Rheb Binds Tuberous Sclerosis Complex 2 (TSC2) and Promotes S6 Kinase Activation in a Rapamycin- and Farnesylation-dependent Manner

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Identification of the Tuberous Sclerosis Gene TSC1 on Chromosome 9q34

Slegtenhorst, M. V., Hoogt, R. D., Hermans, C., Nellist, M., Janssen, B., Verhoef, S., Lindhout, D., Ouweland, A. V. D., Halley, D., Young, J., et al. (1997) · Science · doi:10.1126/science.277.5327.805 · Cited by 1,648

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00568-3 · Cited by 1,555

Regulation of translation initiation by FRAP/mTOR

Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Garami, A., Zwartkruis, F. J. T., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., & Thomas, G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00220-x · Cited by 1,043

Mammalian TOR: a homeostatic ATP sensor

Dennis, P. B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S. C., & Thomas, G. (2001) · Science · doi:10.1126/science.1063518 · Cited by 962

Akt regulates growth by directly phosphorylating Tsc2

Potter, C. J., Pedraza, L. G., & Xu, T. (2002) · Nature Cell Biology · doi:10.1038/ncb840 · Cited by 959

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., & Pan, D. (2003) · Nature Cell Biology · doi:10.1038/ncb999 · Cited by 924

Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin

Persaud, A. K., Cormerais, Y., Pouysségur, J., & Rotin, D. (2018) · Journal of Cell Science · doi:10.1242/jcs.211755 · Cited by 30

Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice

Jeong, A., Cheng, S., Zhong, R., Bennett, D. A., Bergö, M. O., & Li, L. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01231-5 · Cited by 31

Identification and Characterization of RHEBL1, a Novel Member of Ras Family, which Activates Transcriptional Activities of NF-Kappa B

Yuan, J., Shan, Y., Chen, X., Tang, W., Luo, K., Ni, J., Wan, B., & Yu, L. (2005) · Molecular Biology Reports · doi:10.1007/s11033-005-0984-x · Cited by 32

Is there a future for prenyltransferase inhibitors in cancer therapy?

Holstein, S. A., & Hohl, R. J. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.06.013 · Cited by 30

Targeting the Phosphatidylinositol 3-Kinase Pathway in Airway Smooth Muscle

Krymskaya, V. P. (2007) · BioDrugs · doi:10.2165/00063030-200721020-00003 · Cited by 30

Ribosomal Protein S6 Kinase Is a Critical Downstream Effector of the Target of Rapamycin Complex 1 for Long-term Facilitation in Aplysia

Weatherill, D. B., Dyer, J., & Sossin, W. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.071142 · Cited by 30

Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bɛ mRNA translation and protein synthesis

Kubica, N., Crispino, J. L., Gallagher, J. W., Kimball, S. R., & Jefferson, L. S. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.04.010 · Cited by 32

Quantification of the effect of amino acids on an integrated mTOR and insulinsignaling pathway

Vinod, P. K. U., & Venkatesh, K. V. (2009) · Molecular BioSystems · doi:10.1039/b816965a · Cited by 30

Differential IKK/NF-κB Activity Is Mediated by TSC2 through mTORC1 in PTEN-Null Prostate Cancer and Tuberous Sclerosis Complex Tumor Cells

Gao, Y., Gartenhaus, R. B., Lapidus, R. G., Hussain, A., Zhang, Y., Wang, X., & Dan, H. C. (2015) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-15-0213 · Cited by 31

Gastroenteropancreatic neuroendocrine neoplasms: epidemiology, genetics, and treatment

Tan, B., Zhang, B., & Chen, H. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1424839 · Cited by 31

Retrospective Review of Combined Sirolimus and Simvastatin Therapy in Lymphangioleiomyomatosis

Taveira‐DaSilva, A. M., Jones, A. M., Julien-Williams, P. A., Stylianou, M. P., & Moss, J. (2014) · CHEST Journal · doi:10.1378/chest.14-0758 · Cited by 28

Renal and liver tumors inTsc2+/− mice, a model of tuberous sclerosis complex, do not respond to treatment with atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor

Finlay, G. A., Malhowski, A. J., Pollizzi, K. N., Malinowska-Kołodziej, I., & Kwiatkowski, D. J. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0055 · Cited by 28

mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases

Sandoval, M. C., Heberle, A. M., Rehbein, U., Barile, C., Pittol, J. M. R., & Thedieck, K. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.761333 · Cited by 30

Rheb promotes cancer cell survival through p27Kip1‐dependent activation of autophagy

Campos, T., Ziehe, J., Palma, M., Escobar, D., Tapia, J. C., Pincheira, R., & Castro, A. F. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22272 · Cited by 29

Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations

Sun, W., Zhu, Y. J., Wang, Z., Zhong, Q., Gao, F., Lou, J., Gong, W., & Xu, W. (2013) · Nature Communications · doi:10.1038/ncomms3135 · Cited by 27

