Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90

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Items 601–700 of 774

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  3. The Future of Epigenetics: Emerging Technologies and Clinical Applications
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  4. [Research Progress of Epigenetics in Pathogenesis and Treatment of Malignant Tumors].
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    Chie Ishikawa, Naoki Mori · 2020 · European Journal Of Haematology
  6. 4-Phenylbutyric acid attenuates amyloid-β proteotoxicity through activation of HSF-1 in an Alzheimer's disease model of the nematode Caenorhabditis elegans
    Stefan Baumanns, Felix Muehlemeyer, Laura C. Miesbauer, Jonas Baake, Eva M. Roloff, Daniel M. Beis, Uwe Wenzel · 2023 · Biochemical and Biophysical Research Communications
  7. Incidence and management of adverse events associated with panobinostat in the treatment of relapsed/refractory multiple myeloma
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  8. Class 1 HDAC and HDAC 6 inhibition inversely regulates CD 38 induction in myeloma cells via interferon‐α and ATRA
    Ariunzaya Bat‐Erdene, Shingen Nakamura, Asuka Oda, Masami Iwasa, Jumpei Teramachi, Mohannad Ashtar, Takeshi Harada, Hirokazu Miki, Hirofumi Tenshin, Masahiro Hiasa et al. · 2018 · British Journal of Haematology
  9. Current status of agents active against the T315I chronic myeloid leukemia phenotype
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  10. Inhibiteurs des histone-désacétylases : la régulation épigénétique sort de l’ombre
    Nicolas Pécuchet, Thomas Cluzeau, Constance Thibault, Nicolas Mounier, Stéphane Vignot · 2010 · Bulletin du Cancer
  11. Ultrasonic Atomizer-Driven Development of Biocompatible and Biodegradable Poly( d , l -lactide-co-glycolide) Nanocarrier-Encapsulated Suberoylanilide Hydroxamic Acid to Combat Brain Cancer
    Jaspreet Kaur, Shweta Jakhmola, Ravi Raj Singh, Bhavana Joshi, Hem Chandra Jha, Abhijeet Joshi · 2021 · ACS Applied Bio Materials
  12. HDAC Inhibition in Cancer Therapy: An Increasingly Intriguing Tale of Chemistry, Biology and Clinical Benefit
    Peter ten Holte, Kristof Van Emelen, Michel Janicot, Peter C.C. Fong, Johann Sebastian De Bono, Janine Arts · 2007 · Topics in medicinal chemistry
  13. Hybrid Histone Deacetylase Inhibitor: An Effective Strategy for Cancer Therapy
    Jiyong Wu, Jing Nie, Yepeng Luan, Yanjiao Ding · 2022 · Current Medicinal Chemistry
  14. Window-of-Opportunity Study of Valproic Acid in Breast Cancer Testing a Gene Expression Biomarker
    Adam Louis Cohen, Leigh A. Neumayer, Kenneth M. Boucher, Rachel E. Factor, Gajendra Shrestha, Mark L. Wade, John G. Lamb, Kylee Arbogast, Stephen Piccolo, Joanna Riegert et al. · 2017 · JCO Precision Oncology
  15. Hsp90 regulates HDAC3-dependent gene transcription while HDAC3 regulates the functions of Hsp90
    Akhil Kotwal, Sreedhar Amere Subbarao · 2020 · Cellular Signalling
  16. CG0006, a novel histone deacetylase inhibitor, induces breast cancer cell death via histone-acetylation and chaperone-disrupting pathways independent of ER status
    Tae Hyun Kim, Choung‐Soo Kim, Je‐Hwan Lee, Se Jin Jang, Jung Jin Hwang, Seonggu Ro, Young‐Lan Hyun, Jene Choi · 2010 · Breast Cancer Research and Treatment
