosome 9q34

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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Regulation of translation initiation by FRAP/mTOR

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Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Garami, A., Zwartkruis, F. J. T., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., & Thomas, G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00220-x · Cited by 1,043

Mammalian TOR: a homeostatic ATP sensor

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Akt regulates growth by directly phosphorylating Tsc2

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., & Pan, D. (2003) · Nature Cell Biology · doi:10.1038/ncb999 · Cited by 924

Upregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex

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Downstream the mTOR: S6 Kinases between Divergence and Redundancy

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Dual-Product Synergistically Enhanced Colorimetric Assay for Sensitive Detection of Lipid Transferase Activity

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Magnetic Resonance Imaging and Characterization of Spontaneous Lesions in a Transgenic Mouse Model of Tuberous Sclerosis as a Model for Endothelial Cell-Based Transgene Delivery

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Farnesyl Transferase Inhibitors

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Liquid biopsy-derived extracellular vesicle protein biomarkers for diagnosis and prognostic assessment of lung squamous cell carcinoma

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The rapamycin sTORy: 50-year journey from Easter Island to the frontiers of biology and medicine

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MAP4K3 inhibits Sirtuin-1 to repress the LKB1–AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex

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mTORC1 Signaling and Hypoxia

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Biochemical and biological characterization of tumor-associated mutations of p110alpha.

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Tuberous Sclerosis Complex: Future Research Directions

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mRNA Translation in Diabetic Nephropathy

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Tuberous Sclerosis Complex: mutations, functions and phenotypes

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Defining the In Vivo Role of mTORC1 in Thyrocytes by Studying the TSC2 Conditional Knockout Mouse Model

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Molecular Characterization and Tissue-specific Expression of a Novel FKBP38 Gene in the Cashmere Goat (Capra hircus)

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Expression, purification, crystallization and preliminary structural characterization of the GTPase domain of human Rheb

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The role of amino acids in liver protein metabolism under a high protein diet : identification of amino acids signal and associated transduction pathways

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Structural basis for growth factor and nutrient signal integration on the lysosomal membrane by mTORC1Preprint

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The impact of exercise on cardiovascular system: Molecular signaling pathway and cardiac adaptations

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Carbonic Anhydrase 2 Deletion Delays the Growth of Kidney Cysts Whereas Foxi1 Deletion Completely Abrogates Cystogenesis in TSC

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An Insight of Scientific Developments in TSC for Better Therapeutic Strategy

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Ras Family Proteins

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Structure and Function of the mTOR Activator Rheb

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Blocking the Farnesyl Pocket of PDEδ Reduces Rheb-Dependent mTORC1 Activation and Survival of Tsc2-Null Cells

Armijo, M. E., Escalona, E., Peña, D., Farías, A., Morı́n, V., Baumann, M., Klebl, B., Pincheira, R., & Castro, A. F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.912688 · Cited by 2

Renal Transcriptome and Metabolome in Mice with Principal Cell-Specific Ablation of the Tsc1 Gene: Derangements in Pathways Associated with Cell Metabolism, Growth and Acid Secretion

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The Role of Target of Rapamycin Signaling in Tuberous Sclerosis Complex

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Modeling Tuberous Sclerosis Complex: Brain Development and Hyperexcitability

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AMPK Signaling Regulates Epithelioid Hemangioendothelioma Cell Growth

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HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

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mTORC1: A Signaling Integration Node Involved in Cell Growth

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Expanding Our Knowledge of Menstrual Irregularities Reported by Females With Tuberous Sclerosis Complex

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TSC2 gene characterization and mechanism of ammonia nitrogen stress inhibiting growth through AMPK/mTOR pathway mediated by TSC2 in Megalobrama amblycephala

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The PI3K Pathway in Colorectal Cancers

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Ras Family G-Proteins in Saccharomyces Cerevisiae and Schizosaccharomyces Pombe

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Animal Models of TSC: Insights from Drosophila

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Metadichol Modulates the DDIT4-mTOR-p70S6K Axis: A Novel Therapeutic Strategy for mTOR-Driven DiseasesPreprint

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Molecular Pathology and Diagnostics of Pancreatic Endocrine Neoplasms

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CHARACTERIZATION AND TREATMENT OF A NOVEL MOUSE MODEL OF TSC-ASSOCIATED AUTISM

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Prevalence of Premature Ovarian Failure in Women with Tuberous Sclerosis

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The Role of AMPK in Viral Infection

Moser, T. S. (2011) · ScholarlyCommons (University of Pennsylvania)