A logic-based method to build signaling networks and propose experimental plans

Rougny, A., Gloaguen, P., Gallay, N., Reiter, É., Crépieux, P., Anne Poupon, B., & Froidevaux, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-26006-2 · Cited by 27

Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity

Yao, Y., Hong, S., Ikeda, T., Mori, H., MacDougald, O. A., Nada, S., Okada, M., & Inoki, K. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.10.004 · Cited by 28

VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation

Mohan, N., Shen, Y., Dokmanovic, M., Endo, Y., Hirsch, D. S., & Wu, W. J. (2016) · Oncotarget · doi:10.18632/oncotarget.10469 · Cited by 28

Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro

Yan, X., Sun, Q., Ji, J., Zhu, Y., Liu, Z., & Zhong, Q. (2012) · Autophagy · doi:10.4161/auto.8.2.18563 · Cited by 29

Mouse Models of Tuberous Sclerosis Complex

Scheidenhelm, D. K., & Gutmann, D. H. (2004) · Journal of Child Neurology · doi:10.1177/08830738040190091401 · Cited by 27

Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe

van Slegtenhorst, M., Mustafa, A., & Henske, E. P. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi317 · Cited by 27

Lysosomal glucose sensing and glycophagy in metabolism

Mancini, M. C., Noland, R. C., Collier, J. J., Burke, S. J., Stadler, K., & Heden, T. D. (2023) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2023.07.008 · Cited by 26

Deregulation of cell growth and malignant transformation.

Šulić, S., Panić, L., Đikić, I., & Volarević, S. (2005) · PubMed · Cited by 27

Analysis of TSC1 truncations defines regions involved in TSC1 stability, aggregation and interaction

Hoogeveen-Westerveld, M., Exalto, C., Maat-Kievit, A., van den Ouweland, A., Halley, D., & Nellist, M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.06.004 · Cited by 25

CRISPR/Cas9 genome-wide loss-of-function screening identifies druggable cellular factors involved in sunitinib resistance in renal cell carcinoma

Makhov, P. B., Sohn, J. A., Serebriiskii, I. G., Fazliyeva, R., Khazak, V., Boumber, Y., Uzzo, R. G., & Kolenko, V. M. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01087-x · Cited by 25

Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue

Hu, Y., Robichaux, W. G., Mei, F. C., Kim, E. R., Wang, H., Tong, Q., Jin, J., Xu, M., Chen, J., & Cheng, X. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.01034-15 · Cited by 24

Use of APO2L/TRAIL with mTOR inhibitors in the treatment of glioblastoma multiforme

Panner, A., Parsa, A. T., & Pieper, R. O. (2006) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.6.9.1313 · Cited by 25

Polymerized Collagen Inhibits Fibroblast Proliferation via a Mechanism Involving the Formation of a β1 Integrin-Protein Phosphatase 2A-Tuberous Sclerosis Complex 2 Complex That Suppresses S6K1 Activity

Hong, X., Nho, R. S., Kleidon, J., Kahm, J., & Henke, C. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707489200 · Cited by 24

Abnormal giant cells in the cerebral lesions of tuberous sclerosis complex

Mizuguchi, M. (2007) · Congenital Anomalies · doi:10.1111/j.1741-4520.2006.00134.x · Cited by 24

Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma

Wu, H., Wei, M., Li, Y., Ma, Q., & Zhang, H. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.910543 · Cited by 26

Adipocytes contain a novel complex similar to the tuberous sclerosis complex

Gridley, S., Chavez, J. A., Lane, W. S., & Lienhard, G. E. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.01.002 · Cited by 23

Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK

Kaur, H., & Moreau, R. F. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109842 · Cited by 24

Suppression of mTORC1 activation in acid-α-glucosidase-deficient cells and mice is ameliorated by leucine supplementation

Shemesh, A., Wang, Y., Yang, Y., Yang, G., Johnson, D., Backer, J., Pessin, J. E., & Zong, H. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00212.2014 · Cited by 23

Expressional Difference of RHEB, HDAC1, and WEE1 Proteins in the Stromal Tumors of the Breast and Their Significance in Tumorigenesis

Eom, M., Han, A., Lee, M. J., & Park, K. H. (2012) · Journal of Pathology and Translational Medicine · doi:10.4132/koreanjpathol.2012.46.4.324 · Cited by 22

The roles of MTOR and miRNAs in endothelial cell senescence

Khor, E.-S., & Wong, P. (2020) · Biogerontology · doi:10.1007/s10522-020-09876-w · Cited by 22

The Role of Tuberin in Cellular Differentiation: Are B‐Raf and MAPK Involved?