  17. Histone Deacetylase Inhibitors in Combinations: Will the Preclinical Promises Be Kept?
    Susan Elaine Bates, Richard Piekarz · 2007 · The Cancer Journal
  18. Role of Additional Novel Therapies in Myeloproliferative Neoplasms
    Warren C. Fiskus, Siddhartha Ganguly, Suman Kambhampati, Kapil N. Bhalla · 2012 · Hematology/Oncology Clinics of North America
  19. Design, Synthesis, Bioactivity Evaluation, Crystal Structures, and In Silico Studies of New α-Amino Amide Derivatives as Potential Histone Deacetylase 6 Inhibitors
    Yangrong Xu, H. Tang, YiJie Xu, Jialin Guo, Xu Zhao, Qingguo Meng, Junhai Xiao · 2022 · Molecules
  20. Emerging alternatives to tyrosine kinase inhibitors for treating chronic myeloid leukemia
    Simon Kavanagh, Aisling Nee, Jeffrey Howard Lipton · 2018 · Expert Opinion on Emerging Drugs
  21. Histone deacetylase 6 expression in metastatic lymph nodes is a valuable prognostic marker for resected node-positive esophageal squamous cell cancer
    Xuan Xie, Kongjia Luo, Yi Li, Yihong Ling, Shuishen Zhang, Xiuying Xie, Jing Wen · 2018 · Cancer Management and Research
  22. Histone Deacetylase Inhibitors in Cancer Prevention and Therapy
    Shahrzad Movafagh, Amanda M. Munson · 2019 · Elsevier eBooks
  23. Improved Anticancer Activities of a New Pentafluorothio-Substituted Vorinostat-Type Histone Deacetylase Inhibitor
    Nils Goehringer, Yayi Peng, Bianca Nitzsche, Hannah Biermann, Rohan Pradhan, Rainer Schobert, Marco Herling, Michael Höpfner, Bernhard Biersack · 2021 · Pharmaceuticals
  24. Unconventional Approaches to Modulating the Immunogenicity of Tumor Cells
    Laurence A. Booth, Jane L. Roberts, John M. Kirkwood, Andrew Stewart Poklepovic, Paul Dent · 2018 · Advances in cancer research
  25. HDAC6 inhibition ameliorates sensory hypersensitivity and reduces immune cell signatures in the dorsal root ganglia in murine chronic pain models
    Ilinca M. Giosan, Randal A. Serafini, Aarthi Ramakrishnan, Madden J. Tuffy, Jeffrey H. Zimering, Alexandru Babeș, Li Shen, Venetia Zachariou · 2025 · Molecular Pharmacology
  26. Identification of a chaperone-code responsible for Rad51-mediated genome repair
    Khushboo Rani, Akanksha Gotmare, Andreas Maier, Ruchira Menghal, Nashat Akhtar, Nupur Fangaria, Johannes Büchner, Sunanda Bhattacharyya · 2024 · Journal of Biological Chemistry
  27. Developing histone deacetylase inhibitors in the therapeutic armamentarium of pancreatic adenocarcinoma
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  28. Epigenetic Modulation in Hematologic Malignancies: Challenges and Progress
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  29. The Emerging Role of Histone Deacetylases (HDACs) in UPR Regulation
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  30. Epigenetics of Prostate Cancer and the Prospect of Identification of Novel Drug Targets by RNAi Screening of Epigenetic Enzymes
    Mari L. Björkman, Juha Rantala, Matthias Nees, Olli Kallioniemi · 2010 · Epigenomics
  31. Differences in Functional Expression of Connexin43 and NaV1.5 by Pan- and Class-Selective Histone Deacetylase Inhibition in Heart
    Xian Zhang, Dakshesh Patel, Qin Xu, Richard D. Veenstra · 2018 · International Journal of Molecular Sciences
  32. Identification of a histone deacetylase inhibitor as a therapeutic candidate for congenital central hypoventilation syndrome
    Chiara Africano, Tiziana Bachetti, Paolo Uva, Gabriel Pitollat, Genny Del Zotto, Francesca Giacopelli, Giada Recchi, Nicolas Lenfant, Amélia Madani, Nathan Beckouche et al. · 2024 · Molecular Therapy — Nucleic Acids
  33. Chimeric tyrosine kinase-HDAC inhibitors as antiproliferative agents
    Andrea Uecker, Marit Sicker, Thomas L. Beckers, Siavosh Mahboobi, Daniel Hägerstrand, Arne Östman, Frank‐D. Böhmer · 2010 · Anti-Cancer Drugs
  34. Downregulation of androgen receptors by NaAsO2 via inhibition of AKT‐NF‐κB and HSP90 in castration resistant prostate cancer
    Yunlim Kim, Sang-Eun Park, Jeong‐Weon Moon, B.-M. Kim, Ha‐Gyeong Kim, In Gab Jeong, Sangjun Yoo, Jae Beom Ahn, Dalsan You, Jhang Ho Pak et al. · 2017 · The Prostate
  35. The Potential of Histone Deacetylase Inhibitors in Lung Cancer
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  36. Design, synthesis, and biological evaluation of aminopyrazine-based ATR/HDACs dual inhibitors