Targeting the mTOR Pathway for Tumor Therapeutics

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The role of the PDK1/PKB kinases in regulating neuronal survival and differentiation: characterization of the PDK1 K465E knock-in mice

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Defining RCE1 and ICMT as Therapeutic Targets in K-RAS-induced Cancer

Wahlstrom, A. M. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Combinations of Cytotoxic Drugs, Ionizing Radiation, and Mammalian Target of Rapamycin (mTOR) Inhibitors

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The link between the centrosome, TSC disease and epithelial differentiation

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Apoptose precoce, proliferação celular sincrônica tardia e perfil de expressão de proteínas ao complexo esclerose tuberosa e às doenças renais policísticas durante tubulogênese in vitro

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The tumor suppressing roles of tissue structure in cervical cancer development

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Recent Advances in the Pathogenesis of Pancreatic Endocrine Neoplasms

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mTOR regulates Aurora A via enhancing protein stability

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Function of mTOR complex 1 and 2 in Skeletal Muscle

Fakultät, P.-N. (2009)

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Glial Tumors in Neurofibromatosis and Tuberous Sclerosis Complex

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The Small Gtpase Rab35 Is A Novel Oncogenic Regulator Of Pi3K/Akt Signaling

Wheeler, D. B. (2015) · eCommons (Cornell University)

Regulation of mRNA translation in renal physiology and

Kasinath, B. S., Féliers, D., Sataranatarajan, K., Choudhury, G. G., Lee, M. J., & Mariappan, M. M. (2009)

Homeostatic role of acid sphingomyelinase in mtor signaling and autophagy

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Role of mechanistic Target of Rapamycin (mTOR) signaling in the crustacean molting gland

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Key factors in mTOR regulation

Jiang, X. B. (2010)

Autophagy Regulation by Lipid Factors with Implications for Parkinson's Disease

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Mecanismes de toxicitat de la dopamina en cèl·lules de neuroblastoma humà SH-SY5Y

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Faculty Opinions recommendation of Coordination of Rheb lysosomal membrane interactions with mTORC1 activation.

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Unravelling novel functions of the MTOR network across subcellular compartments

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G-proteins | Ras Family

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Role of Akt Signaling and its Downstream Pathways in Wood Frog Freeze Tolerance

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mTORC1: Upstream and Downstream

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Dysregulation of Acid Ceramidase-mediated Sphingolipid Metabolism Contributes to Tumor Progression in Tuberous Sclerosis ComplexPreprint

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Data from Selective Inhibition of Growth of Tuberous Sclerosis Complex 2–Null Cells by Atorvastatin Is Associated with Impaired Rheb and Rho GTPase Function and Reduced mTOR/S6 Kinase Activity

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Data from Selective Inhibition of Growth of Tuberous Sclerosis Complex 2–Null Cells by Atorvastatin Is Associated with Impaired Rheb and Rho GTPase Function and Reduced mTOR/S6 Kinase Activity

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Data from Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice

Balasis, M. E., Forinash, K. D., Chen, Y. A., Fulp, W. J., Coppola, D., Hamilton, A. D., Cheng, J. Q., & Sebti, S. M. (2023) · doi:10.1158/1078-0432.c.6519345.v1

Data from Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice

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Supplementary Table from Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma

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Interplay between Phospholipid signaling and autophagy

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Esclerosis Tuberosa: patogénesis molecular y modelos animales

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Unraveling the Binding Mode of TSC2–Rheb through Protein Docking and Simulations

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Réseau de contrôle de la traduction par l'Hormone Folliculo-Stimulante

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Tuberous sclerosis complex : molecular target of mTORC1 and the role of S6Ks

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EIF4EBP1 in Breast Cancer: Translational Control, Regulatory Networks, and Therapeutic Frontiers

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Enhancement of recombinant protein production in human embryonic kidney 293 T and Chinese hamster ovary cells via remodeling of the mTOR signaling pathway

Li, H.-H., Yan, S.-L., Chan, Y.-H., Hung, H., Wang, R., Yu, J., & Lai, M. (2026) · Biochemical Engineering Journal · doi:10.1016/j.bej.2026.110419

Mechanisms of Rapamycin Toxicity in Pancreatic Beta Cells

Barlow, A. D. (2011) · Figshare

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

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Biochemical and Functional Characterizations of Small GTPase Rheb and TSC2 GAP Activity

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Regulation of B-Raf Kinase Activity by Tuberin and Rheb Is Mammalian Target of Rapamycin (mTOR)-independent

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Measurements of TSC2 GAP Activity Toward Rheb

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