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Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.
Open accessAbstract
HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human hereditary hemochromatosis. Here we demonstrate that HFE and TFR2 interact in cells, that this interaction is not abrogated by disease-associated mutations of HFE and TFR2, and that TFR2 competes with TFR1 for binding to HFE. We propose a new model for the mechanism of iron status sensing that results in the regulation of iron homeostasis.
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“Taking this into account, we have proposed a model in which TFR2 escorts HFE away from TFR1 when the serum iron level (reflected in the transferrin saturation) is elevated.149,150”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [150]
In the citing paper
“Like TFR1, TFR2 interacts with HFE to form a stable protein complex.150”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [150]
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“There was no difference in TFR2 expression between young and old animals (Fig.”
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“high-Fe or haemochromatosis protein, haemojuvelin (HFE2) and transferrin receptor 2((2,3)).”
BackgroundBuretić‐Tomljanović, A., Vlastelić, I., Badovinac, A. R., Čizmarević, N. S., Nadalin, S., & Ristič, S. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.02.129 · Cited by 16
“Hepcidin, a main regulator of whole-body iron homeostasis, is induced by HFE protein, which represents a part of the systemic iron sensor (20).”
Importance of Iron Absorption in Human Health: An Overview
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“The mechanism potentially involved in such regulation is a decrease of the physical interaction between TFR1 and HFE proteins when transferrin saturation increases [31].”
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“Recently, however, it has been proposed that HFE plays its most important role in iron sensing in the liver by conveying the whole-body iron status, reflected by diferric transferrin from the HFE–TfR1 complex to TfR2, resulting in potential signalling of downstream events [5].”
BackgroundHereditary Hemochromatosis (HFE) genotypes in heart failure: Relation to etiology and prognosis
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“New insights into the function of the HFE protein suggests an iron sensing function, as well as a hepcidin regulating function[20] and subsequently a pivotal role in iron homeostasis.”
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“The presence/absence of WT-, H63D-, and C282Y-HFE in lipid rafts was ascertained because HFE was shown to associate with TfR2, a lipid raft component.”
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Lack of Hfe and TfR2 in Macrophages Impairs Iron Metabolism in the Spleen and the Bone Marrow
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“According to the most recent functional model, Hfe alternatively binds transferrin receptors 1 and 2 (TfR1 and TfR2, respectively) in its extracellular α 1-α 2 domain and is required for the physiological regulation of hepatic synthesis of Hepc [14].”
BackgroundAn Update on Iron Homeostasis: Make New Friends, but Keep the Old
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Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells
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[Progress on epigenetic regulation of iron homeostasis].
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“keltischer Abstammung liegt bei etwa 90% der Patienten mit Hämochromatose eine homozygote Punktmutation (C282Y) im HFE-Gen vor [2, 8, 17].”
Dostalikova‐Cimburova, M., Krátká, K., Balušíková, K., Chmelíková, J., Hejda, V., Hnaníček, J., Neubauerová, J., Vránová, J., Kovár̆, J., & Horák, J. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01458.x · Cited by 9
“The HFE/TFR2 complex is thought to serve as a body iron sensor, which regulates hepcidin expression [9].”
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Buretić‐Tomljanović, A., Vraneković, J., Rubeša, G., Jonovska, S., Tomljanović, D., Jengić, V. Š., Kapović, M., & Ristič, S. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-0974-0 · Cited by 9
“Mutations in the HFE generally affect the ability of the protein to prevent TF from binding its receptors, thereby increasing cellular iron uptake [3].”
Porto, G., Cruz, E., Teles, M. J., & de Sousa, M. A. B. (2019) · Pharmaceuticals · doi:10.3390/ph12030122 · Cited by 8
“sensing and hepcidin signaling [43], thus contributing to the prevention of inappropriate iron accumulation.”
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Hoda, K., Bowlus, C. L., Chu, T. W., & Gruen, J. R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00106-3 · Cited by 8
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In vitro binding of HFE to the cation-independent mannose-6 phosphate receptor
Schimanski, L. M., Drakesmith, H., Sweetland, E., Bastin, J. M., Rezgui, D., Edelmann, M. J., Kessler, B. M., Merryweather‐Clarke, A. T., Robson, K., & Townsend, A. (2009) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2009.03.010 · Cited by 8
Actualités du métabolisme du fer
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Hepcidin Regulation by Bone Morphogenetic Protein Signaling and Iron Homeostasis
Rodova, M., & Kim, S. (2016) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000521 · Cited by 7
“[43], demonstrated that HFE binds both transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2) [44] on the cell membrane.”
BackgroundTransferrin receptor 2 is emerging as a major player in the control of iron metabolism
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“HFE interacts with transferrin receptor 2 (TfR2) (Griffiths and Cox, 2003; Goswami and Andrews, 2006) expressed in a smaller number of cells than TfR1 (Vogt et al. , 2003).”
InfluentialHepcidin production in response to iron is controlled by monocyte-derived humoral factors
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Hereditäre Hämochromatose, Alpha-1-Antitrypsin-Mangel und Morbus Wilson
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Plasma Iron and Iron Delivery to the Tissues
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“Also, HFE maintains its interaction with TFR2 which contains mutations leading to TFR2-associated hemochromatosis in vivo [ 119 ] .”