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  37. Antigenic Dark Matter: Unexplored Post-Translational Modifications of Tumor-Associated and Tumor-Specific Antigens in Pancreatic Cancer
    Amin Safa, Idris Vruzhaj, Marta Gambirasi, Giuseppe Toffoli · 2025 · Cancers
  38. Augmented Global Protein Acetylation Diminishes Cell Growth and Migration of Cholangiocarcinoma Cells
    Saowaluk Saisomboon, Ryusho Kariya, Panupong Mahalapbutr, Tonkla Insawang, Kanlayanee Sawanyawisuth, Ubon Cha’on, Thanyada Rungrotmongkol, Sopit Wongkham, Sarawut Jitrapakdee, Seiji Okada et al. · 2024 · International Journal of Molecular Sciences
  39. Pharmacoepigenetics of Histone Deacetylase Inhibitors in Cancer
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  40. Characterization of the MYB-inhibitory potential of the Pan-HDAC inhibitor LAQ824
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  41. MOF negatively regulates estrogen receptor α signaling via CUL4B-mediated protein degradation in breast cancer
    Xu Zhang, Yang Yang, Danyang Li, Zhen Wu, Haoyu Liu, Ziyan Zhao, Hongying Zhu, Fei Xie, Xiangzhi Li · 2022 · Frontiers in Oncology
  42. Machine Learning Approaches to Predict the Selectivity of Compounds against HDAC1 and HDAC6
    Berna Doğan · 2024 · Journal of Computational Biophysics and Chemistry
  43. Finding the place of histone deacetylase inhibitors in prostate cancer therapy
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  44. Exploiting Cancer Dependence on Molecular Chaperones
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  45. The Next Generation of Therapies for Chronic Myeloid Leukemia
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  46. Novel nuclear role of HDAC6 in prognosis and therapeutic target for colorectal cancer
    Daniel J. García-Domínguez, Lourdes Hontecillas‐Prieto, Maciej A. Kaliszczak, Miaomiao He, Miguel Ángel Burguillos, Rajaa El Bekay, Vahitha B. Abdul‐Salam, Combiz Khozoie, Khalid Shah, Kevin O’Neill et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  47. Targeting Oncogenic Activity and Signalling of Mutant Receptor Tyrosine Kinase FLT3
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  48. Design and Synthesis of c-Met and HDAC Dual Inhibitors for the Treatment of Breast Cancer
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  49. A Triple combination formulation of an HDAC inhibitor treats chronic pain in rodent spared nerve injury model
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  50. Cleavage of HSP90β induced by histone deacetylase inhibitor and proteasome inhibitor modulates cell growth and apoptosis
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  51. Sulfhydryl-Reactive Phytochemicals as Dual Activators of Transcription Factors NRF2 and HSF1
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  53. HSP90-specific inhibitor, PSY-2–12, ameliorates cellular senescence via activating autophagy: A potential senotherapeutic target against acute kidney injury
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  54. Flavonoid-Based Derivatives for Modulating Various Targets of Alzheimer’s Disease
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  55. In‐solution structure and oligomerization of human histone deacetylase 6 – an integrative approach
    Shivam Shukla, Jan Komárek, Zora Nováková, Jana Nedvědová, Kseniya Ustinova, Pavla Vaňková, Alan Kádek, Charlotte Uetrecht, Haydyn D. T. Mertens, Cyril Bařinka · 2022 · FEBS Journal
  56. Contribution of HSP90 Cleavage to the Cytotoxic Effect of Suberoylanilide Hydroxamic Acid In Vivo and the Involvement of TXNIP in HSP90 Cleavage
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  57. Design, synthesis, insilco study and biological evaluation of new isatin-sulfonamide derivatives by using mono amide linker as possible as histone deacetylase inhibitors
    Ammar Abdul Aziz Alibeg, Mohammed Hassan Mohammed · 2024 · Polski Merkuriusz Lekarski
  58. Targeting Mantle Cell Lymphoma with a Strategy of Combined Proteasome and Histone Deacetylase Inhibition
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  59. Effect of HDAC Inhibitors on Corneal Keratocyte Mechanical Phenotypes in 3-D Collagen Matrices.
