The DOI matches its Crossref record; 19 of the 20 references it cites were found in a registry or an index.
Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.
Open accessAbstract
HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human hereditary hemochromatosis. Here we demonstrate that HFE and TFR2 interact in cells, that this interaction is not abrogated by disease-associated mutations of HFE and TFR2, and that TFR2 competes with TFR1 for binding to HFE. We propose a new model for the mechanism of iron status sensing that results in the regulation of iron homeostasis.
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“Taking this into account, we have proposed a model in which TFR2 escorts HFE away from TFR1 when the serum iron level (reflected in the transferrin saturation) is elevated.149,150”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [150]
In the citing paper
“Like TFR1, TFR2 interacts with HFE to form a stable protein complex.150”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [150]
Citations
Cites
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Cited by
Sorted by citations
Two to tango: Regulation of Mammalian iron metabolism
Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120
Ganz, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00008.2013 · Cited by 1,122
Muckenthaler, M. U., Galy, B., & Hentze, M. W. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155521 · Cited by 701
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“HFE can bind to both TfR2 and to the classic transferrin receptor TfR1.(23,30) In addition, both HFE and TfR2 may interact with HJV, suggesting that a complex of HFE and TfR2 may play a regulatory role in BMP6 signaling.”
Transferrin and transferrin receptors update
Kawabata, H. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.037 · Cited by 719
Metadata
- Authors
- Goswami, T., & Andrews, N. C.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Andrews, Nancy C.
- ORCID
- Andrews, Nancy C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 281
- Issue
- 39
- Pages
- 28494-28498
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1983970155
- Cited by
- 352
- References
- 20
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 4 · 2021: 15 · 2020: 13 · 2019: 12 · 2018: 12 · 2017: 18 · 2016: 16 · 2015: 16 · 2014: 18 · 2013: 31 · 2012: 17
- FWCI
- 19.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK53813, R01DK053813)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- hereditary hemochromatosis, HFE gene, transferrin receptor 2, transferrin receptor 1, protein-protein interaction, iron homeostasis, iron sensing, disease-associated mutations
- MeSH terms
- Hemochromatosis Protein, Animals, Hemochromatosis, Homeostasis, Humans, Iron, Membrane Proteins, Models, Biological, Mutation, Receptors, Transferrin, Histocompatibility Antigens Class I, Antigens, CD, Mice
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