Karbowniczek, M., & Henske, E. P. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1339.045 · Cited by 22

Mapping of mTOR drug targets: Featured platforms for anti-cancer drug discovery

Shams, R. S., Ito, Y., & Miyatake, H. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108012 · Cited by 22

Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous sclerosis complex and cancer

Lacher, M. D., Pincheira, R., & Castro, A. F. (2011) · Small GTPases · doi:10.4161/sgtp.2.4.16703 · Cited by 21

Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma

Javaid, S., Schaefer, A., Goodwin, C. M., Nguyen, V. V., Massey, F. L., Pierobon, M., Gambrell-Sanders, D., Waters, A. M., Lambert, K. N., Diehl, J. N., et al. (2022) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0142 · Cited by 21

The Ragulator complex: delving its multifunctional impact on metabolism and beyond

Tsujimoto, K., Takamatsu, H., & Kumanogoh, A. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00278-2 · Cited by 22

Targeting Rb inactivation in cancers by synthetic lethality.

Gordon, G. M., & Du, W. (2011) · PubMed · Cited by 20

Translational control and cancer therapy

Mavrakis, K. J., & Wendel, H. (2008) · Cell Cycle · doi:10.4161/cc.7.18.6683 · Cited by 20

A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection

Yi, P., Liang, Y., Yuan, D. M. K., Jie, Z., Kwota, Z., Chen, Y., Cong, Y., Fan, X., & Sun, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-04260-0 · Cited by 21

TSC2 regulates tumor susceptibility to TRAIL‐mediated T‐cell killing by orchestrating mTOR signaling

Lin, C., Traets, J. J. H., Vredevoogd, D. W., Visser, N. L., & Peeper, D. S. (2023) · The EMBO Journal · doi:10.15252/embj.2022111614 · Cited by 19

Optimizing treatments for lymphangioleiomyomatosis

Taveira‐DaSilva, A. M., & Moss, J. (2012) · Expert Review of Respiratory Medicine · doi:10.1586/ers.12.26 · Cited by 19

Phase I Study of the Farnesyltransferase Inhibitor BMS-214662 Given Weekly in Patients with Solid Tumors

Papadimitrakopoulou, V., Agelaki, S., Tran, H. T., Kies, M. S., Gagel, R. F., Zinner, R., Kim, E. J.-H., Ayers, G. D., Wright, J., & Khuri, F. R. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1659 · Cited by 19

The TOR kinase pathway is relevant for nitrogen signaling and antagonism of the mycoparasite Trichoderma atroviride

Segreto, R., Bazafkan, H., Millinger, J., Schenk, M., Atanasova, L., Doppler, M., Bueschl, C., Boeckstaens, M., Diaz, S. S., Schreiner, U., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0262180 · Cited by 17

The variation of AkT/TSC1-TSC1/mTOR signal pathway in hepatocytes after partial hepatectomy in rats.

Chen, P., Yan, H.-T., Chen, Y., & He, Z.-L. (2009) · Experimental and molecular pathology (Print) · doi:10.1016/j.yexmp.2009.01.013 · Cited by 20

Inhibition of MAPK pathway is essential for suppressing Rheb-Y35N driven tumor growth

Wang, Y., Hong, X., Wang, J., Yin, Y., Zhang, Y., Zhou, Y., Piao, H.-L., Liang, Z., Zhang, L., Li, G., et al. (2016) · Oncogene · doi:10.1038/onc.2016.246 · Cited by 17

Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington’s Disease

Child, D. D., Lee, J. H., Pascua, C. J., Chen, Y. H., Monteys, A. M., & Davidson, B. L. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.117 · Cited by 17

Tuberin Regulates Prostaglandin Receptor–Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells

Li, C., Liu, X., Yang, L., Zhang, E. Y., Medepalli, K., Masuda, K., Li, N., Wikenheiser‐Brokamp, K. A., Osterburg, A. R., Borchers, M. T., et al. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0077 · Cited by 17

Review: The PI3K-AKT-mTOR signal transduction pathway in canine cancer

Meuten, T., Dean, G. A., & Thamm, D. H. (2023) · Veterinary Pathology · doi:10.1177/03009858231207021 · Cited by 17

Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2‐null ELT3 cells: A potential treatment for lymphangioleiomyomatosis

Makovski, V., Haklai, R., & Kloog, Y. (2011) · International Journal of Cancer · doi:10.1002/ijc.26139 · Cited by 16

Experimental Approaches in Delineating mTOR Signaling

Qian, J., Su, S., & Liu, P. (2020) · Genes · doi:10.3390/genes11070738 · Cited by 17

Exploration of Aspergillus fumigatus Ras pathways for novel antifungal drug targets

Abdallah, Q. A., & Fortwendel, J. R. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00128 · Cited by 16

Effects of RhebL1 silencing on the mTOR pathway

Bonneau, A. R., & Parmar, N. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-0960-6 · Cited by 15

