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BRI2 homodimerizes with the involvement of intermolecular disulfide bonds

Tsachaki, M., Ghiso, J. A., Rostagno, A. A., & Efthimiopoulos, S. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.004 · Cited by 20 · see citing works

Expression and regulation of type II integral membrane protein family members in mouse male reproductive tissues

Rengaraj, D., Gao, F., Liang, X., & Yang, Z. (2007) · Endocrine · doi:10.1007/s12020-007-0027-6 · Cited by 20 · see citing works

Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10

Tsachaki, M., Serlidaki, D., Fetani, A., Zarkou, V., Rozani, I., Ghiso, J. A., & Efthimiopoulos, S. (2011) · Glycobiology · doi:10.1093/glycob/cwr097 · Cited by 20 · see citing works

BRI2 Interacts with BACE1 and Regulates Its Cellular Levels by Promoting its Degradation and Reducing Its mRNA Levels

Tsachaki, M., Fotinopoulou, A., Slavi, N., Zarkou, V., Ghiso, J. A., & Efthimiopoulos, S. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310050009 · Cited by 20 · see citing works

Anti-amyloidogenic property of human gastrokine 1

Altieri, F., Stadio, C. S. D., Severino, V., Sandomenico, A., Minopoli, G., Miselli, G., Maro, A. D., Ruvo, M., Chambery, A., Quagliariello, V., et al. (2014) · Biochimie · doi:10.1016/j.biochi.2014.08.004 · Cited by 19 · see citing works

The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases

Baron, B. W., Baron, R. M., & Baron, J. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.12.018 · Cited by 19 · see citing works

Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia

Marcora, M. S., Fernández-Gamba, A. C., Avendaño, L. A., Rotondaro, C., Podhajcer, O. L., Vidal, R., Morelli, L., Ceriani, M. F., & Castaño, E. M. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-5 · Cited by 19 · see citing works

Trem2 Splicing and Expression are Preserved in a Human Aβ-producing, Rat Knock-in Model of Trem2-R47H Alzheimer’s Risk Variant

Tambini, M. D., & D'adamio, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-60800-1 · Cited by 15 · see citing works

BRI2 and BRI3 are functionally distinct phosphoproteins

Martins, F., Rebelo, S., Santos, M., Cotrim, C. Z., Silva, E. F. D. C. E., & Silva, O. A. B. D. C. E. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.10.012 · Cited by 16 · see citing works

Endogenous Human Proteins Interfering with Amyloid Formation

Gharibyan, A. L., Jayaweera, S. W., Lehmann, M., Anan, I., & Olofsson, A. (2022) · Biomolecules · doi:10.3390/biom12030446 · Cited by 17 · see citing works

Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory

Biundo, F., Ishiwari, K., Del Prete, D., & D’Adamio, L. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.10.009 · Cited by 13 · see citing works

Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Aβ by insulin degrading enzyme (IDE) in Alzheimer’s disease

Campo, M. D., Stargardt, A., Veerhuis, R., Reits, E. A., & Teunissen, C. E. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.01.036 · Cited by 16 · see citing works

A familial Danish dementia rat shows impaired presynaptic and postsynaptic glutamatergic transmission

Yin, T., Yao, W., Norris, K. A., & D’Adamio, L. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101089 · Cited by 14 · see citing works

BRI2 as an anti-Alzheimer gene

Matsuda, S., & Senda, T. (2018) · Medical Molecular Morphology · doi:10.1007/s00795-018-0191-1 · Cited by 13 · see citing works

Identification and characterization of the BRI2 interactome in the brain

Martins, F., Marafona, A. M., Pereira, C. D., Müller, T., Looße, C., Kolbe, K., Silva, O. A. B. D. C. E., & Rebelo, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-21453-3 · Cited by 15 · see citing works

The presubiculum is preserved from neurodegenerative changes in Alzheimer’s disease

Murray, C. E., Gami‐Patel, P., Gkanatsiou, E., Brinkmalm, G., Portelius, E., Wirths, O., Heywood, W., Blennow, K., Ghiso, J. A., Holton, J. L., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0563-8 · Cited by 15 · see citing works

First identification of ITM2B interactome in the human retina

Wohlschlegel, J., Argentini, M., Michiels, C., Letellier, C., Forster, V., Condroyer, C., He, Z., Thuret, G., Zeitz, C., Léger, T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-96571-6 · Cited by 13 · see citing works

BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cells

Campo, M. D., Oliveira, C. R., Scheper, W., Zwart, R., Korth, C., Müller‐Schiffmann, A., Kostallas, G., Biverstål, H., Presto, J., Johansson, J., et al. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1769-y · Cited by 12 · see citing works

Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease

Maccioni, R., Travisan, C., Badman, J., Zerial, S., Wagener, A., Andrade‐Talavera, Y., Picciau, F., Grassi, C., Chen, G., Lemoine, L., et al. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102585 · Cited by 11 · see citing works

Deciphering the Morphological Difference of Amyloid-β Fibrils in Familial and Sporadic Alzheimer’s Diseases

Huang, G., Song, Z., Xu, Y., Sun, Y., & Ding, F. (2024) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c01471 · Cited by 11 · see citing works

Isobaric Tag‐Based Protein Profiling of a Nicotine‐Treated Alpha7 Nicotinic Receptor‐Null Human Haploid Cell Line

Paulo, J. A., & Gygi, S. P. (2018) · PROTEOMICS · doi:10.1002/pmic.201700475 · Cited by 10 · see citing works

Amyloid and intracellular accumulation of BRI2

Garringer, H. J., Sammeta, N., Oblak, A. L., Ghetti, B. F., & Vidal, R. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.12.018 · Cited by 11 · see citing works

Role of human GKN1 on APP processing in gastric cancer

Stadio, C. S. D., Altieri, F., Minopoli, G., Miselli, G., Rippa, E., & Arcari, P. (2017) · Biochimie · doi:10.1016/j.biochi.2017.02.007 · Cited by 9 · see citing works

Analyses Mutations in GSN, CST3, TTR, and ITM2B Genes in Chinese Patients With Alzheimer’s Disease

Jiang, Y., Jiao, B., Liao, X., Xiao, X., Liu, X., & Shen, L. H. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.581524 · Cited by 9 · see citing works

Proteomic Characterization of a Mouse Model of Familial Danish Dementia

Vitale, M., Renzone, G., Matsuda, S., Scaloni, A., D'adamio, L., & Zambrano, N. (2012) · BioMed Research International · doi:10.1155/2012/728178 · Cited by 8 · see citing works

Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia

Arber, C., Casey, J. M., Crawford, S., Rambarack, N., Yaman, Ü., Wiethoff, S., Augustin, E., Piers, T. M., Price, M., Rostagno, A. A., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02820-z · Cited by 8 · see citing works

Identification of cytoskeletal proteins as binding partners of Bri2 BRICHOS domain

Shimozawa, M., Tigro, H., Biverstål, H., Shevchenko, G., Bergquist, J., Moaddel, R., Johansson, J., & Nilsson, P. (2023) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103843 · Cited by 7 · see citing works

Differential expression and regulation of integral membrane protein 2b in rat male reproductive tissues

Rengaraj, D., Liang, X., Gao, F., Deng, W., Mills, N., & Yang, Z. (2008) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2008.00360.x · Cited by 7 · see citing works

Lessons from a Rare Familial Dementia: Amyloid and Beyond

Cantlon, A., Frigerio, C. S., & Walsh, D. M. (2015) · Journal of Parkinson’s Disease and Alzheimer’s Disease · doi:10.13188/2376-922x.1000009 · Cited by 7 · see citing works

Deconvolution of the MBP-Bri2 Interaction by a Yeast Two Hybrid System and Synergy of the AlphaFold2 and High Ambiguity Driven Protein-Protein Docking

Smirnova, E. V., Rakitina, T. V., Saratov, G. A., Kudriaeva, A. A., & Belogurov, A. A. (2022) · Crystals · doi:10.3390/cryst12020197 · Cited by 6 · see citing works

Structural and Regulatory Elements of the Interaction between Amyloid-β Protein Precursor and Homer3

Kyratzi, E., Liakos, A., Papadogiannaki, G., & Efthimiopoulos, S. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141992 · Cited by 6 · see citing works

DEEP PHENOTYPING AND FURTHER INSIGHTS INTO ITM2B-RELATED RETINAL DYSTROPHY

Nassisi, M., Wohlschlegel, J., Liu, B., Letellier, C., Michiels, C., Aubois, A., Mohand‐Saïd, S., Habas, C., Sahel, J., Zeitz, C., et al. (2020) · Retina · doi:10.1097/iae.0000000000002953 · Cited by 5 · see citing works