BackgroundPhysiopathologie et génétique de l'hémochromatose HFE de type 1
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A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression
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Métabolisme du fer : physiologie et pathologie
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“…transferrin stabilises TFR2 (Johnson & Enns, 2004) and, by displacing of HFE from binding to transferrin receptor 1, makes HFE available to interact with the BMP receptor complex (Goswami & Andrews, 2006), allowing hepcidin synthesis to be sensitive to circulating transferrin saturation.”
BackgroundLiu, S., Tsyplenkova, S., Charlebois, E., Wallace, D. F., Subramaniam, V. N., Fillebeen, C., & Pantopoulos, K. (2026) · Blood · doi:10.1182/blood.2025030054 · Cited by 4
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“Though the precise mechanisms of action of HFE are still not well understood, its role in regulating monocytemacrophage iron content is well established; overall, HFE C282Y homozygosity results in systemic intracellular iron loading of cells other than macrophage-monocytes, due to a combination of unregulated gut iron…”
BackgroundIron Metabolism and Related Disorders
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“Additional investigations indicate that hepatic hepcidin expression also depends on the HFE/TfR2 interaction (38, 39), the HFE/ALK3 interaction (40), the NEO1/ALK3 interaction (30, 41), and the formation of HFE/TfR2/HJV complex (42).”
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“Hemojuvelin [12, 13], involved in signal communication upon binding of the Bmp ligands, and whose interaction leads to the activation of hepcidin transcription [14–16].”
BackgroundMolecular Regulation of Systemic Iron Metabolism
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Hong, Y., Xu, Z., Zheng, Y., Liu, J., Huang, Z., Chen, J.-S., Zhang, Y., & Liu, B. (2023) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2023.3705 · Cited by 1
Management of Renal Anemia in Children with Chronic Kidney Disease
Yorgin, P. D., & Zaritsky, J. J. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0721-8_27 · Cited by 1
Classical and atypical HFE hemochromatosis
Barton, J. C., Edwards, C. Q., Phatak, P. D., Britton, R. S., & Bacon, B. R. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777035.010 · Cited by 1
Sox2 function as a negative regulator to control HAMP expression
Song, B., Bian, Q., Shao, C., Liu, A.-A., Jing, W., Liu, R., Zhang, Y., Zhou, Y., Li, G., & Jin, G. (2015) · Biological Research · doi:10.1186/s40659-015-0013-z · Cited by 1
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Pietrangelo, A., & Torbenson, M. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-7020-8228-3.00004-1 · Cited by 1
Santrampurwala, N. (2016) · The University of Queensland · doi:10.14264/uql.2016.365 · Cited by 1
Molecular coordination of iron homeostasis by microRNA
Davis, M. (2013) · SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University) · Cited by 1
Genetic Markers, Birth Characteristics, and Childhood Leukemia Risk
Kennedy, A. E. (2013) · doi:10.25148/etd.fi13120601
Mousavi, S. A., Mahmood, F. A., Aandahl, A., Knutsen, T. R., & Llohn, A. H. (2015) · BioMed Research International · doi:10.1155/2015/241784
“Some authors have proposed that increased transferrin saturation leads to dissociation of HFE protein from TfR1 which subsequently forms a complex with TfR2, which in turn upregulates hepatic hepcidin expression [25].”
BackgroundIlkovska, B., Trifunova, B. K., & Трифунов, Г. (2015) · Macedonian Medical Electronic Journal · doi:10.3889/mmej.2015.50010
“Иако точните молекуларни механизми се уште не се целосно разjaснети, овoj коскен морфогенетски протеински (BMP) рецепторен – комплекс, се поврзува со трансферински рецептори 1 и 2, најверојатно поврзувајќи ја чувствителноста за серумското железо со синтезата на хепцидин [97, 98].”
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Regulation of hepcidin and iron homeostasis: progress and prospects
Barrios, M. F., Delgado, N. F., & Hernández-Ramírez, P. (2012) · Revista cubana de hematología, inmunología y hemoterapia
Metadata
- Authors
- Goswami, T., & Andrews, N. C.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Andrews, Nancy C.
- ORCID
- Andrews, Nancy C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 281
- Issue
- 39
- Pages
- 28494-28498
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1983970155
- Cited by
- 352
- References
- 20
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 4 · 2021: 15 · 2020: 13 · 2019: 12 · 2018: 12 · 2017: 18 · 2016: 16 · 2015: 16 · 2014: 18 · 2013: 31 · 2012: 17
- FWCI
- 19.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK53813, R01DK053813)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- hereditary hemochromatosis, HFE gene, transferrin receptor 2, transferrin receptor 1, protein-protein interaction, iron homeostasis, iron sensing, disease-associated mutations
- MeSH terms
- Hemochromatosis Protein, Animals, Hemochromatosis, Homeostasis, Humans, Iron, Membrane Proteins, Models, Biological, Mutation, Receptors, Transferrin, Histocompatibility Antigens Class I, Antigens, CD, Mice
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