Light it up: Highly efficient multigene delivery in mammalian cells

Trowitzsch, S., Klumpp, M., Thoma, R., Carralot, J., & Berger, I. (2011) · BioEssays · doi:10.1002/bies.201100109 · Cited by 15

Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling

Nelson, N. C., & Clark, G. J. (2016) · Oncotarget · doi:10.18632/oncotarget.8447 · Cited by 15

Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia

Karp, J. E., & Lancet (2008) · Biologics · doi:10.2147/btt.s3485 · Cited by 15

mTOR signaling pathway

Yonezawa, K. (2004) · Hepatology Research · doi:10.1016/j.hepres.2004.08.011 · Cited by 14

mTORC1 silencing during intestinal epithelial Caco-2 cell differentiation is mediated by the activation of the AMPK/TSC2 pathway

Kaur, H., & Moreau, R. F. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.01.070 · Cited by 13

Clinical, cellular, and molecular characterisation of cardiac rhabdomyoma in tuberous sclerosis

Kindi, H. N. A., Ibrahim, A. M., Roshdy, M., Abdelghany, B. S., Yehia, D., Masoud, A. N., Simry, W., Aguib, Y., & Yacoub, M. H. (2021) · Cardiology in the Young · doi:10.1017/s1047951121000172 · Cited by 13

Signal integration in the (m)TORC1 growth pathway

Ramlaul, K., & Aylett, C. H. S. (2018) · Frontiers in Biology · doi:10.1007/s11515-018-1501-7 · Cited by 12

Autophagy, a Highly Regulated Intracellular System Essential to Skeletal Muscle Homeostasis — Role in Disease, Exercise and Altitude Exposure

Sanchez, A. M. J., Candau, R. B., Raibon, A., & Bernardi, H. (2015) · InTech eBooks · doi:10.5772/60698 · Cited by 13

Identification of tipifarnib sensitivity biomarkers in T-cell acute lymphoblastic leukemia and T-cell lymphoma

Alonso‐Alonso, R., Mondejar, R., Martı́nez, N., García‐Díaz, N., Pérez, C., Merino, D., Rodríguez, M., Esteve‐Codina, A., Fusté, B., Gut, M. O., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-63434-5 · Cited by 11

Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway

Makovski, V., Jacob‐Hirsch, J., Gefen-Dor, C., Shai, B., Ehrlich, M., Rechavi, G., & Kloog, Y. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.502 · Cited by 11

Farnesyl transferase inhibitor resistance probed by target mutagenesis

Raz, T., Nardi, V., Azam, M., Cortes, J. E., & Daley, G. Q. (2007) · Blood · doi:10.1182/blood-2006-12-064907 · Cited by 11

Characterization of AND‐34 Function and Signaling

Felekkis, K. N., Quilliam, L. A., & Lerner, A. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)07006-0 · Cited by 11

Statins markedly potentiate aminopeptidase inhibitor activity against (drug-resistant) human acute myeloid leukemia cells

Jansen, G., Al, M., Assaraf, Y. G., Kammerer, S., van Meerloo, J., Ossenkoppele, G. J., Cloos, J. J., & Peters, G. J. (2023) · Cancer Drug Resistance · doi:10.20517/cdr.2023.20 · Cited by 10

Structure of the human TSC:WIPI3 lysosomal recruitment complex

Bayly-Jones, C., Lupton, C. J., D’Andrea, L., Chang, Y., Jones, G. D., Steele, J. R., Venugopal, H., Schittenhelm, R. B., Halls, M. L., & Ellisdon, A. M. (2024) · Science Advances · doi:10.1126/sciadv.adr5807 · Cited by 10

Inhibiting the PI3K signaling pathway: buparlisib as a new targeted option in breast carcinoma

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Mammalian Target of Rapamycin (mTOR)

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Convergence of signaling pathways in mediating actions of leucine and IGF-1 on mTORC1 in L6 myoblasts

Roberson, P. A., Jefferson, L. S., & Kimball, S. R. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00183.2022 · Cited by 10

mTORC1 Activity in Psoriatic Lesions Is Mediated by Aberrant Regulation through the Tuberous Sclerosis Complex

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Decoding of novel missense TSC2 gene variants using in-silico methods

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Deacetylated αβ-tubulin acts as a positive regulator of Rheb GTPase through increasing its GTP-loading

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Unraveling the Role of Ras Homolog Enriched in Brain (Rheb1 and Rheb2): Bridging Neuronal Dynamics and Cancer Pathogenesis through Mechanistic Target of Rapamycin Signaling

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The Target of Rapamycin: Structure and Functions

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Evaluation of the Binding Kinetics of RHEB with mTORC1 by In-Cell and In Vitro Assays

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Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain

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Human TSC2 mutant cells exhibit aberrations in early neurodevelopment accompanied by changes in the DNA Methylome

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