Rheb Binds Tuberous Sclerosis Complex 2 (TSC2) and Promotes S6 Kinase Activation in a Rapamycin- and Farnesylation-dependent Manner

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Identification of the Tuberous Sclerosis Gene TSC1 on Chromosome 9q34

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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Regulation of translation initiation by FRAP/mTOR

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Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

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Mammalian TOR: a homeostatic ATP sensor

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Akt regulates growth by directly phosphorylating Tsc2

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

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Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent mannerPreprint

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A small molecule inhibitor of Rheb selectively targets mTORC1 signaling

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Deconvoluting mTOR biology

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Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast

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High Affinity for Farnesyltransferase and Alternative Prenylation Contribute Individually to K-Ras4B Resistance to Farnesyltransferase Inhibitors

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Structural Basis for the Unique Biological Function of Small GTPase RHEB

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Molecular Genetic Basis of Tuberous Sclerosis Complex: From Bench to Bedside

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Hamartin and tuberin: Working together for tumour suppression

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Non‐canonical functions of the tuberous sclerosis complex‐Rheb signalling axis

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Tuberous Sclerosis Tumor Suppressor Complex-like Complexes Act as GTPase-activating Proteins for Ral GTPases

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PI3K/mTORC1 activation in hamartoma syndromes: Therapeutic prospects

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LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap

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Rheb Inhibits C-Raf Activity and B-Raf/C-Raf Heterodimerization

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mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics

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Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner

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mTORC1‐ and mTORC2‐interacting proteins keep their multifunctional partners focused

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Distinct effects of single amino-acid changes to tuberin on the function of the tuberin–hamartin complex

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The Birt-Hogg-Dube and Tuberous Sclerosis Complex Homologs Have Opposing Roles in Amino Acid Homeostasis in Schizosaccharomyces pombe

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RalA Functions as an Indispensable Signal Mediator for the Nutrient-sensing System

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Point mutations of the mTOR-RHEB pathway in renal cell carcinoma

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Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers

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Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets

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Mammalian target of rapamycin

Meric‐Bernstam, F. (2004) · Seminars in Oncology · doi:10.1053/j.seminoncol.2004.10.013 · Cited by 75

Direct activation of mTOR in B lymphocytes confers impairment in B‐cell maturation andloss of marginal zone B cells

Benhamron, S., & Tirosh, B. (2011) · European Journal of Immunology · doi:10.1002/eji.201041336 · Cited by 73

Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation

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Paligenosis: Cellular Remodeling During Tissue Repair

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Cancer, type 2 diabetes, and ageing: news from flies and worms

Hafen, E. (2004) · Swiss Medical Weekly · doi:10.4414/smw.2004.09885 · Cited by 71

mTOR Signaling in Autophagy Regulation in the Kidney

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Abnormal Growth of Smooth Muscle–Like Cells in Lymphangioleiomyomatosis

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Estrogen-Induced Activation of Mammalian Target of Rapamycin Is Mediated via Tuberin and the Small GTPase Ras Homologue Enriched in Brain

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Signaling and other functions of lipids in autophagy: a review

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Mammalian target of rapamycin: master regulator of cell growth in the nervous system.

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Regulation of mRNA translation in renal physiology and disease

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Biology and treatment of metastatic gastrointestinal neuroendocrine tumors.

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Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells

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The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development

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Positive and Negative Regulation of TSC2 Activity and Its Effects on Downstream Effectors of the mTOR Pathway

Jozwiak, J., Jozwiak, S., Grzela, T., & Lazarczyk, M. (2005) · NeuroMolecular Medicine · doi:10.1385/nmm:7:4:287 · Cited by 63

Constitutively active Rheb induces oncogenic transformation

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Selective Inhibition of Growth of Tuberous Sclerosis Complex 2 –Null Cells by Atorvastatin Is Associated with Impaired Rheb and Rho GTPase Function and Reduced mTOR/S6 Kinase Activity

Finlay, G. A., Malhowski, A. J., Liu, Y., Fanburg, B. L., Kwiatkowski, D. J., & Toksoz, D. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1394 · Cited by 62

Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress

Patel, P. H., & Tamanoi, F. (2006) · Journal of Cell Science · doi:10.1242/jcs.03199 · Cited by 61