    Vindhya Koppaka, Neema Lakshman, W. Matthew Petroll · 2015 · Europe PMC (PubMed Central)
  60. Hyperthermia and Pharmacological Intervention of Heat Shock Proteins in Anticancer Treatments
    Amere Subbarao Sreedhar · 2006 · Thermal Medicine(Japanese Journal of Hyperthermic Oncology)
  61. Histone Deacetylase Inhibitors in Multiple Myeloma
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  62. The Construction of ceRNA Regulatory Network Unraveled Prognostic Biomarkers and Repositioned Drug Candidates for the Management of Pancreatic Ductal Adenocarcinoma
    Büşra Aydın, Keziban Okutan, Ozge Onluturk Aydogan, Raghu Sinha, Beste Turanlı · 2025 · Current Issues in Molecular Biology
  63. The Dual Histone Deacetylase-Proteasome Inhibitor RTS-V5 Acts Synergistically With Ritonavir to Induce Endoplasmic Reticulum Stress in Bladder Cancer Cells
    Kazuki Okubo, Nina Reßing, Wolfgang A. Schulz, Finn Kristian Hansen, Takako Asano, Akinori Sato · 2021 · Anticancer Research
  64. HDAC inhibitor and proteasome inhibitor induce cleavage and exosome-mediated secretion of HSP90 in mouse pluripotent stem cells
    Jun-Kyu Choi, Sangkyu Park, Jeong-A Park, Ha-Eun Shin, Yeram Choi, Younghee Lee · 2022 · Biochemical and Biophysical Research Communications
  65. The Role of Histone Deacetylases in Neurodegenerative Diseases and Small-Molecule Inhibitors as a Potential Therapeutic Approach
    Roland W. Bürli, Elizabeth A. Thomas, Vahri Beaumont · 2010 · Topics in medicinal chemistry
  66. Current perspective of histone deacetylase inhibitors: A review
    Bhavini K Gharia, Jagatkumar Upadhyay, Bhanubhai N. Suhagia, Shailesh Amritlal Shah · 2018 · International Journal of Pharmaceutical Chemistry and Analysis
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    Berna Doğan · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
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  72. A comprehensive review on azole-based hydroxamic acid analogs as histone deacetylases (HDACs) inhibitors
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  73. Epigenetic Regulation of Myeloma Within Its Bone Marrow Microenvironment
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  74. The Molecular Biology of Kidney Cancer and Its Clinical Translation into Treatment Strategies
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  76. HDAC6-HSP90 pathway-mediated protein folding and degradation regulates tumor cell proliferation and metastasis
    Rui Tian, Xiaoyu Yan, Sihang Yu, Long Xu, Yuanxin Zhao, Liankun Sun, Jing Su · 2020 · Chinese Science Bulletin (Chinese Version)
  77. Clinical Applications of HDAC Inhibitors as Anticancer Agents in Prostate, Breast, Ovarian, and Cervical Cancers
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  78. HSP90 Inhibition as an Anticancer Strategy: Novel Approaches and Future Directions
    Marissa V. Powers, Paul Workman · 2009 · Springer eBooks
  79. HSP90 inhibitors: targeting the cancer chaperone for combinatorial blockade of oncogenic pathways
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  80. HDAC6 Regulation of Androgen Signaling in Prostate Cancer
    Junkui Ai, Zhou Wang · 2013 · Springer eBooks
  81. Extracellular HSP90 in Cancer Invasion and Metastasis: From Translational Research to Clinical Prospects