SecretePipe: A Screening Pipeline for Secreted Proteins with Competence to Identify Potential Membrane-Bound Shed Markers

Tien, W.-S., Chen, Y.-T., & Wu, K. (2013) · Journal of Proteome Research · doi:10.1021/pr3009012 · Cited by 4 · see citing works

Caenorhabditis elegans BRICHOS Domain–Containing Protein C09F5.1 Maintains Thermotolerance and Decreases Cytotoxicity of Aβ42 by Activating the UPR

Song, M., Song, K., Kim, S., Lee, J.-Y., Hwang, S., & Han, C. (2018) · Genes · doi:10.3390/genes9030160 · Cited by 4 · see citing works

Identification of glycolytic proteins as binding partners of Bri2 BRICHOS domain

Tigro, H., Shimozawa, M., Nilsson, P., Lyashkov, A. E., Khadeer, M., Järving, I., Ferrucci, L., Shimmo, R., Johansson, J., & Moaddel, R. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115465 · Cited by 3 · see citing works

Assessing Co‐Localization of ITM2B With Alzheimer's Disease and Limbic‐Predominant Age‐Related TDP ‐43 Encephalopathy Neuropathologic Changes

Shahidehpour, R. K., Nelson, P. T., Srinivasan, S., Zhong, Y., & Bachstetter, A. D. (2025) · Neuropathology · doi:10.1111/neup.70003 · Cited by 2 · see citing works

Insights into the intramembrane protease SPPL2b and its substrates: Functions and disease implications

Badman, J., Parracino, A., Kumar, R., & Tambaro, S. (2025) · Science Signaling · doi:10.1126/scisignal.adt2272 · Cited by 3 · see citing works

Review of the evidence on the influence of Wi-Fi 2.4 GHz radiation on oxidative stress and its possible relationship with Alzheimer’s disease

Quiroz, D. A. L., Argüelles, N., Lluncor, A., Huaman, D. C., Moyano, J., Ubillus, J., Calero, M. M. P., Paredes, M., Hernández, I., Guerra, A., et al. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1616435 · Cited by 1 · see citing works

Myelin Basic Protein Attenuates Furin-Mediated Bri2 Cleavage and Postpones Its Membrane Trafficking

Smirnova, E. V., Timofeev, V. I., Rakitina, T. V., Petrenko, D. E., Elmeeva, O. S., Saratov, G. A., Kudriaeva, A. A., Bocharov, E. V., & Belogurov, A. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052608 · Cited by 1 · see citing works

Human Gastrokine 1 and its anti-amyloidogenic properties

Arcari, P. (2017) · Journal of Neurology and Neuromedicine · doi:10.29245/2572.942x/2017/6.1132 · Cited by 1 · see citing works

O2–03–06: BRI2 modulates amyloid precursor protein processing and inhibits aβ generation

Tsachaki, M., Fotinopoulou, A., Vlavaki, M., Poulopoulos, A., Rostagno, A. A., Frangione, B., Ghiso, J. A., & Efthimiopoulos, S. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.125

The Familial Dementia BRI2 Gene Binds the Alzheimer Gene Amyloid-β Precursor Protein and Inhibits Amyloid-β Production

Matsuda, S., Giliberto, L., Matsuda, Y., Davies, P., McGowan, E., Pickford, F., Ghiso, J., Frangione, B., & D'Adamio, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500217200 · Cited by 141 · see citing works

BRI2 Inhibits Amyloid β-Peptide Precursor Protein Processing by Interfering with the Docking of Secretases to the Substrate

Matsuda, S., Giliberto, L., Matsuda, Y., McGowan, E. M., & D'adamio, L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2094-08.2008 · Cited by 95 · see citing works

O1–02–04: Regulation of APP processing by the familial dementia gene BRI2

D'adamio, L., Matsuda, S., Matsuda, Y., & Giliberto, L. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.256

The extracellular domain of Bri2 (ITM2B) binds the ABri peptide (1–23) and amyloid β-peptide (Aβ1–40): Implications for Bri2 effects on processing of amyloid precursor protein and Aβ aggregation

Peng, S., Landreh, M., Jörnvall, H., & Johansson, J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.122 · Cited by 53 · see citing works