The small GTPase Rheb is a key component linking amino acid signaling and TOR in the nutritional pathway that controls mosquito egg development

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Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice

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mRNA Translation

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Local translation of TC10 is required for membrane expansion during axon outgrowth

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PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals

Ha, S. H., Kim, D., Kim, I.-S., Kim, J. H., Lee, M. N., Lee, H. J., Jong Heon, K. I. M., Jang, S. K., Suh, P., & Ryu, S. H. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.05.021 · Cited by 59

Lymphangioleiomyomatosis (LAM): Molecular insights lead to targeted therapies

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Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments inTsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways

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Farnesylthiosalicylic Acid Inhibits Mammalian Target of Rapamycin (mTOR) Activity Both in Cells andin Vitroby Promoting Dissociation of the mTOR-Raptor Complex

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Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide

Karp, J. E., Flatten, K. S., Feldman, E. J., Greer, J. M., Loegering, D. A., Ricklis, R. M., Morris, L. E., Ritchie, E. K., Smith, B. D., Ironside, V., et al. (2008) · Blood · doi:10.1182/blood-2008-08-172726 · Cited by 53

Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors

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Mechanisms Underlying Muscle Protein Imbalance Induced by Alcohol

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The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb– mTORC1 signalling and leads to chronic heart failure

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The changing face of a rare disease: lymphangioleiomyomatosis

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Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids

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Regulation of Microtubule-Dependent Protein Transport by the TSC2/Mammalian Target of Rapamycin Pathway

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Rheb and mammalian target of rapamycin in mitochondrial homoeostasis

Groenewoud, M. J., & Zwartkruis, F. J. T. (2013) · Open Biology · doi:10.1098/rsob.130185 · Cited by 51

Suppression of the mTOR-Raptor Signaling Pathway by the Inhibitor of Heat Shock Protein 90 Geldanamycin

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Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models

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The Neurobiology of Tuberous Sclerosis Complex

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In pulmonary lymphangioleiomyomatosis expression of progesterone receptor is frequently higher than that of estrogen receptor

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Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas

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Molecular activity of sirolimus and its possible application in tuberous sclerosis treatment

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Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila

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Structural basis for mTORC1 activation on the lysosomal membrane

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Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis

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AMPK‐mediated phosphorylation of murine p27 at T197 promotes binding of 14‐3‐3 proteins and increases p27 stability

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Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction

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Characterization of the Rheb‐mTOR Signaling Pathway in Mammalian Cells: Constitutive Active Mutants of Rheb and mTOR

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The Rheb Switch 2 Segment Is Critical for Signaling to Target of Rapamycin Complex 1

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The mTOR Pathway in Breast Cancer

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Mammalian Target of Rapamycin Complex 1 (mTORC1) Enhances Bortezomib-induced Death in Tuberous Sclerosis Complex (TSC)-null Cells by a c-MYC-dependent Induction of the Unfolded Protein Response

Babcock, J. T., Nguyen, H., He, Y., Hendricks, J. W., Wek, R. C., & Quilliam, L. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.431056 · Cited by 43

Tubers and tumors: rapamycin therapy for benign and malignant tumors

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Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling

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Rheb G-Proteins and the Activation of mTORC1

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Coordination of Rheb lysosomal membrane interactions with mTORC1 activation

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Structure of the TBC1D7–TSC1 complex reveals that TBC1D7 stabilizes dimerization of the TSC1 C-terminal coiled coil region

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Rap1 Promotes Multiple Pancreatic Islet Cell Functions and Signals through Mammalian Target of Rapamycin Complex 1 to Enhance Proliferation

Kelly, P., Bailey, C. L., Fueger, P. T., Newgard, C. B., Casey, P. J., & Kimple, M. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.069112 · Cited by 39

Rheb signaling and tumorigenesis: mTORC1 and new horizons

Armijo, M. E., Campos, T., Fuentes‐Villalobos, F., Palma, M., Pincheira, R., & Castro, A. F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29707 · Cited by 38

Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7)

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Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium

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Molecular Regulation of Skeletal Muscle Growth and Organelle Biosynthesis: Practical Recommendations for Exercise Training

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Aborted Autophagy and Nonapoptotic Death Induced by Farnesyl Transferase Inhibitor and Lovastatin

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