    Dimitra Thomaidou, Evangelia Patsavoudi · 2015 · Journal of Analytical Oncology
  82. The application of the improved 3D rat testicular cells co-culture model on thein vitrotoxicity research of HZ1006
    Xiaofang Zhang, Zhu Yuping, Yijun Tian, Han Yan, Lijun Ren, Wenjing Shi, Zhu Jiangbo, Tianbao Zhang · 2018 · Drug and Chemical Toxicology
  83. Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance
    Yun Dai, Steven Grant · 2011 · Humana Press eBooks
  84. ER Stress Signaling in Alzheimer's Disease
    M. M. Rahman, Looniva Shrestha, Mst Ara Gulshan · 2020 · Advances in medical diagnosis, treatment, and care (AMDTC) book series
  85. Activity of the histone deacetylase inhibitors LBH589 and LAQ824 in hematologic malignancies
    Kapil N. Bhalla · 2009 · Hematology Meeting Reports
  86. HDAC inhibitor research: still in its infancy.
    Serena Tsan-Lai Wong, Mark N. Stein · 2010 · PubMed
  87. New Therapies in Chronic Lymphocytic Leukemia
    John C. Byrd, Farrukh Tauseef Awan, Thomas S. Lin, Michael R. Grever · 2008 · CRC Press eBooks
  88. Drugging the Hsp90 molecular chaperone machine for cancer treatment
    Joanna L. Holmes, Swee Y. Sharp, Paul Workman · 2007 · Springer eBooks
  89. Phosphorylation of Histone Deacetylase 6 within its C-terminal Region by Extracellular Signal Regulated Kinase 1
    Kendra A. Williams · 2013 · Digital Commons - University of South Florida (University of South Florida)
  90. The Role of Heat Shock Protein 90 as a Therapeutic Target for Multiple Myeloma
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  91. The Impact of Molecularly Targeted Therapy in Multi-Modality Therapy
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  92. Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis
    Yishan Lee · 2008 · DukeSpace (Duke University)
  93. Targeting Ectopic Hsp90 in Breast Cancer
    Jared James Barrott · 2014
  94. Emerging Therapeutics for AML
    Edward A. Sausville · 2007 · Humana Press eBooks
  95. Targeting HER-2 Signaling Network: Implication in Radiation Response
    In Ah · 2011 · InTech eBooks
  96. Development and validation of a LC‐MS assay for the quantification of ikh12 a novel anti‐tumor candidate in rat plasma and tissues and its application in a pharmacokinetic study
    Dorleta Otaegui, Carme Masdeu, Eneko Aldaba, Yosu Vara, Aizpea Zubia, Eider San Sebastián, Maria Alcalá, Sergio Villafruela, Fernando Pedro Cossío, Alicia Rodríguez‐Gascón · 2015 · Biomedical Chromatography
  97. Combinations of Novel Histone Deacetylase and Bcr-Abl Inhibitors in the Therapy of Imatinib Mesylate-Sensitive and Refractory Bcr-Abl Expressing Leukemia
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  98. Potential of Heat Shock Protein Targeting for Human Therapy
    Laszlo Jr Otvos · 2011
  99. Histone Deacetylase Inhibitors: A Brief Overview Of Their Role And Medicinal Chemistry
    Patrick R. Angibaud, Kristof Van Emelen, Janine Arts · 2010 · Wiley eBooks
  100. Recovery of Genes Epigenetically Altered by the Histone Deacetylase Inhibitor Scriptaid and Demethylating Agent 5-Azacytidine in Human Leukemia Cells
    Eunkyung Park, Eun Hyung Jeon, In-Ho Kim, Seonyang Park · 2010 · Genomics & Informatics